Gene

KWMTBOMO06973

Pre Gene Modal

BGIBMGA010494

Annotation

PREDICTED:_WASH_complex_subunit_CCDC53_homolog_[Plutella_xylostella]

Location

Bomo_Chr12(+):936822-938155      View in EpiBrowser

Full name

WASH complex subunit 3      

Alternative Name

Coiled-coil domain-containing protein 53

Location in the cell

Extracellular   Reliability : 1.797 Nuclear   Reliability : 1.352

CDS

ATGACCATCCAAGAAGATTTAACTCAATCCGAATCCCCACAAACGGATTTAACTAAGGTTGCGGCATTACATCAAAAACGTACATTGGCATTTGTAAATCATTTCCTAACAATAAATGTACAATTTCTGAATAACTTTATGACGAATTGCGAGCAGAAACTGATGCAGTTTGAGAGAAAATTAGAAAAAGTTAATGCTGCCATGGTTTTGTTAGAATCTAAGTTATCTTCAATACCAGAATTAGACATTCCTAAGCAGACAAATACAAGTAATGTTACAGAGACTGAATCTACTGAAAGTCAAAATGAAACAGAACTCCAAGAAGAAAATCTAGAAAGAAAACTAGAAGACCAAGCCCCAGCAGAAATGAAAACTAAACCTGAATATGATAAATTTGTTAAAATGGTTCAAGTAGGAGTGCCATTGCAGGCAGTGAAACTCAAAGTCTCGTTAGAAGGTCTCGATCCTGAAATACTGGAGCAATTAATAAAATAA

Protein

MTIQEDLTQSESPQTDLTKVAALHQKRTLAFVNHFLTINVQFLNNFMTNCEQKLMQFERKLEKVNAAMVLLESKLSSIPELDIPKQTNTSNVTETESTESQNETELQEENLERKLEDQAPAEMKTKPEYDKFVKMVQVGVPLQAVKLKVSLEGLDPEILEQLIK

Description

Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting.

Subunit

Component of the WASH core complex also described as WASH regulatory complex (SHRC) composed of WASHC1, WASHC2, WASHC3, WASHC4 and WASHC5 (PubMed:20498093). The WASH core complex associates via WASHC2 with the F-actin-capping protein dimer (formed by CAPZA1, CAPZA2 or CAPZA3 and CAPZB) in a transient or substoichiometric manner which was initially described as WASH complex.

Similarity

Belongs to the CCDC53 family.

Keywords

Acetylation   Coiled coil   Complete proteome   Endosome   Protein transport   Reference proteome   Transport  

Feature

chain  WASH complex subunit 3

Uniprot

H9JLU2   A0A2W1BAF7   A0A2H1WFR9   A0A3S2TNA4   S4PY06   A0A1E1VY18   + More
A0A194QIZ0   A0A194QMT2   A0A0L7L900   A0A2A4JR21   A0A2J7RC32   A0A067R2C2   E2ACK3   A0A1A9V6X1   A0A026W4Y1   A0A1B0FQV8   A0A1W4WXW8   A0A0L7RE15   A0A310SMC1   B4KEB9   A0A1Y1KM04   A0A0M9A1N2   M3WP73   A0A1I8P6U7   A0A2U3ZTS2   A0A3Q7PUA0   A0A2A3EFW5   K7IQL8   A0A3Q7VTG0   A0A232FI47   A0A2Y9IU85   A0A0L0CIK4   A0A1B0A5Y3   A0A1B6CWU9   A0A3P4RW87   L8IDR9   D2A1Y8   A0A2U3ZYM5   A0A2U3WUW3   A0A3Q7PTM8   M1EI65   M3YKE6   A0A0A9ZG80   A0A383YSV1   F6RA14   A0A3Q7TUL0   A0A151JM96   A0A2U3XIR1   A0A2Y9GVA7   G1LIA8   A0A1B0BWB7   A0A2Y9IYA4   W5Q1R9   F1MBF8   A0A340WQI4   A0A2U3V3U3   A0A341ABA3   A0A2Y9QDX2   A0A2Y9F8U3   A0A2Y9IQW5   A0A384DAY3   A0A3Q7WN20   A0A2U3ZYK9   F4WLW1   N6TM26   A0A087ZZ45   A0A3Q2H550   B4JBZ8   R7V6W9   A0A2Y9DFT9   A0A2Y9FZ69   A0A2U3ZYM2   A0A3Q7UNL6   A0A195FWV3   Q05B58   K9IYP8   L5LJ14   A0A1S3WHF0   A0A158NXU9   A0A287AZW1   E2R836   A0A1U7TA57   A0A2Y9IQD2   G3T0S1   E2B5G2   S7Q0C6   A0A170XIZ0   A0A287D488   G1NT78   H0WMJ4   A0A154PB94   A0A1B0D737   A0A1A9WDM0   A0A1U7T3N7   A0A1S3A1U4   A0A1S3FFV1   A0A1I8N7N8   A0A1B6KWC5   A0A1W4ZPF7   A0A2K6ELP7  

