Gene

KWMTBOMO07117  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA010541

Annotation

ubiquitin-conjugating_enzyme_E2-17_kDa_[Papilio_polytes]

Location

Bomo_Chr12(+):4993128-4995234      View in EpiBrowser

Full name

Ubiquitin-conjugating enzyme E2-17 kDa      

Alternative Name

E2 ubiquitin-conjugating enzyme D1
Protein effete
Ubiquitin carrier protein
Ubiquitin-protein ligase

Location in the cell

Extracellular   Reliability : 1.011 Nuclear   Reliability : 1.309

CDS

ATGGCGTTAAAAAGAATTAATAGGGAATTACAAGATCTGGGCAGGGATCCACCAGCACAATGTTCGGCAGGCCCACACGGTGAAGATCTGTTCCATTGGCAAGCCACAATTATGGGCCCAGTTGACAGTCCTTATCAAGGAGGAGTTTTCTTCCTTACCATACATTTCCCTACAGACTACCCTTTCAAACCACCAAAAGTTGCATTCACAACACGTATTTATCATCCTAACATAAACAGTAATGGTTCCATCTGTCTTGACATTCTGCGTGCACAGTGGTCACCAGCGCTCACCATATCCAAAGTGTTGCTCTCAATCTGCTCACTTCTATGCGATCCCAACCCAGACGACCCTTTGGTGCCAGAAATTGCTAGGATCTATAAAACAGACAGAGAAAAGTACAATGAATTAGCCCGTGAGTGGACGAGGAAGTATGCCATGTGA

Protein

MALKRINRELQDLGRDPPAQCSAGPHGEDLFHWQATIMGPVDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRAQWSPALTISKVLLSICSLLCDPNPDDPLVPEIARIYKTDREKYNELAREWTRKYAM

Description

Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Required for proper telomere behavior during cell divisions and possibly for ubiquitination of proteins involved in postmeiotic stages of spermatogenesis. Deletion mutations are lethal in homozygotes.

Catalytic Activity

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.

Similarity

Belongs to the ubiquitin-conjugating enzyme family.

Keywords

ATP-binding   Cell cycle   Cell division   Complete proteome   Meiosis   Nucleotide-binding   Reference proteome   Transferase   Ubl conjugation pathway  

Feature

chain  Ubiquitin-conjugating enzyme E2-17 kDa

Uniprot

I4DMN2   A0A194QNM7   A0A3S2P5K3   S4PY84   I4DJL0   A0A2W1BT72   + More
A0A2A4J9N6   A0A1E1W2E0   A0A2H1WH50   A0A212EJW9   R4WD50   A0A1W4VMH1   A0A1Y1L272   A0A1L8DST5   B4LW93   B4QZS0   A0A1I8N9E2   A0A2H8TD91   A0A1W4W7P8   A0A0P4VRM6   A0A1A9UXF7   T1E371   T1E8G1   B5DVF8   A0A1Q3EUM9   B4G6D8   K7J079   U5EX56   D6WA84   B4PSQ0   A0A0V0G3A8   A0A023F5W1   Q6PPH5   A0A0J7NNQ2   A0A1J1J773   A0A067R5A9   A0A1B6KZF7   A0A2M4CTB0   A0A1B6H1S3   A0A0C9RDK1   A0A1I8PUD6   B3LWS2   A0A158NLI4   B4NAD1   B4HEJ3   B4JY44   B3P3N1   A0A0P6JMZ4   A0A2M3Z099   A0A1L8EHR8   A0A2M4A8G4   A0A1B6D5J5   A0A1B6JLT1   A0A3L8DQ00   A0A0K8TP71   A0A069DPB9   A0A2M4C2H7   A0A1A9WU63   A0A0K8VL46   A0A182QYD8   B4K908   R4FMS4   J3JXP2   A0A182N1D5   A0A182W538   D3TS06   A0A0B4KHJ1   Q1HR02   Q7PRY1   A0A0A9WAC2   A0A182FJT2   Q201W8   A0A2C9GQ33   P25867   D1FQ31   A0A170XWQ0   A0A0P5AG33   A0A2A3EG12   V9IJ25   A0A088AG51   A0A2R5LNE8   E7D1F1   A0A0P6G783   A0A1W7R9B5   A0A131Y4L1   A0A023GF12   A0A224ZAU3   A0A131YU78   A0A023FEA5   L7M345   A0A1E1X0Y6   A0A1D2NFE7   A0A131XHJ9   A0A2I9LPW8   A0A0L7KYD3   A0A0N8BF22   A0A0A7UXJ4   F5ANJ1   A0A183HY60   A0A2G5U3U1  

