Silkworm Genome Informatics Database

Gene

KWMTBOMO07108

Pre Gene Modal

BGIBMGA010539

Annotation

PREDICTED:_WW_domain-containing_oxidoreductase-like_[Bombyx_mori]

Location

Bomo_Chr12(+):4738742-4743720 View in EpiBrowser

Full name

WW domain-containing oxidoreductase

Location in the cell

Extracellular Reliability : 1.434

CDS

ATGCAGAATGTTCTTGATTCAGATAGTGAAGACGAATTACCGCCTGGCTGGGAAGAAAAGTCTACAGAAGATGGAAATGTTTACTTTGTAAATACTTATACAAAAAAGACCCAGTGGACCCATCCTCACACGGGTTGCAAGAAGGTTATTCCAAAAGATTTACCGTTTGGCTGGTCTAAAACAGTGGATGAAACCAGCAAAACAATCTATGTCAATAGAGAAACTGGTAATAAGACGTATGTAGACCCAAGACTTGCTTTTGCAAAAGAAGAGAAGAAGCATGTGCACGACTTTAGACAAAGGTTCGATGGGTCATCTACAGCATACCAGGTTCTCCATGGTGTTGATTTGTCTGGTAAGTATGCCTTGATAACTGGTTCTAATACAGGTATAGGCTATGAAACTGCTAAATCATTAGCCAGGCATGGATGTAATATATTATTTGCAAATCGTAATATGGAAGCTACAGATAAAGCTATTAAGGAGATTGTGAAAGAAACAAATGCATCAGAAGAAAATTTAAAATCTATATATTTGGACTTAGCTTCATTAGAGAGTGTCAAGCAATGCGCTCAAGCGGTCGAAACAGTTTTCTCTGACCATTTAGATATGTTAATACTGAATGCGGGTGTATTTGGCCTGCCATACACAGAAACTCAAGATAAACTGGAGACTACTTTTCAAGTTAATCACCTAAGCCACATGTATTTTGCACTGCTACTTGAGCGACTGTTGAAACGAGGTTCCAGAGTAGTATTTGTATCATCAGAATCACATAGGTTTGCCAATTTAACAAATATTTTTACTAATCAAAATCTTGCAATGACAAAAGATCAATACTCTGCTATGATGGCATATAATAATTCAAAATTATACAATGTCATAACAGCAAAGATGTTAAGCGAAAAATGGAAGGCAAAAGGTATATGCGTGAATTCTCTGCATCCAGGTAATATGGTATCTACAAACTTGAGCAAATCGTGGTGGCTGTATAGATTGGCATTCTTTTTAGTAAGGCCCTTCACTAAATCTTTGCAACAAGCAGCAGCGACGACTGTCTACGCAGCGACCGCCTCAGAGCTCGAAGGCGTCACAGGATTGTACTTCAACAACTGTTTCTATTGCGAAGAGTCTGCGCTGGCAAGGGACAAAGAAATAGCACAAGCCGTCTACGACATGTCGCTTAGGCTGATCGAAGATATCTCGAAGACATGA

Protein

MQNVLDSDSEDELPPGWEEKSTEDGNVYFVNTYTKKTQWTHPHTGCKKVIPKDLPFGWSKTVDETSKTIYVNRETGNKTYVDPRLAFAKEEKKHVHDFRQRFDGSSTAYQVLHGVDLSGKYALITGSNTGIGYETAKSLARHGCNILFANRNMEATDKAIKEIVKETNASEENLKSIYLDLASLESVKQCAQAVETVFSDHLDMLILNAGVFGLPYTETQDKLETTFQVNHLSHMYFALLLERLLKRGSRVVFVSSESHRFANLTNIFTNQNLAMTKDQYSAMMAYNNSKLYNVITAKMLSEKWKAKGICVNSLHPGNMVSTNLSKSWWLYRLAFFLVRPFTKSLQQAAATTVYAATASELEGVTGLYFNNCFYCEESALARDKEIAQAVYDMSLRLIEDISKT

Description

Putative oxidoreductase. May control genotoxic stress-induced cell death. May play a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. May play a role in Wnt signaling (By similarity).
Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Required for normal bone development. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm (By similarity).

