Gene

KWMTBOMO07002

Pre Gene Modal

BGIBMGA010474

Annotation

PREDICTED:_dynein_heavy_chain_2?_axonemal_[Amyelois_transitella]

Location

Bomo_Chr12(-):1570401-1575979      View in EpiBrowser

Full name

Dynein heavy chain 2, axonemal      

Alternative Name

Axonemal beta dynein heavy chain 2
Ciliary dynein heavy chain 2

Location in the cell

Cytoplasmic   Reliability : 3.354

CDS

ATGGAAAAAGAACTGGAAAAGCTGGAAGAGGTTTGGGGATTAGTTTTTCAATGGGAGGAGTCGTGGGAAAAATACAAAACTCAAACGTTCTGGGAGATGGAAACCGATGAAATGGAAGAGAACGTTATGTTTTTGTTTCGTAACTTTAATAGATTATCAAGGCAGCTGAAAGATAAAGGATGGGACGTCATTGAGACAACGCGGGTAAAGGTGGACGCATTTAGGCGCACTCTGCCTCTAATTGGTGACTTGAAGAACCCGTGCATGAGAGAGAGGCATTGGGAACGAATCAAAACTTTGATGGCGGTAGAGTTTGATGAGAATTCGGAAGATTTCAAACTAGAGGTCATAATGCGTCTCAACTTCCAAGCATACTCAGATGAAATAGCAGAAATATCGAATGCTGCCACAATGGAATTGAATATAGAAAACGGATTGAAGGCCATCAGAGAAGTGTGGAAGAACACGACTTACGAGATGCAACAGCACAAGGGAGAAATGTATAGAATTAAGAATGTCGAAGACGTTATGCAGTTCTTGGAGGATCATCAAGTGCAACTGTCGTCGATGAAATCAACCAAATACGTTGAGCCGTTCATAAAGGAAGTCGATTACTGGGAAAAGTCTTTGGGCTATGTTGCCGAGTGTATTGAGATTGCATTGCAAGTGCAACGACGTTATTTGTATCTCGAAAGTATTTTTTGCGGTGAAGACATAAGAAAACAATTGCCGAGCGAAGTGCAAATATTCGATGCGCTGACGGATGACTGGACTGAGATAACGAGCAACATGTACGCGGGAACAAATGCTGTGGAGGCTTGTCTGTATAACCCTGCTCCGTACGTGTATAATAAGTTAAACTCGATGGTTGACAATTTGGATGGTATATTAAGAGCACTGGAAAAGTATTTGGAAACAAAACGCCAATTATTCCCGAGATTTTATTTCGTTTCTAATGATGATATGCTTGAGATTTTGGGAAATTCGAAAAAGCCACAGCTTATTCAAACACATTTGAAAAAGCTGTTTGATAACGTTAACAAGATTCGAATCGACAAGTAA

Protein

MEKELEKLEEVWGLVFQWEESWEKYKTQTFWEMETDEMEENVMFLFRNFNRLSRQLKDKGWDVIETTRVKVDAFRRTLPLIGDLKNPCMRERHWERIKTLMAVEFDENSEDFKLEVIMRLNFQAYSDEIAEISNAATMELNIENGLKAIREVWKNTTYEMQQHKGEMYRIKNVEDVMQFLEDHQVQLSSMKSTKYVEPFIKEVDYWEKSLGYVAECIEIALQVQRRYLYLESIFCGEDIRKQLPSEVQIFDALTDDWTEITSNMYAGTNAVEACLYNPAPYVYNKLNSMVDNLDGILRALEKYLETKRQLFPRFYFVSNDDMLEILGNSKKPQLIQTHLKKLFDNVNKIRIDK

Description

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).

Subunit

Consists of at least two heavy chains and a number of intermediate and light chains.

Similarity

Belongs to the dynein heavy chain family.

