Gene

KWMTBOMO06971  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA010489

Annotation

PREDICTED:_ubiquitin_thioesterase_otubain-like_[Amyelois_transitella]

Location

Bomo_Chr12(-):925321-928281      View in EpiBrowser

Full name

Ubiquitin thioesterase      

Location in the cell

Nuclear   Reliability : 2.74

CDS

ATGGCGGATGATGCATCAAGCAGTAGCGGTATTACCGGTAATACGGTTGAAAATTCAATTAATCAAGATGAATTGATAATGAAACAGCAACGTGAAATAGAAAAAGAGATATCGGAAACAATACCGTTGGTTGGTGAAATTGAAGAATTGCAGACTTTAGAGAAAGAATATAACGAGGATCCGATTTATTTGCTCAAAGTGAAAGATTTGTCTTCGAAATACAAAAGCATTAGACGAACGCGTCCCGATGGCAATTGTTTCTTTCGCGCGTTCTCATACGCATATTTGGAACGCTTACTGACTGATAAGCAGGAATATGATAAGTTTTACGAAATAGCAAAAAATTCTAAAGATATTCTCGTCGCCTTAGGGTTTTCGCAGTTCACCGTTGAAGATTTTTACGAAACTTTTATGGAAGTAATCCAAAGAGTAGGGGAACATGCTGGTTCTACTCCGGATTTGATAGAAACAGTTCGTATGGAGCTTCATGATAAGTTCAACAAGCAGGGATATTCTGATTACATAGTGGTGTACCTTCGTCTTATTACATCTGGCCAGCTGCAGACAGACCAAGAATTTTATCAGAATTTTATTGAAGGACCACGCACTGTTACTGAGTTTTGTAGACAGGAAGTGGAACCGATGTACAAAGAGTCTGACCATATCCATATCATAGCATTGAGTAATGCACTCAAGGTGTGCGTCCGAGTGAAGTACATGGATCGGGGTGAAGGTAGCCAGGTGATAGCACATGATTTTCCAGAGGGTTCTACTCCGCTTGTCCATCTACTTTACCGGCCTGGCCACTATGATATATTGTATGCGTGA

Protein

MADDASSSSGITGNTVENSINQDELIMKQQREIEKEISETIPLVGEIEELQTLEKEYNEDPIYLLKVKDLSSKYKSIRRTRPDGNCFFRAFSYAYLERLLTDKQEYDKFYEIAKNSKDILVALGFSQFTVEDFYETFMEVIQRVGEHAGSTPDLIETVRMELHDKFNKQGYSDYIVVYLRLITSGQLQTDQEFYQNFIEGPRTVTEFCRQEVEPMYKESDHIHIIALSNALKVCVRVKYMDRGEGSQVIAHDFPEGSTPLVHLLYRPGHYDILYA

Catalytic Activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Similarity

Belongs to the peptidase C65 family.

Uniprot

A0A2A4JP82   A0A2W1BH02   A0A212F1Y1   A0A2A4JQ76   H9JLT7   A0A3S2M4J4   + More
A0A194QPC8   S4NR76   A0A194QKU3   I4DKD4   A0A0L7LQU2   A0A0C9PJP5   E2BIQ7   A0A2P8YV12   A0A026VX29   A0A067R7P7   A0A195ERK9   E2AFG1   A0A195DI07   A0A195BSP7   A0A158NQI7   A0A151XAX2   A0A0J7KIW3   F4WKC1   A0A2A3E467   A0A088A8Z5   A0A0M8ZVF8   A0A154PNB9   E0VRS2   A0A2J7QYB4   A0A2J7QYC5   K7J206   N6UKN8   A0A0L7QYF6   J3JYU6   A0A232EGA3   D2A0J1   A0A084VPG7   U5EWC6   A0A1B6KAZ5   A0A182ILS5   A0A1B6DY32   A0A1B6K4V1   A0A1W4WU53   A0A1B6G3J0   A0A2S2P804   A0A2H8TDF9   A0A1L8DT46   J9KB03   A0A1L8DT44   A0A182QKQ9   A0A182Y5U9   A0A0K8TLP4   A0A0L0CHQ9   A0A1I8MJ56   A0A182VUY5   A0A1B0GKB7   A0A182PD86   A0A182RGE6   B0W5S7   A0A182NEF7   A0A182K0P0   A0A182X7L9   Q7PSC3   A0A182IE48   A0A2S2R6E8   A0A1Q3F881   A0A1A9V2B6   Q171B5   A0A0T6AYU1   A0A023ENH1   A0A1B0A4T8   D3TRD1   B4KJ22   A0A0M4E563   B4LIG0   A0A224XHN8   A0A1A9W5B6   T1DGM1   A0A182FWX6   A0A0A9XPZ2   A0A2M4AMW1   A0A023FAM4   A0A1I8P2P8   B4LR05   A0A1W4UG15   A0A0Q9WJ48   B4JPP9   B4NQQ1   B4L0G4   W5J7Q4   R4G5F9   L7M4G7   W8BFI7   A0A224Z335   A0A3B0K977   B7QJ34   A0A131YLX5   B4HCF4   Q29CR8  

