Gene

KWMTBOMO07001  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA010475

Annotation

putative_1-beta_dynein_[Danaus_plexippus]

Location

Bomo_Chr12(-):1563821-1569809      View in EpiBrowser

Full name

Dynein heavy chain 2, axonemal      

Alternative Name

Axonemal beta dynein heavy chain 2
Ciliary dynein heavy chain 2
Dynein heavy chain domain-containing protein 3

Location in the cell

Mitochondrial   Reliability : 1.379 PlasmaMembrane   Reliability : 1.136

CDS

ATGCTGGATAAAGAATTGCTAGATAAATGTTATTTTATCCCAAAAGATGTAATGCTAAAAGTCCTTGCAATGCTCGAATCTTCCACTCCGTGGAAATCGACAAGTGACATATGCAGAAGGAACTTGGCATCAATCCAAGGCTTTCGGAGTTCTCCCAAATTCAGAGATGACAGCCTGGCTCCTCACGGCCTAAAAAGTTTACATCACTTGGCTCTCAACAAGGCTATATATGCTCAAGACTGGGATAAGCTTTTGTATGTTTTGAAGAAAATACCTCCTTGGAAGTTTAAATTCTCTCGCCCCAGTCATGCTGCTGTGTATTATCGGGCAATGACAATATTACTGCTAAACCATCCAACAGCTCAAGCCAACAGTCTCATGAATGAATTCCTACATATGGTCCTTTCTTGTAGGTCTGATGCTGACAAGAAGGCTATTCTCAAAATACTTTTAAGTTTACCTAGTCTTCCAGTCGCTAAAGCCATGATGTCTGAAGACGGAGAATGTATTGAATGGAAATATAATTTGGTATTGGATGGTCCTGCTGAAGTGTGGTTACTTGGCTTGGAGCATACCATGAGAGTAGTTCTGAGAGAGATCCAATGGACGTCAGATTGCACAAGAACTTTGTGCCGATGCGAAATCATGAACGAAAAAAAACCGATGAAGAAATTGCGCAAGAAACAAAATCAAATATTGAGCACCTTACAAATGATGTCGAGGAAGGAGATTTCGAAGATACTGAGGTGTAAAGTCAACGCTTTGTGCGTCATAGAGATACACTCCCGGGATATGGTCGATAAGATGTATAAATTAGGTTGTATGACAGTTTCTGCGTTCGAATGGTTTTCTCAGCTGAAGTTCTACTGGGATAGAGAACGAGAAGACTGCTACATTCGACAGACAAATACGAACTCTATTTACACATACGAATATATCGGGAATTCTGGACGTTTGGTCATTACACCGCTCACTGACAGATGCTATATAACGTTAACAACAGCCCTCCATCTGTTCCGAGGAGGAAGTCCTCAGGGTCCAGCTGGTACAGGAAAGACTGAGACCACTAAGGATCTTGGCAGAGCTCTGGCTCGATGGGTGGTTGTGACCAATTGCTCTGATGGGTTGGACTATAAGTCGATGGCGAAATGCTTTGCAGGTATAGCCCAAAGTGGATGCTGGGGATGCTTTGACGAGTTCAATCGCATCAACATTGAGGTGCTCTCGGTGGTCGCTCAGCAAATCCTGGCCGTACTGTTGGCACTGTCTCTGTACCAGAAGAAGTTCGTCTTCGAAGGTTCCGAGATCAAACTGGACGGCAACTGCGGAATATTCATAACGATGAACCCTGGGTGA

Protein

MLDKELLDKCYFIPKDVMLKVLAMLESSTPWKSTSDICRRNLASIQGFRSSPKFRDDSLAPHGLKSLHHLALNKAIYAQDWDKLLYVLKKIPPWKFKFSRPSHAAVYYRAMTILLLNHPTAQANSLMNEFLHMVLSCRSDADKKAILKILLSLPSLPVAKAMMSEDGECIEWKYNLVLDGPAEVWLLGLEHTMRVVLREIQWTSDCTRTLCRCEIMNEKKPMKKLRKKQNQILSTLQMMSRKEISKILRCKVNALCVIEIHSRDMVDKMYKLGCMTVSAFEWFSQLKFYWDREREDCYIRQTNTNSIYTYEYIGNSGRLVITPLTDRCYITLTTALHLFRGGSPQGPAGTGKTETTKDLGRALARWVVVTNCSDGLDYKSMAKCFAGIAQSGCWGCFDEFNRINIEVLSVVAQQILAVLLALSLYQKKFVFEGSEIKLDGNCGIFITMNPG

Description

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).