Keywords

ATP-binding   Cell projection   Cilium   Coiled coil   Complete proteome   Cytoplasm   Cytoskeleton   Dynein   Microtubule   Motor protein   Nucleotide-binding   Reference proteome   Repeat   TPR repeat  

Feature

chain  Dynein heavy chain 2, axonemal

Uniprot

A0A3S2LVM1   A0A194PIV2   A0A194QNC6   A0A2A4K6E7   A0A2W1BCK7   A0A2H1WSD3   + More
A0A0L7LI11   N6UED3   A0A139WBF9   A0A034VKJ5   A0A0A1XRG0   A0A0K8VTB1   B4YLL8   A0A0K8W319   A0A0K8W9W9   B4YLL6   E0VRS1   B4YLM3   Q9GPN8   T1GA20   B4YLM5   A0A0U1RVI8   Q5LJP0   A0A1I8MW68   A0A1B6GI93   B4YLL7   B4YLL5   A0A0L0CHS0   K7J522   A0A1I8PQ03   U4TX33   A0A1A9X8E5   A0A1B0C1D8   A0A088AGE0   B4YLL9   A0A154PKQ9   A0A1A9X8E6   A0A026VYL0   A0A3L8E1T2   A0A1B0G1Q7   A0A1B0A5J4   A0A310SN52   A0A1A9ZES5   E2C2D9   A0A1A9UZ62   B4YLM0   A0A2A3EFU6   A0A183PHB9   A0A1B6E9Y9   A0A1B6CE00   A0A151IDR4   E1ZVJ0   G7Y2Y9   A0A1S8WJ22   W8C8E6   F4WJJ9   A0A151WED7   A0A151J3Q5   A0A1A6GMM7   A0A2T7NDA5   A0A183JC66   A0A0G2JYL5   Q2KML4   G4M0H0   K7FDQ8   A0A074ZWJ9   F6YZ23   A0A2C9JP23   A0A2C9JP30   H0WK84   A0A1S3JQN3   A0A1B8Y1E3   W4Y9K4   Q5F222   P0C6F1   A0A3Q0CN01   A0A1I8H908   W4ZLH2   D3Z667   A0A158NBM9   A0A1I8J9I4   A0A1I8J8T8   A0A1I8GHU8   H9GFT5   A0A1S3EVY5   V4AL85   A0A3Q0KTZ4   A0A1L8H3M0   A0A0D9RFJ2   G3GY64   G1T3V7   G1TV13   A0A095AEL6   I3M0N5   L9KLG2   A0A2K5XKM5   A0A2K6Q5M2   A0A2K6FUH7   A0A2K6KXM7   A0A1W4ZGS2  

Pubmed

26354079    28756777    26227816    23537049    18362917    19820115    + More
25348373    25830018    20566863    11069293    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    25315136    26108605    20075255    24508170    30249741    20798317    22023798    24495485    21719571    15057822    19710508    22253936    17381049    17495919    15562597    20431018    19468303    9373155    16141072    21183079    28071753    26392545    21347285    21881562    23254933    27762356    21804562    21993624    22246508    23385571    25362486   