EC Number

3.4.19.12

Pubmed

28756777    22118469    19121390    26354079    23622113    22651552    + More
26227816    20798317    29403074    24508170    30249741    24845553    21347285    21719571    20566863    20075255    23537049    22516182    28648823    18362917    19820115    24438588    25244985    26369729    26108605    25315136    12364791    14747013    17210077    17510324    24945155    26483478    20353571    17994087    25401762    26823975    25474469    20920257    23761445    25576852    24495485    28797301    26830274    15632085   

EMBL

NWSH01000849    PCG73857.1    KZ150222    PZC72086.1    AGBW02010785    OWR47755.1    + More
PCG73858.1    BABH01005117    RSAL01000043    RVE50753.1    KQ461194    KPJ06830.1    GAIX01014552    JAA78008.1    KQ458671    KPJ05525.1    AK401752    BAM18374.1    JTDY01000356    KOB77566.1    GBYB01001178    JAG70945.1    GL448525    EFN84422.1    PYGN01000344    PSN48067.1    KK107648    QOIP01000008    EZA48348.1    RLU19785.1    KK852886    KDR14368.1    KQ982021    KYN30537.1    GL439108    EFN67854.1    KQ980824    KYN12472.1    KQ976419    KYM89320.1    ADTU01023338    KQ982335    KYQ57497.1    LBMM01006986    KMQ90141.1    GL888199    EGI65345.1    KZ288379    PBC26553.1    KQ435827    KOX71940.1    KQ434996    KZC13227.1    DS235494    EEB16078.1    NEVH01009108    PNF33575.1    PNF33574.1    APGK01014411    KB739299    KB632337    ENN82315.1    ERL92850.1    KQ414693    KOC63581.1    BT128427    AEE63384.1    NNAY01004803    OXU17389.1    KQ971338    EFA02513.1    ATLV01015004    KE524999    KFB39861.1    GANO01001480    JAB58391.1    GEBQ01031356    JAT08621.1    GEDC01019338    GEDC01015882    GEDC01006727    GEDC01006098    JAS17960.1    JAS21416.1    JAS30571.1    JAS31200.1    GECU01004907    GECU01001226    JAT02800.1    JAT06481.1    GECZ01012896    JAS56873.1    GGMR01012883    MBY25502.1    GFXV01000319    MBW12124.1    GFDF01004451    JAV09633.1    ABLF02023335    GFDF01004452    JAV09632.1    AXCN02000859    GDAI01002344    JAI15259.1    JRES01000384    KNC31752.1    AJWK01028650    DS231844    EDS35730.1    AAAB01008839    EAA05859.5    APCN01004564    GGMS01016335    MBY85538.1    GFDL01011332    JAV23713.1    CH477460    EAT40574.1    LJIG01022503    KRT80226.1    JXUM01058233    GAPW01003122    KQ561993    JAC10476.1    KXJ76963.1    CCAG010000708    EZ423983    ADD20259.1    CH933807    EDW13535.1    CP012523    ALC39184.1    CH940647    EDW70747.1    GFTR01004419    JAW12007.1    GAMD01002726    JAA98864.1    GBHO01020792    GBRD01018049    GDHC01009554    JAG22812.1    JAG47778.1    JAQ09075.1    GGFK01008766    MBW42087.1    GBBI01000754    JAC17958.1    CH940649    EDW64544.1    KRF81697.1    CH916372    EDV98879.1    CH964295    EDW86690.1    CH933809    EDW19133.1    ADMH02002089    ETN59398.1    ACPB03020164    GAHY01000605    JAA76905.1    GACK01007045    JAA57989.1    GAMC01009093    JAB97462.1    GFPF01013120    MAA24266.1    OUUW01000006    SPP81581.1    ABJB010228526    ABJB011056175    ABJB011099124    DS949314    EEC18856.1    GEDV01009005    JAP79552.1    CH479321    EDW26663.1    CH475420    EAL29366.1   