Subunit

Consists of at least two heavy chains and a number of intermediate and light chains.

Similarity

Belongs to the dynein heavy chain family.

Keywords

Alternative splicing   ATP-binding   Cell projection   Cilium   Coiled coil   Complete proteome   Cytoplasm   Cytoskeleton   Dynein   Microtubule   Motor protein   Nucleotide-binding   Polymorphism   Reference proteome   Repeat   RNA editing   TPR repeat  

Feature

chain  Dynein heavy chain 2, axonemal
splice variant  In isoform 3.
sequence variant  In dbSNP:rs35664870.

Uniprot

A0A194QMU4   A0A2H1WQT6   A0A0L7LI11   A0A3S2LVM1   A0A2W1BIZ8   A0A0Q9X4M4   + More
W8BW85   A0A139WBF9   E0VRS1   A0A0L0CHS0   U4TX33   A0A0Q9XHD6   B4YLL9   A0A3P7ZAJ4   A0A183LX26   A0A088AGE0   B4YLM3   A0A2R7VQD9   A0A1I8MW68   A0A1I8PQ03   A0A1B6CE00   A0A1B6E9Y9   A0A068W9H0   A0A2P8XNQ1   A0A0P8Y0L8   A0A1B0C1D8   B4YLM5   A0A0R1E7P3   A0A151IDR4   A0A1A9UZ62   A0A1A9X8E6   B4YLL8   A0A151WED7   A0A068Y8G0   B4YLL5   B4YLL7   W6UYB0   A0A026VYL0   A0A3L8E1T2   B4YLL6   A0A0K8VTB1   A0A1A9ZES5   A0A0K8W319   A0A1B0A5J4   A0A0K8W9W9   A0A151J3Q5   A0A0R3W2Z7   A0A0R3X108   B4YLM0   A0A1A9X8E5   Q9GPN8   Q5LJP0   A0A158QUQ4   G4M0H0   A0A3Q0KTZ4   A0A095AEL6   G3WPQ1   A0A195FFT1   A0A183AJZ6   A0A3P8FWE5   A0A068XIV6   A0A1S8WJ22   A0A0R3SSW0   F6YZ23   G7Y2Y9   A0A158NBM9   A0A212D9E6   A0A2T7NDA5   F4P9W6   A0A154PKQ9   A0A177WX63   A0A195BEV7   A0A177WW26   K7J522   A0A3B4EWX7   A0A3P8QFZ5   A0A183S7F1   A0A3P7BFW5   A0A1S8VZE4   A0A232FJ76   A0A0U1RVI8   A0A1I8H908   A0A1I8J8T8   A0A139ARW2   H9GFT5   A0A1I8GHU8   A0A2D0RCT1   A0A2D0RCS2   A0A2D0RCS7   A0A2D0RCT3   Q9P225-2   A0A267GNC8   Q9P225   A0A2R9BNK1   A0A1Y3NC71   R7TTV6  

Pubmed

26354079    26227816    28756777    17994087    24495485    18362917    + More
19820115    20566863    26108605    23537049    25315136    23485966    29403074    17550304    24013640    24508170    30249741    11069293    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    22253936    22246508    21709235    17495919    22023798    21347285    20075255    28648823    26392545    25977457    21881562    10819331    14702039    16625196    15489334    9256245    20835228    22722832    23254933   

