Gene

KWMTBOMO07103  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA010423

Annotation

cytosolic_malate_dehydrogenase_[Bombyx_mori]

Location

Bomo_Chr12(-):4641811-4643381      View in EpiBrowser

Full name

Malate dehydrogenase      

Location in the cell

Cytoplasmic   Reliability : 2.022

CDS

ATGGCTGAACCTATCAGAGTTGTTGTAACTGGTGCTGCCGGACAAATTGCATACTCACTTCTTTATCAAATTGCGTCTGGAGCAGTTTTTGGACCTCAGCAACCTGTCTTCCTCCACCTTCTTGATATTGCGCCTATGATGGGTGTACTTGAAGGTGTTGTCATGGAGTTGGCTGACTGTGCTCTGCCACTTTTGGCTGGGGTTCTTCCTACAGCAAATCCTGAAGAAGCTTTCAAAGATGTTGCTGCTGCTTTCCTAGTTGGTGCTATGCCCAGAAAGGAAGGTATGGAGAGGAAGGATCTTCTTGCTGCTAATGTGCGCATCTTCAAAGAGCAGGGCCAGGCTTTGGACAAAGTGGCTCGTAAAGATGTGAAGGTCCTTGTTGTTGGCAACCCAGCCAATACAAATGCTCTAATATGTTCTAAGTATGCTCCATCTATTCCAAAAGAAAATTTCACTGCCATGACTCGTCTCGATCAAAACAGGGCTCAGTCCCAACTTGCTGCTAAAATTGGAGTACCGGTTAAAGATGTTAAGAGAGTAATCATCTGGGGAAACCATTCATCAACCCAGTTCCCTGATGCTTCGAATGCTGTAGCTATTGTTGGAGGTGCTCAAAAATCTGTTTCTGAAATTATCAATGACGATGCATATTTGAAAGGCGCATTTGTAACAACGGTTCAAAAACGTGGTGCTGCCGTTATTGCTGCCAGGAAAATGTCATCTGCTCTTTCTGCTGCTAAAGCTGCATCAGACCACATGAGAGATTGGTTCCTTGGCACTGAAGACAGATGGGTTAGCATGGGAGTTGTTTCAGATGGATCTTATGGTACTCCGCGTGATGTTGTATATTCATTCCCTGTTACTGTTACCAATGGAAAGTGGAAAATTGTTGAGGGTCTCACTATCTCTGATTTTGCCCGTCAAATGCTCGATGCTACTGGCAAAGAGTTGGTTGAAGAAAAACAGGAGGCTTTAGATGTCTGCAAAGATTGA

Protein

MAEPIRVVVTGAAGQIAYSLLYQIASGAVFGPQQPVFLHLLDIAPMMGVLEGVVMELADCALPLLAGVLPTANPEEAFKDVAAAFLVGAMPRKEGMERKDLLAANVRIFKEQGQALDKVARKDVKVLVVGNPANTNALICSKYAPSIPKENFTAMTRLDQNRAQSQLAAKIGVPVKDVKRVIIWGNHSSTQFPDASNAVAIVGGAQKSVSEIINDDAYLKGAFVTTVQKRGAAVIAARKMSSALSAAKAASDHMRDWFLGTEDRWVSMGVVSDGSYGTPRDVVYSFPVTVTNGKWKIVEGLTISDFARQMLDATGKELVEEKQEALDVCKD

Catalytic Activity

(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate

Similarity

Belongs to the LDH/MDH superfamily.

