Gene

KWMTBOMO07046

Pre Gene Modal

BGIBMGA010451

Annotation

PREDICTED:_protein_dachsous-like_[Bombyx_mori]

Location

Bomo_Chr12(-):2709045-2720224      View in EpiBrowser

Full name

Protein dachsous      

Alternative Name

Adherin

Location in the cell

Nuclear   Reliability : 1.667

CDS

ATGTGGCGCGTCGTGTTGCTGGCGATGGTCGCGGCGGCGGCAAGCGAGCACGTGCGCGAGTTCGCCGTGCGAGAGAACGCACGTGCCGACACCCTCGTGGGCCACCTCGGCGACGAGCTGCCCGACGCGGCGCCGCCCTACACCATCGTCCCCGTACCCGGCAGCGCCGTCAACGACGACTTACGCGTAGATCCCCATACGGGCGAAATTCGCACCCGAGCCCCCCTTGACCGCGAGCACCGGGACCATTACGCGCTCGTCGCCATCCCCGCCTCTGGAGACAACATCAGGGTTGTCGTCCGCGTCCTCGACGAGAACGACAACGCTCCCGTCTTCCCTGCAGCCGTAATGAACGTCGAGTTCTCAGAGAACACTCCGAGGGACGTGAAAAGGAAACTTAATCCGGCCAGGGATCAAGATTTAGGGACTTTCAACACGCAACGGTACAATATAGTGTCTGGAAATACAGATAACGCGTTTAGGCTGTCCTCGCACAGGGAACGAGACGGTGTGCTGTATTTAGATTTGCAAATCAACGGATTTCTCGATAGGGAAACGACCGATCATTATCAGTTAGTTATAGAGGCGTTGGACGGCGGCACCCCACCGCTGCGGGGCACAATGACAGTGAACATTACGATATTGGACGTGAACGATAATCCCCCGGTGTTCGCTGAGAGTGTTTACTCGGCTACCATACCGGAAAACGCGACAGTCGGGACCGCGGTGCTTAAAGTGTCCGCCACCGATTCTGACGCAGGCGATAACGGTCTCATCGAGTACTCAATAAACAGGCGACAGAGTGATAAAGAGAACAATTTTAAAATCGATCCGGAAACAGGCGAGATCACTGTAAACAAGGCACTGGATTTTGAGACCAAAGATCTGCACGAATTGGTGGTGGTCGCCAGAGACAAAGGCCTCCAGCCATTAGAGACCACCGCGTTTGTTTCCATCAGAGTGACGGACGTGAACGATAATCAGCCTACTATAGACGTGATATTCTTAAGTGACGACGCCACTCCGAAAATATCAGAGTCCGCCCAATTAGATGAGTTCGTCGCGAGGATATCCGTCCACGATCCCGACTCTAAGACAGAATATTCGAACGTGAATGTGACATTGAGTGGAGGTGACGGTCACTTTGATTTGCGTACGCACGATAACATAATTTATTTGGTCGTGGTCGCGCTACCACTGGATCGCGAATCTCGATCCTCCTACACACTGAACGTTGTCGCGACGGACAAAGGTTCGCCTCCGCTGCACGCGTCTCGGATAATCTCGCTTCGAGTGACGGATGTGAACGATAATGCGCCCGCTTTTGTTGAGTCCGAATACAAAGCGAGCGTCCCGGAAGCCACCGCCCCGGGTACGCCGGTGGTTCAAGTGTCTGCTTCTGATGCCGACGAAGGCGAAAACTCGGAGATTAGGTACAGTTTGTTGACGACGCCCCAATCGGATTGGTTTTCGATTGACGAGCGCTCAGGGTTGGTCACGACTCGGTCGCGAGTCGATTGCGAGACGAACCCGATGCCTCGTTTGACGGTGGTGGCGAGGGACCGCGGCAACCCTCCGCTGTCTTCGACCGCAACGCTGCTCATCACCGTCCTGGATGTGAACGACAATGAGCCGATCTTCGACCAGTCATTCTACAACGTCACCGTGCCGGAGAGCGAAGCTGTGGGCAGCTGCATATTAAAGTGCGTCCCCAGCGCCGCTCTGGCCCCAGGCCTCGAGTGTTACGGCTACGCTATGTGCGAACTATGGGTCGGTATTTAA