EMBL

KQ461194    KPJ06858.1    ODYU01010314    SOQ55336.1    JTDY01001105    KOB74866.1    + More
RSAL01000003    RVE54736.1    KZ150161    PZC72710.1    CH964257    KRF99792.1    GAMC01003088    JAC03468.1    KQ971372    KYB25181.1    DS235494    EEB16077.1    JRES01000383    KNC31762.1    KB631679    ERL85347.1    CH933962    KRG07830.1    EU595400    ACC62143.2    UZAI01003602    VDO81017.1    EU595402    ACC62147.2    KK854027    PTY09733.1    GEDC01025778    JAS11520.1    GEDC01002624    JAS34674.1    LK028576    CDS16263.1    PYGN01001635    PSN33631.1    CH902817    KPU75310.1    JXJN01023990    JXJN01023991    EU595403    ACC62149.2    CH891580    KRK05049.1    KQ977978    KYM98389.1    EU595399    ACC62142.1    KQ983238    KYQ46233.1    LN902841    CDS41066.1    EU595396    ACC62139.1    EU595398    ACC62141.2    APAU02000006    EUB63607.1    KK107574    EZA48745.1    QOIP01000002    RLU26149.1    EU595397    ACC62140.2    GDHF01021646    GDHF01010187    JAI30668.1    JAI42127.1    GDHF01006808    JAI45506.1    GDHF01004437    JAI47877.1    KQ980259    KYN17075.1    UYRS01018337    VDK33118.1    UYWX01020326    VDM31109.1    EU595401    ACC62144.2    AF313479    AAG29545.1    CP007106    EAL24531.5    UXSR01005277    VDD80599.1    CABG01000078    CCD60638.1    KL250497    KGB32251.1    AEFK01165155    AEFK01165156    AEFK01165157    AEFK01165158    AEFK01165159    AEFK01165160    AEFK01165161    AEFK01165162    KQ981606    KYN39560.1    UZAN01044389    VDP80672.1    KV906761    OON14263.1    UYSG01011077    VDL60739.1    DF142834    GAA47333.1    ADTU01000355    ADTU01000356    ADTU01000357    ADTU01000358    ADTU01000359    MKHE01000005    OWK14871.1    PZQS01000014    PVD19154.1    GL882890    EGF78014.1    KQ434948    KZC12413.1    DS022311    OAJ44091.1    KQ976509    KYM82700.1    OAJ44092.1    AAZX01000330    UYSU01000080    VDL84400.1    LYON01000360    OON07681.1    NNAY01000118    OXU30796.1    EU685283    ACE79738.1    KQ965739    KXS19215.1    AAWZ02031537    AAWZ02031538    AAWZ02031539    AB040936    AK128517    AK292607    AC025335    AC087388    BC034225    U83570    NIVC01000227    PAA87525.1    AJFE02031318    AJFE02031319    AJFE02031320    AJFE02031321    AJFE02031322    AJFE02031323    AJFE02031324    AJFE02031325    AJFE02031326    AJFE02031327    KZ150836    OUM65356.1    AMQN01010963    KB308597    ELT97318.1   

Proteomes

UP000053240    UP000037510    UP000283053    UP000007798    UP000007266    UP000009046    + More
UP000037069    UP000030742    UP000009192    UP000277204    UP000050790    UP000005203    UP000095301    UP000095300    UP000245037    UP000007801    UP000092460    UP000002282    UP000078542    UP000078200    UP000092443    UP000075809    UP000017246    UP000019149    UP000053097    UP000279307    UP000092445    UP000078492    UP000046400    UP000282613    UP000046396    UP000274429    UP000000803    UP000046399    UP000267029    UP000008854    UP000007648    UP000078541    UP000050740    UP000046397    UP000274504    UP000002280    UP000005205    UP000245119    UP000007241    UP000076502    UP000077115    UP000078540    UP000002358    UP000261460    UP000265100    UP000050788    UP000275846    UP000189906    UP000215335    UP000095280    UP000070544    UP000001646    UP000221080    UP000005640    UP000215902    UP000240080    UP000195826    UP000014760   

PRIDE

Q9GPN8    Q5LJP0    Q9P225   

Pfam

PF12774   AAA_6        + More
PF12781   AAA_9
PF03028   Dynein_heavy
PF18198   AAA_lid_11
PF12780   AAA_8
PF18199   Dynein_C
PF17852   Dynein_AAA_lid
PF17857   AAA_lid_1
PF12777   MT
PF08393   DHC_N2
PF08385   DHC_N1
PF01740   STAS
PF00916   Sulfate_transp
PF00781   DAGK_cat