Pubmed

19121390    28756777    23622113    26354079    26227816    24845553    + More
20798317    24508170    30249741    17994087    28004739    17975172    20075255    28648823    26108605    22751099    18362917    19820115    23236062    25401762    26823975    19892987    20010809    20809919    19393038    24813606    21719571    23537049    23254933    20498093    21347285    16341006    21993624    25315136   

EMBL

BABH01005120    KZ150222    PZC72088.1    ODYU01008383    SOQ51928.1    RSAL01000043    + More
RVE50751.1    GAIX01004123    JAA88437.1    GDQN01011428    JAT79626.1    KQ458671    KPJ05523.1    KQ461194    KPJ06832.1    JTDY01002245    KOB71814.1    NWSH01000849    PCG73860.1    NEVH01005887    PNF38397.1    KK852758    KDR17048.1    GL438539    EFN68838.1    KK107419    QOIP01000003    EZA51112.1    RLU25208.1    CCAG010010711    KQ414613    KOC69055.1    KQ759870    OAD62395.1    CH933807    EDW12887.1    GEZM01081915    JAV61481.1    KQ435765    KOX75357.1    AANG04003655    KZ288269    PBC29881.1    NNAY01000191    OXU30129.1    JRES01000438    KNC31314.1    GEDC01019635    JAS17663.1    CYRY02043873    VCX38542.1    JH881444    ELR54338.1    KQ971338    EFA02065.2    JP007066    AER95663.1    AEYP01012326    AEYP01012327    GBHO01001096    GBRD01003906    GDHC01017767    JAG42508.1    JAG61915.1    JAQ00862.1    KQ978931    KYN27454.1    ACTA01034526    ACTA01042525    JXJN01021707    AMGL01081931    AMGL01081932    AMGL01081933    AMGL01081934    GL888216    EGI64843.1    APGK01030195    KB740761    ENN79043.1    CH916368    EDW04101.1    AMQN01004898    AMQN01004899    AMQN01004900    KB294622    ELU14314.1    KQ981204    KYN44918.1    BC122780    GABZ01008066    JAA45459.1    KB111329    ELK25970.1    ADTU01003568    AEMK02000037    AAEX03009982    GL445827    EFN89048.1    KE164293    EPQ16723.1    GEMB01004360    JAR98913.1    AGTP01024724    AAPE02006856    AAQR03016605    AAQR03016606    AAQR03016607    AAQR03016608    KQ434864    KZC09122.1    AJVK01026617    GEBQ01024228    JAT15749.1   

