Gene

KWMTBOMO07168

Pre Gene Modal

BGIBMGA010399

Annotation

PREDICTED:_transmembrane_protein_62-like_[Bombyx_mori]

Location

Bomo_Chr12(-):7021902-7026628      View in EpiBrowser

Full name

Tubby-like protein       + More
Guanylate cyclase      

Location in the cell

PlasmaMembrane   Reliability : 4.827

CDS

ATGATATTTTCTAAATCAGCAATATGGTTACTTTGCGCTTTGTTGTTGTTATCGGTATTTATGGCAAATTTACTGAATATTATTGCGACAGACCAAAACTTCTATTCAGACAATAAAAATTTATCAGTAAATTACACAAAGCATTTAGAGAGAAAAATTGGACAAATCACAGATACATCGGAAAATCTTATATGGTTCCTACAAATTTCAGATATACACATCAGTATATTTCGGGATCCCGGGAGAATAACGCAGTTTCAACAATTTTGCGACAGTACAGTGAAGAAAATTAAGCCAATGGCTGTTTTAGCCTCTGGTGATTTAACAGATGCAAAAGCCAAAGATAATTTAGGTAGTTCTCAAGTAAAACAAGAATGGGTATATTACTCTAGCATCATCAAAGAATCTGGTGTTACTGCTGACACCATTTGGCTAGATATCAGAGGCAATCATGATAATTTTAACATAAGAAGTATTAATTCAGAAGAAAATTATTTTAAAAACTATTCAGTTCAAGGGCCAAATCATCCAAAATCTTATTTACATGTACTTGAAAAGAATGGAGTCAGCTTAGCATTTGTTGGTATAGATGCTTGTCCTGAGCCTGGTTTACGGAGACCATTTAATTTTATTGGTATGTTAGATGCACAAGAACAGCAAATGTTAGAGAAACTCAAGAAGGAAGCTGAATCTAAGGCTGATTATATTGTTTGGTTTGGTCACTATCCTACATCATGTATTATATCCATAGAAAAAGATTCTGAAAGATTGGATTTACGTCAGCTCATAGGGAGCAGTCCAGCTTCAAGAGCATACTTGTGTGGTCATTTACATGCTATGGGAGGTCTAGTCCCAAAAATGTACACGAAGCAAAAGAGGGGATTTTTAGAACTTGAGTTAGAAGATTGGAAAGATAACAGAATGTATCGTTTGGCAGCAATTGATCATGGCCACTTTTCGTTTGTAGATCAAAAACACAATGTATGGCCACTTGTCTTAGTGACTAATCCAAAACATGCCAGATACAATTTACCAGGACGGGAACCTTTAAATCTTATACATAGTTCCACATATATTAGGATTATTGCATTTAGTGATGTGAATATAGACATGGTGAAAGTATCTTTTGACAAGGATAGTTGGATGAATTGTCTTCACAAGGAAGGACCTTTGTATGTTTGTAAATGGCTACCACACTTGTTTAATAATGGCTTACATTATTTATATGTTGCTGCTACTGATGAGTTGGGAAGGGAAGCCTTTTTAAAACATCCATTTTCATTAGATGGCACCTCAGTATATTTTGAAATTATACCAAGAATATTATTAATGGTTAACGGTGGGACAGTGTTTCAGTCAATTTTTGGAACTCTATTGATAATTAATGTTCTGCCTTTAGTTATTTTGCGCTTTCATAAGACCCCTCCGAAAATACGAAGACGGTATGGATATAACTTTGTAAAGAGGGTGTGGCTACTATCAAAAATCGATAGAGTGTTTTGGCCCATTGTATTGTATGCAATTTATTTACCATTTGGTCCGTGGGCCATTGGCAAACTTTTAGATGAACATATTGGAGTTATATTTGCCTGGGGAATAGTTATAAAAGGAGTATTCCTGCCTGAACCATTTACCTATATGTATGGTGGTGTACAACTAATGTTTATTCAAATACCATTAGTACACATTTTGGCCTACTGTTTAGAGATTCGGCTGTTCAAGAGTAATATAAGAGGTGCTCGACGTTTGATTATGCAATTACCATTTATATTTTTACTCAGCATTCAATTGTTATTGGCATATTTTTTCTGGTTGGAGTATGGTACATTGTCATTTTTGTTTGGACCACTGCGGACTTGGAGTGTTGTGTTAACGATACTGCTCTGGTATAGAACCATCACATTACCTGTCGACTATTGCAGCAAATTAAGGAAATTGGATCAAACACCAACATAA

