Gene

KWMTBOMO07016

Pre Gene Modal

BGIBMGA010466

Annotation

PREDICTED:_neutral_ceramidase-like_[Papilio_polytes]

Location

Bomo_Chr12(-):1883655-1899553      View in EpiBrowser

Full name

Neutral ceramidase      

Alternative Name

Acylsphingosine deacylase
N-acylsphingosine amidohydrolase

Location in the cell

Mitochondrial   Reliability : 1.3

CDS

ATGAAATTACCCCCAAAGACTAACTACCTATCTATAAAGACAGCGGCATATGAAACCAACACAGATGATTTGCTGACCCAAGTGCGGATAGAGAAAGGGGATGGAAGCCTCCATGGAGTGATGAACTGGTTCTCAGTGCACACGACTAGCATGAACATGACTAATAAGCTGGTCTCCTCAGATAACCTGGGCTATGCCGCTCTGAGGATGGAGAAGGAATTGAATCCAAGTAATTTGCCTGGAAAGCCGGATATCGTGGCCGGTTTCTTCTCGTCGAGTCTGGGTGATGTGTCGCCGAACACGCGCGGGGCTCGTTGTGAGTTCAGCAATGAGGAATGCGATCATCAGTTCCTGCTGTGCGCTGCTCAGGAGAGATGTTTCTCGAAAGGACCCGGGGAGGATATGTTCGAGAGTACCAGGATCATTGGCACCAAAGTATTTGAGGGAGCTATGGAGGCACTTCGTTCTCCTGGTGTAGAGCTACAAGGCGACCTGGCGGTTGTTCATCAGTTCGTCGAGATGTCGCAAGAAGTGGTTCCTAAATACGATCCAATCAAGAAGACATTTAACACGAATGAGCCAGTACGCGGCTGTTTTCCCGCCCTGGGCTACAGTTTCGCTTCAGGCACTATTGACGGAGCTAACACATTAAATATTACGCAGGGTACGCTACAAGGGAATCCCCTGCTGGATATCGTGGGTGGAATCGTGGCCAGACCTACTGCTGACGATGTGGAGTGTCACGCACCTAAACCTATACTTTTGGCTACGGGAAGAGCGAACTTCCCTATACCTTGGCATCCTCACATCATCTCTCTGTCGCTGATATGGCTCGGAGACCTCGCTATCGTGGGAGTGCCGGGAGAGCCCACCACCATGTCGGGAAGGAGGATGAAGGCAATGGTGGGAGACGTGATGCAGCGCCGCGGGTTCAAGCCCCGCGTTGTCATCTCCGGACTCACCAATGAATATATTCACTATGTTACAACCTTTGAAGAGTATCAGGTACAAAGATACGAAGCCGCCTCCACTATTTACGGTCCGAACACGCTGGATATAATGCTGAATAAGTTTTCGGAGTTCACTGTAGCGGCTATTGAGAAAGGTGACGTCCCGCCCGGGCGAGAGCCGGCTGACAATCGTGCGCGCACGCTCTCTCTGATCATGCCGGTTATCGCCGACAATCCTCCTGTGAGGAGGAAGTTCGGTGACGTCATTGCACAACCTCCTGCTGTTGTACCAAGGGGGACCACTGTGACCGCTACTTTTGTCGGAGCGAACCCCCGTAACGACTTGAAGCAAGAAGAAAGTCACGCAGTTGTCCAGCGTCTGGAGCTCGGCCGGTGGATCGATGTCGCCAATGACGCTGACTGGGACACAAGATTTTACTGGAAGCGTCTCTCCACAATAGCTGGCACGAGCGAGGTGAGGTTCTCTTGGCGGGTTCCCGAGAGCGCGCAGTCAGCCCCGCACCGCGTGGAGTACCGCGGCGCCGCGCGGAGCCTCTTCGGAAGGATCACGCATTTCACGGCCCAAACCGACAGCTTCTCTATACAATAA