Protein

MWRVVLLAMVAAAASEHVREFAVRENARADTLVGHLGDELPDAAPPYTIVPVPGSAVNDDLRVDPHTGEIRTRAPLDREHRDHYALVAIPASGDNIRVVVRVLDENDNAPVFPAAVMNVEFSENTPRDVKRKLNPARDQDLGTFNTQRYNIVSGNTDNAFRLSSHRERDGVLYLDLQINGFLDRETTDHYQLVIEALDGGTPPLRGTMTVNITILDVNDNPPVFAESVYSATIPENATVGTAVLKVSATDSDAGDNGLIEYSINRRQSDKENNFKIDPETGEITVNKALDFETKDLHELVVVARDKGLQPLETTAFVSIRVTDVNDNQPTIDVIFLSDDATPKISESAQLDEFVARISVHDPDSKTEYSNVNVTLSGGDGHFDLRTHDNIIYLVVVALPLDRESRSSYTLNVVATDKGSPPLHASRIISLRVTDVNDNAPAFVESEYKASVPEATAPGTPVVQVSASDADEGENSEIRYSLLTTPQSDWFSIDERSGLVTTRSRVDCETNPMPRLTVVARDRGNPPLSSTATLLITVLDVNDNEPIFDQSFYNVTVPESEAVGSCILKCVPSAALAPGLECYGYAMCELWVGI

Description

Required for normal morphogenesis of adult structures derived from imaginal disks (PubMed:7601355, PubMed:26073018). Plays a role in planar cell polarity and in determining body left-right asymmetry. Expression in segment H1 of the imaginal ring and interaction with Myo31DF are required to induce changes of cell shape and orientation in segment H2, which then gives rise to normal, dextral looping of the adult hindgut (PubMed:26073018).
Cadherins are calcium-dependent cell adhesion proteins.

Subunit

Interacts (via cytoplasmic region) with Myo31DF.

Miscellaneous

Overexpression in segment H1 of the imaginal ring causes aberrant gut looping in about 40% of the cases, but no phenotype is observed when both Myo31DF and ds are overexpressed.

Keywords

Calcium   Cell adhesion   Cell junction   Cell membrane   Complete proteome   Developmental protein   Glycoprotein   Membrane   Phosphoprotein   Reference proteome   Repeat   Signal   Transmembrane   Transmembrane helix  

Feature

chain  Protein dachsous

Uniprot

H9JLP9   A0A2W1BTD6   A0A2H1WX99   A0A194QMY6   A0A194PJP2   A0A212FNF8   + More
A0A0L7LQH3   A0A139WJW8   A0A2P8ZEV4   A0A1B0CAS0   Q17NI9   A0A067RQ34   A0A1B0DJW5   W8C4R4   A0A084VNY9   B0W508   W5J7E0   A0A2J7RC54   A0A182F4H9   A0A1I8PHT0   A0A182PME1   A0A182W9R3   A0A182STV1   A0A182RBN9   A0A182MJQ2   A0A1I8NCF2   A0A182TVC9   A0A182HVA0   A0A182WTA6   A0A1I8NCF1   A0A182Q273   A0A0K8V577   A0A182V120   A0A182YGW5   A0A0L0C915   A0A0K8TXM6   A0A182JT87   A0A2R7WTQ1   A0A0K8UZA4   A0A1J1I115   A0A1Y1JUP0   A0A182IKY5   A0A1W4WLJ5   T1IGF3   A0A1A9WW14   B4Q669   A0A3B0K446   B4P2W3   A0A0J9QT98   X2J8E9   Q24292   A0A0S1RUS1   A0A1B0GD91   B3N7T5   A0A1A9V4W2   B5DIW2   A0A1A9ZVA6   B4GPR0   A0A1W4V2Q6   B4LTP4   A0A1B0BHQ9   B4KF91   B4JDS3   B3MLQ6   A0A336LSR0   B4N0S5   A0A0M5IVU2   A0A2S2P2R1   J9LPE0   A0A2H8TRA6   A0A2P6LCN6   E9FRI4   A0A0P5QQV1   A0A0P6A4A4   A0A0P5RW78   A0A0P6FJE9   A0A0P5IJQ0   A0A0P5IPN6   A0A0P5HCT2   A0A0P6GTD1   A0A0P5QQ49   A0A0P5NCC0   A0A0P5ERX1   A0A0P5A0G7   A0A0P5AT68   A0A0P5A6D9   A0A0P5BJS1   A0A0P6AL29   A0A0P5DZ38   A0A0N7ZML0   A0A0P5DNW1   A0A0P5V9G7   A0A0P4Y9Z2   A0A164YHC3   A0A0P5BGP6   A0A0P5YF89   A0A0P5DCH6   A0A0P5P0B0   A0A088AN25   A0A2A3EJI6  

Pubmed

19121390    28756777    26354079    22118469    26227816    18362917    + More
19820115    29403074    17510324    24845553    24495485    24438588    20920257    23761445    25315136    25244985    26108605    28004739    17994087    17550304    22936249    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    7601355    18327897    18635802    26073018    26497083    15632085    23185243    18057021    21292972   

EMBL

BABH01005277    KZ150015    PZC74993.1    ODYU01011694    SOQ57596.1    KQ461194    + More
KPJ06888.1    KQ459603    KPI92949.1    AGBW02005533    OWR55281.1    JTDY01000335    KOB77649.1    KQ971338    KYB28095.1    PYGN01000077    PSN55018.1    AJWK01004216    CH477199    EAT48227.1    KK852532    KDR21854.1    AJVK01001169    GAMC01002212    JAC04344.1    ATLV01014963    KE524999    KFB39683.1    DS231840    EDS34574.1    ADMH02002093    ETN59313.1    NEVH01005887    PNF38395.1    AXCM01004691    APCN01002503    AXCN02000870    GDHF01018416    JAI33898.1    JRES01000753    KNC28737.1    GDHF01033273    JAI19041.1    KK855479    PTY22751.1    GDHF01020649    JAI31665.1    CVRI01000038    CRK94039.1    GEZM01100129    JAV53004.1    ACPB03011283    ACPB03011284    ACPB03011285    ACPB03011286    ACPB03011287    CM000361    EDX03253.1    OUUW01000004    SPP79741.1    CM000157    EDW87170.1    CM002910    KMY87352.1    AE014134    AHN54066.1    L08811    AAF51468.3    KT935293    ALL98470.1    CCAG010015659    CH954177    EDV57261.1    CH379060    EDY70255.1    KRT04402.1    CH479187    EDW39582.1    CH940649    EDW65017.2    KRF81978.1    JXJN01014537    CH933807    EDW13074.2    CH916368    EDW03443.1    CH902620    EDV30777.1    UFQS01000093    UFQT01000093    SSW99239.1    SSX19619.1    CH963920    EDW77688.2    CP012523    ALC37924.1    GGMR01011162    MBY23781.1    ABLF02030011    ABLF02030014    GFXV01004929    MBW16734.1    MWRG01000368    PRD36340.1    GL732523    EFX90172.1    GDIQ01110813    JAL40913.1    GDIP01035182    JAM68533.1    GDIQ01095416    JAL56310.1    GDIQ01056483    JAN38254.1    GDIQ01212529    JAK39196.1    GDIQ01212528    JAK39197.1    GDIQ01229421    JAK22304.1    GDIQ01265465    GDIQ01029947    JAN64790.1    GDIQ01120959    JAL30767.1    GDIQ01154897    JAK96828.1    GDIQ01265362    JAJ86362.1    GDIP01205714    GDIP01205713    GDIP01199758    GDIP01039279    JAJ17688.1    GDIP01198310    GDIP01198309    GDIP01198308    JAJ25093.1    GDIP01203558    GDIP01203557    JAJ19844.1    GDIP01183558    JAJ39844.1    GDIP01183560    GDIP01183559    GDIP01028092    JAM75623.1    GDIP01153613    JAJ69789.1    GDIP01230657    JAI92744.1    GDIP01154663    JAJ68739.1    GDIP01102817    JAM00898.1    GDIP01230658    JAI92743.1    LRGB01000915    KZS15253.1    GDIP01184908    JAJ38494.1    GDIP01058528    GDIP01058477    JAM45187.1    GDIP01159564    JAJ63838.1    GDIQ01145352    JAL06374.1    KZ288245    PBC31191.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000007151    UP000037510    UP000007266    + More
UP000245037    UP000092461    UP000008820    UP000027135    UP000092462    UP000030765    UP000002320    UP000000673    UP000235965    UP000069272    UP000095300    UP000075885    UP000075920    UP000075901    UP000075900    UP000075883    UP000095301    UP000075902    UP000075840    UP000076407    UP000075886    UP000075903    UP000076408    UP000037069    UP000075881    UP000183832    UP000075880    UP000192223    UP000015103    UP000091820    UP000000304    UP000268350    UP000002282    UP000000803    UP000092444    UP000008711    UP000078200    UP000001819    UP000092445    UP000008744    UP000192221    UP000008792    UP000092460    UP000009192    UP000001070    UP000007801    UP000007798    UP000092553    UP000007819    UP000000305    UP000076858    UP000005203    UP000242457   

