Gene

KWMTBOMO07185

Pre Gene Modal

BGIBMGA010391

Annotation

juvenile_hormone_acid_O-methyltransferase_[Bombyx_mori]

Location

Bomo_Chr12(-):7267747-7273731      View in EpiBrowser

Full name

Juvenile hormone acid O-methyltransferase      

Alternative Name

Juvenile hormone acid methyltransferase

Location in the cell

Cytoplasmic   Reliability : 3.123

CDS

ATGAACAATGCAGATTTATACCGCAAAAGTAACAGCCTCCAAAAGAGAGATGCTCTGCGCTGCCTCGAGGAACATGCGAATAAGATTAAGTGGAAAAAAATCGGTGATAGAGTCATAGATTTGGGTTGCGCTGACGGTAGTGTTACTGATATTTTGAAAGTTTACATGCCAAAAAATTACGGAAGATTAGTTGGCTGCGACATAAGCGAAGAAATGGTGAAATACGCGAATAAACACCACGGCTTCGGTAGGACTTCGTTCAGGGTGCTCGACATAGAGGGCGATTTGACCGCAGACCTGAAACAAGGCTTTGATCACGTTTTCTCTTTTTACACCCTCCACTGGATCAGAGACCAGGAACGAGCTTTCCGGAACATTTTCAATCTGCTTGGCGACGAAGGAGATTGCTTACTTCTGTTCCTGGGCCACACTCCTATCTTTGATGTTTACCGCACACTCTCGCATACAGAAAAATGGCATTCTTGGCTCGAGCACGTCGATCGATTTATATCACCTTACCATGACAATGAAGATCCCGAAAAAGAAGTTAAGAAGATAATGGAAAGAGTTGGATTTAGCAATATTGAAGTGCAATGCAAAACGTTGTTCTATGTATACGATGATTTGGATGTTTTAAAAAAATCAGTAGCAGCTATCAATCCATTTAATATCCCGAAAGACATACTTGAAGACTTTTTAGAAGATTACATAGATGTAGTACGGGAGATGAGGCTGCTCGACAGGTGTAATAACAATGTCGGTGAATCAGTGTCTATAAAATTTAACTACAAAGTCATCAGTGTTTACGCGAGAAAATTATGTTTAAGTTTAATGTAA

Protein

MNNADLYRKSNSLQKRDALRCLEEHANKIKWKKIGDRVIDLGCADGSVTDILKVYMPKNYGRLVGCDISEEMVKYANKHHGFGRTSFRVLDIEGDLTADLKQGFDHVFSFYTLHWIRDQERAFRNIFNLLGDEGDCLLLFLGHTPIFDVYRTLSHTEKWHSWLEHVDRFISPYHDNEDPEKEVKKIMERVGFSNIEVQCKTLFYVYDDLDVLKKSVAAINPFNIPKDILEDFLEDYIDVVREMRLLDRCNNNVGESVSIKFNYKVISVYARKLCLSLM

Description

O-methyltransferase that transfers a methyl group from S-adenosyl-L-methionine (SAM) to the carboxyl group of juvenile hormone acids to produce active juvenile hormones in the corpora allata, the last step during juvenile hormone biosynthesis (PubMed:14530389). Also able to methylate farnesoate to methyl farnesoate (PubMed:14530389).
O-methyltransferase that transfers a methyl group from S-adenosyl-L-methionine (SAM) to the carboxyl group of juvenile hormone acids to produce active juvenile hormones in the corpora allata, the last step during juvenile hormone biosynthesis (PubMed:18549957). Also able to methylate farnesoate to methyl farnesoate (PubMed:18549957).

Catalytic Activity

(2E,6E)-farnesoate + S-adenosyl-L-methionine = methyl (2E,6E)-farnesoate + S-adenosyl-L-homocysteine
juvenile hormone III carboxylate + S-adenosyl-L-methionine = juvenile hormone III + S-adenosyl-L-homocysteine

Biophysicochemical Properties

3.32 uM for juvenile hormone III acid
0.18 uM for farnesoate

Similarity

Belongs to the methyltransferase superfamily.

Keywords

Complete proteome   Methyltransferase   Reference proteome   S-adenosyl-L-methionine   Transferase  