Subunit

Interacts with TP53, p73/TP73 and MAPK8. Interacts with MAPT/TAU, RUNX2 and HYAL2 (By similarity). Forms a ternary complex with TP53 and MDM2. Interacts with ERBB4, LITAF and WBP1. Interacts with DVL1, DVL2 and DVL3. May interact with FAM189B and SCOTIN (By similarity). Interacts with TNK2 (By similarity). Interacts with TMEM207 (By similarity).

Similarity

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Keywords

Apoptosis Complete proteome Cytoplasm NADP Oxidoreductase Phosphoprotein Reference proteome Repeat Wnt signaling pathway Mitochondrion Nucleus Tumor suppressor Ubl conjugation

Feature

chain WW domain-containing oxidoreductase

Uniprot

A0A212EYE6 A0A2A4K763 A0A2W1BS02 A0A194QPP0 A0A194PHJ3 A0A2H1X0A6 + More
A0A2J7PWQ7 A0A0K8TKQ7 A0A1W4X8N9 A0A067R7F5 A0A1Y1LL89 B0WCM6 A0A0M4EFS5 B4JAP5 B4Q681 A0A1W4W8U5 B4LTS9 B4KGA7 B3MJQ7 B4HYC9 B3N6R6 X2J7F1 Q9VLU5 A0A1L8E4S7 B4MVS4 B4NWB6 A0A182IC26 Q7Q4J0 Q17K82 A0A0A9WTG0 Q1HQF3 A0A1A9XKX5 A0A1Q3FHK3 A0A182HAA8 A0A1B0A0P3 A0A1Q3FHM0 A0A1B0BCB9 A0A1B0FHX1 A0A3B0JAT8 A0A2M4ALH4 A0A2M4CUW6 A0A2M4CUG5 A0A2M3Z8N1 A0A2M4BPW5 Q29LV4 A0A2J7PWP7 B4G7D1 A0A0L0BZA8 A0A1A9WHK3 A0A151X589 A0A195DRL7 A0A158NAK8 A0A182GME3 F4X276 A0A1I8MCZ5 A0A0P4VKQ3 T1HNX1 A0A023EYB3 A0A182RG27 A0A1B6E0E8 A0A026WCJ1 A0A1I8NS07 A0A151INK6 A0A069DTX2 E2A102 E2BKL5 A0A0V0G846 A0A224XDE6 A0A1B0DHY2 A0A0L7RI52 A0A1B6G638 A0A1J1IU20 A0A154PPU7 A0A088A8B9 A0A1D2N5P5 A0A1B6H7A0 A0A232EZ24 V9KUE4 A0A0N0BGS5 K7IRI6 E0VY39 K1RNM4 A0A087TND9 V4BFR0 A0A210PNE8 A0A2A3E898 H0UXE5 N6SVB7 A0A2T7NIQ0 A0A195EVG5 Q0P5N4 E1U8D1 Q5R9W5 A0A1S3EWV3 A0A2R7VRT7 H2NRJ9 F6S5M5 A0A2K5XSQ0 A0A2K6NGE3

EC Number

1.1.1.-

Pubmed

22118469 28756777 26354079 26369729 24845553 28004739 + More
17994087 22936249 10731132 12537568 12537572 12537573 12537574 16110336 17569856 17569867 12537569 16007179 17550304 12364791 14747013 17210077 17510324 25401762 26823975 17204158 26483478 15632085 26108605 21347285 21719571 25315136 27129103 25474469 24508170 30249741 26334808 20798317 27289101 28648823 24402279 20075255 20566863 22992520 23254933 28812685 21993624 23537049 20016169 19393038 17431167 25362486

