Gene

KWMTBOMO07196

Pre Gene Modal

BGIBMGA010384

Annotation

PREDICTED:_decapentaplegic_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr12(-):7734437-7737476      View in EpiBrowser

Full name

Protein decapentaplegic      

Location in the cell

Mitochondrial   Reliability : 1.555 Nuclear   Reliability : 1.46

CDS

ATGCGTGGGGCGTGCGCATGCGCGGTGGTGTGCGCGTTGGTGGCGCTGTGCGCAGCCGCGGGCCTCGACGAAGCGACGCGTGTTGCTGCAGAGAAGCAGTTATTGGCGTTGTTGGGTCTGCCGAAGAGACCGTCGCGTCGATCCGCTCCAGTACCGCCTATACCACGCGCCATGCGAATGCTTTACGAGGCAAGCGGAGCCATACCGGCCGCTGCGGCAAACACGGCCCGTTCATATCAGCACGTACCGACGGAGCTCGATGCGAGGTTCCCAGGCGAACATCGTTTTCGCCTATTCTTCAACCTAAGTGGAGTACCCTCTGATGAAGTAGCTCGTGGTGCTGATCTCAAATTTCATCGCGCGACTGAAGAGACGGGTCCTCAGCGCCTATTACTATATGACGTTGTACGTCCTGGTCGTCGAGGGAAAACGACTCCAATTCTAAGACTTCTCGATTCCGTGACATTATTGCCAGGCGAGGGCACAGTGACAGCAGACGCCATTGACGCAGTGCGACGGTGGCTCCTTGAAACTGATCAAAACCATGGACTATTAGTGCGTGTTATTGAAGAAGGCCAACACAACGTTGATGCAAAACGGCCACACGTAAGAGTTCGAAGACGAGCGACCGAAGACGAAGAAGAATGGCGCTCTCAGCAACCCTTGCTGTTGCTGTACACTGAAGATGCGCGAGCCAGAGAAGCACGCGAGAATGGGGAGTCGCGTCTAACTCGAAATAAAAGAGCAACACAACGGCGTGGTCATCGACCTCACCACCGTCGTAAAGAAGCTCGTGAAATCTGCCAGCGGCGGCCACTGTTTGTCGACTTCGCGGAAGTCGGCTGGAGCGACTGGATTGTCGCGCCTCCTGGTTACGAAGCTTATTTCTGTCAGGGTGACTGCCCGTTCCCGCTCGCAGATCATCTAAATGGCACTAATCACGCAATAGTGCAAACTTTAGTGAATTCAGTGGACCCAGCCTTAGTGCCTAAAGCGTGTTGTATACCAACACAACTATCGCCTATTTCTATGTTATATATGGACGAACATAATCAAGTGGTGCTTAAAAACTATCAGGATATGATGGTGATGGGTTGCGGTTGCCGATGA

Protein

MRGACACAVVCALVALCAAAGLDEATRVAAEKQLLALLGLPKRPSRRSAPVPPIPRAMRMLYEASGAIPAAAANTARSYQHVPTELDARFPGEHRFRLFFNLSGVPSDEVARGADLKFHRATEETGPQRLLLYDVVRPGRRGKTTPILRLLDSVTLLPGEGTVTADAIDAVRRWLLETDQNHGLLVRVIEEGQHNVDAKRPHVRVRRRATEDEEEWRSQQPLLLLYTEDARAREARENGESRLTRNKRATQRRGHRPHHRRKEAREICQRRPLFVDFAEVGWSDWIVAPPGYEAYFCQGDCPFPLADHLNGTNHAIVQTLVNSVDPALVPKACCIPTQLSPISMLYMDEHNQVVLKNYQDMMVMGCGCR

Description

Required during oogenesis for eggshell patterning and dorsal/ventral patterning of the embryo. Acts as a morphogen during embryogenesis to pattern the dorsal/ventral axis, specifying dorsal ectoderm and amnioserosa cell fate within the dorsal half of the embryo; this activity is antagonized by binding to sog and tsg. Induces the formation of visceral mesoderm and the heart in early embryos. Required later in embryogenesis for dorsal closure and patterning of the hindgut. Also functions postembryonically as a long-range morphogen during imaginal disk development; is responsible for the progression of the morphogenetic furrow during eye development. Patterns the wing imaginal disk along its anterior/posterior axis and has a role in positioning pro-veins. Also required to subdivide the wing disk along the proximal/distal axis into body wall (notum) and wing. Ensures the correct architecture of wing epithelial cells. Has multiple roles in the developing tracheal system, controlling directed tracheal cell migration during embryogenesis and later specifying the fate of fusion cells in the tracheal branches. Required for viability of larvae. Essential for the maintenance and division of germline stem cells in the ovary. Signals via the type I receptor tkv, the type II receptor punt, and in some tissues via the type I receptor sax, in a signaling cascade that leads to activation and repression of target genes.
Acts as an extracellular morphogen to establish at least two cellular response thresholds within the dorsal half of the drosophila embryo. Required for the proper development of the embryonic dorsal hypoderm, for viability of larvae and for cell viability of the epithelial cells in the imaginal disks. Acts together with scw (By similarity).

