Gene

KWMTBOMO07115

Pre Gene Modal

BGIBMGA010418

Annotation

pituitary_homeobox1_[Bombyx_mori]

Location

Bomo_Chr12(-):4882586-4945601      View in EpiBrowser

Full name

Homeobox protein       + More
Pituitary homeobox homolog Ptx1      

Transcription factor

Homeobox

Location in the cell

Nuclear   Reliability : 4.745

CDS

ATGGAGCCGCTAAGCGAGAACGGGCTCTGCCTGTCCGAACTGGACTTGCACGGAGGCGGTCACCTACACGAGTCCGTGGCCGCTTCCGTCGGCTCGGCCATATCAAGTCTGATGGCTCCCCTGCACCACGAGCCTCAGCACACGCCCCTCCACCACGCGCCGCCACTGCACCACGAGCCTCTGGAGAAATTAAAACTATGGGCAGAGACGGGCGAATTTCGAGACAGCGGTCACTCTTCTCTCACATCAGGTGGCTCTGGCGTGGAACAATCCTCGTTGTATGCACCGGCAAGACCCCGACGCGATAGAAAAATGACAGACGACAGTAATCGCCCACTGACATCAGAGCCCACGATTAAAACGGAATCCACGACACCAGGAGTGGGACCTGAAGAACCGAATTTAGACGACAAAGGCGATAAGAAAAACAAGAGGCAGCGTCGGCAGCGGACTCACTTCACCAGCCAACAGCTTCAAGAACTAGAGGCGACTTTTGCAAGGAATCGTTATCCAGATATGTCCACGCGCGAAGAGATCGCCATGTGGACTAACTTAACAGAGGCTAGAGTTAGGGTATGGTTTAAAAACCGGAGAGCCAAGTGGCGAAAACGAGAAAGGAATGCAATGAATGCGGCAGCCGCGGCTGCTGCCGATTTCAAAAACGGCTTCAGCACTCAATTTAACGGCTTAATGCAGCCGTTCCCGGACACCGATGCGCTTTACTCGTCGTATCCCTATAATAACTGGGCTGCGAAAGTACCTAGTCCACTAGGAACGAAAAGTTTTCCGTGGCCTGTCAATCCCCTCGGATCAGTGGTACCGGCAAGTCATCATCAGGGTTCGGTAAACTGTTTCAACACGGCGACTTCAATGGGAGGAGTCGGAGGCGGCGGGATGGGAGGCGTCGGGGGATCAGCCGGTGTAGGAGGTGGTGTTGCTCCGTGCCCTTACACTGCACCTCCCAATCCTTACAGCATGTACAGGACAGAGCCGTGTCCGGCAATGTCGTCATCGATAGCGTCGCTAAGGTTGAAGGCGAAGCAGCACTCATCAGGGTTCGGCGGGAGCTACGGGTCAGTGTCGCCGGTGTCGAGGGCCGGGTCCGCGCCGCTGTCAGCGTGCCAGTACGCGGGCGGAGTGGGAGTGTCGGACCGCGTGCTCTGA

Protein

MEPLSENGLCLSELDLHGGGHLHESVAASVGSAISSLMAPLHHEPQHTPLHHAPPLHHEPLEKLKLWAETGEFRDSGHSSLTSGGSGVEQSSLYAPARPRRDRKMTDDSNRPLTSEPTIKTESTTPGVGPEEPNLDDKGDKKNKRQRRQRTHFTSQQLQELEATFARNRYPDMSTREEIAMWTNLTEARVRVWFKNRRAKWRKRERNAMNAAAAAAADFKNGFSTQFNGLMQPFPDTDALYSSYPYNNWAAKVPSPLGTKSFPWPVNPLGSVVPASHHQGSVNCFNTATSMGGVGGGGMGGVGGSAGVGGGVAPCPYTAPPNPYSMYRTEPCPAMSSSIASLRLKAKQHSSGFGGSYGSVSPVSRAGSAPLSACQYAGGVGVSDRVL

Description

Appears to control physiological cell functions rather than pattern formation during embryogenesis.

