Gene

KWMTBOMO07193  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA010385

Annotation

PREDICTED:_non-lysosomal_glucosylceramidase-like_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr12(-):7661108-7664246      View in EpiBrowser

Full name

Non-lysosomal glucosylceramidase      

Location in the cell

Cytoplasmic   Reliability : 2.187 Nuclear   Reliability : 1.609

CDS

ATGAATAAAATCGATTTGGAAAGGTATTCTGAGGACTATACGTGCGGAGTTTCGTTAGAGCAAAGAATCGGCGAAAGCTTATGTACGTTTACGATAGCGAAAAAGAAAGTCGATGACGAAACGATCCACCAGGGCTATTGCCTGTGGAACGCGGCGAAGACTTCCAACTACGTTTGGGAATGCATAAAGAAAGATGGGAAGCTAACTCCGGATCCAAACTTAACTCCACCGCCGCCCAAACTTCCCGACAAAGACGCACAAAAGAAAAAGAAAGACAAAGAAAAAAAGAAACTGTATAAATGTGATTCAGTCGCCCTGTCCAGCGTCATATCGTTAGATCCAGGGGGAGTTAGTTCAACGGAGTTTTGTCTGGCCTGGGATATGCCTGTAGTTAAATATAGAAACGACAAAAAAATTCACAGAAGATTTTACACGAAATATTTTGGTAGTGACGGCATAGCCGGTGCGAGCATAGCTGCCTACGCTCTAAAGCATTACAAAAATTGGGAAAAACAGCTTCTTGAATGGCAGGAGCCAATTTTAACTAATTACAATATACCAGACTGGTTGAAAAGTGCCTTAATGAACGAGCTTTATTTTGTCGCCGATGGCGGAACGATTTGGTTTGATGCAAGCGACGAATTTCCAGAAACGGATCCTAGGTAA

Protein

MNKIDLERYSEDYTCGVSLEQRIGESLCTFTIAKKKVDDETIHQGYCLWNAAKTSNYVWECIKKDGKLTPDPNLTPPPPKLPDKDAQKKKKDKEKKKLYKCDSVALSSVISLDPGGVSSTEFCLAWDMPVVKYRNDKKIHRRFYTKYFGSDGIAGASIAAYALKHYKNWEKQLLEWQEPILTNYNIPDWLKSALMNELYFVADGGTIWFDASDEFPETDPR

Description

Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide.

Catalytic Activity

a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose

Similarity

Belongs to the non-lysosomal glucosylceramidase family.

Uniprot

A0A194R067   A0A194PHH7   A0A2H1WWR2   A0A212EKV0   A0A212FL48   A0A3S2MAG2   + More
A0A1E1WJ95   A0A0L7KYM6   A0A1L8E2K8   A0A2C9GPH9   A0A1L8E229   A0A1I8MB61   A0A1I8MB60   W5JIF6   A0A2M4CTR6   A0A0L0BZ66   A0A2M4AD48   A0A1Y1M339   A0A1I8Q3F9   A0A1Y1M8M0   A0A1Y1M460   A0A1I8Q3I3   A0A1Y1M7I9   B4MZB3   A0A1Y1M6Q4   A0A1Y1M3J2   A0A1Y1M358   B4P0J9  

EC Number

3.2.1.45

Pubmed

26354079    22118469    26227816    25315136    20920257    23761445    + More
26108605    28004739    17994087    17550304   

EMBL

KQ460883    KPJ11193.1    KQ459603    KPI92767.1    ODYU01011634    SOQ57503.1    + More
AGBW02014207    OWR42113.1    AGBW02007871    OWR54456.1    RSAL01000003    RVE54749.1    GDQN01003974    JAT87080.1    JTDY01004287    KOB68332.1    GFDF01001349    JAV12735.1    APCN01003341    APCN01003342    GFDF01001350    JAV12734.1    ADMH02001302    ETN63073.1    GGFL01004568    MBW68746.1    JRES01001125    KNC25310.1    GGFK01005378    MBW38699.1    GEZM01041582    JAV80272.1    GEZM01041577    JAV80276.1    GEZM01041585    JAV80271.1    GEZM01041578    JAV80275.1    CH963913    EDW77386.1    GEZM01041586    JAV80270.1    GEZM01041580    JAV80273.1    GEZM01041579    JAV80274.1    CM000157    EDW88993.1   

Proteomes

UP000053240    UP000053268    UP000007151    UP000283053    UP000037510    UP000075840    + More
UP000095301    UP000000673    UP000037069    UP000095300    UP000007798    UP000002282   

Pfam

PF04685   DUF608        + More
PF12215   Glyco_hydr_116N

Interpro

IPR012341   6hp_glycosidase-like_sf        + More
IPR008928   6-hairpin_glycosidase_sf       
IPR006775   GH116_catalytic       
IPR024462   GH116_N       
IPR014551   B_Glucosidase_GBA2-typ       

SUPFAM

SSF48208   SSF48208       

Gene 3D

1.50.10.10    

ProteinModelPortal

A0A194R067   A0A194PHH7   A0A2H1WWR2   A0A212EKV0   A0A212FL48   A0A3S2MAG2   + More
A0A1E1WJ95   A0A0L7KYM6   A0A1L8E2K8   A0A2C9GPH9   A0A1L8E229   A0A1I8MB61   A0A1I8MB60   W5JIF6   A0A2M4CTR6   A0A0L0BZ66   A0A2M4AD48   A0A1Y1M339   A0A1I8Q3F9   A0A1Y1M8M0   A0A1Y1M460   A0A1I8Q3I3   A0A1Y1M7I9   B4MZB3   A0A1Y1M6Q4   A0A1Y1M3J2   A0A1Y1M358   B4P0J9  

PDB

5OST     E-value=1.71818e-18,     Score=224

KEGG

101743464    K17108 non-lysosomal glucosylceramidase [EC:3.2.1.45] | (RefSeq) non-lysosomal glucosylceramidase-li

GO

GO:0004553   GO:0006680   GO:0016020   GO:0004348   GO:0006629   GO:0016021  

Length:

221

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

2.71859

Exp number, first 60 AAs:

0.00037

Total prob of N-in:

0.25037

outside

1  -  221

 

 

Pi

50.045779

Theta

83.931124

Tajima's D

-1.170216

CLR

76.870641

CSRT

0.107944602769862

Interpretation

Uncertain