Silkworm Genome Informatics Database

Gene

KWMTBOMO07192 Validated by peptides from experiments

Pre Gene Modal

BGIBMGA010385

Annotation

PREDICTED:_non-lysosomal_glucosylceramidase-like_[Bombyx_mori]

Location

Bomo_Chr12(-):7638021-7660536 View in EpiBrowser

Full name

Non-lysosomal glucosylceramidase

Location in the cell

Cytoplasmic Reliability : 1.101

CDS

ATGTACAATACATATGACGTCCATTTTTACGCGTCTTTTGCTCTAGCGCAGCTGTGGCCAAATTTACAGGTGGCGCTGCAGTATATGTTTCGCGATACTATAGGTCTTGAAAGTGAAAAAAGTAGAAAGTCATTATATGACGGTAAAGTAGTGAAATTCAAGATCAAAGATTCCGTACCTCACGACCTAGGCGATCCAGATGGAAAGCCGTTTGTGAATATAAATTCTTACAATATCCACGATGTCAGCGATTGGAAGGATCTCAATTTGAAGTTTATCCTTCAAGTGATACGGGACTATAGAGTCTTACGTGCCTACGCTGCTCCCTTCACCGATGACAAGTTGTACAGGTCCATGCCGTTCATAGACGACGTGAGGGAGGGAACCGAGGACGACCTGTACTCTCGCGCCACGGGACAGTGCGACGAGTCCGCGCGTCCCGCCCCCGCGCCGTCCCCCCCGCCGCCCCCCGCCGCGACGCCGCAGGATCGCGCGCCGCGTGACGTCGCCGACATCCTCGAGCTGCTGTACAGAAGCGGCGAGGAGGAGGTCGGCGCCGGCGAGAGCGTCGCGGAGCCGCGCGACCCCCCCGCCAACGTGTGGCAGGACAGTCGCTACCTCGCCGACATGTACCCCGCCTGCGTCTCGCTGCTGCGCCGCGCCGCCGCCTGGGACCGCGACGGCGACGGACTCATCGAGAACGACGGCTTCCCCGACCAGACCTACGACATATGGGTGATGACGGGACCCAGCGCGTACTGCGGCGGGCTGTGGGTGGCGGCGCTGGGCGCGGTGCGGACCATGGCGCAGATCCTCGGCCGCGAGGACGACGAGCGCGAGTTCGCCGAGCGCCTGCAGAGGGCGCAGGCCGCGTACCAAGAGAAGCTCTGGGTCGGCTCCTACTACCGGTTCGACACCAAACCGGCCAACGAAAAAGTGATAATGGCGGATCAATTGGCGGGACACTGGTTCCTGCGGGCGTCCGGATGGACCGAAGCGGTGTTCCCGCAAGCGAATGTGCGAAAAGCACTGAAAACAATTTTCGACAATAACGTGATGAAGTTCAAAGGGGGCAAAATGGGCGCCGTGAACGGATTTGTGGCCGAAGGGAAGGGGCACGTGCACACCGTCGCGCTGCAGAGCGAGGAGGTCTGGATCGGAGTCACGTACGGCCTGGCCTCGCTCATGGTCTACGAAGATATGCACGACGAAGCGTTCGTGACTGCGGGTGGTCTGTACCACACGCTGACGCAGATGGGTCTGTCGTTCGAGACCCCGGAGGCGCTGTACGAGAACGGCAACCACCGCTCCATCGCCAATGTCTCTATTAAGAAGTTTATCACTAAGATCGATAGAAAGAACAGTTTAGATCAACCACCTAAATTCGGATTGAAATTGCGGTTGGATCATGAATTTCCGTTGCAGAGCAAACAAGGCCATGGGATACGTCCTTCGCAACTCTTTGATGTGATGCCTTTGACAGCGAGATATTTCAAATACTGTGTTGGTATGAAGCTAAATAACAGACGTCCAATTATGGATTTTTTGCATAGAGTTTCAGCACAGAGAATGTACGGATGTCCTATTGGGGGTATAGGCGGAGGTACTATCGGAAGAGGTTTTAAGGGCGAGTTCTGCCGTTTTCAGTTACAGCCTGGTCTATACGAGTATGTTACAGTACCGGAATGTCAGTTTATTGTCAACATTAAAAATGATAAAAACGAAACGATATACCAAACCGTTCTGTCTACTTACAGTAAGCCCAAGAATGCCCCTGAATCGTGGGAATGGAACTTAAATGGCGCCGATTGTGAATACACGGCTCTATATCCGAGAGCTTGGACAACGTACGATTTATCAAAATACGGAATTAAACTCGTTTGTCGACAAATATCTCCGGTCATACCTCATAATTACGAAGACAGCAGTCTACCGTGTGCGGTGTTCGCGTTCAGCGCACTGAATGTAAGCAATGAACATAGAAACGTCAGTGTCACACTCACCTGGACTGAAGTACTGAACAAAAGTAAAAACGCAGAGGTCGGGAGCTACACCCAAACTAAAAGCTGCGGTGTATACCTTAGACAAAAAATCGGAGAGAGTCCATGTACTTTTACAATAAGTAAAAATAATATTGAAAGCCAAAGTCTCACCGAAGATTACACTTTCTGGAACTCTGCTAAAACATCACACTACGTTTGGGAATGTATTCAGAAACATGGAAAATTATCACCCGATCCTAGAACTGTTCCGACGCCAAGATGTAGTTCTGAGAAAGAAAATAAGCAAAAACAAAATAAAGTCATTTACTGCGATTCAATAGCGCTTTCTAGTGTTTTATCTCTGGAACCGCAAAGTACGGGCTCAACCGAACTAAGTCTCGTTTGGGATATGCCCACGATAAAATACAGAAAGGACGAAAAGAAACATAAGAGGTTTTACACAAAATTCTACAGCAGCGATGGAAACGCTGGTTCGAACATAGCTACTTATGCTCTGAATAATTTTACGAATTGGGAGACGCAGTTGAATGTTTGGCAAGAATCGATTTTGAATAATGGGAGTATACCGGATTGGTTGAAAAGTGCGTTATTCAACGAACTCTATTACGTAGCAGACGGAGGTACGATATGGCTGGACGTTCATGACGAGTATCCGGATACAGACCCTAGGAAAGAGTTTGGTCTGTTCGGTTATTTAGAAGGCCACGAATACAGAATGTACAATTCGTATGACGTCCATTTTTACGCATCTTTTGCTTTGGCACAGCTGTGGCCTAATTTACAGGTCGTGATACAGTATATGTTTCGTGACACTGTTGCAATGGAGACCGAGAAAAGCAGAAAATCGCTCTATGATGGAAAAATAGTGAAATATAAAACCAAAGATTCAATACCTCATGATTTAGGTGATCCAGGCGATATGCCCTTTTTTCACATCAATGCTTACAATATTCACGACGTGAGTGATTGGAAAGATCTCAACTTTAAATTCATCCTTCAGGTGATACGCGACTACCATTTGATGACTTTCATGGACACGAGTGAAGAGAAAACCGGATCATCTGCCGCTGTGTGGCCGAGCAAACGTTATCTCGCCGACATGTACCCCGCCTGCGTCACTCTGCTGCGCCGCGCCGCCGCCTGGGACCGCGACGGCGACGGACTCATCGAGAACGACGGCACTCCCGACCAGACCTACGACATATGGGTGATGACGGGACCCAGCGCGTATTGCGGCGGACTTTGGGTGGCGTCTGTGAAGGCGGTGCACACGATGGCGAATATCCTCGGTCACGAGGACGACGAGCGAGAATTTGGTGAATGGCTGCAGAGAGCGCAGCGTGCCTACCAAGACAAGCTCTGGGCGGGTACACACTACCGCTTCGACACCAAGCCTTGTAACGAGAATGTAATCATGGCGGATCAGTTGGCGGGTCACTGGTTCCTTCGTGCTTCAGGACTGAATGAGTCCGTATTTCCAGAAGAGAATGTACAAAAAGCACTGAAAACGATCTATGAGAATAATGTGTTGCATTTCAAGAATGGGACCATGGGAGCTGTCAACGGCTTTGTAAGAGAAGGCAAAGGTCATATTGAAACGCGAACTATGCACAGCGAAGAAATATGGGTCGGCACGACGTACGGTGTCTCTGCGCTAATGATTTTTGAAGGTATGCATAAGGAGGCGTTCGCGACGGCGGGTGGTCTGTACCACACTCTGACGCAGATGGGTCTGTCGTTCGAGACCCCGGAGGCGCTGTACGAGAACGGCAACCACCGCTCCATCGCGTACATGCGCCCGCTGGCGGTCTGGGCGCTGCACCAGGCGCTGCTGGCGCGTCCCGTTCCGTAA

