Gene

KWMTBOMO06929  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA004657

Annotation

proteasome_subunit_alpha_type_6-A_[Bombyx_mori]

Location

Bomo_Chr11(-):20279325-20282517      View in EpiBrowser

Full name

Proteasome subunit alpha type       + More
Proteasome endopeptidase complex      

Location in the cell

Mitochondrial   Reliability : 1.284

CDS

ATGGCTCGAGAAAGCAGTGCCGGATTCGACAGACATATTACTATCTTTTCACCTGAGGGAAGACTGTATCAAGTTGAATATGCATTGAAAGCTATAAACCAGGGTGGGTTGACATCTGTGGCATTACGCGGTACAGATGCAGCTGTAGTGGCAGCTCAACGCAAGGTCCCAGACAGACTACTTGATCCTGTCTCTGTTACTCATCTATTTGCTCTTACTGATAGAATTGGATGTGTCATGACCGGGATGATTGCTGATAGCCGGTCTCAAGTACAACGAGCTCGCTACGAGGCTGCCAACTGGCAGTACAAGTATGGGTCTGAGATACCTGTGCATATCTTATGCAGACGCATAGCTGATATCTCTCAAGTTTACACCCAAAATGCAGAGATGAGACCTCTGGGTTGCAGTATGATGCTGATAGCGTACGACGATGAAGCCGGGCCCTGTGTGTACAAAACAGACCCCTCCGGCTACTACTGCTCCTATAAAGCTGTAGCTGCTGGTGCTAAGACAGTTGATGGAAACGCTTATCTCGAAAAGAAACTAAAAAAACGCTCGGACCTCAGCACCGATGATGCGATTCAGCTTGCCATCTCTTGTCTGTCTCAAGTGTTGTCTGTCGACTTCAAGTCCTCTGAGATTGAGATTGGTGTTGTCAGCAAAGATAATCCTAAGTTTCGGGTGTTGACTGAAACTGAAATCGACAGACATCTCACGGCAATCGCTGAAAAGGATTAA

Protein

MARESSAGFDRHITIFSPEGRLYQVEYALKAINQGGLTSVALRGTDAAVVAAQRKVPDRLLDPVSVTHLFALTDRIGCVMTGMIADSRSQVQRARYEAANWQYKYGSEIPVHILCRRIADISQVYTQNAEMRPLGCSMMLIAYDDEAGPCVYKTDPSGYYCSYKAVAAGAKTVDGNAYLEKKLKKRSDLSTDDAIQLAISCLSQVLSVDFKSSEIEIGVVSKDNPKFRVLTETEIDRHLTAIAEKD

Description

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.

Catalytic Activity

Cleavage of peptide bonds with very broad specificity.

Subunit

The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

Similarity

Belongs to the peptidase T1A family.

Uniprot

Q1HPR1   H9J567   A0A2W1BTA5   A0A2A4JY31   A0A2H1W7W9   A0A1E1WKL4   + More
A0A212FLT9   A0A3S2PH76   S4PTB5   A0A194QV38   I4DMJ9   I4DKX7   A0A2J7QYC4   A0A151I7N5   E2C5K7   A0A151JNM4   F4WKP2   A0A158NJ80   A0A195BJP3   A0A151WEA7   A0A1B6J933   A0A1B6H343   E2AJ67   K7ISL4   A0A026WXD0   A0A0J7N1R1   A0A1B6ECE7   A0A151JV70   R4UVY8   E9J1R8   A0A2A3E585   A0A1Q3FFG7   B0W3G3   A0A067R5N5   Q16UH5   E0VLY3   A0A182G942   A0A023EL07   R4G8P0   E2J7E5   A2IAA3   A0A1B0CBQ7   A0A224XVB3   U5EX64   A0A069DQ64   A0A0V0G3S8   A0A182PK35   A0A1L8DSK5   A0A0L7RBS3   A0A084W942   A0A023FCW9   T1E8H5   A0A2M3Z7L5   A0A2M4AF32   A0A2M4BYA8   A0A182FNY3   A0A0P4VNA4   A0A182J2G1   A0A182VAX2   W5J336   A0A182U7E3   A0A182XH14   A0A182KMV9   Q7Q2B0   A0A182I8D9   A0A182N6S9   A0A182XXL2   A0A0K8TNR5   A0A182M649   A0A182KFJ6   C3XZ66   A0A0P5YRK1   A0A1S3K3R9   A0A164PR99   A0A1D2NKE6   A0A232F000   A0A182Q3Z1   A0A182RY65   A0A1J1ISY9   A0A182VQG5   A0A0N8ECU1   A0A0P5AIU9   A0A0P4YNB4   A0A0P5MC31   A0A0P5BCN4   A0A0P4ZF56   E9HAP5   A0A0P5IEI8   A0A0P5ASX6   A0A0N8AJF2   A0A0P4ZB74   A0A2R7X246   A0A0P4YTZ2   A0A0N8BH29   V9L6Y5   A0A0P5WZX1   T1JGS3   R7UBE7   A0A131Z275   K4GK00  

EC Number

3.4.25.1

Pubmed

19121390    28756777    22118469    23622113    26354079    22651552    + More
20798317    21719571    21347285    20075255    24508170    30249741    21282665    24845553    17510324    20566863    26483478    24945155    17437641    26334808    24438588    25474469    27129103    20920257    23761445    20966253    12364791    14747013    17210077    25244985    26369729    18563158    27289101    28648823    21292972    24402279    23254933    26830274    23056606   