EMBL

RSAL01000003    RVE54736.1    KQ459603    KPI92978.1    KQ461194    KPJ06859.1    + More
NWSH01000120    PCG79343.1    KZ150161    PZC72708.1    ODYU01010314    SOQ55334.1    JTDY01001105    KOB74866.1    APGK01038535    APGK01038536    APGK01038537    APGK01038538    APGK01038539    KB740960    ENN77012.1    KQ971372    KYB25181.1    GAKP01015943    JAC43009.1    GBXI01000730    JAD13562.1    GDHF01021646    GDHF01010187    JAI30668.1    JAI42127.1    EU595399    ACC62142.1    GDHF01006808    JAI45506.1    GDHF01004437    JAI47877.1    EU595397    ACC62140.2    DS235494    EEB16077.1    EU595402    ACC62147.2    AF313479    AAG29545.1    CAQQ02000411    CAQQ02000412    CAQQ02000413    EU595403    ACC62149.2    EU685283    ACE79738.1    CP007106    EAL24531.5    GECZ01007615    JAS62154.1    EU595398    ACC62141.2    EU595396    ACC62139.1    JRES01000383    KNC31762.1    AAZX01000330    KB631679    ERL85347.1    JXJN01023990    JXJN01023991    EU595400    ACC62143.2    KQ434948    KZC12413.1    KK107574    EZA48745.1    QOIP01000002    RLU26149.1    CCAG010017219    KQ759821    OAD62685.1    GL452124    EFN77889.1    EU595401    ACC62144.2    KZ288271    PBC29861.1    UZAL01033862    VDP64270.1    GEDC01002624    JAS34674.1    GEDC01025778    JAS11520.1    KQ977978    KYM98389.1    GL434547    EFN74800.1    DF142834    GAA47333.1    KV906761    OON14263.1    GAMC01003089    JAC03467.1    GL888184    EGI65615.1    KQ983238    KYQ46233.1    KQ980259    KYN17075.1    LZPO01078627    OBS67543.1    PZQS01000014    PVD19154.1    UZAK01000159    VDO60534.1    AABR07029859    AABR07029860    AABR07072134    AC136563    AY903242    AY903243    AY903244    AAX85372.1    AAX85373.1    AAX85374.1    CABG01000078    CCD60638.1    AGCU01171631    AGCU01171632    AGCU01171633    AGCU01171634    AGCU01171635    AGCU01171636    AGCU01171637    AGCU01171638    AGCU01171639    AGCU01171640    KL596716    KER27710.1    AAQR03080620    AAQR03080621    AAQR03080622    AAQR03080623    AAQR03080624    AAQR03080625    AAQR03080626    AAQR03080627    AAQR03080628    AAQR03080629    KV460567    OCA16756.1    AAGJ04130935    AAGJ04130936    AAGJ04130937    AAGJ04130938    AAGJ04130939    AL731687    AL596125    CAI52011.1    Z83813    AK029791    AAGJ04130940    AAGJ04130941    AAGJ04130942    AAGJ04130943    AAGJ04130944    ADTU01000355    ADTU01000356    ADTU01000357    ADTU01000358    ADTU01000359    AAWZ02031537    AAWZ02031538    AAWZ02031539    KB199651    ESP04959.1    CM004470    OCT90707.1    AQIB01138131    AQIB01138132    AQIB01138133    AQIB01138134    AQIB01138135    AQIB01138136    JH000064    EGV93880.1    AAGW02049557    AAGW02049558    AAGW02049559    AAGW02049560    AAGW02049561    AAGW02049562    KL250497    KGB32251.1    AGTP01070912    AGTP01070913    AGTP01070914    AGTP01070915    KB320771    ELW63591.1   

Proteomes

UP000283053    UP000053268    UP000053240    UP000218220    UP000037510    UP000019118    + More
UP000007266    UP000009046    UP000015102    UP000000803    UP000095301    UP000037069    UP000002358    UP000095300    UP000030742    UP000092443    UP000092460    UP000005203    UP000076502    UP000053097    UP000279307    UP000092444    UP000092445    UP000008237    UP000078200    UP000242457    UP000050791    UP000078542    UP000000311    UP000007755    UP000075809    UP000078492    UP000092124    UP000245119    UP000050789    UP000002494    UP000008854    UP000007267    UP000002280    UP000076420    UP000005225    UP000085678    UP000008143    UP000007110    UP000000589    UP000189706    UP000095280    UP000005205    UP000001646    UP000081671    UP000030746    UP000186698    UP000029965    UP000001075    UP000001811    UP000005215    UP000011518    UP000233140    UP000233200    UP000233160    UP000233180    UP000192224   

PRIDE

Q9GPN8    Q5LJP0    P0C6F1    D3Z667    G3GY64   

Pfam

PF12774   AAA_6        + More
PF08393   DHC_N2
PF12780   AAA_8
PF08385   DHC_N1
PF17857   AAA_lid_1
PF17852   Dynein_AAA_lid
PF12781   AAA_9
PF12777   MT
PF18199   Dynein_C
PF18198   AAA_lid_11
PF03028   Dynein_heavy