Uniprot

Q2F5P8   H9JLM2   A0A2A4K6Q8   A0A2A4K5R7   A0A2W1BLI1   A0A2H1WV70   + More
I3RRT0   A0A194PHJ8   I4DKD3   A0A194QPN6   A0A212EYD5   A0A220K8N0   A0A3S2P348   S4PWZ8   A0A0L7KT71   J3JTT8   D8VJF0   D8VJH0   D8VJD0   D8VJE2   D8VJI8   D8VJF1   D8VJH1   D8VJD9   A0A1W5YLL5   V5GL68   A0A023EPX1   A0A336LJF6   A0A336LI46   A0A336MYN4   A0A182GEL7   A0A182GAF8   A0A1S4FHF8   A0A0L0CHM9   B3MJG6   A0A0P5EX35   T1P7W6   A0A1L8EFR3   A0A1Q3FJK9   A0A1I8NGI3   A0A1I8NZF7   A0A0P5EZ88   A0A0P5P0A4   A0A1W4USV7   Q8MQS7   B3N9N7   Q9VKX2   B4NZN3   A0A0P5XNA2   A0A1A9V2A7   G3K809   G3K7Y9   B4HWN2   G3K811   A0A0P5Y320   A0A0P5L6B1   Q171B2   B4Q988   G3K7Z3   D3TLF0   A0A0P4XFV9   G3K804   G3K808   G3K7Z5   G3K801   A0A0P5GU82   G3K7Z9   G3K7Z6   A0A0P5GUI1   A0A0P5NVC8   G3K7Y7   A0A0P5JLW8   G3K7Z8   A0A1A9W5C1   G3K802   G3K7Z0   G3K807   G3K7Z2   G3K806   A0A0P5EUD8   A0A0N8A3T0   G3K800   G3K7Y8   A0A1B0A4T6   A0A034W6Y2   G3K7Z7   W8CCW0   E9HA96   R4WN61   B3TGZ5   G3K803   A0A0P4WVN4   A0A1D2NAR9   A0A0K8UJL7   A0A3B0JHE0   B4NQQ2   A0A0P5JLT4   A0A182IZK3   K7J699   A0A0A1WL85  

EC Number

1.1.1.37

Pubmed

19121390    28756777    26354079    22651552    22118469    28630352    + More
23622113    26227816    22516182    23537049    20442862    24945155    26483478    26108605    17994087    25315136    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    17550304    21841803    17510324    22936249    20353571    25348373    24495485    21292972    23691247    27289101    20075255    25830018   