Feature

chain  Juvenile hormone acid O-methyltransferase

Uniprot

Q767F1   A0A1P1ENW6   Q1KN64   A0A194PH70   A0A194R0H9   A0A212F9H0   + More
A5LFV6   A0A173GZJ8   A0A3S2M9U8   A0A2A4K0R4   D2Y4U6   A0A2H1VCR6   A0A0R5ZNF1   A0A2A4JYY3   A0A1W5ZM45   A5LFV5   A0A2H1VCN4   A0A0L7L836   H9JWV0   Q206L4   A0A1B0D0M7   A0A1I8NU96   Q9U4Z8   A0A182T4X4   A0A0L0C8K2   A0A2J7RC57   A0A182KF39   A0A146IWP0   A0A182ILY4   A0A0M3QU49   B4KKK5   A0A182M749   B4JZ63   H9JLJ1   A0A182YBZ0   A0A084VUE9   A0A1W4VJN5   A0A0K8TS48   B4I231   B3MUK9   A0A182PFZ1   B4G7P2   A0A0J9TPF7   A0A1W4VSL6   A0A1I8MHF6   Q29LS0   B2DCQ0   B4LVM0   A0A3B0K301   B4MZR7   T1GFV4   A0A182HNS9   Q7Q9F0   A0A2M3Z4G9   A0A2M3Z4F9   A0A2M3Z4E3   A0A182FCT5   W5JAE4   A0A2M4BW66   A0A2M4BWC8   A0A1B3PD94   Q9VJK8   A0A1A9Z807   A0A1B3PDM2   A0A2M4ALK9   A0A2M4BVZ2   A0A336L491   A0A1A9VCC9   B4P880   A0A182WMH0   A0A1B0G4E2   A0A2R4N6F4   A0A034W1Z2   B3NNG6   A0A182RP42   A0A1A9XET3   A0A1B0BCZ1   R4IKD3   A0A024BT15   A0A1I8MHL4   A0A075W3Z0   A0A1A9WKH6   B0WTB6   A0A2C9DK13   A0A182X8H7   A0A0A1WN75   A0A1L2BNI6   A0A182N9N0   A0A182LGS6   W8BZU3   A0A0H4SZT2   A0A3S5X9D4   A0A182U4K2   A0A182PZH2   A0A146J3Z5   A0A146KYR9   A0A0A9XHP0   A0A0K8S8Y3   A0A1I8PAX7   A0A182GXP5  

EC Number

2.1.1.325

Pubmed

14530389    19121390    18839418    26354079    22118469    28382786    + More
26227816    17510324    10620045    26108605    17994087    25244985    24438588    26369729    22936249    25315136    15632085    18435763    18362917    19820115    12364791    14747013    17210077    20920257    23761445    18549957    10731132    12537572    12537569    17550304    25348373    23499946    28536442    25830018    20966253    24495485    26894583    26823975    25401762    26483478   

EMBL

AB113578    JN851817    BABH01005674    DQ465408    ABE98256.1    KQ459603    + More
KPI92751.1    KQ460883    KPJ11207.1    AGBW02009587    OWR50378.1    AB127945    BAF63630.1    KX289532    ANI21405.1    RSAL01000003    RVE54742.1    NWSH01000345    PCG77232.1    GU323798    ADA83703.1    ODYU01001839    SOQ38586.1    KM926339    AJR27469.1    PCG77231.1    KY421777    ARI71313.1    AB127944    BAF63629.1    SOQ38587.1    JTDY01002391    KOB71509.1    BABH01018740    DQ409061    CH477383    ABD65474.1    EAT42177.1    AJVK01009988    AF117590    AAF16712.1    JRES01000751    KNC28768.1    NEVH01005887    PNF38426.1    LC049616    BAU78328.1    CP012523    ALC40009.1    CH933807    EDW11655.1    AXCM01012846    CH916379    EDV94172.1    BABH01005671    ATLV01016737    KE525103    KFB41593.1    GDAI01000627    JAI16976.1    CH480820    EDW54588.1    CH902624    EDV33538.1    CH479180    EDW29313.1    CM002910    KMY90515.1    CH379060    EAL33975.2    AB360763    KQ971338    BAG30999.1    EFA02917.1    CH940649    EDW64414.1    OUUW01000004    SPP79391.1    CH963920    EDW77852.1    CAQQ02017873    CAQQ02017874    CAQQ02017875    CAQQ02017876    CAQQ02017877    CAQQ02017878    APCN01002761    AAAB01008900    EAA09331.1    GGFM01002642    MBW23393.1    GGFM01002660    MBW23411.1    GGFM01002633    MBW23384.1    ADMH02002051    ETN59754.1    GGFJ01008101    MBW57242.1    GGFJ01008100    MBW57241.1    KU659901    AOG17700.1    AB113579    AE014134    AY075194    KU660028    AOG17826.1    GGFK01008333    MBW41654.1    GGFJ01008104    MBW57245.1    UFQS01000997    UFQT01000997    SSX08344.1    SSX28367.1    CM000158    EDW90127.1    CCAG010005611    MG269999    AVX28147.1    GAKP01009356    JAC49596.1    CH954179    EDV56617.1    JXJN01012210    JX291120    AFQ01089.1    KJ188030    AHZ20738.1    KM212828    AIG94926.1    DS232084    EDS34350.1    KX880373    ARE68679.1    GBXI01014449    JAC99842.1    KU159280    ALT10380.1    GAMC01001658    JAC04898.1    KP274881    AKQ00043.1    KT869353    ALO17567.1    AXCN02001010    LC055463    BAU79434.1    GDHC01017106    JAQ01523.1    GBHO01024463    GBHO01010623    GDHC01003517    JAG19141.1    JAG32981.1    JAQ15112.1    GBRD01016222    JAG49604.1    JXUM01095947    JXUM01095948    KQ564233    KXJ72554.1   

