SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO07192  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA010385
Annotation
PREDICTED:_non-lysosomal_glucosylceramidase-like_[Bombyx_mori]
Full name
Non-lysosomal glucosylceramidase      
Location in the cell
Cytoplasmic   Reliability : 1.101
 

Sequence

CDS
ATGTACAATACATATGACGTCCATTTTTACGCGTCTTTTGCTCTAGCGCAGCTGTGGCCAAATTTACAGGTGGCGCTGCAGTATATGTTTCGCGATACTATAGGTCTTGAAAGTGAAAAAAGTAGAAAGTCATTATATGACGGTAAAGTAGTGAAATTCAAGATCAAAGATTCCGTACCTCACGACCTAGGCGATCCAGATGGAAAGCCGTTTGTGAATATAAATTCTTACAATATCCACGATGTCAGCGATTGGAAGGATCTCAATTTGAAGTTTATCCTTCAAGTGATACGGGACTATAGAGTCTTACGTGCCTACGCTGCTCCCTTCACCGATGACAAGTTGTACAGGTCCATGCCGTTCATAGACGACGTGAGGGAGGGAACCGAGGACGACCTGTACTCTCGCGCCACGGGACAGTGCGACGAGTCCGCGCGTCCCGCCCCCGCGCCGTCCCCCCCGCCGCCCCCCGCCGCGACGCCGCAGGATCGCGCGCCGCGTGACGTCGCCGACATCCTCGAGCTGCTGTACAGAAGCGGCGAGGAGGAGGTCGGCGCCGGCGAGAGCGTCGCGGAGCCGCGCGACCCCCCCGCCAACGTGTGGCAGGACAGTCGCTACCTCGCCGACATGTACCCCGCCTGCGTCTCGCTGCTGCGCCGCGCCGCCGCCTGGGACCGCGACGGCGACGGACTCATCGAGAACGACGGCTTCCCCGACCAGACCTACGACATATGGGTGATGACGGGACCCAGCGCGTACTGCGGCGGGCTGTGGGTGGCGGCGCTGGGCGCGGTGCGGACCATGGCGCAGATCCTCGGCCGCGAGGACGACGAGCGCGAGTTCGCCGAGCGCCTGCAGAGGGCGCAGGCCGCGTACCAAGAGAAGCTCTGGGTCGGCTCCTACTACCGGTTCGACACCAAACCGGCCAACGAAAAAGTGATAATGGCGGATCAATTGGCGGGACACTGGTTCCTGCGGGCGTCCGGATGGACCGAAGCGGTGTTCCCGCAAGCGAATGTGCGAAAAGCACTGAAAACAATTTTCGACAATAACGTGATGAAGTTCAAAGGGGGCAAAATGGGCGCCGTGAACGGATTTGTGGCCGAAGGGAAGGGGCACGTGCACACCGTCGCGCTGCAGAGCGAGGAGGTCTGGATCGGAGTCACGTACGGCCTGGCCTCGCTCATGGTCTACGAAGATATGCACGACGAAGCGTTCGTGACTGCGGGTGGTCTGTACCACACGCTGACGCAGATGGGTCTGTCGTTCGAGACCCCGGAGGCGCTGTACGAGAACGGCAACCACCGCTCCATCGCCAATGTCTCTATTAAGAAGTTTATCACTAAGATCGATAGAAAGAACAGTTTAGATCAACCACCTAAATTCGGATTGAAATTGCGGTTGGATCATGAATTTCCGTTGCAGAGCAAACAAGGCCATGGGATACGTCCTTCGCAACTCTTTGATGTGATGCCTTTGACAGCGAGATATTTCAAATACTGTGTTGGTATGAAGCTAAATAACAGACGTCCAATTATGGATTTTTTGCATAGAGTTTCAGCACAGAGAATGTACGGATGTCCTATTGGGGGTATAGGCGGAGGTACTATCGGAAGAGGTTTTAAGGGCGAGTTCTGCCGTTTTCAGTTACAGCCTGGTCTATACGAGTATGTTACAGTACCGGAATGTCAGTTTATTGTCAACATTAAAAATGATAAAAACGAAACGATATACCAAACCGTTCTGTCTACTTACAGTAAGCCCAAGAATGCCCCTGAATCGTGGGAATGGAACTTAAATGGCGCCGATTGTGAATACACGGCTCTATATCCGAGAGCTTGGACAACGTACGATTTATCAAAATACGGAATTAAACTCGTTTGTCGACAAATATCTCCGGTCATACCTCATAATTACGAAGACAGCAGTCTACCGTGTGCGGTGTTCGCGTTCAGCGCACTGAATGTAAGCAATGAACATAGAAACGTCAGTGTCACACTCACCTGGACTGAAGTACTGAACAAAAGTAAAAACGCAGAGGTCGGGAGCTACACCCAAACTAAAAGCTGCGGTGTATACCTTAGACAAAAAATCGGAGAGAGTCCATGTACTTTTACAATAAGTAAAAATAATATTGAAAGCCAAAGTCTCACCGAAGATTACACTTTCTGGAACTCTGCTAAAACATCACACTACGTTTGGGAATGTATTCAGAAACATGGAAAATTATCACCCGATCCTAGAACTGTTCCGACGCCAAGATGTAGTTCTGAGAAAGAAAATAAGCAAAAACAAAATAAAGTCATTTACTGCGATTCAATAGCGCTTTCTAGTGTTTTATCTCTGGAACCGCAAAGTACGGGCTCAACCGAACTAAGTCTCGTTTGGGATATGCCCACGATAAAATACAGAAAGGACGAAAAGAAACATAAGAGGTTTTACACAAAATTCTACAGCAGCGATGGAAACGCTGGTTCGAACATAGCTACTTATGCTCTGAATAATTTTACGAATTGGGAGACGCAGTTGAATGTTTGGCAAGAATCGATTTTGAATAATGGGAGTATACCGGATTGGTTGAAAAGTGCGTTATTCAACGAACTCTATTACGTAGCAGACGGAGGTACGATATGGCTGGACGTTCATGACGAGTATCCGGATACAGACCCTAGGAAAGAGTTTGGTCTGTTCGGTTATTTAGAAGGCCACGAATACAGAATGTACAATTCGTATGACGTCCATTTTTACGCATCTTTTGCTTTGGCACAGCTGTGGCCTAATTTACAGGTCGTGATACAGTATATGTTTCGTGACACTGTTGCAATGGAGACCGAGAAAAGCAGAAAATCGCTCTATGATGGAAAAATAGTGAAATATAAAACCAAAGATTCAATACCTCATGATTTAGGTGATCCAGGCGATATGCCCTTTTTTCACATCAATGCTTACAATATTCACGACGTGAGTGATTGGAAAGATCTCAACTTTAAATTCATCCTTCAGGTGATACGCGACTACCATTTGATGACTTTCATGGACACGAGTGAAGAGAAAACCGGATCATCTGCCGCTGTGTGGCCGAGCAAACGTTATCTCGCCGACATGTACCCCGCCTGCGTCACTCTGCTGCGCCGCGCCGCCGCCTGGGACCGCGACGGCGACGGACTCATCGAGAACGACGGCACTCCCGACCAGACCTACGACATATGGGTGATGACGGGACCCAGCGCGTATTGCGGCGGACTTTGGGTGGCGTCTGTGAAGGCGGTGCACACGATGGCGAATATCCTCGGTCACGAGGACGACGAGCGAGAATTTGGTGAATGGCTGCAGAGAGCGCAGCGTGCCTACCAAGACAAGCTCTGGGCGGGTACACACTACCGCTTCGACACCAAGCCTTGTAACGAGAATGTAATCATGGCGGATCAGTTGGCGGGTCACTGGTTCCTTCGTGCTTCAGGACTGAATGAGTCCGTATTTCCAGAAGAGAATGTACAAAAAGCACTGAAAACGATCTATGAGAATAATGTGTTGCATTTCAAGAATGGGACCATGGGAGCTGTCAACGGCTTTGTAAGAGAAGGCAAAGGTCATATTGAAACGCGAACTATGCACAGCGAAGAAATATGGGTCGGCACGACGTACGGTGTCTCTGCGCTAATGATTTTTGAAGGTATGCATAAGGAGGCGTTCGCGACGGCGGGTGGTCTGTACCACACTCTGACGCAGATGGGTCTGTCGTTCGAGACCCCGGAGGCGCTGTACGAGAACGGCAACCACCGCTCCATCGCGTACATGCGCCCGCTGGCGGTCTGGGCGCTGCACCAGGCGCTGCTGGCGCGTCCCGTTCCGTAA
Protein