Protein

MKLPPKTNYLSIKTAAYETNTDDLLTQVRIEKGDGSLHGVMNWFSVHTTSMNMTNKLVSSDNLGYAALRMEKELNPSNLPGKPDIVAGFFSSSLGDVSPNTRGARCEFSNEECDHQFLLCAAQERCFSKGPGEDMFESTRIIGTKVFEGAMEALRSPGVELQGDLAVVHQFVEMSQEVVPKYDPIKKTFNTNEPVRGCFPALGYSFASGTIDGANTLNITQGTLQGNPLLDIVGGIVARPTADDVECHAPKPILLATGRANFPIPWHPHIISLSLIWLGDLAIVGVPGEPTTMSGRRMKAMVGDVMQRRGFKPRVVISGLTNEYIHYVTTFEEYQVQRYEAASTIYGPNTLDIMLNKFSEFTVAAIEKGDVPPGREPADNRARTLSLIMPVIADNPPVRRKFGDVIAQPPAVVPRGTTVTATFVGANPRNDLKQEESHAVVQRLELGRWIDVANDADWDTRFYWKRLSTIAGTSEVRFSWRVPESAQSAPHRVEYRGAARSLFGRITHFTAQTDSFSIQ

Description

Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-7.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface (By similarity).

Catalytic Activity

an N-acylsphing-4-enine + H2O = a fatty acid + sphing-4-enine

Similarity

Belongs to the neutral ceramidase family.

Keywords

Complete proteome   Glycoprotein   Hydrolase   Lipid metabolism   Reference proteome   Secreted   Signal   Sphingolipid metabolism  

Feature

chain  Neutral ceramidase

Uniprot

H9JLR4   A0A2W1BEQ2   A0A2A4K9P2   A0A1E1VZH0   A0A3S2LIR5   A0A2H1VBN7   + More
A0A194PJR3   A0A194QND7   A0A212EIG5   A0A212EIH2   A0A194PI22   H9JLR3   A0A194QTJ8   A0A2A4K9C0   A0A2H1VYE1   A0A1E1WP24   A0A0C9RVC1   A0A2W1B8Z5   A0A3L8DSF7   A0A026W3S6   A0A154P9R8   U5EWG2   A0A0A9WE73   A0A0A9W5T8   A0A146ME47   A0A158NBE4   A0A195DRJ6   A0A0P4VKF0   R4N4U2   A0A195FCN6   A0A232F654   A0A0A1WKA2   A0A0A1WH00   A0A1Q3FNZ9   A0A0L0BLG6   A0A1J1J8W7   K7ITX7   A0A1Q3FNN9   A0A1Q3FNM7   A0A1Q3FNI5   B0WGE6   A0A0K8USE8   A0A067RJZ6   A0A182G996   A0A023F618   A0A1S4FFJ2   Q173S2   W8BUB2   A0A034V4F0   T1PE63   A0A182SP30   A0A1A9VVI4   E9IBK4   A0A1A9ZZK7   A0A1L8DPV5   I2CMG2   A0A1B0FRH6   E0VU50   A0A1B0CQR1   A0A1L8EGU5   A0A1Q3FFS2   A0A1Q3FFS1   A0A1A9WN33   A0A1L8EGN3   U5ESX4   A0A2K8JRS6   A0A182W445   A0A1Q3FFN4   A0A1Q3FFP1   A0A1L8DQ15   A0A182QIH4   D6X3Y4   A0A224XFS4   A0A0A1X7Z2   A0A1S3IXJ9   A0A182U547   A0A2R2MQ33   A0A084VN16   A0A1I8PNB8   B0XDM1   A0A182RL44   A0A182PPX0   A0A182Y541   Q7QI06   A0A336ML87   B4JVA2   A0A1B0BUR0   B4K8R6   A0A1A9XTC7   W5JJX8   B3P584   A0A182MZX1   B4PLW9   A0A3B0K2B9   A0A0M4EGS5   A0A0R3NKD0   Q29C43   A0A182JG20  

EC Number

3.5.1.23

Pubmed

19121390    28756777    26354079    22118469    30249741    24508170    + More
25401762    26823975    21347285    27129103    23601004    28648823    25830018    26108605    20075255    24845553    26483478    25474469    17510324    24495485    25348373    25315136    21282665    22517621    20566863    18362917    19820115    24438588    25244985    12364791    14747013    17210077    17994087    18057021    20920257    23761445    17550304    15632085   