EMBL

AGBW02011531 OWR46512.1 NWSH01000098 PCG79603.1 KZ149975 PZC75947.1 + More
KQ461194 KPJ06945.1 KQ459603 KPI92886.1 ODYU01012422 SOQ58717.1 NEVH01020869 PNF20761.1 GDAI01002699 JAI14904.1 KK852655 KDR19283.1 GEZM01052549 JAV74444.1 DS231889 EDS43677.1 CP012523 ALC39367.1 CH916368 EDW03853.1 CM000361 CM002910 EDX04157.1 KMY88893.1 CH940649 EDW63980.1 CH933807 EDW11094.1 CH902620 EDV31396.1 CH480818 EDW52059.1 CH954177 EDV59282.1 AE014134 AHN54249.1 AY119574 GFDF01000418 JAV13666.1 CH963857 EDW75794.2 CM000157 EDW88433.1 APCN01000774 AAAB01008964 EAA12850.4 CH477227 EAT47103.1 GBHO01035504 GBHO01035503 GBRD01002303 GDHC01002727 GDHC01000239 JAG08100.1 JAG08101.1 JAG63518.1 JAQ15902.1 JAQ18390.1 DQ440491 CH477468 ABF18524.1 EAT40479.1 GFDL01008017 JAV27028.1 JXUM01032067 KQ560944 KXJ80241.1 GFDL01008023 JAV27022.1 JXJN01011917 JXJN01011918 CCAG010002083 CCAG010002084 OUUW01000004 SPP79444.1 GGFK01008310 MBW41631.1 GGFL01004783 MBW68961.1 GGFL01004782 MBW68960.1 GGFM01004136 MBW24887.1 GGFJ01005862 MBW55003.1 CH379060 EAL33941.2 PNF20763.1 CH479180 EDW29264.1 JRES01001119 KNC25397.1 KQ982519 KYQ55566.1 KQ980612 KYN15144.1 ADTU01010368 JXUM01014080 KQ560393 KXJ82655.1 GL888565 EGI59492.1 GDKW01001666 JAI54929.1 ACPB03002668 GBBI01004397 JAC14315.1 GEDC01008769 GEDC01005903 JAS28529.1 JAS31395.1 KK107276 QOIP01000006 EZA53638.1 RLU21110.1 KQ976932 KYN07046.1 GBGD01001668 JAC87221.1 GL435626 EFN73055.1 GL448819 EFN83713.1 GECL01001868 JAP04256.1 GFTR01005940 JAW10486.1 AJVK01006048 AJVK01006049 KQ414584 KOC70667.1 GECZ01011863 JAS57906.1 CVRI01000059 CRL03608.1 KQ435022 KZC13916.1 LJIJ01000210 ODN00385.1 GECU01037164 GECU01017505 GECU01004028 JAS70542.1 JAS90201.1 JAT03679.1 NNAY01001561 OXU23593.1 JW869638 AFP02156.1 KQ435768 KOX75212.1 DS235843 EEB18295.1 JH815822 EKC35996.1 KK116036 KFM66628.1 KB202823 ESO87819.1 NEDP02005575 OWF38011.1 KZ288325 PBC27993.1 AAKN02052532 AAKN02052533 AAKN02052534 AAKN02052535 AAKN02052536 APGK01055295 KB741261 KB630089 KB632310 ENN71649.1 ERL83380.1 ERL92129.1 PZQS01000012 PVD21049.1 KQ981954 KYN32250.1 BC119823 FJ978047 AAI19824.1 ADC84386.1 FJ978046 ADC84385.1 CR859266 KK854015 PTY09390.1 ABGA01080060 ABGA01080061 ABGA01080062 ABGA01080063 ABGA01080064 ABGA01080065 ABGA01080066 ABGA01080067 ABGA01080068 ABGA01080069 NDHI03003408 PNJ61942.1 JSUE03026689 JSUE03026690 JSUE03026691 JSUE03026692 JSUE03026693 JSUE03026694 JSUE03026695 JSUE03026696 JSUE03026697 JSUE03026698

Proteomes

UP000007151 UP000218220 UP000053240 UP000053268 UP000235965 UP000192223 + More
UP000027135 UP000002320 UP000092553 UP000001070 UP000000304 UP000192221 UP000008792 UP000009192 UP000007801 UP000001292 UP000008711 UP000000803 UP000007798 UP000002282 UP000075840 UP000007062 UP000008820 UP000092443 UP000069940 UP000249989 UP000092445 UP000092460 UP000092444 UP000268350 UP000001819 UP000008744 UP000037069 UP000091820 UP000075809 UP000078492 UP000005205 UP000007755 UP000095301 UP000015103 UP000075900 UP000053097 UP000279307 UP000095300 UP000078542 UP000000311 UP000008237 UP000092462 UP000053825 UP000183832 UP000076502 UP000005203 UP000094527 UP000215335 UP000053105 UP000002358 UP000009046 UP000005408 UP000054359 UP000030746 UP000242188 UP000242457 UP000005447 UP000019118 UP000030742 UP000245119 UP000078541 UP000009136 UP000001595 UP000081671 UP000006718 UP000233140 UP000233200

