Gene
KWMTBOMO07034
Pre Gene Modal
BGIBMGA010511
Annotation
PREDICTED:_putative_fatty_acyl-CoA_reductase_CG5065_[Bombyx_mori]
Full name
Fatty acyl-CoA reductase
+ More
Fatty acyl-CoA reductase 1
Fatty acyl-CoA reductase 1
Location in the cell
Cytoplasmic Reliability : 1.107 Mitochondrial Reliability : 1.637
Sequence
CDS
ATGCAAAAGATTGAATCCTTCGTACATGTTTCCTCTGTATATGCACAAGCGCTTGATGGAGGGAAGATAGTTAAGGAGACCTTGTACCCGCCGCCGGCTAATCACAAAGAACTAGAGACCTTCATATCGAAGTACGACAACGACAAAGAGGAAACAAAGAAATTTTTTCAGCAACGTTGTAATACATACGCTTATGGTAAAGCGTTGACGGAGAACTTTGTGGCTGAAAACCATGGCACAATACCGACATGCATAGTTAGACCATCTATGATTACTTCGAAAGCCGACGAGCCTTTACCTGGGTGGTTAGACAACTGGTACGGACCGGCGCGTCTCTTATACAACGTATCTCGTGGATGGGATCGTTCGTGCTTCATTCGAAGAGAATTCTTAGTTGACATGATACCAGTGGACTATGTCGCGAACCTCTGTATCGTTGCGGGAGCGAGAAACGACAGTTGTGTCGATGTCGCGGTATTCAACAGTTGTACCACAGGAGCGAATCCAATAACCTGGGAAGATGCACATAAGCGCATGATAGAAGTTACAGTTAAGAATAAATTGAATGATTGGCCATATCCATTTGTGTTATACACACAGTCAAAGCTACTATTCTCACTTTATACGATGTTTCTGCAGTTAATTCCTGCAAAAATAGCGGACGGTTGGCTGTGGGTTACTGGAAGAAGTCCAAAGTATACAAAAATACAGAAGAAAGTAATAAATAATAAAGTGGTCATTGTGACTGGAAGCAGTTCGGGTATTGGAGAAGCTATTGCTGCAGAATTAGTATCTCAAGAAGCAAAAGTTGTTATAATTGGCAGAAGAGAACATAAACTGAAGTTAATAACAGCAAGATGTGAACTAGTTGGTACAAGGCCATTGGTAATCAGAGCAAATATGACTAAAGACGATGATAGAAGAATGATCATTAACAAGACAAGACAAGACAAGAAGGGTCGTCGTACCCCCTTTCGGGGGCACGGAACGGGCCTCGGGGCAAACCCCACTACCCGGGACGGAGCTCCCTGCCACACAGGGCAGGGGTGA
Protein
MQKIESFVHVSSVYAQALDGGKIVKETLYPPPANHKELETFISKYDNDKEETKKFFQQRCNTYAYGKALTENFVAENHGTIPTCIVRPSMITSKADEPLPGWLDNWYGPARLLYNVSRGWDRSCFIRREFLVDMIPVDYVANLCIVAGARNDSCVDVAVFNSCTTGANPITWEDAHKRMIEVTVKNKLNDWPYPFVLYTQSKLLFSLYTMFLQLIPAKIADGWLWVTGRSPKYTKIQKKVINNKVVIVTGSSSGIGEAIAAELVSQEAKVVIIGRREHKLKLITARCELVGTRPLVIRANMTKDDDRRMIINKTRQDKKGRRTPFRGHGTGLGANPTTRDGAPCHTGQG
Summary
Description
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Catalyzes the reduction of saturated and unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. It plays an essential role in the production of ether lipids/plasmalogens which synthesis requires fatty alcohols. In parallel, it is also required for wax monoesters production since fatty alcohols also constitute a substrate for their synthesis.
Catalyzes the reduction of saturated and unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. It plays an essential role in the production of ether lipids/plasmalogens which synthesis requires fatty alcohols. In parallel, it is also required for wax monoesters production since fatty alcohols also constitute a substrate for their synthesis.
Catalytic Activity
a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP(+)
Similarity
Belongs to the fatty acyl-CoA reductase family.
Keywords
Lipid biosynthesis
Lipid metabolism
Membrane
NADP
Oxidoreductase
Peroxisome
Transmembrane
Transmembrane helix
Feature
chain Fatty acyl-CoA reductase 1
Uniprot
EC Number
1.2.1.84
Pubmed
Proteomes
Interpro
SUPFAM
SSF51735
SSF51735
CDD
ProteinModelPortal
PDB
3ENN
E-value=0.00178374,
Score=97
Ontologies
PANTHER
Topology
Subcellular location
Peroxisome membrane
Length:
349
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
1.79424
Exp number, first 60 AAs:
0.00059
Total prob of N-in:
0.03653
outside
1 - 349
Population Genetic Test Statistics
Pi
152.704831
Theta
20.160386
Tajima's D
-0.481918
CLR
1.828412
CSRT
0.246937653117344
Interpretation
Uncertain