EMBL

DQ311375    ABD36319.1    BABH01005443    NWSH01000098    PCG79594.1    PCG79595.1    + More
KZ149975    PZC75942.1    ODYU01011308    SOQ56969.1    JQ730683    AFK28500.1    KQ459603    KPI92891.1    AK401751    BAM18373.1    KQ461194    KPJ06940.1    AGBW02011531    OWR46508.1    MF319729    ASJ26443.1    RSAL01002350    RVE40506.1    GAIX01005913    JAA86647.1    JTDY01006181    KOB66214.1    BT126647    KB632390    AEE61610.1    ERL94450.1    GQ987207    GQ987209    GQ987210    GQ987211    GQ987212    GQ987215    GQ987217    GQ987221    GQ987223    ADI81894.1    GQ987227    GQ987229    GQ987230    GQ987231    GQ987232    GQ987233    GQ987234    GQ987237    GQ987238    GQ987239    GQ987240    GQ987241    GQ987242    GQ987243    GQ987244    GQ987246    ADI81914.1    GQ987187    GQ987188    GQ987189    GQ987190    GQ987191    GQ987192    GQ987193    GQ987194    GQ987195    GQ987197    GQ987198    GQ987202    GQ987203    GQ987204    GQ987205    GQ987206    ADI81874.1    GQ987199    GQ987200    GQ987201    ADI81886.1    GQ987245    ADI81932.1    GQ987208    GQ987213    GQ987214    GQ987216    GQ987218    GQ987219    GQ987220    GQ987222    GQ987224    GQ987225    GQ987226    ADI81895.1    GQ987228    GQ987235    GQ987236    ADI81915.1    GQ987196    ADI81883.1    KX147676    ARI45080.1    GALX01003627    JAB64839.1    GAPW01002495    JAC11103.1    UFQS01005467    UFQT01005467    SSX16823.1    SSX36004.1    UFQS01004279    UFQT01004279    SSX16303.1    SSX35623.1    UFQT01003982    SSX35406.1    JXUM01058239    JXUM01058240    JXUM01058241    KQ561993    KXJ76965.1    JXUM01050947    JXUM01050948    JXUM01050949    KQ561669    KXJ77853.1    JRES01000384    KNC31756.1    CH902620    EDV32334.1    GDIQ01268852    JAJ82872.1    KA644721    AFP59350.1    GFDG01001237    JAV17562.1    GFDL01007379    JAV27666.1    GDIP01200441    GDIP01195646    GDIQ01270092    GDIQ01199368    GDIQ01182332    GDIP01088100    GDIP01037918    GDIQ01049131    LRGB01003024    JAJ22961.1    JAJ81632.1    KZS05014.1    GDIQ01142046    JAL09680.1    AY128413    AAM75006.1    CH954177    EDV58532.1    AE014134    BT128780    AAF52935.2    AEK87152.1    CM000157    EDW88817.1    GDIP01071211    JAM32504.1    JN174131    JN174132    AEN67674.1    AEN67675.1    JN174111    JN174113    AEN67654.1    AEN67656.1    CH480818    EDW52427.1    JN174133    AEN67676.1    GDIP01063712    JAM40003.1    GDIQ01199367    JAK52358.1    CH477460    EAT40580.1    CM000361    CM002910    EDX04530.1    KMY89518.1    JN174115    AEN67658.1    EZ422252    ADD18528.1    GDIP01251443    JAI71958.1    JN174126    AEN67669.1    JN174130    AEN67673.1    JN174116    JN174117    AEN67659.1    AEN67660.1    JN174123    AEN67666.1    GDIQ01235557    JAK16168.1    JN174121    AEN67664.1    JN174118    AEN67661.1    GDIQ01242410    JAK09315.1    GDIQ01158727    JAK92998.1    JN174109    AEN67652.1    GDIQ01196572    JAK55153.1    JN174120    AEN67663.1    JN174124    AEN67667.1    JN174112    AEN67655.1    JN174129    AEN67672.1    JN174114    AEN67657.1    JN174128    AEN67671.1    GDIQ01270040    JAJ81684.1    GDIP01185297    JAJ38105.1    JN174122    AEN67665.1    JN174110    AEN67653.1    GAKP01009066    GAKP01009057    JAC49895.1    JN174119    AEN67662.1    GAMC01003011    JAC03545.1    GL732611    EFX71334.1    AK417036    BAN20251.1    EU141617    ABX57441.1    JN174125    AEN67668.1    GDIP01251444    JAI71957.1    LJIJ01000115    ODN02348.1    GDHF01025412    JAI26902.1    OUUW01000006    SPP81605.1    CH964295    EDW86691.2    GDIQ01203069    JAK48656.1    GBXI01015124    JAC99167.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000007151    UP000283053    + More
UP000037510    UP000030742    UP000069940    UP000249989    UP000037069    UP000007801    UP000095301    UP000095300    UP000076858    UP000192221    UP000008711    UP000000803    UP000002282    UP000078200    UP000001292    UP000008820    UP000000304    UP000091820    UP000092445    UP000000305    UP000094527    UP000268350    UP000007798    UP000075880    UP000002358   

PRIDE

Q2F5P8    H9JLM2    Q8MQS7    Q9VKX2    B3TGZ5   

Pfam

PF02866   Ldh_1_C        + More
PF00056   Ldh_1_N
PF14529   Exo_endo_phos_2
PF00078   RVT_1

Interpro

IPR015955   Lactate_DH/Glyco_Ohase_4_C        + More
IPR001557   L-lactate/malate_DH       
IPR010945   Malate_DH_type2       
IPR022383   Lactate/malate_DH_C       
IPR011274   Malate_DH_NAD-dep_euk       
IPR036291   NAD(P)-bd_dom_sf       
IPR001252   Malate_DH_AS       
IPR001236   Lactate/malate_DH_N       
IPR000477   RT_dom       
IPR036691   Endo/exonu/phosph_ase_sf       
IPR005135   Endo/exonuclease/phosphatase       