EMBL

BABH01005206    BABH01005207    BABH01005208    KZ150341    PZC71310.1    NWSH01000039    + More
PCG80382.1    GDQN01010918    JAT80136.1    RSAL01000003    RVE54728.1    ODYU01001690    SOQ38260.1    KQ459603    KPI92969.1    KQ461194    KPJ06869.1    AGBW02014643    OWR41276.1    OWR41277.1    KPI92967.1    BABH01005209    BABH01005210    KPJ06871.1    PCG80383.1    ODYU01005218    SOQ45860.1    GDQN01002261    JAT88793.1    GBYB01011646    JAG81413.1    PZC71311.1    QOIP01000004    RLU23242.1    KK107453    EZA50648.1    KQ434839    KZC07968.1    GANO01001432    JAB58439.1    GBHO01040464    GBRD01013007    GBRD01013005    JAG03140.1    JAG52819.1    GBHO01040465    GBRD01013004    GBRD01013003    JAG03139.1    JAG52822.1    GDHC01001347    JAQ17282.1    ADTU01011000    ADTU01011001    ADTU01011002    ADTU01011003    ADTU01011004    ADTU01011005    ADTU01011006    ADTU01011007    ADTU01011008    ADTU01011009    KQ980581    KYN15461.1    GDKW01001794    JAI54801.1    JX569799    AGL39308.1    KQ981673    KYN38173.1    NNAY01000885    OXU26062.1    GBXI01015337    JAC98954.1    GBXI01016527    JAC97764.1    GFDL01005839    JAV29206.1    JRES01001702    KNC20803.1    CVRI01000074    CRL07958.1    GFDL01005826    JAV29219.1    GFDL01005878    JAV29167.1    GFDL01005885    JAV29160.1    DS231926    EDS26943.1    GDHF01022808    GDHF01014766    GDHF01001327    JAI29506.1    JAI37548.1    JAI50987.1    KK852425    KDR24151.1    JXUM01049339    KQ561600    KXJ78038.1    GBBI01002065    JAC16647.1    CH477417    EAT41313.1    GAMC01013846    GAMC01013845    JAB92709.1    GAKP01021563    JAC37389.1    KA646243    AFP60872.1    GL762111    EFZ22084.1    GFDF01005592    JAV08492.1    JQ308540    AFJ68095.1    CCAG010022123    DS235780    EEB16906.1    AJWK01023885    AJWK01023886    AJWK01023887    GFDG01000986    JAV17813.1    GFDL01008646    JAV26399.1    GFDL01008649    JAV26396.1    GFDG01000985    JAV17814.1    GANO01002178    JAB57693.1    KY030989    ATU82740.1    GFDL01008699    JAV26346.1    GFDL01008667    JAV26378.1    GFDF01005593    JAV08491.1    AXCN02002023    KQ971379    EEZ97353.1    GFTR01007768    JAW08658.1    GBXI01007045    JAD07247.1    ATLV01014673    KE524978    KFB39360.1    DS232767    EDS45531.1    AAAB01008811    EAA04917.3    UFQT01001467    SSX30700.1    CH916374    EDV91422.1    JXJN01020882    JXJN01020883    CH933806    EDW15485.1    KRG01581.1    ADMH02000912    ETN64687.1    CH954182    EDV53067.1    CM000160    EDW99106.1    KRK04661.1    KRK04662.1    OUUW01000005    SPP80099.1    CP012526    ALC47628.1    CM000070    KRS99567.1   

Proteomes

UP000005204    UP000218220    UP000283053    UP000053268    UP000053240    UP000007151    + More
UP000279307    UP000053097    UP000076502    UP000005205    UP000078492    UP000078541    UP000215335    UP000037069    UP000183832    UP000002358    UP000002320    UP000027135    UP000069940    UP000249989    UP000008820    UP000095301    UP000075901    UP000078200    UP000092445    UP000092444    UP000009046    UP000092461    UP000091820    UP000075920    UP000075886    UP000007266    UP000085678    UP000075902    UP000030765    UP000095300    UP000075900    UP000075885    UP000076408    UP000007062    UP000001070    UP000092460    UP000009192    UP000092443    UP000000673    UP000008711    UP000075884    UP000002282    UP000268350    UP000092553    UP000001819    UP000075880   

