Gene

KWMTBOMO07068  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA010439

Annotation

lysozyme_[Manduca_sexta]

Location

Bomo_Chr12(-):3095892-3100247      View in EpiBrowser

Full name

Lysozyme       + More
Lysozyme c-1      

Alternative Name

1,4-beta-N-acetylmuramidase

Location in the cell

Extracellular   Reliability : 4.242

CDS

ATGCAGAAGTTAATTATTTTCGCTTTGGTTGTCCTCTGCGTTGGTTCTGAAGCCAAAACGTTCACGAGATGCGGTCTCGTGCATGAGCTGAGGAAACATGGCTTCGAAGAAAATCTCATGAGGAACTGGGTATGTCTGGTCGAGCACGAGAGCAGCCGTGACACATCCAAGACGAACACGAACCGTAACGGCTCGAAGGACTACGGATTGTTCCAGATCAACGACCGGTACTGGTGCAGCAAAGGCGCCAGTCCAGGCAAAGACTGCAACGTTAAGTGCTCCGACCTCCTGACTGACGACATCACTAAGGCAGCGAAATGCGCTAAGAAAATTTACAAACGTCACCGCTTCGATGCCTGGTACGGTTGGAAGAACCACTGCCAGGGCTCTCTGCCTGATATTAGCAGCTGCTAA

Protein

MQKLIIFALVVLCVGSEAKTFTRCGLVHELRKHGFEENLMRNWVCLVEHESSRDTSKTNTNRNGSKDYGLFQINDRYWCSKGASPGKDCNVKCSDLLTDDITKAAKCAKKIYKRHRFDAWYGWKNHCQGSLPDISSC

Description

Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Active against E.coli and M.luteus.
Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.

Catalytic Activity

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Subunit

Monomer.

Similarity

Belongs to the glycosyl hydrolase 22 family.

Keywords

3D-structure   Antibiotic   Antimicrobial   Bacteriolytic enzyme   Complete proteome   Direct protein sequencing   Disulfide bond   Glycosidase   Hydrolase   Reference proteome   Signal   Polymorphism  

Feature

chain  Lysozyme

Uniprot

P48816   Q26363   Q8I808   P50718   Q6QMF0   A0A2H1VQA9   + More
Q86FK1   B6DZS0   A0A0G3DRZ6   A0A0G3DJB1   A0A1C9CJ68   Q2L7D2   P05105   A0A0G3DPZ6   Q68KS6   A0A2A4JR56   O96862   Q6QEJ9   Q7SID7   Q9GNL4   A0A194QN18   A0A194PHN2   D8L124   F8RGS8   B8YI23   A0A0L7LQW1   P50717   A0A0A7DPR2   A0A3Q8RVM8   A0A3S2TLR1   A9P5Q4   E7DN60   A0A178F6L2   A0A3S2P441   A0A194QNH0   A0A194PP71   S4P2Y8   Q19R28   T2C8V4   A0A3S2LKK5   A0A194PHN8   A0A194PIQ1   A0A346RAE8   P82174   A0A0G3DN23   A0A3S2NN33   A0A3Q8RVZ5   A0A212ETA1   A0A2R7WKI5   T1DGW5   A0A2A4JQM6   A0A2H1VQD1   A0A3Q8RVV0   A0A346RAF0   R4WCI1   B0WEH8   Q9GRF3   B8RJ76   A0A182H4Y7   A0A023EGT6   Q8T3T7   A0A1I8JV61   A0A182VG89   A0A023EFF3   A0A1Y9J0F1   A0A1Y9GKS2   Q17005   A0A182KR20   A0A2A4JPT3   A9XXB6   Q672J4   A0A2H1W700   F5GTS1   F5GTR9   B5M0V6   F5GTS0   F5GTR8   F5GTS2   Q86M91   A0A0G3DJN7   F5GTS3   T2C7G6   I1XB30   D1FPY3   A0A2K8JM74   D1FPX6   A0A023F6U5   A0A240PP26   A0A182MSU2   A0A240PMX4   T1E1T1   A0A182H6E4   R4FPH4   T1D598   A0A067R3S2   A0A240PKQ8   I1XB31   A0A224XNP5   T1IGM3   A0A2Y9D1G9  

EC Number

3.2.1.17

Pubmed

7665079    7876591    7517269    8882660    16291089    12831771    + More
25993013    27575006    2007608    16453632    3840100    9662476    11522783    11290453    26354079    15724965    26227816    21167833    23622113    18615707    24155672    29910977    22118469    24330624    23691247    11122464    17510324    26483478    24945155    12477497    8890741    16137842    12364791    20966253    18154650    15663778    22182526    19166301    12826099    25244985    25474469    24845553   