Similarity

Belongs to the paired homeobox family. Bicoid subfamily.
Belongs to the paired homeobox family.

Keywords

Activator   Complete proteome   Developmental protein   DNA-binding   Homeobox   Nucleus   Reference proteome   Transcription   Transcription regulation  

Feature

chain  Pituitary homeobox homolog Ptx1

Uniprot

A1IGG8   A0A212EYE4   A0A2A4K7G5   A0A2A4K5T1   A0A2H1W442   A0A0L7LAK0   + More
A0A1B0CDX2   A0A1L8DI49   A0A1L8DI52   A0A1L8DIF6   A0A1J1J6M6   A0A1B6FM42   A0A1B6F0D8   A0A034VGF4   A0A139WMW8   A0A0K8UVR1   A0A0K8VC27   W8C0D8   A0A0A1WWH7   A0A0A1WZ84   E0VSZ1   A0A0K8V0L3   A0A0K8UH08   A0A336LRN3   B4NH09   B4GN99   A0A3B0JFF3   Q29CC6   B4JY40   B3MT67   A0A0M5JCE7   B4LW90   B4K913   O18400   Q7KRT5   A0A1Y1LB34   B4PMN1   A0A0L0CQU1   B7Z0S4   A0A1W4UJU9   A0A1W4U705   A0A2C9H879   A0A1I8M861   Q7PRW5   B4R2B4   A0A0K8V7Q0   A0A1I8P2F6   B3P7U9   A0A2C9GPV0   A0A1S4FI95   Q16ZY9   A0A1W4U6C7   B4HZX1   A0A1B6F840   A0A1B6FFQ5   A0A2S2PLF4   J9K748   A0A0K8UMR9   A0A0K8U2Q0   A0A2H8THK8   B0WZ28   B0X9P9   A0A0A9WBL0   A0A2R7VNB2   A0A026WZ30   A0A3L8DT02   A0A0C9RJN8   A0A0C9QTM7   A0A0N9JKX8  

Pubmed

22118469    26227816    25348373    18362917    19820115    24495485    + More
25830018    20566863    17994087    15632085    9431811    10731132    12537572    12537568    12537573    12537574    16110336    17569856    17569867    28004739    17550304    26108605    25315136    12364791    14747013    17210077    17510324    25401762    24508170    30249741    26402456   

EMBL

AB162107    BAF44479.1    AGBW02011531    OWR46518.1    NWSH01000098    PCG79592.1    + More
PCG79591.1    ODYU01006211    SOQ47860.1    JTDY01002052    KOB72231.1    AJWK01008346    AJWK01008347    GFDF01007935    JAV06149.1    GFDF01007936    JAV06148.1    GFDF01007937    JAV06147.1    CVRI01000073    CRL07634.1    GECZ01018519    JAS51250.1    GECZ01026124    JAS43645.1    GAKP01018324    JAC40628.1    KQ971312    KYB29282.1    GDHF01021686    JAI30628.1    GDHF01015800    JAI36514.1    GAMC01011489    GAMC01011487    GAMC01011486    GAMC01011485    JAB95069.1    GBXI01011442    JAD02850.1    GBXI01010125    JAD04167.1    DS235758    EEB16497.1    GDHF01019991    JAI32323.1    GDHF01026347    JAI25967.1    UFQT01000137    SSX20676.1    CH964272    EDW84506.2    CH479186    EDW39225.1    OUUW01000005    SPP80855.1    CM000070    EAL26720.3    CH916377    EDV90602.1    CH902623    EDV30457.2    CP012526    ALC46356.1    CH940650    EDW67624.2    CH933806    EDW16610.2    AJ001519    AE014297    BT009990    AAS65234.1    GEZM01064396    JAV68786.1    CM000160    EDW99165.2    JRES01000032    KNC34740.1    ACL83586.2    AAAB01008846    EAA06466.6    CM000364    EDX15070.1    GDHF01017418    JAI34896.1    CH954182    EDV53007.1    APCN01003925    CH477480    EAT40235.1    CH480819    EDW53578.1    GECZ01023371    JAS46398.1    GECZ01020805    JAS48964.1    GGMR01017662    MBY30281.1    ABLF02036956    ABLF02036964    ABLF02036965    GDHF01024337    JAI27977.1    GDHF01031275    JAI21039.1    GFXV01001812    MBW13617.1    DS232203    EDS37342.1    DS232544    EDS43251.1    GBHO01037762    JAG05842.1    KK854003    PTY08994.1    KK107063    EZA61073.1    QOIP01000005    RLU22898.1    GBYB01007081    JAG76848.1    GBYB01007079    JAG76846.1    KR181941    ALG35689.1   