PRIDE

X2J7F1 Q9VLU5

Pfam

PF00106 adh_short + More
PF00397 WW

Interpro

IPR001202   WW_dom        + More
IPR002347   SDR_fam
IPR036020   WW_dom_sf
IPR036291   NAD(P)-bd_dom_sf
IPR020904   Sc_DH/Rdtase_CS
IPR002048   EF_hand_dom
IPR011992   EF-hand-dom_pair
IPR018247   EF_Hand_1_Ca_BS

SUPFAM

SSF51735   SSF51735        + More
SSF51045   SSF51045
SSF47473   SSF47473

CDD

cd00201 WW

ProteinModelPortal

A0A212EYE6 A0A2A4K763 A0A2W1BS02 A0A194QPP0 A0A194PHJ3 A0A2H1X0A6 + More
A0A2J7PWQ7 A0A0K8TKQ7 A0A1W4X8N9 A0A067R7F5 A0A1Y1LL89 B0WCM6 A0A0M4EFS5 B4JAP5 B4Q681 A0A1W4W8U5 B4LTS9 B4KGA7 B3MJQ7 B4HYC9 B3N6R6 X2J7F1 Q9VLU5 A0A1L8E4S7 B4MVS4 B4NWB6 A0A182IC26 Q7Q4J0 Q17K82 A0A0A9WTG0 Q1HQF3 A0A1A9XKX5 A0A1Q3FHK3 A0A182HAA8 A0A1B0A0P3 A0A1Q3FHM0 A0A1B0BCB9 A0A1B0FHX1 A0A3B0JAT8 A0A2M4ALH4 A0A2M4CUW6 A0A2M4CUG5 A0A2M3Z8N1 A0A2M4BPW5 Q29LV4 A0A2J7PWP7 B4G7D1 A0A0L0BZA8 A0A1A9WHK3 A0A151X589 A0A195DRL7 A0A158NAK8 A0A182GME3 F4X276 A0A1I8MCZ5 A0A0P4VKQ3 T1HNX1 A0A023EYB3 A0A182RG27 A0A1B6E0E8 A0A026WCJ1 A0A1I8NS07 A0A151INK6 A0A069DTX2 E2A102 E2BKL5 A0A0V0G846 A0A224XDE6 A0A1B0DHY2 A0A0L7RI52 A0A1B6G638 A0A1J1IU20 A0A154PPU7 A0A088A8B9 A0A1D2N5P5 A0A1B6H7A0 A0A232EZ24 V9KUE4 A0A0N0BGS5 K7IRI6 E0VY39 K1RNM4 A0A087TND9 V4BFR0 A0A210PNE8 A0A2A3E898 H0UXE5 N6SVB7 A0A2T7NIQ0 A0A195EVG5 Q0P5N4 E1U8D1 Q5R9W5 A0A1S3EWV3 A0A2R7VRT7 H2NRJ9 F6S5M5 A0A2K5XSQ0 A0A2K6NGE3

PDB

3RD5 E-value=9.4342e-20, Score=238

KEGG

101742509 K19329 WW domain-containing oxidoreductase | (RefSeq) WW domain-containing oxidoreductase-like

GO

GO:0016491 GO:0050829 GO:0010212 GO:2000377 GO:0005737 GO:0006915 GO:0016055 GO:0005509 GO:0016630 GO:0005794 GO:0048705 GO:0030178 GO:0005902 GO:0005739 GO:0097191 GO:0005829 GO:0001649 GO:0090575 GO:0071560 GO:0045944 GO:2001241 GO:0072332 GO:0019899 GO:0005886 GO:0003713 GO:0005634 GO:0005515 GO:0016615 GO:0003824 GO:0005975 GO:0016616 GO:0030060 GO:0019752 GO:0016295 GO:0016296

Subcellular location

Cytoplasm
Nucleus   Partially localizes to the mitochondria. Translocates to the nucleus upon genotoxic stress or TNF stimulation (By similarity). Translocates to the nucleus in response to TGFB1 (By similarity).   With evidence from 2 publications.
Mitochondrion   Partially localizes to the mitochondria. Translocates to the nucleus upon genotoxic stress or TNF stimulation (By similarity). Translocates to the nucleus in response to TGFB1 (By similarity).   With evidence from 2 publications.

Length:

404

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.024

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00701

outside

1 - 404

Pi

204.352274

Theta

173.812462

Tajima's D

0.670487

CLR

0.226994

CSRT

0.569421528923554

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics