Gene

KWMTBOMO07079

Pre Gene Modal

BGIBMGA010433

Annotation

UDP-glycosyltransferase_UGT46A2_precursor_[Bombyx_mori]

Location

Bomo_Chr12(-):3194338-3208637      View in EpiBrowser

Full name

UDP-glucuronosyltransferase      

Location in the cell

PlasmaMembrane   Reliability : 3.559

CDS

ATGCGAGCTCACATCGCGTGCATCGTGCTGATCGCACACGCAGTCGCGTCCGCGAAAATATTAGGCCTTTTCCCGCACACAGGCAAAAGCCATCAAATGGTGTTCGACCCTTTATTGAGAAGATTGGCGGAGAAAGGCCACCATGTTACTGTAGTATCCTTTTTTCCCGTCAAAAATCCCCCAGCAAATTACACGAACATCAGCCTCGAGAGCTTAGCCAAATTAGGAGTTGAAACGATTGATTTGTCCTGGTATGAAAGCTCGAACTCCATACTCAAGATGACGGGACCGGAAAAAATATATGAAGAATTGACAGCGATGCAGCCGCTATCTTATATGGCCGTGGATGTGTGTTCCAAATTAGTTGGCTTCGAACCTTTGGCACGAACCTTGAGGCAGGATTACGATGTCATTTTAGTGGAGAATTTCAACAGTGACTGTATGCTGGGCCTGGCACATATATACGGTCAGAAAGCGCCAATTATAGCCTTATTATCAAGCTCGTTAATGGATTGGTCTCCGAGTCGTATTGGGGTATCAGATAATCCATCATACGTACCTATAGTCACTTCTACGTTTACTACCCCTATGTCGTTCGTGCAAAGATTGAAGAACACAGTTTTAAATATTTACTACAAGCTGTGGTTTCGTTACGCGATCCAATTGAAGGAGAAAGAAATAATTGAGAACCATTACGGTAGAAAGATCGTTGACCTCGAAGAATTAGCGAGAAATACGACATTAATGTTTGTTAACGTGCACCACAGTTTCAACGGTGTCAGACCTTTATTGCCCGGTATAGTAGAAGTGGGTGGCATGCATTTGGATCACAAAAGAAAGCCCATTCCAGAATTTTTCGAACGTTTCCTAAACGACTCTGAACACGGTGTAGTTTTATTTAGTTTTGGGTCCTTAATCAAGACATCTACGCTACCCAAGTACAAGGAGGATATTATAATGAAAACTCTTTCCCAACTGAAGCAGAGAGTTATCTGGAAATATGAAGATAGCGCTGAAGAAGGCACCCTTGTAGGAAACGTACTGAAAGTGAAGTGGATTCCTCAATATGATCTGTTACAGCATTCCAAAATAATTGCGTTCGTTGGGCACGGAGGACTTTTGGGCATGACCGAATCAATCTCAGCCGGCAAGCCCATGCTGGTGATACCGTTCTTCGGAGACCAGCACCTGAACGGCGCTCAAGCTGAAAAGATAGGGTTCGGTAAGGTGGTATCTTATGCTGATCTCTCGGAGAAGACGTTTCTGGATGGACTGCAAAGCGTGCTATCTCCTGAAATGCGATTGAGCGCACGAAGAGCGTCGAACATTTGGAGCGACCGACAAGCCGACCCGCTGGACACGGCCGTCTATTGGACAGAAAGGGTCATCCGTTGGGGACACCGAGCTCCCCTCCACTCGCCCGCGAGAGACTTGCCACTCCACCAGTATTTGTTGCTAGACGTTGCAGCAGCGATTTTAGTAGCAATTCTTGTGTTAATAGCGATTTTAAGATTGATTGTTGTATTGATAATCCGATTTTTCAGCGGTAGTGTCACTGCTAAAGAGAAATTACACTAA

Protein

MRAHIACIVLIAHAVASAKILGLFPHTGKSHQMVFDPLLRRLAEKGHHVTVVSFFPVKNPPANYTNISLESLAKLGVETIDLSWYESSNSILKMTGPEKIYEELTAMQPLSYMAVDVCSKLVGFEPLARTLRQDYDVILVENFNSDCMLGLAHIYGQKAPIIALLSSSLMDWSPSRIGVSDNPSYVPIVTSTFTTPMSFVQRLKNTVLNIYYKLWFRYAIQLKEKEIIENHYGRKIVDLEELARNTTLMFVNVHHSFNGVRPLLPGIVEVGGMHLDHKRKPIPEFFERFLNDSEHGVVLFSFGSLIKTSTLPKYKEDIIMKTLSQLKQRVIWKYEDSAEEGTLVGNVLKVKWIPQYDLLQHSKIIAFVGHGGLLGMTESISAGKPMLVIPFFGDQHLNGAQAEKIGFGKVVSYADLSEKTFLDGLQSVLSPEMRLSARRASNIWSDRQADPLDTAVYWTERVIRWGHRAPLHSPARDLPLHQYLLLDVAAAILVAILVLIAILRLIVVLIIRFFSGSVTAKEKLH

Catalytic Activity

glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP

Similarity

Belongs to the UDP-glycosyltransferase family.

Feature

chain  UDP-glucuronosyltransferase

Uniprot

G9LPW1   G9LPW0   A0A2A4JGJ6   G9LPR6   A0A024AG07   A0A191T2K5   + More
G9LPR7   A0A286MXP6   A0A2H4WB48   A0A194QN29   A0A212FA80   A0A194PHM3   A0A212FA68   A0A194QTP4   A0A194PP57   G9LPR8   A0A2H1VU07   A0A2A4JI28   A0A2J7R4W8   A0A2P8ZG78   A0A2J7R4W2   A0A067RAD1   A0A2J7R4S8   A0A1W4WYE4   D2A2V5   A0A2H4WB56   V5H2B2   A0A2J7R4W4   A0A1B6F5J1   A0A2R4FXJ3   A0A1W4WMC9   A0A182RBM8   A0A1L8D6F4   A0A182HV86   A0A1B6KXR8   A0A182YGV2   A0A2P8ZG71   A0A182WT93   A0A1S4GXF8   A0A1B6FW51   A0A2H4WB57   A0A084VP43   A0A0L7L3K3   W8AR85   A0A336KCF6   Q17HG0   A0A182V6Z3   A0A182GI26   A0A182W9Q0   A0A182UEM4   A0A1S4F2K0   A0A2J7R4T0   A0A182PJ64   A0A182NE44   A0A1W4WMF1   A0A182SC34   A0A182QSB1   A0A1I8N2C0   A0A1B6D7V3   A0A182IX39   A0A034V788   A0A1B6DCV6   A0A182F4M1   A0A2M3Z1Z1   T1PFI1   A0A0K8UM10   A0A2M3Z1Z8   W5J9T2   A0A0C9RNU1   A0A0K8UGE5   A0A1B6L8F2   A0A0K8VSF2   A0A151X0M2   A0A139WIV0   A0A0L0C9T9   A0A2S2NGA3   A0A191T1P6   Q7Q3K2   A0A2S2NJQ5   A0A0A1WW96   A0A1W7R8J2   A0A3S2LHF3   A0A2P8ZG70   B0WBP4   A0A1Q3FPW9   A0A139WIW7   F4WW48   A0A1Q3FPY1   A0A1I8NWF4   A0A1Y1LMI4  

EC Number

2.4.1.17

Pubmed

22155036    24698447    19954531    25299618    29027758    26354079    + More
22118469    29403074    24845553    18362917    19820115    25244985    12364791    24438588    26227816    24495485    17510324    26483478    25315136    25348373    20920257    23761445    26108605    25830018    21719571    28004739   

EMBL

JQ070268    AEW43184.1    JQ070267    AEW43183.1    NWSH01001533    PCG70939.1    + More
JQ070223    AEW43139.1    KF777119    AHY99690.1    KU680309    ANI22015.1    JQ070224    AEW43140.1    MF684364    ASX93998.1    KY202928    AUC64272.1    KQ461194    KPJ06917.1    AGBW02009509    OWR50646.1    KQ459603    KPI92916.1    OWR50645.1    KPJ06916.1    KPI92915.1    JQ070225    AEW43141.1    ODYU01004162    SOQ43734.1    NWSH01001496    PCG71080.1    NEVH01007402    PNF35870.1    PYGN01000068    PSN55501.1    PNF35872.1    KK852590    KDR20744.1    PNF35836.1    KQ971338    EFA02977.2    KY202929    AUC64273.1    GALX01001513    JAB66953.1    PNF35869.1    GECZ01024322    GECZ01008492    JAS45447.1    JAS61277.1    MF034860    AVT42226.1    GEYN01000096    JAV02033.1    APCN01002501    GEBQ01023933    JAT16044.1    PSN55491.1    AAAB01008964    GECZ01015337    JAS54432.1    KY202930    AUC64274.1    ATLV01014974    KE524999    KFB39737.1    JTDY01003254    KOB69869.1    GAMC01019493    GAMC01019492    GAMC01019491    JAB87063.1    UFQS01000219    UFQT01000219    SSX01542.1    SSX21922.1    CH477249    EAT46102.1    JXUM01065169    KQ562333    KXJ76125.1    PNF35837.1    AXCN02000871    GEDC01015537    JAS21761.1    GAKP01020965    JAC37987.1    GEDC01013767    JAS23531.1    GGFM01001770    MBW22521.1    KA647552    AFP62181.1    GDHF01024708    JAI27606.1    GGFM01001806    MBW22557.1    ADMH02001962    ETN60168.1    GBYB01008756    JAG78523.1    GDHF01026592    JAI25722.1    GEBQ01020086    JAT19891.1    GDHF01010498    JAI41816.1    KQ982611    KYQ53888.1    KYB27844.1    JRES01000714    KNC29017.1    GGMR01003614    MBY16233.1    KU680306    ANI22012.1    EAA12774.4    GGMR01004776    MBY17395.1    GBXI01011391    JAD02901.1    GEHC01000181    JAV47464.1    RSAL01000119    RVE46732.1    PSN55494.1    DS231880    EDS42579.1    GFDL01005396    JAV29649.1    KYB27856.1    GL888404    EGI61637.1    GFDL01005384    JAV29661.1    GEZM01054554    JAV73560.1   

Proteomes

UP000218220    UP000053240    UP000007151    UP000053268    UP000235965    UP000245037    + More
UP000027135    UP000192223    UP000007266    UP000075900    UP000075840    UP000076408    UP000076407    UP000030765    UP000037510    UP000008820    UP000075903    UP000069940    UP000249989    UP000075920    UP000075902    UP000075885    UP000075884    UP000075901    UP000075886    UP000095301    UP000075880    UP000069272    UP000000673    UP000075809    UP000037069    UP000007062    UP000283053    UP000002320    UP000007755    UP000095300   

PRIDE

G9LPW1    G9LPW0   

Pfam

PF00201   UDPGT        + More
PF00108   Thiolase_N
PF02803   Thiolase_C
PF02036   SCP2

Interpro

IPR035595   UDP_glycos_trans_CS        + More
IPR002213   UDP_glucos_trans       
IPR020613   Thiolase_CS       
IPR020617   Thiolase_C       
IPR016039   Thiolase-like       
IPR003033   SCP2_sterol-bd_dom       
IPR020615   Thiolase_acyl_enz_int_AS       
IPR020616   Thiolase_N       
IPR036527   SCP2_sterol-bd_dom_sf       