EC Number

2.3.2.23

Pubmed

22651552    26354079    23622113    28756777    22118469    23691247    + More
28004739    17994087    25315136    27129103    24330624    15632085    20075255    18362917    19820115    17550304    25474469    24845553    21347285    30249741    26369729    26334808    18057021    22516182    23537049    20353571    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    17204158    17510324    12364791    14747013    17210077    25401762    26823975    1310935    12537569    9106658    28797301    26830274    25576852    28503490    27289101    28049606    29248469    26227816   

EMBL

AK402550    BAM19172.1    KQ461194    KPJ06959.1    RSAL01000017    RVE52962.1    + More
GAIX01003733    JAA88827.1    AK401478    KQ459603    BAM18100.1    KPI92877.1    KZ149975    PZC75960.1    NWSH01002353    PCG68466.1    GDQN01009914    JAT81140.1    ODYU01008565    SOQ52276.1    AGBW02014375    OWR41774.1    AK417393    BAN20608.1    GEZM01068615    JAV66861.1    GFDF01004689    JAV09395.1    CH940650    EDW67627.1    CM000364    EDX12918.1    GFXV01000254    MBW12059.1    GDKW01000869    JAI55726.1    GALA01000635    JAA94217.1    GAMD01002212    JAA99378.1    CM000070    EDY67763.1    GFDL01016032    JAV19013.1    CH479179    EDW23896.1    GANO01001105    JAB58766.1    KQ971312    EEZ99199.1    CM000160    EDW97546.1    GECL01003529    JAP02595.1    GBBI01002135    JAC16577.1    AY588071    AAT01083.1    LBMM01002974    KMQ94120.1    CVRI01000073    CRL07628.1    KK852692    KDR18345.1    GEBQ01023145    JAT16832.1    GGFL01004233    MBW68411.1    GECZ01001140    JAS68629.1    GBYB01005051    JAG74818.1    CH902617    EDV42710.1    ADTU01019447    CH964232    EDW80745.1    CH480815    EDW42150.1    CH916377    EDV90606.1    CH954181    EDV48919.1    GDIQ01002605    JAN92132.1    GGFM01001199    MBW21950.1    GFDG01000519    JAV18280.1    GGFK01003734    MBW37055.1    GEDC01016382    JAS20916.1    GECU01007512    JAT00195.1    QOIP01000005    RLU22441.1    GDAI01001459    JAI16144.1    GBGD01003358    JAC85531.1    GGFJ01010379    MBW59520.1    GDHF01026453    GDHF01012703    JAI25861.1    JAI39611.1    AXCN02001308    CH933806    EDW16605.1    KRG02227.1    ACPB03017455    GAHY01000858    JAA76652.1    APGK01020275    APGK01020276    APGK01020277    APGK01020278    BT128012    KB740187    KB632345    AEE62974.1    ENN81177.1    ERL93069.1    CCAG010005295    EZ424208    ADD20484.1    AE014297    KX531702    KX532146    AGB95959.1    AGB95960.1    ANY27512.1    ANY27956.1    DQ440292    CH477262    ABF18325.1    EAT45631.1    AAAB01008846    EAA06420.3    GBHO01038885    GBHO01038884    GBRD01011246    GDHC01016173    JAG04719.1    JAG04720.1    JAG54578.1    JAQ02456.1    ABLF02035308    ABLF02035313    DQ413218    AK341713    ABD72686.1    BAH72034.1    APCN01003964    APCN01003965    X62575    AY060304    U68298    EZ419931    ACZ28286.1    GEMB01003949    JAR99307.1    GDIP01199354    JAJ24048.1    KZ288262    PBC30424.1    JR047765    AEY60501.1    GGLE01006905    MBY11031.1    HQ005899    ADV40195.1    GDIQ01037486    JAN57251.1    GFAH01000656    JAV47733.1    GEFM01002348    JAP73448.1    GBBM01002979    JAC32439.1    GFPF01013127    MAA24273.1    GEDV01006455    JAP82102.1    GBBK01004171    JAC20311.1    GACK01006288    JAA58746.1    GFAC01006482    JAT92706.1    LJIJ01000058    ODN03983.1    GEFH01001998    JAP66583.1    GFWZ01000442    MBW20432.1    JTDY01004493    KOB68081.1    GDIQ01184083    JAK67642.1    KP203888    AJA90881.1    HQ436509    AEC48730.1    UZAJ01039839    VDP11285.1    PDUG01000004    PIC34210.1   