Proteomes

UP000007151    UP000218220    UP000037510    UP000092461    UP000183832    UP000007266    + More
UP000009046    UP000007798    UP000008744    UP000268350    UP000001819    UP000001070    UP000007801    UP000092553    UP000008792    UP000009192    UP000000803    UP000002282    UP000037069    UP000192221    UP000076407    UP000095301    UP000007062    UP000000304    UP000095300    UP000008711    UP000075840    UP000008820    UP000001292    UP000007819    UP000002320    UP000053097    UP000279307   

PRIDE

A1IGG8    O18400    Q7KRT5   

Pfam

PF00046   Homeodomain        + More
PF03826   OAR

Interpro

IPR017970   Homeobox_CS        + More
IPR003654   OAR_dom       
IPR001356   Homeobox_dom       
IPR016233   Homeobox_Pitx/unc30       
IPR009057   Homeobox-like_sf       
IPR020479   Homeobox_metazoa       

SUPFAM

SSF46689   SSF46689       

CDD

cd00086  homeodomain

ProteinModelPortal

A1IGG8   A0A212EYE4   A0A2A4K7G5   A0A2A4K5T1   A0A2H1W442   A0A0L7LAK0   + More
A0A1B0CDX2   A0A1L8DI49   A0A1L8DI52   A0A1L8DIF6   A0A1J1J6M6   A0A1B6FM42   A0A1B6F0D8   A0A034VGF4   A0A139WMW8   A0A0K8UVR1   A0A0K8VC27   W8C0D8   A0A0A1WWH7   A0A0A1WZ84   E0VSZ1   A0A0K8V0L3   A0A0K8UH08   A0A336LRN3   B4NH09   B4GN99   A0A3B0JFF3   Q29CC6   B4JY40   B3MT67   A0A0M5JCE7   B4LW90   B4K913   O18400   Q7KRT5   A0A1Y1LB34   B4PMN1   A0A0L0CQU1   B7Z0S4   A0A1W4UJU9   A0A1W4U705   A0A2C9H879   A0A1I8M861   Q7PRW5   B4R2B4   A0A0K8V7Q0   A0A1I8P2F6   B3P7U9   A0A2C9GPV0   A0A1S4FI95   Q16ZY9   A0A1W4U6C7   B4HZX1   A0A1B6F840   A0A1B6FFQ5   A0A2S2PLF4   J9K748   A0A0K8UMR9   A0A0K8U2Q0   A0A2H8THK8   B0WZ28   B0X9P9   A0A0A9WBL0   A0A2R7VNB2   A0A026WZ30   A0A3L8DT02   A0A0C9RJN8   A0A0C9QTM7   A0A0N9JKX8  

PDB

2LKX     E-value=1.80679e-26,     Score=296

KEGG

100037433    K04686 paired-like homeodomain transcription factor 2 | (RefSeq) Ptx1, Bmptx1; pituitary homeobox1

PATHWAY

04350    TGF-beta signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0005634   GO:0007275   GO:0043565   GO:0003700   GO:0006355   GO:0001085   GO:0000978   GO:0009653   GO:0005667   GO:0006357   GO:0003677   GO:0006228   GO:0006241   GO:0030060   GO:0019752   GO:0016491   GO:0016295   GO:0016296  

Subcellular location

Nucleus  

Length:

387

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.07698

Exp number, first 60 AAs:

0.00083

Total prob of N-in:

0.00218

outside

1  -  387

 

 

Pi

189.078161

Theta

165.845252

Tajima's D

-0.847276

CLR

1.227441

CSRT

0.166991650417479

Interpretation

Uncertain