Gene

KWMTBOMO06984

Pre Gene Modal

BGIBMGA010485

Annotation

PREDICTED:_gamma-secretase_subunit_Aph-1-like_[Plutella_xylostella]

Location

Bomo_Chr12(-):1091724-1093141      View in EpiBrowser

Full name

Gamma-secretase subunit Aph-1      

Alternative Name

Presenilin-stabilization factor

Location in the cell

PlasmaMembrane   Reliability : 4.983

CDS

ATGACACTCGCGGAGTTCTTTAGTTGTTCCCTGCTGGCGTTTGGGGCTCCGATCGTGATGTTCGCGATGACTGTGGCCACGGATCCAGTGCGCATCATCATTATGATAGCAGCGGCGTTTGGGTGGTTACTGTCTTTTTTGTTATCCTCGTTAGTATGGTACGCTGTGGTTCCTCTTAGATCATACTTGGTTTTTGGAATGATCTTCGCTATAATATTTCAGGAATTATTCCGGTATGGAATGTATCTCTTACTCAGAAAAACTGAGGCTGGCCTCAAAGAGATATCAGAGAACCATGAGATTGGTAGTAATAAGCTAGAGATGGCTTATGTGTCTGGCCTAGGATTTGGAACAATGAGTGGAGCATTTGCACTAGTTAATGTATTAGCTGACTCGATTGGCCCTGGCACATTAGGCCTGAGTGGTGGGACAGAATACTTTTTTGTGACAAGTTCTGCAATGACTCTTTGTATGATACTACTCAACACATTCTGGAGTATCATATTCTTTAGTGGTTTTGATGAAAAGAACTATCTAAAAATTCTCTGGGTTATCATATCACATTTCTTTGTATCATTTCTAAGTTTATTGAACAGCAGGGAGCTCTATGCAGCTTCAATCTTGCCTTCGTACATTGTTCTTATGATAACTTCATATATTGCGTTTCGCTGTGCCGGAGGATCTAGTAAAACTTTTATACAAAGTTTCTCTGCACGGTCATAG

Protein

MTLAEFFSCSLLAFGAPIVMFAMTVATDPVRIIIMIAAAFGWLLSFLLSSLVWYAVVPLRSYLVFGMIFAIIFQELFRYGMYLLLRKTEAGLKEISENHEIGSNKLEMAYVSGLGFGTMSGAFALVNVLADSIGPGTLGLSGGTEYFFVTSSAMTLCMILLNTFWSIIFFSGFDEKNYLKILWVIISHFFVSFLSLLNSRELYAASILPSYIVLMITSYIAFRCAGGSSKTFIQSFSARS

Description

Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.

Subunit

Component of the gamma-secretase complex, a complex composed of a presenilin (Psn) homodimer, nicastrin (Nct), Aph-1 and Pen-2.

Similarity

Belongs to the APH-1 family.

Keywords

Complete proteome   Membrane   Notch signaling pathway   Reference proteome   Transmembrane   Transmembrane helix  

Feature

chain  Gamma-secretase subunit Aph-1

Uniprot

H9JLT3   A0A2A4K3U6   A0A2W1BVC6   A0A1E1WET7   A0A2H1W1A2   A0A3S2NGV4   + More
A0A0L7LLW0   S4PKF3   A0A212EX56   A0A194QKS3   A0A194QMS9   A0A088ADL0   A0A2P8Y8H3   B4N0H3   A0A026WAL9   A0A0N0U3A7   A0A1Q3FDV0   B4LUU8   A0A3B0KDV9   B0W1C9   A0A2A3EN11   Q29KW5   M9PCE6   Q9VQG2   B3N1A6   B4GSQ0   E2ASE0   B4Q8K1   F4WSX8   A0A195AYW0   A0A158NYE1   B4NWU3   B3NA56   Q17IE9   B4KLD6   A0A195F747   B4I2P9   A0A151J587   A0A1B0GPQ1   A0A151I981   B4JQQ3   A0A0M4E4Z5   E2B844   A0A1B0GKH2   A0A154PAW5   A0A0L7RGR0   A0A023EKQ4   A0A182H3W0   A0A1B0A5X9   D3TRK2   A0A1L8D8P7   A0A0K8TNE8   A0A1A9V6W9   A0A2J7Q8B8   A0A1W4UTZ2   A0A1A9X620   A0A336LV56   A0A067RK20   A0A0K8VT06   U5EZH0   A0A1Y1LK71   A0A084WG43   N6U744   U4U763   A0A1Y1LK49   J3JYH3   A0A2L2YS01   A0A0T6ASH9   A0A087TGE2   A0A182IJF1   A0A182MPQ8   A0A182YSM5   A0A182TA48   A0A182P319   A0A182QFU0   A0A182TK15   A0A182XGC8   A0A182KTU5   Q7PM79   A0A182HRQ7   A0A182WGP7   A0A232F694   A0A182NBZ3   A0A182RHA3   A0A1A9WDM5   A0A0A1WPQ9   A0A1D2MIF5   K7J1S6   A0A1I8P1R7   E9HA24   V4AKW6   A0A0L0CI69   T1JIC3   A0A2M3ZBF1   A0A1W4XMD9   A0A1S3JE99   A0A182F531   A0A2M4APZ4   A0A2M4AQQ5   D6WLF1  