Subunit

Heterodimers of scw/dpp are the active subunit, dpp/dpp homodimers elicit a basal response and scw/scw homodimers alone are ineffective in specifying a dorsal pattern. Component of a complex composed of dpp, sog and tsg.
Heterodimers of scw/dpp are the active subunit, dpp/dpp homodimers elicit a basal response and scw/scw homodimers alone are ineffective in specifying a dorsal pattern.

Similarity

Belongs to the TGF-beta family.

Keywords

Complete proteome   Developmental protein   Differentiation   Direct protein sequencing   Disulfide bond   Glycoprotein   Growth factor   Polymorphism   Reference proteome   Secreted   Signal  

Feature

chain  Protein decapentaplegic

Uniprot

H9JLI3   A0A0F7IQS1   B8YPW1   A0A194PHI0   A0A2A4JRC3   A0A212FL92   + More
A0A2H1WNA7   A0A194R100   E3UKJ8   A0A1B0DI00   A0A1B0CNU7   A0A1L8DL37   A0A1L8DLA2   A0A1L8DJC3   A0A2A4JR18   A0A1B6MG22   A0A1S4F007   A0A1J1IM20   Q17JZ3   A0A182GD36   Q75WK6   A0A1S4JCR2   B0WCI2   A0A182NTL6   A0A2J7Q4Z8   A0A182J5G4   A0A182XZW8   A0A182K0K3   A0A182QNM0   Q7Q3Q7   A0A0C9RHG2   A0A182P4R0   A0A2P8YVQ1   A0A336LZP6   A0A182L1W9   A0A182RFJ7   A0A182TTR3   A0A182F1K1   W5JTS3   A0A1B6DZH3   A0A182UWV4   A0A182HV19   A0A182WT22   A0A1S4GXL4   A0A151XAT1   E2B9W4   A0A151J8N4   A0A195BSU4   A0A158P1S4   I3WD96   W8BL12   A0A0K8WG48   F4W6N8   E2AGL6   A0A2M4CGV9   A0A195ERI5   A0A182W7F5   A0A0K8U826   A0A3L8DG15   A0A026W2E0   A0A034VC06   A0A195CMC5   A0A1Y1LN98   A0A0A1X980   A0A0L0C8W2   A0A154P4L3   K7IMN3   A0A140AX77   A0A0L7R784   V9IGS0   A0A140AX76   A0A1W4WXB0   A0A1I8P6N3   T1PJE3   A0A1S3DKS8   A0A1B0REL8   T1H8Q4   A0A224XSA9   A0A1I8MHF7   A0A290Y240   A0A0N0BCB8   B4MU02   A0A023F2N8   B4KGU4   B4Q848   A0A182LWX6   A0A0M3QT42   B3NA13   P07713   P91706   Q1WKY7   Q1WKY8   B4NWQ1   Q1WKY6   A0A0Q5W8W8   A0A088AJM8   A0A0R1DRG4   A0A067YM92   D0QWH2  

Pubmed

19121390    26354079    22118469    17510324    26483478    14872342    + More
25244985    12364791    15302159    14747013    17210077    29403074    20966253    20920257    23761445    20798317    21347285    24495485    21719571    30249741    24508170    25348373    28004739    25830018    26108605    20075255    26881804    25315136    17994087    25474469    18057021    3467201    9071586    10731132    12537572    12618399    1692958    3123323    8252627    7720583    7700357    9226445    9695953    9636086    10495279    11136981    11136982    10903186    11432817    11231061    11260716    12135920    15797386    15867930    9071585    16387879    17550304    24886828    19859648   