PRIDE

H9JLP9    Q24292   

Pfam

PF00028   Cadherin        + More
PF01049   Cadherin_C

Interpro

IPR015919   Cadherin-like_sf        + More
IPR020894   Cadherin_CS       
IPR002126   Cadherin-like_dom       
IPR000233   Cadherin_cytoplasmic-dom       

SUPFAM

SSF49313   SSF49313       

ProteinModelPortal

H9JLP9   A0A2W1BTD6   A0A2H1WX99   A0A194QMY6   A0A194PJP2   A0A212FNF8   + More
A0A0L7LQH3   A0A139WJW8   A0A2P8ZEV4   A0A1B0CAS0   Q17NI9   A0A067RQ34   A0A1B0DJW5   W8C4R4   A0A084VNY9   B0W508   W5J7E0   A0A2J7RC54   A0A182F4H9   A0A1I8PHT0   A0A182PME1   A0A182W9R3   A0A182STV1   A0A182RBN9   A0A182MJQ2   A0A1I8NCF2   A0A182TVC9   A0A182HVA0   A0A182WTA6   A0A1I8NCF1   A0A182Q273   A0A0K8V577   A0A182V120   A0A182YGW5   A0A0L0C915   A0A0K8TXM6   A0A182JT87   A0A2R7WTQ1   A0A0K8UZA4   A0A1J1I115   A0A1Y1JUP0   A0A182IKY5   A0A1W4WLJ5   T1IGF3   A0A1A9WW14   B4Q669   A0A3B0K446   B4P2W3   A0A0J9QT98   X2J8E9   Q24292   A0A0S1RUS1   A0A1B0GD91   B3N7T5   A0A1A9V4W2   B5DIW2   A0A1A9ZVA6   B4GPR0   A0A1W4V2Q6   B4LTP4   A0A1B0BHQ9   B4KF91   B4JDS3   B3MLQ6   A0A336LSR0   B4N0S5   A0A0M5IVU2   A0A2S2P2R1   J9LPE0   A0A2H8TRA6   A0A2P6LCN6   E9FRI4   A0A0P5QQV1   A0A0P6A4A4   A0A0P5RW78   A0A0P6FJE9   A0A0P5IJQ0   A0A0P5IPN6   A0A0P5HCT2   A0A0P6GTD1   A0A0P5QQ49   A0A0P5NCC0   A0A0P5ERX1   A0A0P5A0G7   A0A0P5AT68   A0A0P5A6D9   A0A0P5BJS1   A0A0P6AL29   A0A0P5DZ38   A0A0N7ZML0   A0A0P5DNW1   A0A0P5V9G7   A0A0P4Y9Z2   A0A164YHC3   A0A0P5BGP6   A0A0P5YF89   A0A0P5DCH6   A0A0P5P0B0   A0A088AN25   A0A2A3EJI6  

PDB

5T9T     E-value=3.31593e-67,     Score=649

KEGG

101746395    K16507 protocadherin-16/23 | (RefSeq) protein dachsous-like

PATHWAY

04391    Hippo signaling pathway - fly - Bombyx mori (domestic silkworm)
04392    Hippo signaling pathway - multiple species - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0007156   GO:0005886   GO:0005509   GO:0007155   GO:0005887   GO:0045296   GO:0044331   GO:0016339   GO:0045317   GO:0045198   GO:0007480   GO:0007157   GO:0001737   GO:0090176   GO:0035222   GO:0090175   GO:0035159   GO:0007164   GO:0048592   GO:0016318   GO:0001736   GO:0098609   GO:0007476   GO:0042067   GO:0030010   GO:0035331   GO:0060071   GO:0016327   GO:0000904   GO:0008283   GO:0030054   GO:0018149   GO:0090251   GO:0035332   GO:0016020   GO:0005515   GO:0004319   GO:0004320   GO:0016295   GO:0016296  

Subcellular location

Cell membrane   Colocalizes with Myo32DF at cell contact sites.   With evidence from 5 publications.
Cell junction   Colocalizes with Myo32DF at cell contact sites.   With evidence from 5 publications.

SignalP

Position:   1 - 14,         Likelihood:  0.973414

 

 

Length:

593

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01154

Exp number, first 60 AAs:

0.00252

Total prob of N-in:

0.00053

outside

1  -  593

 

 

Pi

205.021873

Theta

175.623859

Tajima's D

0.990177

CLR

0.204251

CSRT

0.657967101644918

Interpretation

Uncertain