MYNTYDVHFYASFALAQLWPNLQVALQYMFRDTIGLESEKSRKSLYDGKVVKFKIKDSVPHDLGDPDGKPFVNINSYNIHDVSDWKDLNLKFILQVIRDYRVLRAYAAPFTDDKLYRSMPFIDDVREGTEDDLYSRATGQCDESARPAPAPSPPPPPAATPQDRAPRDVADILELLYRSGEEEVGAGESVAEPRDPPANVWQDSRYLADMYPACVSLLRRAAAWDRDGDGLIENDGFPDQTYDIWVMTGPSAYCGGLWVAALGAVRTMAQILGREDDEREFAERLQRAQAAYQEKLWVGSYYRFDTKPANEKVIMADQLAGHWFLRASGWTEAVFPQANVRKALKTIFDNNVMKFKGGKMGAVNGFVAEGKGHVHTVALQSEEVWIGVTYGLASLMVYEDMHDEAFVTAGGLYHTLTQMGLSFETPEALYENGNHRSIANVSIKKFITKIDRKNSLDQPPKFGLKLRLDHEFPLQSKQGHGIRPSQLFDVMPLTARYFKYCVGMKLNNRRPIMDFLHRVSAQRMYGCPIGGIGGGTIGRGFKGEFCRFQLQPGLYEYVTVPECQFIVNIKNDKNETIYQTVLSTYSKPKNAPESWEWNLNGADCEYTALYPRAWTTYDLSKYGIKLVCRQISPVIPHNYEDSSLPCAVFAFSALNVSNEHRNVSVTLTWTEVLNKSKNAEVGSYTQTKSCGVYLRQKIGESPCTFTISKNNIESQSLTEDYTFWNSAKTSHYVWECIQKHGKLSPDPRTVPTPRCSSEKENKQKQNKVIYCDSIALSSVLSLEPQSTGSTELSLVWDMPTIKYRKDEKKHKRFYTKFYSSDGNAGSNIATYALNNFTNWETQLNVWQESILNNGSIPDWLKSALFNELYYVADGGTIWLDVHDEYPDTDPRKEFGLFGYLEGHEYRMYNSYDVHFYASFALAQLWPNLQVVIQYMFRDTVAMETEKSRKSLYDGKIVKYKTKDSIPHDLGDPGDMPFFHINAYNIHDVSDWKDLNFKFILQVIRDYHLMTFMDTSEEKTGSSAAVWPSKRYLADMYPACVTLLRRAAAWDRDGDGLIENDGTPDQTYDIWVMTGPSAYCGGLWVASVKAVHTMANILGHEDDEREFGEWLQRAQRAYQDKLWAGTHYRFDTKPCNENVIMADQLAGHWFLRASGLNESVFPEENVQKALKTIYENNVLHFKNGTMGAVNGFVREGKGHIETRTMHSEEIWVGTTYGVSALMIFEGMHKEAFATAGGLYHTLTQMGLSFETPEALYENGNHRSIAYMRPLAVWALHQALLARPVP

Summary

Description
Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide.
Catalytic Activity
a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose
Similarity
Belongs to the non-lysosomal glucosylceramidase family.
EC Number
3.2.1.45
Pfam
PF12215   Glyco_hydr_116N        + More
PF04685   DUF608
Interpro
IPR008928   6-hairpin_glycosidase_sf        + More
IPR024462   GH116_N       
IPR006775   GH116_catalytic       
IPR012341   6hp_glycosidase-like_sf       
IPR014551   B_Glucosidase_GBA2-typ       
SUPFAM
SSF48208   SSF48208       
Gene 3D
ProteinModelPortal
PDB
5OST     E-value=2.04748e-120,     Score=1111

Ontologies

Topology

Length:
1284
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
4.70451999999999
Exp number, first 60 AAs:
4.35977
Total prob of N-in:
0.22163
outside
1  -  1284
 
 

Population Genetic Test Statistics

Pi
170.364646
Theta
171.179471
Tajima's D
-2.434031
CLR
152.774716
CSRT
0.00154992250387481
Interpretation
Uncertain

Multiple alignment of Orthologues

 
 

Gene Tree

 
 
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