EMBL

BABH01005698    KP861420    AKG96797.1    FJ572058    ACL97675.1    KQ459603    + More
KPI92772.1    NWSH01000781    PCG74258.1    AGBW02007871    OWR54459.1    ODYU01009769    SOQ54422.1    KQ460883    KPJ11189.1    HM449872    ADO33007.1    AJVK01006118    AJWK01020933    GFDF01006908    JAV07176.1    GFDF01006862    JAV07222.1    GFDF01007617    JAV06467.1    PCG74259.1    GEBQ01005121    JAT34856.1    CVRI01000055    CRL01208.1    CH477229    EAT47007.1    JXUM01055189    JXUM01055190    JXUM01055191    KQ561855    KXJ77311.1    AB121072    BAD08319.1    DS231888    EDS43553.1    NEVH01018372    PNF23658.1    AXCN02000795    AY578800    AAAB01008964    AAT07305.1    EAA12482.2    GBYB01012642    JAG82409.1    PYGN01000334    PSN48329.1    UFQT01000238    SSX22219.1    ADMH02000511    ETN66149.1    GEDC01006216    GEDC01005432    JAS31082.1    JAS31866.1    APCN01002490    KQ982335    KYQ57449.1    GL446605    EFN87551.1    KQ979492    KYN21220.1    KQ976419    KYM89365.1    ADTU01006778    ADTU01006779    JX021498    AFL02791.1    GAMC01008877    JAB97678.1    GDHF01002499    JAI49815.1    GL887707    EGI70114.1    GL439322    EFN67436.1    GGFL01000366    MBW64544.1    KQ982021    KYN30489.1    GDHF01029591    JAI22723.1    QOIP01000008    RLU19395.1    KK107536    EZA49199.1    GAKP01019652    JAC39300.1    KQ977595    KYN01622.1    GEZM01052697    GEZM01052695    JAV74318.1    GBXI01015540    GBXI01006488    JAC98751.1    JAD07804.1    JRES01000753    KNC28677.1    KQ434816    KZC06856.1    KT750953    ALG65084.1    KQ414642    KOC66742.1    JR046821    AEY60260.1    KT750952    KZ288349    ALG65083.1    PBC27446.1    KA648814    AFP63443.1    KM264380    AKE98360.1    ACPB03020299    GFTR01005403    JAW11023.1    KX951674    ATD85058.1    KQ435916    KOX68761.1    CH963852    EDW75591.1    GBBI01003269    JAC15443.1    CH933807    EDW11144.2    KRG02541.1    CM000361    EDX03470.1    AXCM01006054    CP012523    ALC38229.1    CH954177    EDV57476.1    KQS70002.1    M30116    U63857    AE014134    BT015227    AF459545    AF459546    AF459547    AF459548    AF459549    AF459550    AF459551    AF459552    AF459553    AF459554    AF459555    AF459556    AF459557    AF459558    AF459559    AF459560    AF459561    AF459562    AF459563    AF459564    U63854    AH015352    ABB29567.1    AH015351    ABB29566.1    CM000157    EDW87393.2    AH015353    DQ167739    ABB29568.1    KQS70001.1    KRJ97142.1    KF630593    AHC98624.1    FJ821028    ACN94671.1   

Proteomes

UP000005204    UP000053268    UP000218220    UP000007151    UP000053240    UP000092462    + More
UP000092461    UP000183832    UP000008820    UP000069940    UP000249989    UP000002320    UP000075884    UP000235965    UP000075880    UP000076408    UP000075881    UP000075886    UP000007062    UP000075885    UP000245037    UP000075882    UP000075900    UP000075902    UP000069272    UP000000673    UP000075903    UP000075840    UP000076407    UP000075809    UP000008237    UP000078492    UP000078540    UP000005205    UP000007755    UP000000311    UP000078541    UP000075920    UP000279307    UP000053097    UP000078542    UP000037069    UP000076502    UP000002358    UP000053825    UP000242457    UP000192223    UP000095300    UP000079169    UP000015103    UP000095301    UP000053105    UP000007798    UP000009192    UP000000304    UP000075883    UP000092553    UP000008711    UP000000803    UP000002282    UP000005203   

PRIDE

H9JLI3    B8YPW1    P07713   

Pfam

PF00688   TGFb_propeptide        + More
PF00019   TGF_beta

Interpro

IPR001111   TGF-b_propeptide        + More
IPR015615   TGF-beta-rel       
IPR017948   TGFb_CS       
IPR001839   TGF-b_C       
IPR029034   Cystine-knot_cytokine       
IPR027417   P-loop_NTPase       

