Gene

KWMTBOMO06977  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA014087

Annotation

peroxiredoxin_[Bombyx_mori]

Location

Bomo_Chr12(+):964002-968672      View in EpiBrowser

Full name

Peroxiredoxin      

Location in the cell

Cytoplasmic   Reliability : 1.304 Extracellular   Reliability : 1.343

CDS

ATGGCACCAATTAAGGTCGGGGATCAGCTGCCTGCTGCTGATTTATTCGAAGATTCTCCCGCTAATAAGGTGAATATTTGTGAGTTGACGGCGGGAAAGAAGGTTGTATTATTTGCGGTGCCGGGCGCCTTCACCCCGGGATGTTCTAAAACACACTTGCCGGGATACGTACAGAACGCAGATAAACTGAAATCGGATGGAGTTGCTGAAATAGTGTGCGTGTCTGTTAATGACCCGTATGTGATGGCGGCTTGGGGAGCTCAGCACAACACTAAAGGAAAGGTGCGTATGCTAGCCGATCCCAGCGGCAACTTCATCAAGGCTCTGGACCTGGGCACCAATCTGCCGCCGCTCGGAGGTTTCCGCTCCAAAAGGTTCTCGATGGTCATCGTTGACAGCAAGGTCCAAGATCTGAATGTGGAGCCCGATGGCACTGGCCTGTCTTGTTCTCTCGCCGATAAGATCAAAGTGAAGTAG

Protein

MAPIKVGDQLPAADLFEDSPANKVNICELTAGKKVVLFAVPGAFTPGCSKTHLPGYVQNADKLKSDGVAEIVCVSVNDPYVMAAWGAQHNTKGKVRMLADPSGNFIKALDLGTNLPPLGGFRSKRFSMVIVDSKVQDLNVEPDGTGLSCSLADKIKVK

Description

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

Catalytic Activity

[protein]-dithiol + a hydroperoxide = [protein]-disulfide + an alcohol + H2O

Similarity

Belongs to the peroxiredoxin family. Prx5 subfamily.

Uniprot

Q1HQ45   H9JX22   A0A194QPV0   S4P1X4   A0A212F1Z5   I4DJY2   + More
A0A194QPD3   I4DN44   A0A2S0RQQ2   A0A3G1T1G6   A0A2A4JQH8   A0A2W1B8Y3   A0A2H1VLR7   A0A068LE92   A0A0L7L6R3   W8CE18   T1DIT5   A0A2M4CSI4   A0A2M4C0G9   A0A2M3Z451   A0A2M3Z481   A0A2M4A3W2   A0A2C9GH06   A0A0A1XIS4   A0A2M3Z505   T1DN66   T1D4Z0   A0A087ZJU1   F4YSY7   Q5UG08   A0A023EHM5   Q173J1   A0A182GU91   A0A023EJ85   A0A0C9Q5Z5   A0A182P9L5   A0A182MPI7   A0A034V1V6   A0A0K8V2N3   A0A182Q7B9   A0A182UES7   A0A182RNL3   A0A182X9M3   A0A3F2YUT3   A0A182HKK7   A0A182IKM5   A0NH65   A0A182YBC5   A0A1Q3G410   A0A182V9T0   W5J4A6   A0A182TN34   B0WM11   A0A1B0D6A3   A0A182S7J3   A0A182NQJ0   A0A182K595   A0A224XLM6   A0A1Y1LXP9   A8CA01   A0A023EIV1   A0A1L8DU06   A0A023F8A5   A0A1I8NES2   T1P7W5   A0A1I8NQW7   A0A161MH80   A0A1L8EEU4   A0A0V0G2U3   F1AG56   A0A0K8TSR3   U5EPT3   A0A0A9YT48   A0A0K8SP46   A0A1A9XWA4   A0A1B0FCN0   A0A0A9YQP0   A0A0K8SQ33   A0A1L7LQG2   Q694A8   A0A067RJ59   K7J041   A0A1A9WJL9   A0A1A9VFL3   A0A154P4C3   B4JUT0   B4LZ87   B4PL69   B4QV16   B3P0D6   Q6XHE3   B4IBA3   A0A1W4UK91   R4G2Z2   A0A1J1I9M5   A0A232EV52   B5DX88   B4GLK9   Q960M4   L0AUL0  