Protein

MIFSKSAIWLLCALLLLSVFMANLLNIIATDQNFYSDNKNLSVNYTKHLERKIGQITDTSENLIWFLQISDIHISIFRDPGRITQFQQFCDSTVKKIKPMAVLASGDLTDAKAKDNLGSSQVKQEWVYYSSIIKESGVTADTIWLDIRGNHDNFNIRSINSEENYFKNYSVQGPNHPKSYLHVLEKNGVSLAFVGIDACPEPGLRRPFNFIGMLDAQEQQMLEKLKKEAESKADYIVWFGHYPTSCIISIEKDSERLDLRQLIGSSPASRAYLCGHLHAMGGLVPKMYTKQKRGFLELELEDWKDNRMYRLAAIDHGHFSFVDQKHNVWPLVLVTNPKHARYNLPGREPLNLIHSSTYIRIIAFSDVNIDMVKVSFDKDSWMNCLHKEGPLYVCKWLPHLFNNGLHYLYVAATDELGREAFLKHPFSLDGTSVYFEIIPRILLMVNGGTVFQSIFGTLLIINVLPLVILRFHKTPPKIRRRYGYNFVKRVWLLSKIDRVFWPIVLYAIYLPFGPWAIGKLLDEHIGVIFAWGIVIKGVFLPEPFTYMYGGVQLMFIQIPLVHILAYCLEIRLFKSNIRGARRLIMQLPFIFLLSIQLLLAYFFWLEYGTLSFLFGPLRTWSVVLTILLWYRTITLPVDYCSKLRKLDQTPT

Catalytic Activity

GTP = 3',5'-cyclic GMP + diphosphate

Similarity

Belongs to the TUB family.
Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Feature

chain  Tubby-like protein

Uniprot

A0A2H1V3X9   A0A2A4JZN7   A0A194PNP1   A0A212FLN6   A0A0L7KTZ6   A0A0T6BDG2   + More
A0A067R532   E2BRR1   A0A0M9A5Q7   A0A2A3EKL9   A0A088A445   D2A253   A0A0L7R5W9   A0A2P8XM99   A0A1Y1LHZ8   A0A0C9RN89   A0A232FIX1   A0A023F0B0   A0A1B6GM26   E2AIM1   A0A1Q3F916   A0A1Q3F8I1   A0A1Q3F9G0   A0A2J7QYB7   A0A026WXI2   A0A1D2N060   A0A0P4VXB6   A0A1B6LP93   Q17M09   E0W3X1   A0A0C9R6X6   A0A0V0GBF7   A0A182FMT7   A0A182JVU1   A0A2M3ZKX5   A0A084WD46   A0A182GHH9   A0A2M3Z3M8   A0A182VLY0   B0X3Q7   T1HFT1   A0A182VSZ6   A0A182R6U5   A0A182XB52   A0A182P8B9   A0A2M4AJU2   Q7Q0R0   T1DHM8   A0A182YHB3   A0A2M4AJZ2   A0A3F2YVF3   A0A2M4CTX0   A0A182I0P6   A0A182N8P4   A0A2M4CVC6   A0A2M4BG93   A0A2M4BH01   A0A151HZH0   A0A158NSR5   A0A2M4BGA0   A0A1B6E2R8   A0A195CPZ0   A0A0K8T7G8   A0A1L8D9N6   A0A0A9YRK4   F4W6Y6   A0A1Y1LK38   A0A1I8JV31   A0A1B0CFM4   A0A151WXB9   A0A195DUV2   A0A1Y1LX72   A0A182IXY8   A0A1Y1LNU2   A0A1Q3G207   A0A195EWQ0   A0A182KJR3   T1IQP5   E9IDK5   A0A2J7QYB0   A0A1B0D177   A0A182S7J7   A0A1B6D3N4   A0A2S2NKJ5   A0A2H8U021   J9K305   A0A336KPL4   A0A2R2MT35   A0A2S2Q9P0   N6T9V6   A0A2P2I9C2   A0A1J1IVW9   A0A2M3Z5K7   R0LHJ7   A0A1B6CCS3  

EC Number

4.6.1.2

Pubmed

26354079    22118469    26227816    24845553    20798317    18362917    + More
19820115    29403074    28004739    28648823    25474469    24508170    27289101    27129103    17510324    20566863    24438588    26483478    12364791    14747013    17210077    25244985    21347285    25401762    21719571    20966253    21282665    23537049   

