Gene

KWMTBOMO07178

Pre Gene Modal

BGIBMGA010563

Annotation

PREDICTED:_LOW_QUALITY_PROTEIN:_uncharacterized_protein_LOC101742799_[Bombyx_mori]

Location

Bomo_Chr12(+):7154709-7162843      View in EpiBrowser

Full name

Juvenile hormone acid O-methyltransferase      

Alternative Name

Juvenile hormone acid methyltransferase

Location in the cell

Cytoplasmic   Reliability : 2.911

CDS

ATGGTTGGTCAAAATCAAGTCAGGAACGGAAACTCATTCAGGTTTTCCATGAACGACGATGCAGAATTATACGAAAATAGTAACAGTATTCCGAGGCAGGATGCAGCTGACACTTTAAATGAGTATTCGTCAAGATTAAACTGGAAAGAAACGGGAGAAAGTATATTAGACATAGGATGTGGCGATGGAAGTGTCACTGATATCCTGAGATCATACTTACCAACAAGTAGAAAGATTTTGTTGGGCTGCGATATCAACGAGAGAATGGTCAAACACGCCGAAGAGCGTTACGGAAATAAGACGACAGCATTTACTGTACTTAATATAGAAGGGGATATTCCCGATGAGATGAAAGGACAATTCGATCATGTTTTCTCATTTTACACATTACATTGGATTCGGAACCAGGAAAAAGGGTTTACAAATATTCATAATCTGATGAGTAATGATGGAGAATGCCTTTTAACCTTTCTCGCATATTCGCCAATGTATAGTTTGTTCGAAGGACTCAAAGACTCCCCCAAATGGACTGCATGGCTTAAGGATTTCAATCTATTCGTTTCGCCTTATCATGACTGTATGGAACCGGATCGTGTTATTGAAAAACTGTTTAAGAAAATCGGCTTTCGATTCATAGATGTTCGTTCCAGACAAAAGAAATTTGTATACAACAAGATATCCGATTTCAAAATTACAGCGTCAGCAATAAATCCCTTCAAAATCCCGGAACATATGCTAGAAGAATTTTTGAACGACCTTATGGAAGTGGGAGAAGGAATGGGAATAATTGATAAAACAAAAAATACCGTTAATATGTTATATAATTTGCTTATAGTACACGGTAGAAAATAA

Protein

MVGQNQVRNGNSFRFSMNDDAELYENSNSIPRQDAADTLNEYSSRLNWKETGESILDIGCGDGSVTDILRSYLPTSRKILLGCDINERMVKHAEERYGNKTTAFTVLNIEGDIPDEMKGQFDHVFSFYTLHWIRNQEKGFTNIHNLMSNDGECLLTFLAYSPMYSLFEGLKDSPKWTAWLKDFNLFVSPYHDCMEPDRVIEKLFKKIGFRFIDVRSRQKKFVYNKISDFKITASAINPFKIPEHMLEEFLNDLMEVGEGMGIIDKTKNTVNMLYNLLIVHGRK

Description

O-methyltransferase that transfers a methyl group from S-adenosyl-L-methionine (SAM) to the carboxyl group of juvenile hormone acids to produce active juvenile hormones in the corpora allata, the last step during juvenile hormone biosynthesis (PubMed:14530389). Also able to methylate farnesoate to methyl farnesoate (PubMed:14530389).
O-methyltransferase that transfers a methyl group from S-adenosyl-L-methionine (SAM) to the carboxyl group of juvenile hormone acids to produce active juvenile hormones in the corpora allata, the last step during juvenile hormone biosynthesis (PubMed:18549957). Also able to methylate farnesoate to methyl farnesoate (PubMed:18549957).

Catalytic Activity

(2E,6E)-farnesoate + S-adenosyl-L-methionine = methyl (2E,6E)-farnesoate + S-adenosyl-L-homocysteine
juvenile hormone III carboxylate + S-adenosyl-L-methionine = juvenile hormone III + S-adenosyl-L-homocysteine

Biophysicochemical Properties

3.32 uM for juvenile hormone III acid
0.18 uM for farnesoate

Similarity

Belongs to the methyltransferase superfamily.

Keywords

Complete proteome   Methyltransferase   Reference proteome   S-adenosyl-L-methionine   Transferase  

Feature

chain  Juvenile hormone acid O-methyltransferase

Uniprot

H9JWV0   A0A2H1VCR6   A5LFV6   A0A173GZJ8   A0A2A4K0R4   A0A212F9H0   + More
A0A194R0H9   D2Y4U6   A0A194PH70   A0A2A4JYY3   Q767F1   Q1KN64   A0A0R5ZNF1   A0A1P1ENW6   A5LFV5   A0A3S2M9U8   H9JLJ1   A0A2H1VCN4   A0A1W5ZM45   Q9U4Z8   A0A0L7L836   B4MZR7   Q206L4   A0A2J7RC57   B4LVM0   B4KKK5   A0A182M749   A0A1B0D0M7   B3MUK9   A0A075W3Z0   A0A1W4VJN5   A0A182T4X4   A0A146IWP0   A0A182HNS9   Q7Q9F0   A0A1W4VSL6   B4P880   A0A182KF39   B3NNG6   B4JZ63   A0A182LGS6   A0A084VUE9   A0A024BT15   A0A182WMH0   A0A0M3QU49   B4I231   Q9VJK8   A0A182PFZ1   A0A0L0C8K2   A0A0J9TPF7   A0A1B3PD94   A0A182U4K2   A0A1A9Z807   A0A1A9VCC9   R4IKD3   A0A1B0G4E2   A0A3B0K301   A0A1A9XET3   A0A1B0BCZ1   A0A182X8H7   E7EAU2   A0A1I8MHL4   A0A182ILY4   A0A182YBZ0   A0A2M4BWC8   A0A2M4BW66   B4G7P2   A0A182RP42   A0A2M3Z4F9   A0A1I8NU96   A0A0K8TS48   Q29LS0   A0A182FCT5   A0A2M3Z4G9   A0A2M4BVZ2   A0A2C9DK13   A0A2M3Z4E3   A0A336L491   T1GFV4   A0A2R4N6F4   A0A034W1Z2   A0A3S5X9D4   A0A0A1WN75   A0A1L2BNI6   A0A1I8MHF6   A0A1B3PDM2   W5JAE4   A0A2M4ALK9   A0A2P1AAW4   A0A1A9WKH6   A0A182V5V8   A0A346D9Y3   A0A146KYR9   A0A1I8Q8P6   A0A0A9XHP0   A0A1I8MED4   A0A1I8PAX7  

EC Number

2.1.1.325

Pubmed

19121390    22118469    26354079    14530389    18839418    28382786    + More
10620045    26227816    17994087    17510324    12364791    14747013    17210077    17550304    20966253    24438588    18549957    10731132    12537572    12537569    26108605    22936249    23499946    21195178    25315136    25244985    26369729    15632085    28536442    25348373    25830018    20920257    23761445    29136191    26823975    25401762   

EMBL

BABH01018740    ODYU01001839    SOQ38586.1    AB127945    BAF63630.1    KX289532    + More
ANI21405.1    NWSH01000345    PCG77232.1    AGBW02009587    OWR50378.1    KQ460883    KPJ11207.1    GU323798    ADA83703.1    KQ459603    KPI92751.1    PCG77231.1    AB113578    JN851817    DQ465408    ABE98256.1    KM926339    AJR27469.1    BABH01005674    AB127944    BAF63629.1    RSAL01000003    RVE54742.1    BABH01005671    SOQ38587.1    KY421777    ARI71313.1    AF117590    AAF16712.1    JTDY01002391    KOB71509.1    CH963920    EDW77852.1    DQ409061    CH477383    ABD65474.1    EAT42177.1    NEVH01005887    PNF38426.1    CH940649    EDW64414.1    CH933807    EDW11655.1    AXCM01012846    AJVK01009988    CH902624    EDV33538.1    KM212828    AIG94926.1    LC049616    BAU78328.1    APCN01002761    AAAB01008900    EAA09331.1    CM000158    EDW90127.1    CH954179    EDV56617.1    CH916379    EDV94172.1    ATLV01016737    KE525103    KFB41593.1    KJ188030    AHZ20738.1    CP012523    ALC40009.1    CH480820    EDW54588.1    AB113579    AE014134    AY075194    JRES01000751    KNC28768.1    CM002910    KMY90515.1    KU659901    AOG17700.1    JX291120    AFQ01089.1    CCAG010005611    OUUW01000004    SPP79391.1    JXJN01012210    HQ634702    ADV17350.1    GGFJ01008100    MBW57241.1    GGFJ01008101    MBW57242.1    CH479180    EDW29313.1    GGFM01002660    MBW23411.1    GDAI01000627    JAI16976.1    CH379060    EAL33975.2    GGFM01002642    MBW23393.1    GGFJ01008104    MBW57245.1    KX880373    ARE68679.1    GGFM01002633    MBW23384.1    UFQS01000997    UFQT01000997    SSX08344.1    SSX28367.1    CAQQ02017873    CAQQ02017874    CAQQ02017875    CAQQ02017876    CAQQ02017877    CAQQ02017878    MG269999    AVX28147.1    GAKP01009356    JAC49596.1    KT869353    ALO17567.1    GBXI01014449    JAC99842.1    KU159280    ALT10380.1    KU660028    AOG17826.1    ADMH02002051    ETN59754.1    GGFK01008333    MBW41654.1    MF197905    QKKF02019844    AVI10246.1    RZF39563.1    MH176615    AXM43874.1    GDHC01017106    JAQ01523.1    GBHO01024463    GBHO01010623    GDHC01003517    JAG19141.1    JAG32981.1    JAQ15112.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053240    UP000053268    UP000283053    + More
UP000037510    UP000007798    UP000008820    UP000235965    UP000008792    UP000009192    UP000075883    UP000092462    UP000007801    UP000079169    UP000192221    UP000075901    UP000075840    UP000007062    UP000002282    UP000075881    UP000008711    UP000001070    UP000075882    UP000030765    UP000075920    UP000092553    UP000001292    UP000000803    UP000075885    UP000037069    UP000075902    UP000092445    UP000078200    UP000092444    UP000268350    UP000092443    UP000092460    UP000076407    UP000095301    UP000075880    UP000076408    UP000008744    UP000075900    UP000095300    UP000001819    UP000069272    UP000015102    UP000000673    UP000291343    UP000091820    UP000075903   

PRIDE

H9JWV0    Q767F1    H9JLJ1    Q9VJK8   

Pfam

PF13649   Methyltransf_25        + More
PF08241   Methyltransf_11
PF13847   Methyltransf_31
PF08242   Methyltransf_12
PF00071   Ras

Interpro

IPR029063   SAM-dependent_MTases        + More
IPR041698   Methyltransf_25       
IPR013216   Methyltransf_11       
IPR025714   Methyltranfer_dom       
IPR013217   Methyltransf_12       
IPR001806   Small_GTPase       
IPR005225   Small_GTP-bd_dom       
IPR027417   P-loop_NTPase       
IPR037872   Rab3       

SUPFAM

SSF53335   SSF53335        + More
SSF52540   SSF52540       

CDD

cd01865  Rab3

ProteinModelPortal

H9JWV0   A0A2H1VCR6   A5LFV6   A0A173GZJ8   A0A2A4K0R4   A0A212F9H0   + More
A0A194R0H9   D2Y4U6   A0A194PH70   A0A2A4JYY3   Q767F1   Q1KN64   A0A0R5ZNF1   A0A1P1ENW6   A5LFV5   A0A3S2M9U8   H9JLJ1   A0A2H1VCN4   A0A1W5ZM45   Q9U4Z8   A0A0L7L836   B4MZR7   Q206L4   A0A2J7RC57   B4LVM0   B4KKK5   A0A182M749   A0A1B0D0M7   B3MUK9   A0A075W3Z0   A0A1W4VJN5   A0A182T4X4   A0A146IWP0   A0A182HNS9   Q7Q9F0   A0A1W4VSL6   B4P880   A0A182KF39   B3NNG6   B4JZ63   A0A182LGS6   A0A084VUE9   A0A024BT15   A0A182WMH0   A0A0M3QU49   B4I231   Q9VJK8   A0A182PFZ1   A0A0L0C8K2   A0A0J9TPF7   A0A1B3PD94   A0A182U4K2   A0A1A9Z807   A0A1A9VCC9   R4IKD3   A0A1B0G4E2   A0A3B0K301   A0A1A9XET3   A0A1B0BCZ1   A0A182X8H7   E7EAU2   A0A1I8MHL4   A0A182ILY4   A0A182YBZ0   A0A2M4BWC8   A0A2M4BW66   B4G7P2   A0A182RP42   A0A2M3Z4F9   A0A1I8NU96   A0A0K8TS48   Q29LS0   A0A182FCT5   A0A2M3Z4G9   A0A2M4BVZ2   A0A2C9DK13   A0A2M3Z4E3   A0A336L491   T1GFV4   A0A2R4N6F4   A0A034W1Z2   A0A3S5X9D4   A0A0A1WN75   A0A1L2BNI6   A0A1I8MHF6   A0A1B3PDM2   W5JAE4   A0A2M4ALK9   A0A2P1AAW4   A0A1A9WKH6   A0A182V5V8   A0A346D9Y3   A0A146KYR9   A0A1I8Q8P6   A0A0A9XHP0   A0A1I8MED4   A0A1I8PAX7  

PDB

3CCF     E-value=7.9667e-07,     Score=125

KEGG

101742799    K10718 juvenile hormone-III synthase [EC:2.1.1.325] | (RefSeq) uncharacterized LOC101742799

PATHWAY

00981    Insect hormone biosynthesis - Bombyx mori (domestic silkworm)

GO

GO:0008168   GO:0006718   GO:0035049   GO:0032259   GO:0019010   GO:0008049   GO:0016740   GO:0003924   GO:0005525   GO:0016021  

Length:

283

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0173

Exp number, first 60 AAs:

0

Total prob of N-in:

0.09588

outside

1  -  283

 

 

Pi

43.409946

Theta

48.195054

Tajima's D

0.18511

CLR

0.003802

CSRT

0.428528573571321

Interpretation

Uncertain