Proteomes

UP000005204    UP000283053    UP000053268    UP000053240    UP000037510    UP000218220    + More
UP000235965    UP000027135    UP000000311    UP000078200    UP000053097    UP000279307    UP000092444    UP000192223    UP000053825    UP000009192    UP000053105    UP000011712    UP000095300    UP000245340    UP000286641    UP000242457    UP000002358    UP000286642    UP000215335    UP000248482    UP000037069    UP000092445    UP000007266    UP000245320    UP000000715    UP000261681    UP000002281    UP000286640    UP000078492    UP000245341    UP000248481    UP000008912    UP000092460    UP000002356    UP000009136    UP000265300    UP000252040    UP000248483    UP000248484    UP000261680    UP000291021    UP000007755    UP000019118    UP000005203    UP000001070    UP000014760    UP000248480    UP000078541    UP000079721    UP000005205    UP000008227    UP000002254    UP000189704    UP000007646    UP000008237    UP000005215    UP000001074    UP000005225    UP000076502    UP000092462    UP000091820    UP000081671    UP000095301    UP000192224    UP000233160   

PRIDE

H9JLU2   

Pfam

PF10152   CCDC53

Interpro

IPR019309   WASHC3       

ProteinModelPortal

H9JLU2   A0A2W1BAF7   A0A2H1WFR9   A0A3S2TNA4   S4PY06   A0A1E1VY18   + More
A0A194QIZ0   A0A194QMT2   A0A0L7L900   A0A2A4JR21   A0A2J7RC32   A0A067R2C2   E2ACK3   A0A1A9V6X1   A0A026W4Y1   A0A1B0FQV8   A0A1W4WXW8   A0A0L7RE15   A0A310SMC1   B4KEB9   A0A1Y1KM04   A0A0M9A1N2   M3WP73   A0A1I8P6U7   A0A2U3ZTS2   A0A3Q7PUA0   A0A2A3EFW5   K7IQL8   A0A3Q7VTG0   A0A232FI47   A0A2Y9IU85   A0A0L0CIK4   A0A1B0A5Y3   A0A1B6CWU9   A0A3P4RW87   L8IDR9   D2A1Y8   A0A2U3ZYM5   A0A2U3WUW3   A0A3Q7PTM8   M1EI65   M3YKE6   A0A0A9ZG80   A0A383YSV1   F6RA14   A0A3Q7TUL0   A0A151JM96   A0A2U3XIR1   A0A2Y9GVA7   G1LIA8   A0A1B0BWB7   A0A2Y9IYA4   W5Q1R9   F1MBF8   A0A340WQI4   A0A2U3V3U3   A0A341ABA3   A0A2Y9QDX2   A0A2Y9F8U3   A0A2Y9IQW5   A0A384DAY3   A0A3Q7WN20   A0A2U3ZYK9   F4WLW1   N6TM26   A0A087ZZ45   A0A3Q2H550   B4JBZ8   R7V6W9   A0A2Y9DFT9   A0A2Y9FZ69   A0A2U3ZYM2   A0A3Q7UNL6   A0A195FWV3   Q05B58   K9IYP8   L5LJ14   A0A1S3WHF0   A0A158NXU9   A0A287AZW1   E2R836   A0A1U7TA57   A0A2Y9IQD2   G3T0S1   E2B5G2   S7Q0C6   A0A170XIZ0   A0A287D488   G1NT78   H0WMJ4   A0A154PB94   A0A1B0D737   A0A1A9WDM0   A0A1U7T3N7   A0A1S3A1U4   A0A1S3FFV1   A0A1I8N7N8   A0A1B6KWC5   A0A1W4ZPF7   A0A2K6ELP7  

KEGG

101741584    K18463 WASH complex subunit CCDC53 | (RefSeq) WASH complex subunit CCDC53

PATHWAY

04144    Endocytosis - Bombyx mori (domestic silkworm)

GO

GO:0071203   GO:0016021   GO:0045785   GO:0030041   GO:0006887   GO:0005769   GO:0015031  

PANTHER

PTHR13015  

Subcellular location

Early endosome  

Length:

164

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.646859999999999

Exp number, first 60 AAs:

0.64664

Total prob of N-in:

0.19392

outside

1  -  164

 

 

Pi

197.406344

Theta

201.361819

Tajima's D

-0.086429

CLR

0.799236

CSRT

0.346982650867457

Interpretation

Uncertain