EMBL

L37416    S71028    AAB31190.2    AY164482    AAN87265.1    U38782    + More
AY533676    AAS48094.1    ODYU01003798    SOQ43009.1    AY251271    AAP03061.1    FJ188380    ACI16106.1    KP056536    AKJ54518.1    KP056538    AKJ54520.1    KX385907    AOM73731.1    DQ353869    ABC73705.1    M60914    X02765    M34923    KP056537    AKJ54519.1    AY684242    AAT94286.1    NWSH01000775    PCG74299.1    U50551    AAD00078.1    AY544998    AAS50157.1    AB048258    BAB20806.1    KQ461194    KPJ06907.1    KQ459603    KPI92926.1    FJ438391    ACR82289.1    HM588761    AEB77713.1    FJ535250    ACL51928.1    JTDY01000298    KOB77820.1    U23786    KF960049    AIW49876.1    MG692502    AZJ51074.1    RSAL01000063    RVE49532.1    EF120625    ABN54797.1    HQ260967    ADU33188.1    LHPN01000102    OAL68001.1    RSAL01000028    RVE51866.1    KPJ06904.1    KPI92930.1    GAIX01008286    JAA84274.1    DQ493869    ABF51015.1    KF146181    AGV28585.1    RSAL01000079    RVE48686.1    KPI92931.1    KPI92928.1    MH200938    AXS59148.1    KP056539    AKJ54521.1    RVE51865.1    MG692501    AZJ51073.1    AGBW02012613    OWR44725.1    KK854991    PTY20156.1    GALA01000032    JAA94820.1    PCG74301.1    SOQ43008.1    MG692500    AZJ51072.1    MH200940    AXS59150.1    AK416888    BAN20103.1    DS231909    EDS45638.1    AJ290428    CH477280    CAC19819.1    EAT44944.1    EZ000501    ACJ64375.1    JXUM01025836    KQ560735    KXJ81084.1    GAPW01005552    JAC08046.1    AY089957    AAM11885.1    GAPW01005551    JAC08047.1    APCN01000195    U28809    DQ007317    AAAB01008807    NWSH01000938    PCG73453.1    EU016395    ABV68862.1    AY693973    AAU09087.1    EAT44943.1    ODYU01006743    SOQ48875.1    JI626234    AEB96469.1    JI626232    AEB96467.1    EU930292    ACH56920.1    JI626233    AEB96468.1    JI626231    AEB96466.1    JI626235    AEB96470.1    AY226458    AB104688    AAO74844.1    BAC82382.1    KP056540    AKJ54522.1    JI626236    AEB96471.1    KF146180    AGV28584.1    JQ754175    AFI81523.1    EZ419883    ACZ28238.1    KY031158    ATU82909.1    EZ419876    ACZ28231.1    GBBI01001606    JAC17106.1    AXCM01004053    GALA01001384    JAA93468.1    JXUM01027018    KQ560774    KXJ80942.1    GAHY01000879    JAA76631.1    GALA01000628    JAA94224.1    KK852779    KDR16709.1    JQ754176    AFI81524.1    GFTR01002321    JAW14105.1    ACPB03012359   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000037510    UP000283053    + More
UP000243519    UP000007151    UP000002320    UP000008820    UP000069940    UP000249989    UP000075902    UP000075903    UP000076407    UP000075840    UP000007062    UP000075882    UP000076408    UP000075880    UP000075883    UP000075881    UP000027135    UP000015103   

PRIDE

P48816    Q17005   

Pfam

PF00062   Lys

Interpro

IPR000974   Glyco_hydro_22_lys        + More
IPR001916   Glyco_hydro_22       
IPR023346   Lysozyme-like_dom_sf       
IPR019799   Glyco_hydro_22_CS       

SUPFAM

SSF53955   SSF53955       

CDD

cd00119  LYZ1

ProteinModelPortal

P48816   Q26363   Q8I808   P50718   Q6QMF0   A0A2H1VQA9   + More
Q86FK1   B6DZS0   A0A0G3DRZ6   A0A0G3DJB1   A0A1C9CJ68   Q2L7D2   P05105   A0A0G3DPZ6   Q68KS6   A0A2A4JR56   O96862   Q6QEJ9   Q7SID7   Q9GNL4   A0A194QN18   A0A194PHN2   D8L124   F8RGS8   B8YI23   A0A0L7LQW1   P50717   A0A0A7DPR2   A0A3Q8RVM8   A0A3S2TLR1   A9P5Q4   E7DN60   A0A178F6L2   A0A3S2P441   A0A194QNH0   A0A194PP71   S4P2Y8   Q19R28   T2C8V4   A0A3S2LKK5   A0A194PHN8   A0A194PIQ1   A0A346RAE8   P82174   A0A0G3DN23   A0A3S2NN33   A0A3Q8RVZ5   A0A212ETA1   A0A2R7WKI5   T1DGW5   A0A2A4JQM6   A0A2H1VQD1   A0A3Q8RVV0   A0A346RAF0   R4WCI1   B0WEH8   Q9GRF3   B8RJ76   A0A182H4Y7   A0A023EGT6   Q8T3T7   A0A1I8JV61   A0A182VG89   A0A023EFF3   A0A1Y9J0F1   A0A1Y9GKS2   Q17005   A0A182KR20   A0A2A4JPT3   A9XXB6   Q672J4   A0A2H1W700   F5GTS1   F5GTR9   B5M0V6   F5GTS0   F5GTR8   F5GTS2   Q86M91   A0A0G3DJN7   F5GTS3   T2C7G6   I1XB30   D1FPY3   A0A2K8JM74   D1FPX6   A0A023F6U5   A0A240PP26   A0A182MSU2   A0A240PMX4   T1E1T1   A0A182H6E4   R4FPH4   T1D598   A0A067R3S2   A0A240PKQ8   I1XB31   A0A224XNP5   T1IGM3   A0A2Y9D1G9  

PDB

2RSC     E-value=1.79692e-63,     Score=608

KEGG

693015    K13915 lysozyme C [EC:3.2.1.17] | (RefSeq) Lzm, BmLys; lysozyme

GO

GO:0003796   GO:0042742   GO:0019835   GO:0008152   GO:0016868   GO:0000287   GO:0005634   GO:0008270   GO:0005515   GO:0004319   GO:0004320   GO:0016295   GO:0016296  

SignalP

Position:   1 - 18,         Likelihood:  0.998811

 

 

Length:

137

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.76331

Exp number, first 60 AAs:

0.76331

Total prob of N-in:

0.06734

outside

1  -  137

 

 

Pi

206.019109

Theta

154.11265

Tajima's D

0.825442

CLR

0.430645

CSRT

0.612669366531673

Interpretation

Uncertain