Proteomes

UP000053240    UP000283053    UP000053268    UP000218220    UP000007151    UP000192221    + More
UP000008792    UP000000304    UP000095301    UP000192223    UP000078200    UP000001819    UP000008744    UP000002358    UP000007266    UP000002282    UP000036403    UP000183832    UP000027135    UP000095300    UP000007801    UP000005205    UP000007798    UP000001292    UP000001070    UP000008711    UP000279307    UP000091820    UP000075886    UP000009192    UP000015103    UP000019118    UP000030742    UP000075884    UP000075920    UP000092444    UP000000803    UP000008820    UP000007062    UP000069272    UP000007819    UP000075840    UP000242457    UP000005203    UP000094527    UP000037510    UP000050787    UP000230233   

PRIDE

P25867    L7M345   

Pfam

PF00179   UQ_con

Interpro

IPR016135   UBQ-conjugating_enzyme/RWD        + More
IPR000608   UBQ-conjugat_E2       
IPR023313   UBQ-conjugating_AS       

SUPFAM

SSF54495   SSF54495       

Gene 3D

3.10.110.10    

CDD

cd00195  UBCc

ProteinModelPortal

I4DMN2   A0A194QNM7   A0A3S2P5K3   S4PY84   I4DJL0   A0A2W1BT72   + More
A0A2A4J9N6   A0A1E1W2E0   A0A2H1WH50   A0A212EJW9   R4WD50   A0A1W4VMH1   A0A1Y1L272   A0A1L8DST5   B4LW93   B4QZS0   A0A1I8N9E2   A0A2H8TD91   A0A1W4W7P8   A0A0P4VRM6   A0A1A9UXF7   T1E371   T1E8G1   B5DVF8   A0A1Q3EUM9   B4G6D8   K7J079   U5EX56   D6WA84   B4PSQ0   A0A0V0G3A8   A0A023F5W1   Q6PPH5   A0A0J7NNQ2   A0A1J1J773   A0A067R5A9   A0A1B6KZF7   A0A2M4CTB0   A0A1B6H1S3   A0A0C9RDK1   A0A1I8PUD6   B3LWS2   A0A158NLI4   B4NAD1   B4HEJ3   B4JY44   B3P3N1   A0A0P6JMZ4   A0A2M3Z099   A0A1L8EHR8   A0A2M4A8G4   A0A1B6D5J5   A0A1B6JLT1   A0A3L8DQ00   A0A0K8TP71   A0A069DPB9   A0A2M4C2H7   A0A1A9WU63   A0A0K8VL46   A0A182QYD8   B4K908   R4FMS4   J3JXP2   A0A182N1D5   A0A182W538   D3TS06   A0A0B4KHJ1   Q1HR02   Q7PRY1   A0A0A9WAC2   A0A182FJT2   Q201W8   A0A2C9GQ33   P25867   D1FQ31   A0A170XWQ0   A0A0P5AG33   A0A2A3EG12   V9IJ25   A0A088AG51   A0A2R5LNE8   E7D1F1   A0A0P6G783   A0A1W7R9B5   A0A131Y4L1   A0A023GF12   A0A224ZAU3   A0A131YU78   A0A023FEA5   L7M345   A0A1E1X0Y6   A0A1D2NFE7   A0A131XHJ9   A0A2I9LPW8   A0A0L7KYD3   A0A0N8BF22   A0A0A7UXJ4   F5ANJ1   A0A183HY60   A0A2G5U3U1  

PDB

4DDI     E-value=7.92934e-81,     Score=759

KEGG

101738264    K06689 ubiquitin-conjugating enzyme E2 D [EC:2.3.2.23] | (RefSeq) ubiquitin-conjugating enzyme E2-17

PATHWAY

04013    MAPK signaling pathway - fly - Bombyx mori (domestic silkworm)
04120    Ubiquitin mediated proteolysis - Bombyx mori (domestic silkworm)
04141    Protein processing in endoplasmic reticulum - Bombyx mori (domestic silkworm)
04624    Toll and Imd signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0005524   GO:0016740   GO:0048132   GO:0000278   GO:0030718   GO:0031145   GO:0097039   GO:0031647   GO:0061630   GO:0016322   GO:0045676   GO:0051276   GO:0045879   GO:0001751   GO:0031625   GO:0061631   GO:0007140   GO:0016874   GO:0000151   GO:0006511   GO:0016567   GO:0000209   GO:0005829   GO:0001745  

Length:

147

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0222

Exp number, first 60 AAs:

0.01584

Total prob of N-in:

0.41428

outside

1  -  147

 

 

Pi

79.477496

Theta

158.448985

Tajima's D

-1.365946

CLR

25.479743

CSRT

0.0776461176941153

Interpretation

Uncertain