SUPFAM

SSF51735   SSF51735        + More
SSF56327   SSF56327       
SSF56219   SSF56219       

Gene 3D

3.90.110.10     3.60.10.10    

CDD

cd01336  MDH_cytoplasmic_cytosolic

ProteinModelPortal

Q2F5P8   H9JLM2   A0A2A4K6Q8   A0A2A4K5R7   A0A2W1BLI1   A0A2H1WV70   + More
I3RRT0   A0A194PHJ8   I4DKD3   A0A194QPN6   A0A212EYD5   A0A220K8N0   A0A3S2P348   S4PWZ8   A0A0L7KT71   J3JTT8   D8VJF0   D8VJH0   D8VJD0   D8VJE2   D8VJI8   D8VJF1   D8VJH1   D8VJD9   A0A1W5YLL5   V5GL68   A0A023EPX1   A0A336LJF6   A0A336LI46   A0A336MYN4   A0A182GEL7   A0A182GAF8   A0A1S4FHF8   A0A0L0CHM9   B3MJG6   A0A0P5EX35   T1P7W6   A0A1L8EFR3   A0A1Q3FJK9   A0A1I8NGI3   A0A1I8NZF7   A0A0P5EZ88   A0A0P5P0A4   A0A1W4USV7   Q8MQS7   B3N9N7   Q9VKX2   B4NZN3   A0A0P5XNA2   A0A1A9V2A7   G3K809   G3K7Y9   B4HWN2   G3K811   A0A0P5Y320   A0A0P5L6B1   Q171B2   B4Q988   G3K7Z3   D3TLF0   A0A0P4XFV9   G3K804   G3K808   G3K7Z5   G3K801   A0A0P5GU82   G3K7Z9   G3K7Z6   A0A0P5GUI1   A0A0P5NVC8   G3K7Y7   A0A0P5JLW8   G3K7Z8   A0A1A9W5C1   G3K802   G3K7Z0   G3K807   G3K7Z2   G3K806   A0A0P5EUD8   A0A0N8A3T0   G3K800   G3K7Y8   A0A1B0A4T6   A0A034W6Y2   G3K7Z7   W8CCW0   E9HA96   R4WN61   B3TGZ5   G3K803   A0A0P4WVN4   A0A1D2NAR9   A0A0K8UJL7   A0A3B0JHE0   B4NQQ2   A0A0P5JLT4   A0A182IZK3   K7J699   A0A0A1WL85  

PDB

5MDH     E-value=6.2306e-111,     Score=1024

KEGG

692952    K00025 malate dehydrogenase [EC:1.1.1.37] | (RefSeq) MDH; cytosolic malate dehydrogenase

PATHWAY

00020    Citrate cycle (TCA cycle) - Bombyx mori (domestic silkworm)
00270    Cysteine and methionine metabolism - Bombyx mori (domestic silkworm)
00620    Pyruvate metabolism - Bombyx mori (domestic silkworm)
00630    Glyoxylate and dicarboxylate metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01200    Carbon metabolism - Bombyx mori (domestic silkworm)

GO

GO:0030060   GO:0005975   GO:0006099   GO:0006108   GO:0005829   GO:0005777   GO:0016615   GO:0055114   GO:0006734   GO:0006107   GO:0003824   GO:0016616   GO:0019752   GO:0016491   GO:0016295   GO:0016296  

PANTHER

PTHR23382  

Length:

331

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

13.54362

Exp number, first 60 AAs:

13.46683

Total prob of N-in:

0.59303

POSSIBLE N-term signal

sequence

outside

1  -  331

 

 

Pi

218.888333

Theta

217.417974

Tajima's D

-0.2695

CLR

46.919453

CSRT

0.296435178241088

Interpretation

Uncertain