Gene

KWMTBOMO07062

Annotation

Phosphoglucomutase_[Operophtera_brumata]

Location

Bomo_Chr12(-):2962236-2964604      View in EpiBrowser

Full name

Phosphoglucomutase-2      

Alternative Name

Glucose phosphomutase 2
Phosphodeoxyribomutase
Phosphopentomutase

Location in the cell

Extracellular   Reliability : 1.896

CDS

ATGGGCGCACTGCTGGGCTGGTGGCTGCTGACGCAGCACTACAAGAAGGACCCGTCTGCGAATGCCGAGGACCTGTACGTGATCGCCAGCATCGTCAGCTCGAAGATGCTGCGCGCCATCGTCGACGGGAAGGGACAGTTTGTGGAGACACTCACCGGCTTCAAGTGGATGGGTAATTGCTCCCTGCTGCTGGTACAGCAGAACAAGATTCCGGTGTTCGCCTTCGAGGAGGCCCTGGGCTACATGTGCGATGTGCGCGTACCAGACAAAGATGGCGTCTCGGCCGCGGTGCAAGTAAGTATAGTATAG

Protein

MGALLGWWLLTQHYKKDPSANAEDLYVIASIVSSKMLRAIVDGKGQFVETLTGFKWMGNCSLLLVQQNKIPVFAFEEALGYMCDVRVPDKDGVSAAVQVSIV

Description

Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. May also catalyze the interconversion of glucose-1-phosphate and glucose-6-phosphate. Has low glucose 1,6-bisphosphate synthase activity.
Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. May also catalyze the interconversion of glucose-1-phosphate and glucose-6-phosphate. Has low glucose 1,6-bisphosphate synthase activity (By similarity).

Catalytic Activity

alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate
alpha-D-ribose 1-phosphate = D-ribose 5-phosphate
2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-D-ribose 5-phosphate

Cofactor

Mg(2+)

Biophysicochemical Properties

45.7 uM for alpha-D-ribose 1-phosphate
4.1 uM for 2-deoxy-alpha-D-ribose 1-phosphate
114 uM for alpha-D-glucose 1-phosphate

Similarity

Belongs to the phosphohexose mutase family.

Keywords

Acetylation   Alternative splicing   Carbohydrate metabolism   Complete proteome   Cytoplasm   Direct protein sequencing   Glucose metabolism   Isomerase   Magnesium   Metal-binding   Phosphoprotein   Polymorphism   Reference proteome  

Feature

chain  Phosphoglucomutase-2
splice variant  In isoform 2.
sequence variant  In dbSNP:rs17856324.

Uniprot

A0A0L7LMT4   A0A2A4JE52   A0A2W1BQG6   A0A2H1VMC8   A0A3S2TPU5   A0A212ETF5   + More
A0A194QN07   A0A194PJN5   H9JLP3   A0A3S3QJ92   A0A3S3PHL7   A0A2J7R8Q5   A0A2J7R8Q8   A0A1B6E2I8   A0A1Y1N3L1   A0A161ML37   A0A151PA90   A0A131XBP6   A0A210Q4X0   E2AE69   I3MB62   M3Y3H5   A0A2Y9JKR7   A0A023FLK0   B0XBU8   G9KG72   A0A293MVQ6   F7ENI5   F7B0S5   A0A3Q0HD21   A0A2R5LLS1   K7G6P2   K7G6P7   G3VSW5   E2BFH3   D2HTA4   A0A023F3Y4   A0A1S3EJ06   G1LXN4   A0A224Z1A7   L7MCS2   L7MEP4   A0A131YI42   A0A1B0D2T0   A0A0L8HIV4   K9KB11   A0A1Q3FKA7   A0A1Q3FKU7   A0A1V9YYT4   A0A0V0G6E7   L8Y7V8   F6SIC9   F6YK46   M7C5T9   B4DN40   A0A2U3XIL3   A0A1V9X8D7   A0A1L8E1J3   A0A182H7R3   K7ECI9   A0A182GXV6   A0A3Q2I8C1   Q95RR7   A0A2H6N7Z9   S7MK69   A0A3Q7XNU1   A0A0P4WDD6   A0A3Q2GWI8   A0A1Q3FJA4   A0A384CYM7   H9GCD8   G1PBJ6   A0A3Q7Q8Q7   A0A1Q3FKE8   A0A023GLE0   G3MPT2   A0A1B6K757   A0A2U3ZBK0   A0A0J7L3G8   A0A2Y9I4U3   A0A3Q7TDJ7   A0A2K5EMK0   F7FLB2   E2QV12   A0A2K6GR36   A0A1S3QMI8   A0A091UKI1   A0A2K6TGH8   A0A182T912   Q17L34   A0A0C9RME0   M3W2Q7   A0A091DQW1   G1S585   A0A2R9C685   A0A182RMC9   Q96G03   W5PJD0   H2PD34   Q5RFI8  