SUPFAM

SSF57501   SSF57501        + More
SSF52540   SSF52540       

Gene 3D

2.10.90.10    

ProteinModelPortal

H9JLI3   A0A0F7IQS1   B8YPW1   A0A194PHI0   A0A2A4JRC3   A0A212FL92   + More
A0A2H1WNA7   A0A194R100   E3UKJ8   A0A1B0DI00   A0A1B0CNU7   A0A1L8DL37   A0A1L8DLA2   A0A1L8DJC3   A0A2A4JR18   A0A1B6MG22   A0A1S4F007   A0A1J1IM20   Q17JZ3   A0A182GD36   Q75WK6   A0A1S4JCR2   B0WCI2   A0A182NTL6   A0A2J7Q4Z8   A0A182J5G4   A0A182XZW8   A0A182K0K3   A0A182QNM0   Q7Q3Q7   A0A0C9RHG2   A0A182P4R0   A0A2P8YVQ1   A0A336LZP6   A0A182L1W9   A0A182RFJ7   A0A182TTR3   A0A182F1K1   W5JTS3   A0A1B6DZH3   A0A182UWV4   A0A182HV19   A0A182WT22   A0A1S4GXL4   A0A151XAT1   E2B9W4   A0A151J8N4   A0A195BSU4   A0A158P1S4   I3WD96   W8BL12   A0A0K8WG48   F4W6N8   E2AGL6   A0A2M4CGV9   A0A195ERI5   A0A182W7F5   A0A0K8U826   A0A3L8DG15   A0A026W2E0   A0A034VC06   A0A195CMC5   A0A1Y1LN98   A0A0A1X980   A0A0L0C8W2   A0A154P4L3   K7IMN3   A0A140AX77   A0A0L7R784   V9IGS0   A0A140AX76   A0A1W4WXB0   A0A1I8P6N3   T1PJE3   A0A1S3DKS8   A0A1B0REL8   T1H8Q4   A0A224XSA9   A0A1I8MHF7   A0A290Y240   A0A0N0BCB8   B4MU02   A0A023F2N8   B4KGU4   B4Q848   A0A182LWX6   A0A0M3QT42   B3NA13   P07713   P91706   Q1WKY7   Q1WKY8   B4NWQ1   Q1WKY6   A0A0Q5W8W8   A0A088AJM8   A0A0R1DRG4   A0A067YM92   D0QWH2  

PDB

2QJB     E-value=3.32734e-48,     Score=483

KEGG

100270781    K04662 bone morphogenetic protein 4 | (RefSeq) Dpp, BmDPP; decapentaplegic

PATHWAY

04013    MAPK signaling pathway - fly - Bombyx mori (domestic silkworm)
04341    Hedgehog signaling pathway - fly - Bombyx mori (domestic silkworm)
04350    TGF-beta signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0005576   GO:0008083   GO:0016021   GO:0043408   GO:0005615   GO:0042981   GO:0030509   GO:0060395   GO:0005160   GO:0048468   GO:0010862   GO:0005125   GO:0008354   GO:0007458   GO:0070700   GO:0098898   GO:0036099   GO:0035263   GO:0061327   GO:0007498   GO:0035217   GO:0007516   GO:0007352   GO:0036098   GO:0001715   GO:0035224   GO:0035222   GO:0061320   GO:0007427   GO:0061352   GO:0035156   GO:0030721   GO:0045595   GO:0048636   GO:0008201   GO:0046982   GO:0060323   GO:0035158   GO:0042803   GO:0031252   GO:0045572   GO:0007391   GO:0007474   GO:0016015   GO:0035230   GO:0010002   GO:0007455   GO:0005768   GO:0010629   GO:0042078   GO:0007313   GO:0008586   GO:0005518   GO:0035168   GO:0007378   GO:0035309   GO:0046843   GO:0010628   GO:0001708   GO:0001745   GO:0007304   GO:0007440   GO:0008360   GO:0048619   GO:0007448   GO:0001709   GO:0035215   GO:0019827   GO:0048100   GO:0045705   GO:0007479   GO:0008285   GO:0007423   GO:0030718   GO:0045476   GO:0048542   GO:0007476   GO:0007446   GO:0007354   GO:0048066   GO:0009950   GO:0007447   GO:0030707   GO:0007393   GO:0007442   GO:0007179   GO:0009948   GO:0007443   GO:0007507   GO:0007444   GO:0042127   GO:0007473   GO:0007424   GO:0007398   GO:0045570   GO:0009953   GO:0007281   GO:0035214   GO:0007275   GO:0030154   GO:0040007   GO:0016705   GO:0031418   GO:0016491   GO:0004656   GO:0005783   GO:0016702   GO:0016295   GO:0016296  

PANTHER

PTHR11848  

Subcellular location

Secreted  

SignalP

Position:   1 - 19,         Likelihood:  0.966154

 

 

Length:

369

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

10.02578

Exp number, first 60 AAs:

10.02251

Total prob of N-in:

0.51713

POSSIBLE N-term signal

sequence

outside

1  -  369

 

 

Pi

45.490727

Theta

45.835786

Tajima's D

-1.083911

CLR

27.097602

CSRT

0.124943752812359

Interpretation

Uncertain