Pubmed

19121390    28756777    26227816    23622113    22118469    26354079    + More
29403074    17994087    24508170    30249741    15632085    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    12537569    12110170    12660785    20798317    22936249    21719571    21347285    17550304    17510324    24945155    26483478    20353571    26369729    24845553    28004739    24438588    23537049    22516182    26561354    25244985    20966253    12364791    14747013    17210077    28648823    25830018    27289101    20075255    21292972    23254933    26108605    18362917    19820115   

EMBL

BABH01005129    NWSH01000192    PCG78574.1    KZ149906    PZC78311.1    GDQN01005550    + More
JAT85504.1    ODYU01005429    SOQ46264.1    RSAL01000043    RVE50740.1    JTDY01000621    KOB76437.1    GAIX01004530    JAA88030.1    AGBW02011856    OWR46014.1    KQ458671    KPJ05515.1    KQ461194    KPJ06843.1    PYGN01000806    PSN40550.1    CH963920    EDW77586.1    KK107295    QOIP01000003    EZA53117.1    RLU24648.1    KQ435944    KOX68228.1    GFDL01009363    JAV25682.1    CH940649    EDW64275.1    OUUW01000006    SPP81848.1    DS231821    EDS44999.1    KZ288206    PBC33080.1    CH379061    EAL33059.1    AE014134    AGB92500.1    AF508786    AY051658    CH902652    EDV33627.1    CH479189    EDW25409.1    GL442298    EFN63606.1    CM000361    CM002910    EDX03518.1    KMY87730.1    GL888331    EGI62682.1    KQ976701    KYM77227.1    ADTU01003768    CM000157    EDW87435.1    CH954177    EDV57519.1    CH477240    EAT46428.1    CH933807    EDW12817.1    KQ981768    KYN36007.1    CH480820    EDW54044.1    KQ980055    KYN17982.1    AJVK01059953    KQ978296    KYM95362.1    CH916372    EDV99233.1    CP012523    ALC39084.1    GL446282    EFN88136.1    AJWK01028865    KQ434864    KZC08981.1    KQ414596    KOC70013.1    GAPW01003842    JAC09756.1    JXUM01108245    JXUM01109897    KQ565364    KQ565213    KXJ71050.1    KXJ71215.1    CCAG010010711    EZ424054    ADD20330.1    GFDF01011245    JAV02839.1    GDAI01001686    JAI15917.1    NEVH01016966    PNF24828.1    UFQT01000215    SSX21815.1    KK852424    KDR24191.1    GDHF01010310    JAI42004.1    GANO01000814    JAB59057.1    GEZM01053511    JAV74033.1    ATLV01023438    KE525343    KFB49187.1    APGK01046742    KB741067    ENN74412.1    KB631751    ERL85795.1    GEZM01053512    JAV74032.1    BT128301    AEE63259.1    IAAA01058472    LAA10938.1    LJIG01022904    KRT78136.1    KK115097    KFM64181.1    AXCM01001182    AXCN02000693    AAAB01008980    EAA14158.3    APCN01001735    NNAY01000817    OXU26351.1    GBXI01013894    JAD00398.1    LJIJ01001183    ODM92624.1    GL732610    EFX71350.1    KB201656    ESO95350.1    JRES01000438    KNC31194.1    JH431789    GGFM01005088    MBW25839.1    GGFK01009530    MBW42851.1    GGFK01009782    MBW43103.1    KQ971343    EFA04103.1   