EC Number

5.4.2.2

Pubmed

26227816    28756777    22118469    26354079    19121390    28004739    + More
22293439    28049606    28812685    20798317    23236062    17495919    17381049    21709235    20010809    25474469    28797301    25576852    26830274    25527045    23385571    18464734    19892987    23624526    28327890    26483478    24813606    21881562    21993624    22216098    15489334    15057822    22673903    16341006    17510324    17975172    22722832    11230166    14702039    15815621    12665801    17804405    18669648    19413330    20068231    21269460    22223895    22814378    23186163    24275569    20809919   

EMBL

JTDY01000537    KOB76752.1    NWSH01001809    PCG70056.1    KZ150015    PZC74980.1    + More
ODYU01003339    SOQ41967.1    RSAL01000028    RVE51871.1    AGBW02012613    OWR44724.1    KQ461194    KPJ06897.1    KQ459603    KPI92939.1    BABH01005300    NCKU01002418    NCKU01000946    NCKU01000944    RWS09628.1    RWS13567.1    RWS13577.1    NCKU01002341    RWS09801.1    NEVH01006721    PNF37212.1    PNF37214.1    GEDC01011087    GEDC01005156    JAS26211.1    JAS32142.1    GEZM01013572    GEZM01013571    GEZM01013570    GEZM01013569    JAV92473.1    GEMB01002571    JAS00618.1    AKHW03000533    KYO45884.1    GEFH01004192    JAP64389.1    NEDP02004995    OWF43792.1    GL438827    EFN68302.1    AGTP01015495    AEYP01059785    AEYP01059786    AEYP01059787    AEYP01059788    AEYP01059789    GBBK01002468    JAC22014.1    DS232654    EDS44477.1    JP015299    AES03897.1    GFWV01020205    MAA44933.1    GGLE01006313    MBY10439.1    AGCU01130327    AGCU01130328    AGCU01130329    AGCU01130330    AEFK01223666    GL448037    EFN85495.1    GL193334    EFB18287.1    GBBI01003048    JAC15664.1    ACTA01059617    ACTA01067617    ACTA01075617    GFPF01010583    MAA21729.1    GACK01003244    JAA61790.1    GACK01003306    JAA61728.1    GEDV01009638    JAP78919.1    AJVK01002791    KQ418031    KOF89193.1    JL619537    AEP99170.1    GFDL01007129    JAV27916.1    GFDL01006890    JAV28155.1    JNBR01000567    OQR90918.1    GECL01002547    JAP03577.1    KB367707    ELV10446.1    KB527356    EMP35877.1    AK297752    BAG60102.1    MNPL01019665    OQR69827.1    GFDF01001484    JAV12600.1    JXUM01004201    JXUM01004202    KQ560170    KXJ84032.1    JXUM01096349    KQ564258    KXJ72517.1    AY061184    AAL28732.2    IACI01044885    LAA24465.1    KE161555    EPQ04481.1    GDRN01067212    JAI64399.1    GFDL01007334    JAV27711.1    AAWZ02026073    AAPE02017312    GFDL01006988    JAV28057.1    GBBM01000686    JAC34732.1    JO843883    AEO35500.1    GECU01000427    JAT07280.1    LBMM01000816    KMQ97422.1    AABR07015025    AABR07015026    BC160893    AAI60893.1    AAEX03002546    KK455876    KFQ76273.1    CH477219    EAT47392.1    GBYB01014567    JAG84334.1    AANG04001605    KN122111    KFO32853.1    ADFV01182385    ADFV01182386    ADFV01182387    ADFV01182388    AJFE02114342    AJFE02114343    AL136705    AF109360    AK001845    AK303374    CR457274    AK223237    AC021106    AC108022    BC010087    AMGL01098034    ABGA01329922    ABGA01329923    ABGA01329924    ABGA01329925    NDHI03003508    PNJ30749.1    CR857168   

Proteomes

UP000037510    UP000218220    UP000283053    UP000007151    UP000053240    UP000053268    + More
UP000005204    UP000285301    UP000235965    UP000050525    UP000242188    UP000000311    UP000005215    UP000000715    UP000248482    UP000002320    UP000002280    UP000189705    UP000007267    UP000007648    UP000008237    UP000081671    UP000008912    UP000092462    UP000053454    UP000243579    UP000011518    UP000002279    UP000002281    UP000031443    UP000245341    UP000192247    UP000069940    UP000249989    UP000286642    UP000261680    UP000291021    UP000001646    UP000001074    UP000286641    UP000245340    UP000036403    UP000248481    UP000286640    UP000233020    UP000002494    UP000002254    UP000233160    UP000087266    UP000233220    UP000075901    UP000008820    UP000011712    UP000028990    UP000001073    UP000240080    UP000075900    UP000005640    UP000002356    UP000001595   