Proteomes

UP000005204    UP000053268    UP000053240    UP000007151    UP000283053    UP000218220    + More
UP000037510    UP000008820    UP000092462    UP000095300    UP000075901    UP000037069    UP000235965    UP000075881    UP000075880    UP000092553    UP000009192    UP000075883    UP000001070    UP000076408    UP000030765    UP000192221    UP000001292    UP000007801    UP000075885    UP000008744    UP000095301    UP000001819    UP000007266    UP000008792    UP000268350    UP000007798    UP000015102    UP000075840    UP000007062    UP000069272    UP000000673    UP000000803    UP000092445    UP000078200    UP000002282    UP000075920    UP000092444    UP000008711    UP000075900    UP000092443    UP000092460    UP000079169    UP000091820    UP000002320    UP000076407    UP000075884    UP000075882    UP000075902    UP000075886    UP000069940    UP000249989   

PRIDE

Q767F1    H9JWV0    H9JLJ1    Q9VJK8   

Pfam

PF13847   Methyltransf_31        + More
PF13649   Methyltransf_25
PF08241   Methyltransf_11
PF08242   Methyltransf_12
PF00071   Ras

Interpro

IPR029063   SAM-dependent_MTases        + More
IPR025714   Methyltranfer_dom       
IPR041698   Methyltransf_25       
IPR013216   Methyltransf_11       
IPR013217   Methyltransf_12       
IPR027417   P-loop_NTPase       
IPR001806   Small_GTPase       
IPR005225   Small_GTP-bd_dom       
IPR037872   Rab3       

SUPFAM

SSF53335   SSF53335        + More
SSF52540   SSF52540       

CDD

cd01865  Rab3

ProteinModelPortal

Q767F1   A0A1P1ENW6   Q1KN64   A0A194PH70   A0A194R0H9   A0A212F9H0   + More
A5LFV6   A0A173GZJ8   A0A3S2M9U8   A0A2A4K0R4   D2Y4U6   A0A2H1VCR6   A0A0R5ZNF1   A0A2A4JYY3   A0A1W5ZM45   A5LFV5   A0A2H1VCN4   A0A0L7L836   H9JWV0   Q206L4   A0A1B0D0M7   A0A1I8NU96   Q9U4Z8   A0A182T4X4   A0A0L0C8K2   A0A2J7RC57   A0A182KF39   A0A146IWP0   A0A182ILY4   A0A0M3QU49   B4KKK5   A0A182M749   B4JZ63   H9JLJ1   A0A182YBZ0   A0A084VUE9   A0A1W4VJN5   A0A0K8TS48   B4I231   B3MUK9   A0A182PFZ1   B4G7P2   A0A0J9TPF7   A0A1W4VSL6   A0A1I8MHF6   Q29LS0   B2DCQ0   B4LVM0   A0A3B0K301   B4MZR7   T1GFV4   A0A182HNS9   Q7Q9F0   A0A2M3Z4G9   A0A2M3Z4F9   A0A2M3Z4E3   A0A182FCT5   W5JAE4   A0A2M4BW66   A0A2M4BWC8   A0A1B3PD94   Q9VJK8   A0A1A9Z807   A0A1B3PDM2   A0A2M4ALK9   A0A2M4BVZ2   A0A336L491   A0A1A9VCC9   B4P880   A0A182WMH0   A0A1B0G4E2   A0A2R4N6F4   A0A034W1Z2   B3NNG6   A0A182RP42   A0A1A9XET3   A0A1B0BCZ1   R4IKD3   A0A024BT15   A0A1I8MHL4   A0A075W3Z0   A0A1A9WKH6   B0WTB6   A0A2C9DK13   A0A182X8H7   A0A0A1WN75   A0A1L2BNI6   A0A182N9N0   A0A182LGS6   W8BZU3   A0A0H4SZT2   A0A3S5X9D4   A0A182U4K2   A0A182PZH2   A0A146J3Z5   A0A146KYR9   A0A0A9XHP0   A0A0K8S8Y3   A0A1I8PAX7   A0A182GXP5  

PDB

3GGD     E-value=0.00172588,     Score=96

KEGG

692445    K10718 juvenile hormone-III synthase [EC:2.1.1.325] | (RefSeq) Jhamt, BmJHAMT; juvenile hormone acid

PATHWAY

00981    Insect hormone biosynthesis - Bombyx mori (domestic silkworm)

GO

GO:0006718   GO:0035049   GO:0032259   GO:0019010   GO:0008168   GO:0016740   GO:0008049   GO:0003924   GO:0005525   GO:0016021  

Length:

278

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.04498

Exp number, first 60 AAs:

0.00096

Total prob of N-in:

0.13694

outside

1  -  278

 

 

Pi

45.708928

Theta

173.250117

Tajima's D

-0.770021

CLR

0.552141

CSRT

0.182690865456727

Interpretation

Uncertain