SUPFAM

SSF53901   SSF53901        + More
SSF55718   SSF55718       

Gene 3D

3.30.1050.10     3.40.47.10    

ProteinModelPortal

G9LPW1   G9LPW0   A0A2A4JGJ6   G9LPR6   A0A024AG07   A0A191T2K5   + More
G9LPR7   A0A286MXP6   A0A2H4WB48   A0A194QN29   A0A212FA80   A0A194PHM3   A0A212FA68   A0A194QTP4   A0A194PP57   G9LPR8   A0A2H1VU07   A0A2A4JI28   A0A2J7R4W8   A0A2P8ZG78   A0A2J7R4W2   A0A067RAD1   A0A2J7R4S8   A0A1W4WYE4   D2A2V5   A0A2H4WB56   V5H2B2   A0A2J7R4W4   A0A1B6F5J1   A0A2R4FXJ3   A0A1W4WMC9   A0A182RBM8   A0A1L8D6F4   A0A182HV86   A0A1B6KXR8   A0A182YGV2   A0A2P8ZG71   A0A182WT93   A0A1S4GXF8   A0A1B6FW51   A0A2H4WB57   A0A084VP43   A0A0L7L3K3   W8AR85   A0A336KCF6   Q17HG0   A0A182V6Z3   A0A182GI26   A0A182W9Q0   A0A182UEM4   A0A1S4F2K0   A0A2J7R4T0   A0A182PJ64   A0A182NE44   A0A1W4WMF1   A0A182SC34   A0A182QSB1   A0A1I8N2C0   A0A1B6D7V3   A0A182IX39   A0A034V788   A0A1B6DCV6   A0A182F4M1   A0A2M3Z1Z1   T1PFI1   A0A0K8UM10   A0A2M3Z1Z8   W5J9T2   A0A0C9RNU1   A0A0K8UGE5   A0A1B6L8F2   A0A0K8VSF2   A0A151X0M2   A0A139WIV0   A0A0L0C9T9   A0A2S2NGA3   A0A191T1P6   Q7Q3K2   A0A2S2NJQ5   A0A0A1WW96   A0A1W7R8J2   A0A3S2LHF3   A0A2P8ZG70   B0WBP4   A0A1Q3FPW9   A0A139WIW7   F4WW48   A0A1Q3FPY1   A0A1I8NWF4   A0A1Y1LMI4  

PDB

2O6L     E-value=1.46841e-22,     Score=264

KEGG

100862821    K00699 glucuronosyltransferase [EC:2.4.1.17] | (RefSeq) UGT46A2, UGT46A1; UDP-glycosyltransferase UG

PATHWAY

00040    Pentose and glucuronate interconversions - Bombyx mori (domestic silkworm)
00053    Ascorbate and aldarate metabolism - Bombyx mori (domestic silkworm)
00830    Retinol metabolism - Bombyx mori (domestic silkworm)
00860    Porphyrin and chlorophyll metabolism - Bombyx mori (domestic silkworm)
00980    Metabolism of xenobiotics by cytochrome P450 - Bombyx mori (domestic silkworm)
00982    Drug metabolism - cytochrome P450 - Bombyx mori (domestic silkworm)
00983    Drug metabolism - other enzymes - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0015020   GO:0016021   GO:0016758   GO:0008194   GO:0043231   GO:0016747   GO:0016740   GO:0008152   GO:0000287   GO:0005634   GO:0008270   GO:0005515   GO:0004319   GO:0004320   GO:0016295   GO:0016296  

Subcellular location

Membrane  

SignalP

Position:   1 - 18,         Likelihood:  0.956728

 

 

Length:

525

Number of predicted TMHs:

2

Exp number of AAs in TMHs:

38.41431

Exp number, first 60 AAs:

15.18018

Total prob of N-in:

0.70626

POSSIBLE N-term signal

sequence

inside

1  -  4

TMhelix

5  -  27

outside

28  -  488

TMhelix

489  -  511

inside

512  -  525

 

 

Pi

146.745648

Theta

145.850112

Tajima's D

-0.780145

CLR

0.177594

CSRT

0.179391030448478

Interpretation

Uncertain