EC Number

1.11.1.15

Pubmed

19121390    26354079    23622113    22118469    22651552    28756777    + More
24998343    26227816    24495485    24330624    25830018    20920257    21569254    24945155    17510324    26483478    25348373    20966253    12364791    14747013    17210077    25244985    28004739    17760985    25474469    25315136    26369729    25401762    26823975    26760975    28076409    16164604    24845553    20075255    17994087    17550304    14525923    28648823    15632085    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356   

EMBL

DQ443207    ABF51296.1    BABH01042182    KQ458671    KPJ05521.1    GAIX01012275    + More
JAA80285.1    AGBW02010785    OWR47749.1    AK401600    BAM18222.1    KQ461194    KPJ06835.1    AK402712    BAM19334.1    MF979109    AWA45972.1    MG992390    AXY94828.1    NWSH01000849    PCG73854.1    KZ150222    PZC72092.1    ODYU01003254    SOQ41763.1    KJ701601    AIE44746.1    JTDY01002583    KOB71158.1    GAMC01000971    JAC05585.1    GALA01000771    JAA94081.1    GGFL01004095    MBW68273.1    GGFJ01009613    MBW58754.1    GGFM01002551    MBW23302.1    GGFM01002580    MBW23331.1    GGFK01002166    MBW35487.1    GBXI01003023    JAD11269.1    GGFM01002860    MBW23611.1    GAMD01003150    JAA98440.1    GALA01000768    JAA94084.1    GGFL01004099    MBW68277.1    HM119220    ADH94060.1    AY738253    AAV48533.1    GAPW01004715    GAPW01004712    GAPW01004711    JAC08883.1    CH477423    EAT41205.1    JXUM01088820    JXUM01088821    JXUM01088822    JXUM01088823    JXUM01088824    KQ563727    KXJ73433.1    GAPW01004714    JAC08884.1    GBYB01009548    JAG79315.1    AXCM01000656    GAKP01023415    JAC35543.1    GDHF01033577    GDHF01022772    GDHF01019246    JAI18737.1    JAI29542.1    JAI33068.1    AXCN02001519    APCN01000836    AAAB01008987    EAU75715.2    GFDL01000500    JAV34545.1    ADMH02002125    ETN58721.1    DS231993    EDS30825.1    AJVK01025851    GFTR01003051    JAW13375.1    GEZM01049832    JAV75817.1    EU035825    ABV44727.1    GAPW01004713    JAC08885.1    GFDF01004155    JAV09929.1    GBBI01001156    JAC17556.1    KA644614    AFP59243.1    GEMB01002520    JAS00666.1    GFDG01001589    JAV17210.1    GECL01003673    JAP02451.1    GU582134    ADX36414.1    GDAI01000435    JAI17168.1    GANO01003585    JAB56286.1    GBHO01008235    JAG35369.1    GBRD01010917    GBRD01010915    GDHC01005880    JAG54909.1    JAQ12749.1    CCAG010010183    GBHO01008237    JAG35367.1    GBRD01010914    GBRD01010912    JAG54910.1    FX983168    BAV93786.1    AY625504    AAT85821.1    KK852442    KDR23852.1    KQ434813    KZC06799.1    CH916374    EDV91250.1    CH940650    EDW67094.1    CM000160    EDW95851.1    CM000364    EDX12499.1    CH954181    EDV48651.1    AY232240    AAR10263.1    CH480827    EDW44661.1    ACPB03003651    GAHY01002156    JAA75354.1    CVRI01000042    CRK95670.1    NNAY01002054    OXU22226.1    CM000070    EDY68620.1    CH479185    EDW38433.1    AE014297    AY051983    BT003526    AAF55497.2    AAK93407.1    AAO39530.1    JX915907    AFZ78682.1   

Proteomes

UP000005204    UP000053268    UP000007151    UP000053240    UP000218220    UP000037510    + More
UP000069272    UP000008820    UP000069940    UP000249989    UP000075885    UP000075883    UP000075886    UP000075902    UP000075900    UP000076407    UP000075882    UP000075840    UP000075880    UP000007062    UP000076408    UP000075903    UP000000673    UP000002320    UP000092462    UP000075901    UP000075884    UP000075881    UP000095301    UP000095300    UP000092443    UP000092444    UP000027135    UP000002358    UP000091820    UP000078200    UP000076502    UP000001070    UP000008792    UP000002282    UP000000304    UP000008711    UP000001292    UP000192221    UP000015103    UP000183832    UP000215335    UP000001819    UP000008744    UP000000803   