Interpro

IPR024317   Dynein_heavy_chain_D4_dom        + More
IPR042228   Dynein_2_C       
IPR035699   AAA_6       
IPR013594   Dynein_heavy_dom-1       
IPR013602   Dynein_heavy_dom-2       
IPR003593   AAA+_ATPase       
IPR041466   Dynein_AAA5_ext       
IPR027417   P-loop_NTPase       
IPR041589   DNAH3_AAA_lid_1       
IPR042222   Dynein_2_N       
IPR035706   AAA_9       
IPR024743   Dynein_HC_stalk       
IPR041658   AAA_lid_11       
IPR041228   Dynein_C       
IPR004273   Dynein_heavy_D6_P-loop       
IPR042219   AAA_lid_11_sf       
IPR026983   DHC_fam       
IPR018247   EF_Hand_1_Ca_BS       

SUPFAM

SSF52540   SSF52540       

Gene 3D

1.20.140.100     3.20.180.20     1.10.8.720    

ProteinModelPortal

A0A3S2LVM1   A0A194PIV2   A0A194QNC6   A0A2A4K6E7   A0A2W1BCK7   A0A2H1WSD3   + More
A0A0L7LI11   N6UED3   A0A139WBF9   A0A034VKJ5   A0A0A1XRG0   A0A0K8VTB1   B4YLL8   A0A0K8W319   A0A0K8W9W9   B4YLL6   E0VRS1   B4YLM3   Q9GPN8   T1GA20   B4YLM5   A0A0U1RVI8   Q5LJP0   A0A1I8MW68   A0A1B6GI93   B4YLL7   B4YLL5   A0A0L0CHS0   K7J522   A0A1I8PQ03   U4TX33   A0A1A9X8E5   A0A1B0C1D8   A0A088AGE0   B4YLL9   A0A154PKQ9   A0A1A9X8E6   A0A026VYL0   A0A3L8E1T2   A0A1B0G1Q7   A0A1B0A5J4   A0A310SN52   A0A1A9ZES5   E2C2D9   A0A1A9UZ62   B4YLM0   A0A2A3EFU6   A0A183PHB9   A0A1B6E9Y9   A0A1B6CE00   A0A151IDR4   E1ZVJ0   G7Y2Y9   A0A1S8WJ22   W8C8E6   F4WJJ9   A0A151WED7   A0A151J3Q5   A0A1A6GMM7   A0A2T7NDA5   A0A183JC66   A0A0G2JYL5   Q2KML4   G4M0H0   K7FDQ8   A0A074ZWJ9   F6YZ23   A0A2C9JP23   A0A2C9JP30   H0WK84   A0A1S3JQN3   A0A1B8Y1E3   W4Y9K4   Q5F222   P0C6F1   A0A3Q0CN01   A0A1I8H908   W4ZLH2   D3Z667   A0A158NBM9   A0A1I8J9I4   A0A1I8J8T8   A0A1I8GHU8   H9GFT5   A0A1S3EVY5   V4AL85   A0A3Q0KTZ4   A0A1L8H3M0   A0A0D9RFJ2   G3GY64   G1T3V7   G1TV13   A0A095AEL6   I3M0N5   L9KLG2   A0A2K5XKM5   A0A2K6Q5M2   A0A2K6FUH7   A0A2K6KXM7   A0A1W4ZGS2  

PDB

5NUG     E-value=5.40822e-33,     Score=352

KEGG

101737362    K10408 dynein heavy chain, axonemal | (RefSeq) dynein heavy chain 2, axonemal-like

GO

GO:0007018   GO:0003777   GO:0031514   GO:0005524   GO:0030286   GO:0016021   GO:0008569   GO:0003341   GO:0036156   GO:0042623   GO:0005930   GO:0051959   GO:0045505   GO:0045503   GO:0005874  

PANTHER

PTHR10676  

Subcellular location

  

Length:

353

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00063

Exp number, first 60 AAs:

0

Total prob of N-in:

0.01020

outside

1  -  353

 

 

Pi

285.521482

Theta

185.019276

Tajima's D

2.08325

CLR

0.026579

CSRT

0.896255187240638

Interpretation

Uncertain