PRIDE

H9JLP3    F6YK46    B4DN40    Q95RR7    E2QV12    Q96G03    + More
Q5RFI8   

Pfam

PF02880   PGM_PMM_III        + More
PF02879   PGM_PMM_II
PF02878   PGM_PMM_I
PF00408   PGM_PMM_IV

Interpro

IPR016055   A-D-PHexomutase_a/b/a-I/II/III        + More
IPR005846   A-D-PHexomutase_a/b/a-III       
IPR005845   A-D-PHexomutase_a/b/a-II       
IPR016066   A-D-PHexomutase_CS       
IPR036900   A-D-PHexomutase_C_sf       
IPR005844   A-D-PHexomutase_a/b/a-I       
IPR005841   Alpha-D-phosphohexomutase_SF       
IPR005843   A-D-PHexomutase_C       

SUPFAM

SSF53738   SSF53738        + More
SSF55957   SSF55957       

ProteinModelPortal

A0A0L7LMT4   A0A2A4JE52   A0A2W1BQG6   A0A2H1VMC8   A0A3S2TPU5   A0A212ETF5   + More
A0A194QN07   A0A194PJN5   H9JLP3   A0A3S3QJ92   A0A3S3PHL7   A0A2J7R8Q5   A0A2J7R8Q8   A0A1B6E2I8   A0A1Y1N3L1   A0A161ML37   A0A151PA90   A0A131XBP6   A0A210Q4X0   E2AE69   I3MB62   M3Y3H5   A0A2Y9JKR7   A0A023FLK0   B0XBU8   G9KG72   A0A293MVQ6   F7ENI5   F7B0S5   A0A3Q0HD21   A0A2R5LLS1   K7G6P2   K7G6P7   G3VSW5   E2BFH3   D2HTA4   A0A023F3Y4   A0A1S3EJ06   G1LXN4   A0A224Z1A7   L7MCS2   L7MEP4   A0A131YI42   A0A1B0D2T0   A0A0L8HIV4   K9KB11   A0A1Q3FKA7   A0A1Q3FKU7   A0A1V9YYT4   A0A0V0G6E7   L8Y7V8   F6SIC9   F6YK46   M7C5T9   B4DN40   A0A2U3XIL3   A0A1V9X8D7   A0A1L8E1J3   A0A182H7R3   K7ECI9   A0A182GXV6   A0A3Q2I8C1   Q95RR7   A0A2H6N7Z9   S7MK69   A0A3Q7XNU1   A0A0P4WDD6   A0A3Q2GWI8   A0A1Q3FJA4   A0A384CYM7   H9GCD8   G1PBJ6   A0A3Q7Q8Q7   A0A1Q3FKE8   A0A023GLE0   G3MPT2   A0A1B6K757   A0A2U3ZBK0   A0A0J7L3G8   A0A2Y9I4U3   A0A3Q7TDJ7   A0A2K5EMK0   F7FLB2   E2QV12   A0A2K6GR36   A0A1S3QMI8   A0A091UKI1   A0A2K6TGH8   A0A182T912   Q17L34   A0A0C9RME0   M3W2Q7   A0A091DQW1   G1S585   A0A2R9C685   A0A182RMC9   Q96G03   W5PJD0   H2PD34   Q5RFI8  

KEGG

101747131    K15779 phosphoglucomutase / phosphopentomutase [EC:5.4.2.2 5.4.2.7] | (RefSeq) phosphoglucomutase-2

GO

GO:0016868   GO:0005975   GO:0000287   GO:0046872   GO:0008973   GO:0006006   GO:0004614   GO:0016021   GO:0005576   GO:0070062   GO:0034774   GO:0046386   GO:0006098   GO:0019388   GO:0005829   GO:0005980   GO:1904813   GO:0005978   GO:0043312   GO:0005737   GO:0008081   GO:0005634   GO:0008270   GO:0005515   GO:0004319   GO:0004320   GO:0016295   GO:0016296  

Subcellular location

Cytoplasm  

Length:

102

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0285

Exp number, first 60 AAs:

0.02477

Total prob of N-in:

0.02083

outside

1  -  102

 

 

Pi

149.251094

Theta

74.416648

Tajima's D

0.312721

CLR

0.037307

CSRT

0.468376581170941

Interpretation

Uncertain