EMBL

ODYU01000563    SOQ35537.1    NWSH01000345    PCG77236.1    KQ459603    KPI92740.1    + More
AGBW02007731    OWR54646.1    JTDY01005886    KOB66514.1    LJIG01001575    KRT85365.1    KK852886    KDR14364.1    GL449983    EFN81621.1    KQ435728    KOX77780.1    KZ288219    PBC32267.1    KQ971338    EFA02740.2    KQ414648    KOC66270.1    PYGN01001734    PSN33115.1    GEZM01054991    JAV73272.1    GBYB01008551    JAG78318.1    NNAY01000140    OXU30622.1    GBBI01003779    JAC14933.1    GECZ01006319    JAS63450.1    GL439840    EFN66710.1    GFDL01010999    JAV24046.1    GFDL01011247    JAV23798.1    GFDL01010873    JAV24172.1    NEVH01009108    PNF33569.1    KK107078    EZA60451.1    LJIJ01000336    ODM98676.1    GDKW01002374    JAI54221.1    GEBQ01014578    GEBQ01008210    JAT25399.1    JAT31767.1    CH477209    EAT47735.1    DS235883    EEB20327.1    GBYB01008552    JAG78319.1    GECL01000667    JAP05457.1    GGFM01008359    MBW29110.1    ATLV01022933    KE525338    KFB48140.1    JXUM01063741    KQ562265    KXJ76277.1    GGFM01002371    MBW23122.1    DS232320    EDS39949.1    ACPB03018819    GGFK01007732    MBW41053.1    AAAB01008980    EAA13800.4    GAMD01002261    JAA99329.1    GGFK01007731    MBW41052.1    AXCM01000009    GGFL01004609    MBW68787.1    APCN01005229    GGFL01004610    MBW68788.1    GGFJ01002938    MBW52079.1    GGFJ01002937    MBW52078.1    KQ976707    KYM77064.1    ADTU01025009    ADTU01025010    GGFJ01002939    MBW52080.1    GEDC01005097    JAS32201.1    KQ977444    KYN02695.1    GBRD01004460    JAG61361.1    GFDF01010901    JAV03183.1    GBHO01011460    GBHO01011459    JAG32144.1    JAG32145.1    GL887793    EGI70040.1    GEZM01054992    JAV73271.1    AJWK01010181    KQ982667    KYQ52554.1    KQ980322    KYN16653.1    GEZM01044562    JAV78143.1    GEZM01054995    JAV73266.1    GFDL01001200    JAV33845.1    KQ981948    KYN32576.1    JH431312    GL762454    EFZ21350.1    PNF33571.1    AJVK01002435    GEDC01016997    JAS20301.1    GGMR01005094    MBY17713.1    GFXV01007297    MBW19102.1    ABLF02029102    UFQS01000670    UFQT01000670    SSX05992.1    SSX26349.1    GGMS01005242    MBY74445.1    APGK01038464    KB740957    ENN77034.1    IACF01005008    LAB70595.1    CVRI01000063    CRL04248.1    GGFM01003056    MBW23807.1    KB743275    EOA99787.1    GEDC01026087    JAS11211.1   

Proteomes

UP000218220    UP000053268    UP000007151    UP000037510    UP000027135    UP000008237    + More
UP000053105    UP000242457    UP000005203    UP000007266    UP000053825    UP000245037    UP000215335    UP000000311    UP000235965    UP000053097    UP000094527    UP000008820    UP000009046    UP000069272    UP000075881    UP000030765    UP000069940    UP000249989    UP000075903    UP000002320    UP000015103    UP000075920    UP000075900    UP000076407    UP000075885    UP000007062    UP000076408    UP000075883    UP000075840    UP000075884    UP000078540    UP000005205    UP000078542    UP000007755    UP000075902    UP000092461    UP000075809    UP000078492    UP000075880    UP000078541    UP000075882    UP000092462    UP000075901    UP000007819    UP000085678    UP000019118    UP000183832   

Pfam

PF00149   Metallophos        + More
PF01167   Tub
PF01699   Na_Ca_ex
PF06372   Gemin6
PF02931   Neur_chan_LBD
PF01094   ANF_receptor
PF00211   Guanylate_cyc
PF07701   HNOBA
PF07714   Pkinase_Tyr

Interpro

IPR004843   Calcineurin-like_PHP_ApaH        + More
IPR041871   MPP_TMEM62       
IPR029052   Metallo-depent_PP-like       
IPR000007   Tubby_C       
IPR018066   Tubby_C_CS       
IPR025659   Tubby-like_C       
IPR004481   K/Na/Ca-exchanger       
IPR009422   Gemin6       
IPR004837   NaCa_Exmemb       
IPR030232   SLC24A4       
IPR006202   Neur_chan_lig-bd       
IPR036734   Neur_chan_lig-bd_sf       
IPR028082   Peripla_BP_I       
IPR001054   A/G_cyclase       
IPR000719   Prot_kinase_dom       
IPR029787   Nucleotide_cyclase       
IPR011645   HNOB_dom_associated       
IPR001828   ANF_lig-bd_rcpt       
IPR001245   Ser-Thr/Tyr_kinase_cat_dom       
IPR018297   A/G_cyclase_CS       
IPR001170   ANPR/GUC       
IPR011009   Kinase-like_dom_sf       
IPR013783   Ig-like_fold       

SUPFAM

SSF54518   SSF54518        + More
SSF63712   SSF63712       
SSF56112   SSF56112       
SSF53822   SSF53822       
SSF55073   SSF55073       

Gene 3D

3.60.21.10     3.20.90.10     2.70.170.10     3.30.70.1230     2.60.40.10    

CDD

cd07401  MPP_TMEM62_N

ProteinModelPortal

A0A2H1V3X9   A0A2A4JZN7   A0A194PNP1   A0A212FLN6   A0A0L7KTZ6   A0A0T6BDG2   + More
A0A067R532   E2BRR1   A0A0M9A5Q7   A0A2A3EKL9   A0A088A445   D2A253   A0A0L7R5W9   A0A2P8XM99   A0A1Y1LHZ8   A0A0C9RN89   A0A232FIX1   A0A023F0B0   A0A1B6GM26   E2AIM1   A0A1Q3F916   A0A1Q3F8I1   A0A1Q3F9G0   A0A2J7QYB7   A0A026WXI2   A0A1D2N060   A0A0P4VXB6   A0A1B6LP93   Q17M09   E0W3X1   A0A0C9R6X6   A0A0V0GBF7   A0A182FMT7   A0A182JVU1   A0A2M3ZKX5   A0A084WD46   A0A182GHH9   A0A2M3Z3M8   A0A182VLY0   B0X3Q7   T1HFT1   A0A182VSZ6   A0A182R6U5   A0A182XB52   A0A182P8B9   A0A2M4AJU2   Q7Q0R0   T1DHM8   A0A182YHB3   A0A2M4AJZ2   A0A3F2YVF3   A0A2M4CTX0   A0A182I0P6   A0A182N8P4   A0A2M4CVC6   A0A2M4BG93   A0A2M4BH01   A0A151HZH0   A0A158NSR5   A0A2M4BGA0   A0A1B6E2R8   A0A195CPZ0   A0A0K8T7G8   A0A1L8D9N6   A0A0A9YRK4   F4W6Y6   A0A1Y1LK38   A0A1I8JV31   A0A1B0CFM4   A0A151WXB9   A0A195DUV2   A0A1Y1LX72   A0A182IXY8   A0A1Y1LNU2   A0A1Q3G207   A0A195EWQ0   A0A182KJR3   T1IQP5   E9IDK5   A0A2J7QYB0   A0A1B0D177   A0A182S7J7   A0A1B6D3N4   A0A2S2NKJ5   A0A2H8U021   J9K305   A0A336KPL4   A0A2R2MT35   A0A2S2Q9P0   N6T9V6   A0A2P2I9C2   A0A1J1IVW9   A0A2M3Z5K7   R0LHJ7   A0A1B6CCS3  

KEGG

101741585    no KO assigned | (RefSeq) transmembrane protein 62-like

GO

GO:0016787   GO:0016021   GO:0005634   GO:0000245   GO:0055085   GO:0005230   GO:0004672   GO:0004383   GO:0035556   GO:0005524   GO:0016887   GO:0016020   GO:0005515   GO:0031032   GO:0030060   GO:0019752   GO:0016491   GO:0016295   GO:0016296  

PANTHER

PTHR10846:SF21   PTHR10846  

Length:

651

Number of predicted TMHs:

6

Exp number of AAs in TMHs:

129.43675

Exp number, first 60 AAs:

22.70219

Total prob of N-in:

0.99683

POSSIBLE N-term signal

sequence

inside

1  -  6

TMhelix

7  -  29

outside

30  -  448

TMhelix

449  -  471

inside

472  -  498

TMhelix

499  -  518

outside

519  -  547

TMhelix

548  -  570

inside

571  -  582

TMhelix

583  -  605

outside

606  -  619

TMhelix

620  -  637

inside

638  -  651

 

 

Pi

183.30775

Theta

191.8714

Tajima's D

-0.588569

CLR

0.168471

CSRT

0.223088845557722

Interpretation

Uncertain