Proteomes

UP000005204    UP000218220    UP000283053    UP000037510    UP000007151    UP000053268    + More
UP000053240    UP000005203    UP000245037    UP000007798    UP000053097    UP000279307    UP000053105    UP000008792    UP000268350    UP000002320    UP000242457    UP000001819    UP000000803    UP000007801    UP000008744    UP000000311    UP000000304    UP000007755    UP000078540    UP000005205    UP000002282    UP000008711    UP000008820    UP000009192    UP000078541    UP000001292    UP000078492    UP000092462    UP000078542    UP000001070    UP000092553    UP000008237    UP000092461    UP000076502    UP000053825    UP000069940    UP000249989    UP000092445    UP000092444    UP000078200    UP000235965    UP000192221    UP000092443    UP000027135    UP000030765    UP000019118    UP000030742    UP000054359    UP000075880    UP000075883    UP000076408    UP000075901    UP000075885    UP000075886    UP000075902    UP000076407    UP000075882    UP000007062    UP000075840    UP000075920    UP000215335    UP000075884    UP000075900    UP000091820    UP000094527    UP000002358    UP000095300    UP000000305    UP000030746    UP000037069    UP000192223    UP000085678    UP000069272    UP000007266   

PRIDE

H9JLT3    M9PCE6    Q9VQG2   

Pfam

PF06105   Aph-1

Interpro

IPR009294   Aph-1       

ProteinModelPortal

H9JLT3   A0A2A4K3U6   A0A2W1BVC6   A0A1E1WET7   A0A2H1W1A2   A0A3S2NGV4   + More
A0A0L7LLW0   S4PKF3   A0A212EX56   A0A194QKS3   A0A194QMS9   A0A088ADL0   A0A2P8Y8H3   B4N0H3   A0A026WAL9   A0A0N0U3A7   A0A1Q3FDV0   B4LUU8   A0A3B0KDV9   B0W1C9   A0A2A3EN11   Q29KW5   M9PCE6   Q9VQG2   B3N1A6   B4GSQ0   E2ASE0   B4Q8K1   F4WSX8   A0A195AYW0   A0A158NYE1   B4NWU3   B3NA56   Q17IE9   B4KLD6   A0A195F747   B4I2P9   A0A151J587   A0A1B0GPQ1   A0A151I981   B4JQQ3   A0A0M4E4Z5   E2B844   A0A1B0GKH2   A0A154PAW5   A0A0L7RGR0   A0A023EKQ4   A0A182H3W0   A0A1B0A5X9   D3TRK2   A0A1L8D8P7   A0A0K8TNE8   A0A1A9V6W9   A0A2J7Q8B8   A0A1W4UTZ2   A0A1A9X620   A0A336LV56   A0A067RK20   A0A0K8VT06   U5EZH0   A0A1Y1LK71   A0A084WG43   N6U744   U4U763   A0A1Y1LK49   J3JYH3   A0A2L2YS01   A0A0T6ASH9   A0A087TGE2   A0A182IJF1   A0A182MPQ8   A0A182YSM5   A0A182TA48   A0A182P319   A0A182QFU0   A0A182TK15   A0A182XGC8   A0A182KTU5   Q7PM79   A0A182HRQ7   A0A182WGP7   A0A232F694   A0A182NBZ3   A0A182RHA3   A0A1A9WDM5   A0A0A1WPQ9   A0A1D2MIF5   K7J1S6   A0A1I8P1R7   E9HA24   V4AKW6   A0A0L0CI69   T1JIC3   A0A2M3ZBF1   A0A1W4XMD9   A0A1S3JE99   A0A182F531   A0A2M4APZ4   A0A2M4AQQ5   D6WLF1  

PDB

6IYC     E-value=3.6267e-41,     Score=420

KEGG

101742356    K06172 gamma-secretase subunit APH-1A | (RefSeq) gamma-secretase subunit Aph-1

PATHWAY

04330    Notch signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0043085   GO:0016485   GO:0035333   GO:0055037   GO:0004175   GO:0034205   GO:0006509   GO:0005770   GO:0070765   GO:0007219   GO:0005887   GO:0007220   GO:0005783   GO:0005634   GO:0005737   GO:0005515   GO:0004319   GO:0004320   GO:0016295   GO:0016296  

PANTHER

PTHR12889  

Subcellular location

Membrane  

Length:

240

Number of predicted TMHs:

7

Exp number of AAs in TMHs:

147.49734

Exp number, first 60 AAs:

44.89786

Total prob of N-in:

0.76705

POSSIBLE N-term signal

sequence

inside

1  -  4

TMhelix

5  -  27

outside

28  -  31

TMhelix

32  -  54

inside

55  -  60

TMhelix

61  -  83

outside

84  -  107

TMhelix

108  -  130

inside

131  -  146

TMhelix

147  -  169

outside

170  -  178

TMhelix

179  -  196

inside

197  -  202

TMhelix

203  -  222

outside

223  -  240

 

 

Pi

92.121412

Theta

133.101356

Tajima's D

-0.967208

CLR

0.19924

CSRT

0.145342732863357

Interpretation

Uncertain