Protein

MYNTYDVHFYASFALAQLWPNLQVALQYMFRDTIGLESEKSRKSLYDGKVVKFKIKDSVPHDLGDPDGKPFVNINSYNIHDVSDWKDLNLKFILQVIRDYRVLRAYAAPFTDDKLYRSMPFIDDVREGTEDDLYSRATGQCDESARPAPAPSPPPPPAATPQDRAPRDVADILELLYRSGEEEVGAGESVAEPRDPPANVWQDSRYLADMYPACVSLLRRAAAWDRDGDGLIENDGFPDQTYDIWVMTGPSAYCGGLWVAALGAVRTMAQILGREDDEREFAERLQRAQAAYQEKLWVGSYYRFDTKPANEKVIMADQLAGHWFLRASGWTEAVFPQANVRKALKTIFDNNVMKFKGGKMGAVNGFVAEGKGHVHTVALQSEEVWIGVTYGLASLMVYEDMHDEAFVTAGGLYHTLTQMGLSFETPEALYENGNHRSIANVSIKKFITKIDRKNSLDQPPKFGLKLRLDHEFPLQSKQGHGIRPSQLFDVMPLTARYFKYCVGMKLNNRRPIMDFLHRVSAQRMYGCPIGGIGGGTIGRGFKGEFCRFQLQPGLYEYVTVPECQFIVNIKNDKNETIYQTVLSTYSKPKNAPESWEWNLNGADCEYTALYPRAWTTYDLSKYGIKLVCRQISPVIPHNYEDSSLPCAVFAFSALNVSNEHRNVSVTLTWTEVLNKSKNAEVGSYTQTKSCGVYLRQKIGESPCTFTISKNNIESQSLTEDYTFWNSAKTSHYVWECIQKHGKLSPDPRTVPTPRCSSEKENKQKQNKVIYCDSIALSSVLSLEPQSTGSTELSLVWDMPTIKYRKDEKKHKRFYTKFYSSDGNAGSNIATYALNNFTNWETQLNVWQESILNNGSIPDWLKSALFNELYYVADGGTIWLDVHDEYPDTDPRKEFGLFGYLEGHEYRMYNSYDVHFYASFALAQLWPNLQVVIQYMFRDTVAMETEKSRKSLYDGKIVKYKTKDSIPHDLGDPGDMPFFHINAYNIHDVSDWKDLNFKFILQVIRDYHLMTFMDTSEEKTGSSAAVWPSKRYLADMYPACVTLLRRAAAWDRDGDGLIENDGTPDQTYDIWVMTGPSAYCGGLWVASVKAVHTMANILGHEDDEREFGEWLQRAQRAYQDKLWAGTHYRFDTKPCNENVIMADQLAGHWFLRASGLNESVFPEENVQKALKTIYENNVLHFKNGTMGAVNGFVREGKGHIETRTMHSEEIWVGTTYGVSALMIFEGMHKEAFATAGGLYHTLTQMGLSFETPEALYENGNHRSIAYMRPLAVWALHQALLARPVP

Description

Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide.

Catalytic Activity

a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose

Similarity

Belongs to the non-lysosomal glucosylceramidase family.

Uniprot

A0A3S2MAG2

EC Number

3.2.1.45

EMBL

RSAL01000003 RVE54749.1

Proteomes

UP000283053

Pfam

PF12215 Glyco_hydr_116N + More
PF04685 DUF608

Interpro

IPR008928   6-hairpin_glycosidase_sf        + More
IPR024462   GH116_N
IPR006775   GH116_catalytic
IPR012341   6hp_glycosidase-like_sf
IPR014551   B_Glucosidase_GBA2-typ

SUPFAM

SSF48208 SSF48208

Gene 3D

1.50.10.10

ProteinModelPortal

A0A3S2MAG2

PDB

5OST E-value=2.04748e-120, Score=1111

KEGG

101746114 K17108 non-lysosomal glucosylceramidase [EC:3.2.1.45] | (RefSeq) non-lysosomal glucosylceramidase-li

PATHWAY

00511    Other glycan degradation - Bombyx mori (domestic silkworm)
00600    Sphingolipid metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0006629 GO:0016020 GO:0004348 GO:0003824 GO:0004553 GO:0016705 GO:0031418 GO:0016491 GO:0004656 GO:0005783 GO:0016702 GO:0016295 GO:0016296

Length:

1284

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

4.70451999999999

Exp number, first 60 AAs:

4.35977

Total prob of N-in:

0.22163

outside

1 - 1284

Pi

170.364646

Theta

171.179471

Tajima's D

-2.434031

CLR

152.774716

CSRT

0.00154992250387481

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics

Multiple alignment of Orthologues

Gene Tree