Interpro

IPR041466   Dynein_AAA5_ext        + More
IPR003593   AAA+_ATPase       
IPR042219   AAA_lid_11_sf       
IPR004273   Dynein_heavy_D6_P-loop       
IPR035699   AAA_6       
IPR041228   Dynein_C       
IPR041658   AAA_lid_11       
IPR041589   DNAH3_AAA_lid_1       
IPR035706   AAA_9       
IPR024317   Dynein_heavy_chain_D4_dom       
IPR024743   Dynein_HC_stalk       
IPR027417   P-loop_NTPase       
IPR026983   DHC_fam       
IPR042228   Dynein_2_C       
IPR042222   Dynein_2_N       
IPR013602   Dynein_heavy_dom-2       
IPR013594   Dynein_heavy_dom-1       
IPR002645   STAS_dom       
IPR001206   Diacylglycerol_kinase_cat_dom       
IPR036513   STAS_dom_sf       
IPR020846   MFS_dom       
IPR016064   NAD/diacylglycerol_kinase_sf       
IPR017438   ATP-NAD_kinase_N       
IPR011547   SLC26A/SulP_dom       
IPR018247   EF_Hand_1_Ca_BS       
IPR025662   Sigma_54_int_dom_ATP-bd_1       

SUPFAM

SSF52540   SSF52540        + More
SSF111331   SSF111331       
SSF52091   SSF52091       

Gene 3D

1.10.8.720     1.20.140.100     3.20.180.20     3.40.50.10330    

CDD

cd06174  MFS

ProteinModelPortal

A0A194QMU4   A0A2H1WQT6   A0A0L7LI11   A0A3S2LVM1   A0A2W1BIZ8   A0A0Q9X4M4   + More
W8BW85   A0A139WBF9   E0VRS1   A0A0L0CHS0   U4TX33   A0A0Q9XHD6   B4YLL9   A0A3P7ZAJ4   A0A183LX26   A0A088AGE0   B4YLM3   A0A2R7VQD9   A0A1I8MW68   A0A1I8PQ03   A0A1B6CE00   A0A1B6E9Y9   A0A068W9H0   A0A2P8XNQ1   A0A0P8Y0L8   A0A1B0C1D8   B4YLM5   A0A0R1E7P3   A0A151IDR4   A0A1A9UZ62   A0A1A9X8E6   B4YLL8   A0A151WED7   A0A068Y8G0   B4YLL5   B4YLL7   W6UYB0   A0A026VYL0   A0A3L8E1T2   B4YLL6   A0A0K8VTB1   A0A1A9ZES5   A0A0K8W319   A0A1B0A5J4   A0A0K8W9W9   A0A151J3Q5   A0A0R3W2Z7   A0A0R3X108   B4YLM0   A0A1A9X8E5   Q9GPN8   Q5LJP0   A0A158QUQ4   G4M0H0   A0A3Q0KTZ4   A0A095AEL6   G3WPQ1   A0A195FFT1   A0A183AJZ6   A0A3P8FWE5   A0A068XIV6   A0A1S8WJ22   A0A0R3SSW0   F6YZ23   G7Y2Y9   A0A158NBM9   A0A212D9E6   A0A2T7NDA5   F4P9W6   A0A154PKQ9   A0A177WX63   A0A195BEV7   A0A177WW26   K7J522   A0A3B4EWX7   A0A3P8QFZ5   A0A183S7F1   A0A3P7BFW5   A0A1S8VZE4   A0A232FJ76   A0A0U1RVI8   A0A1I8H908   A0A1I8J8T8   A0A139ARW2   H9GFT5   A0A1I8GHU8   A0A2D0RCT1   A0A2D0RCS2   A0A2D0RCS7   A0A2D0RCT3   Q9P225-2   A0A267GNC8   Q9P225   A0A2R9BNK1   A0A1Y3NC71   R7TTV6  

PDB

4RH7     E-value=8.731e-46,     Score=463

KEGG

101737362    K10408 dynein heavy chain, axonemal | (RefSeq) dynein heavy chain 2, axonemal-like

GO

GO:0003777   GO:0005524   GO:0030286   GO:0007018   GO:0016021   GO:0015116   GO:0003951   GO:0008569   GO:0003341   GO:0036156   GO:0042623   GO:0045505   GO:0031514   GO:0045503   GO:0005930   GO:0051959   GO:0060285   GO:0005858   GO:0005874  

PANTHER

PTHR10676  

Subcellular location

  

Length:

451

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.896559999999999

Exp number, first 60 AAs:

0.0002

Total prob of N-in:

0.00989

outside

1  -  451

 

 

Pi

328.140197

Theta

177.104922

Tajima's D

2.532438

CLR

0.00176

CSRT

0.947252637368132

Interpretation

Uncertain