Proteomes

UP000218220    UP000007151    UP000005204    UP000283053    UP000053240    UP000053268    + More
UP000037510    UP000008237    UP000245037    UP000053097    UP000279307    UP000027135    UP000078541    UP000000311    UP000078492    UP000078540    UP000005205    UP000075809    UP000036403    UP000007755    UP000242457    UP000005203    UP000053105    UP000076502    UP000009046    UP000235965    UP000002358    UP000019118    UP000030742    UP000053825    UP000215335    UP000007266    UP000030765    UP000075880    UP000192223    UP000007819    UP000075886    UP000076408    UP000037069    UP000095301    UP000075920    UP000092461    UP000075885    UP000075900    UP000002320    UP000075884    UP000075881    UP000076407    UP000007062    UP000075840    UP000078200    UP000008820    UP000069940    UP000249989    UP000092445    UP000092444    UP000009192    UP000092553    UP000008792    UP000091820    UP000069272    UP000095300    UP000192221    UP000001070    UP000007798    UP000000673    UP000015103    UP000268350    UP000001555    UP000008744    UP000001819   

PRIDE

H9JLT7    B7QJ34   

Pfam

PF10275   Peptidase_C65

Interpro

IPR030298   OTUB1        + More
IPR016615   Otubain       
IPR038765   Papain-like_cys_pep_sf       
IPR003323   OTU_dom       
IPR019400   Peptidase_C65_otubain       

SUPFAM

SSF54001   SSF54001       

ProteinModelPortal

A0A2A4JP82   A0A2W1BH02   A0A212F1Y1   A0A2A4JQ76   H9JLT7   A0A3S2M4J4   + More
A0A194QPC8   S4NR76   A0A194QKU3   I4DKD4   A0A0L7LQU2   A0A0C9PJP5   E2BIQ7   A0A2P8YV12   A0A026VX29   A0A067R7P7   A0A195ERK9   E2AFG1   A0A195DI07   A0A195BSP7   A0A158NQI7   A0A151XAX2   A0A0J7KIW3   F4WKC1   A0A2A3E467   A0A088A8Z5   A0A0M8ZVF8   A0A154PNB9   E0VRS2   A0A2J7QYB4   A0A2J7QYC5   K7J206   N6UKN8   A0A0L7QYF6   J3JYU6   A0A232EGA3   D2A0J1   A0A084VPG7   U5EWC6   A0A1B6KAZ5   A0A182ILS5   A0A1B6DY32   A0A1B6K4V1   A0A1W4WU53   A0A1B6G3J0   A0A2S2P804   A0A2H8TDF9   A0A1L8DT46   J9KB03   A0A1L8DT44   A0A182QKQ9   A0A182Y5U9   A0A0K8TLP4   A0A0L0CHQ9   A0A1I8MJ56   A0A182VUY5   A0A1B0GKB7   A0A182PD86   A0A182RGE6   B0W5S7   A0A182NEF7   A0A182K0P0   A0A182X7L9   Q7PSC3   A0A182IE48   A0A2S2R6E8   A0A1Q3F881   A0A1A9V2B6   Q171B5   A0A0T6AYU1   A0A023ENH1   A0A1B0A4T8   D3TRD1   B4KJ22   A0A0M4E563   B4LIG0   A0A224XHN8   A0A1A9W5B6   T1DGM1   A0A182FWX6   A0A0A9XPZ2   A0A2M4AMW1   A0A023FAM4   A0A1I8P2P8   B4LR05   A0A1W4UG15   A0A0Q9WJ48   B4JPP9   B4NQQ1   B4L0G4   W5J7Q4   R4G5F9   L7M4G7   W8BFI7   A0A224Z335   A0A3B0K977   B7QJ34   A0A131YLX5   B4HCF4   Q29CR8  

PDB

4DDI     E-value=1.12253e-73,     Score=701

KEGG

101741309    K09602 ubiquitin thioesterase protein OTUB1 [EC:3.4.19.12] | (RefSeq) ubiquitin thioesterase otubain

GO

GO:0005634   GO:0043130   GO:0004843   GO:0019784   GO:0071108   GO:0016579   GO:0016787   GO:0043565   GO:0003677   GO:0006886   GO:0004317   GO:0004319   GO:0004320   GO:0016295   GO:0016296  

PANTHER

PTHR12931   PTHR12931:SF19  

Length:

275

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00292000000000001

Exp number, first 60 AAs:

0

Total prob of N-in:

0.02591

outside

1  -  275

 

 

Pi

211.112406

Theta

195.008909

Tajima's D

0.097465

CLR

0.122458

CSRT

0.390730463476826

Interpretation

Uncertain