PRIDE

H9JLR4    H9JLR3   

Pfam

PF17048   Ceramidse_alk_C        + More
PF04734   Ceramidase_alk

Interpro

IPR031329   NEUT/ALK_ceramidase_N        + More
IPR038445   NCDase_C_sf       
IPR006823   Ceramidase_alk       
IPR031331   NEUT/ALK_ceramidase_C       
IPR000953   Chromo/chromo_shadow_dom       
IPR016197   Chromo-like_dom_sf       

SUPFAM

SSF54160   SSF54160       

Gene 3D

2.60.40.2300    

CDD

cd00024  CHROMO

ProteinModelPortal

H9JLR4   A0A2W1BEQ2   A0A2A4K9P2   A0A1E1VZH0   A0A3S2LIR5   A0A2H1VBN7   + More
A0A194PJR3   A0A194QND7   A0A212EIG5   A0A212EIH2   A0A194PI22   H9JLR3   A0A194QTJ8   A0A2A4K9C0   A0A2H1VYE1   A0A1E1WP24   A0A0C9RVC1   A0A2W1B8Z5   A0A3L8DSF7   A0A026W3S6   A0A154P9R8   U5EWG2   A0A0A9WE73   A0A0A9W5T8   A0A146ME47   A0A158NBE4   A0A195DRJ6   A0A0P4VKF0   R4N4U2   A0A195FCN6   A0A232F654   A0A0A1WKA2   A0A0A1WH00   A0A1Q3FNZ9   A0A0L0BLG6   A0A1J1J8W7   K7ITX7   A0A1Q3FNN9   A0A1Q3FNM7   A0A1Q3FNI5   B0WGE6   A0A0K8USE8   A0A067RJZ6   A0A182G996   A0A023F618   A0A1S4FFJ2   Q173S2   W8BUB2   A0A034V4F0   T1PE63   A0A182SP30   A0A1A9VVI4   E9IBK4   A0A1A9ZZK7   A0A1L8DPV5   I2CMG2   A0A1B0FRH6   E0VU50   A0A1B0CQR1   A0A1L8EGU5   A0A1Q3FFS2   A0A1Q3FFS1   A0A1A9WN33   A0A1L8EGN3   U5ESX4   A0A2K8JRS6   A0A182W445   A0A1Q3FFN4   A0A1Q3FFP1   A0A1L8DQ15   A0A182QIH4   D6X3Y4   A0A224XFS4   A0A0A1X7Z2   A0A1S3IXJ9   A0A182U547   A0A2R2MQ33   A0A084VN16   A0A1I8PNB8   B0XDM1   A0A182RL44   A0A182PPX0   A0A182Y541   Q7QI06   A0A336ML87   B4JVA2   A0A1B0BUR0   B4K8R6   A0A1A9XTC7   W5JJX8   B3P584   A0A182MZX1   B4PLW9   A0A3B0K2B9   A0A0M4EGS5   A0A0R3NKD0   Q29C43   A0A182JG20  

PDB

4WGK     E-value=6.13463e-105,     Score=974

KEGG

101744377    K12349 neutral ceramidase [EC:3.5.1.23] | (RefSeq) neutral ceramidase-like

GO

GO:0016021   GO:0017040   GO:0046514   GO:0046512   GO:0005576   GO:0042759   GO:0035187   GO:0045494   GO:0098793   GO:0031629   GO:0005737   GO:0006665   GO:0102121  

PANTHER

PTHR12670  

Subcellular location

Secreted  

Length:

519

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.24847

Exp number, first 60 AAs:

0.00043

Total prob of N-in:

0.00320

outside

1  -  519

 

 

Pi

20.326227

Theta

171.899451

Tajima's D

1.365486

CLR

11.886314

CSRT

0.754812259387031

Interpretation

Uncertain