PRIDE

Q1HQ45    H9JX22    Q960M4   

Pfam

PF08534   Redoxin        + More
PF02301   HORMA

Interpro

IPR037944   PRX5-like        + More
IPR036249   Thioredoxin-like_sf       
IPR013766   Thioredoxin_domain       
IPR013740   Redoxin       
IPR003511   HORMA_dom       
IPR036570   HORMA_dom_sf       

SUPFAM

SSF52833   SSF52833        + More
SSF56019   SSF56019       

Gene 3D

3.30.900.10    

CDD

cd03013  PRX5_like

ProteinModelPortal

Q1HQ45   H9JX22   A0A194QPV0   S4P1X4   A0A212F1Z5   I4DJY2   + More
A0A194QPD3   I4DN44   A0A2S0RQQ2   A0A3G1T1G6   A0A2A4JQH8   A0A2W1B8Y3   A0A2H1VLR7   A0A068LE92   A0A0L7L6R3   W8CE18   T1DIT5   A0A2M4CSI4   A0A2M4C0G9   A0A2M3Z451   A0A2M3Z481   A0A2M4A3W2   A0A2C9GH06   A0A0A1XIS4   A0A2M3Z505   T1DN66   T1D4Z0   A0A087ZJU1   F4YSY7   Q5UG08   A0A023EHM5   Q173J1   A0A182GU91   A0A023EJ85   A0A0C9Q5Z5   A0A182P9L5   A0A182MPI7   A0A034V1V6   A0A0K8V2N3   A0A182Q7B9   A0A182UES7   A0A182RNL3   A0A182X9M3   A0A3F2YUT3   A0A182HKK7   A0A182IKM5   A0NH65   A0A182YBC5   A0A1Q3G410   A0A182V9T0   W5J4A6   A0A182TN34   B0WM11   A0A1B0D6A3   A0A182S7J3   A0A182NQJ0   A0A182K595   A0A224XLM6   A0A1Y1LXP9   A8CA01   A0A023EIV1   A0A1L8DU06   A0A023F8A5   A0A1I8NES2   T1P7W5   A0A1I8NQW7   A0A161MH80   A0A1L8EEU4   A0A0V0G2U3   F1AG56   A0A0K8TSR3   U5EPT3   A0A0A9YT48   A0A0K8SP46   A0A1A9XWA4   A0A1B0FCN0   A0A0A9YQP0   A0A0K8SQ33   A0A1L7LQG2   Q694A8   A0A067RJ59   K7J041   A0A1A9WJL9   A0A1A9VFL3   A0A154P4C3   B4JUT0   B4LZ87   B4PL69   B4QV16   B3P0D6   Q6XHE3   B4IBA3   A0A1W4UK91   R4G2Z2   A0A1J1I9M5   A0A232EV52   B5DX88   B4GLK9   Q960M4   L0AUL0  

PDB

3MNG     E-value=4.34304e-46,     Score=460

KEGG

732921    K11187 peroxiredoxin 5, atypical 2-Cys peroxiredoxin [EC:1.11.1.15] | (RefSeq) peroxiredoxin

PATHWAY

04146    Peroxisome - Bombyx mori (domestic silkworm)

GO

GO:0045454   GO:0004601   GO:0051920   GO:0005623   GO:0005737   GO:0005739   GO:0034599   GO:0042744   GO:0005777   GO:0008379   GO:0016491   GO:0045824   GO:0005829   GO:0043066   GO:0005634   GO:0006979   GO:0008340   GO:0005840   GO:0006412   GO:0006886   GO:0004317   GO:0004319   GO:0004320   GO:0016295   GO:0016296  

PANTHER

PTHR10430  

Length:

158

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.05454

Exp number, first 60 AAs:

0.02317

Total prob of N-in:

0.10110

outside

1  -  158

 

 

Pi

165.316921

Theta

171.190931

Tajima's D

-0.178883

CLR

0.493201

CSRT

0.325033748312584

Interpretation

Uncertain