EMBL

DQ443341    ABF51430.1    BABH01039392    KZ149906    PZC78302.1    NWSH01000369    + More
PCG76925.1    PCG76932.1    ODYU01006893    SOQ49147.1    GDQN01003648    JAT87406.1    AGBW02007696    OWR54697.1    RSAL01000034    RVE51372.1    GAIX01012328    JAA80232.1    KQ461185    KPJ07421.1    AK402517    BAM19139.1    AK401945    KQ459252    BAM18567.1    KPJ02194.1    NEVH01009101    PNF33583.1    KQ978411    KYM94100.1    GL452770    EFN76820.1    KQ978858    KYN27927.1    GL888206    EGI65134.1    ADTU01017554    KQ976453    KYM85393.1    KQ983247    KYQ46160.1    GECU01011980    JAS95726.1    GECZ01000676    JAS69093.1    GL439967    EFN66507.1    KK107078    QOIP01000011    EZA60401.1    RLU16699.1    LBMM01011888    KMQ86570.1    GEDC01001697    JAS35601.1    KQ981703    KYN37439.1    KC571887    AGM32386.1    GL767674    EFZ13292.1    KZ288363    PBC26923.1    GFDL01008793    JAV26252.1    DS231831    EDS31306.1    KK852869    KDR14657.1    CH477622    EAT38162.1    DS235283    EEB14389.1    JXUM01049009    KQ561586    KXJ78094.1    GAPW01003710    JAC09888.1    ACPB03006555    GAHY01000637    JAA76873.1    HP429363    ADN29863.1    EF179417    ABM55423.1    AJWK01005764    GFTR01004066    JAW12360.1    GANO01001090    JAB58781.1    GBGD01002681    JAC86208.1    GECL01003422    JAP02702.1    GFDF01004631    JAV09453.1    KQ414617    KOC68382.1    ATLV01021599    KE525320    KFB46736.1    GBBI01000019    JAC18693.1    GAMD01002763    JAA98827.1    GGFM01003753    MBW24504.1    GGFK01006078    MBW39399.1    GGFJ01008770    MBW57911.1    GDKW01002194    JAI54401.1    ADMH02002149    ETN58251.1    AAAB01008978    EAA13600.2    APCN01002733    GDAI01001571    JAI16032.1    AXCM01006160    GG666475    EEN66630.1    GDIP01054323    GDIQ01030167    JAM49392.1    JAN64570.1    LRGB01002571    KZS07071.1    LJIJ01000018    ODN05707.1    NNAY01001464    OXU23883.1    AXCN02000110    CVRI01000059    CRL03349.1    GDIQ01039340    JAN55397.1    GDIP01203496    JAJ19906.1    GDIP01224840    JAI98561.1    GDIQ01157834    JAK93891.1    GDIP01190602    JAJ32800.1    GDIP01217646    JAJ05756.1    GL732612    EFX71218.1    GDIQ01214522    JAK37203.1    GDIP01199300    JAJ24102.1    GDIQ01269843    JAJ81881.1    GDIP01215303    JAJ08099.1    KK856463    PTY25826.1    GDIP01227295    JAI96106.1    GDIQ01178427    JAK73298.1    JW874556    AFP07073.1    GDIP01079412    JAM24303.1    JH432211    AMQN01001763    KB305378    ELU01128.1    GEDV01003722    JAP84835.1    JX209988    AFM88302.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000283053    UP000053240    UP000053268    + More
UP000235965    UP000078542    UP000008237    UP000078492    UP000007755    UP000005205    UP000078540    UP000075809    UP000000311    UP000002358    UP000053097    UP000279307    UP000036403    UP000078541    UP000242457    UP000002320    UP000027135    UP000008820    UP000009046    UP000069940    UP000249989    UP000015103    UP000092461    UP000075885    UP000053825    UP000030765    UP000069272    UP000075880    UP000075903    UP000000673    UP000075902    UP000076407    UP000075882    UP000007062    UP000075840    UP000075884    UP000076408    UP000075883    UP000075881    UP000001554    UP000085678    UP000076858    UP000094527    UP000215335    UP000075886    UP000075900    UP000183832    UP000075920    UP000000305    UP000014760   

PRIDE

Q1HPR1    H9J567   

Pfam

PF00227   Proteasome        + More
PF10584   Proteasome_A_N

Interpro

IPR001353   Proteasome_sua/b        + More
IPR029055   Ntn_hydrolases_N       
IPR034642   Proteasome_subunit_alpha6       
IPR000426   Proteasome_asu_N       
IPR023332   Proteasome_alpha-type       

SUPFAM

SSF56235   SSF56235       

Gene 3D

3.60.20.10    

CDD

cd03754  proteasome_alpha_type_6

ProteinModelPortal

Q1HPR1   H9J567   A0A2W1BTA5   A0A2A4JY31   A0A2H1W7W9   A0A1E1WKL4   + More
A0A212FLT9   A0A3S2PH76   S4PTB5   A0A194QV38   I4DMJ9   I4DKX7   A0A2J7QYC4   A0A151I7N5   E2C5K7   A0A151JNM4   F4WKP2   A0A158NJ80   A0A195BJP3   A0A151WEA7   A0A1B6J933   A0A1B6H343   E2AJ67   K7ISL4   A0A026WXD0   A0A0J7N1R1   A0A1B6ECE7   A0A151JV70   R4UVY8   E9J1R8   A0A2A3E585   A0A1Q3FFG7   B0W3G3   A0A067R5N5   Q16UH5   E0VLY3   A0A182G942   A0A023EL07   R4G8P0   E2J7E5   A2IAA3   A0A1B0CBQ7   A0A224XVB3   U5EX64   A0A069DQ64   A0A0V0G3S8   A0A182PK35   A0A1L8DSK5   A0A0L7RBS3   A0A084W942   A0A023FCW9   T1E8H5   A0A2M3Z7L5   A0A2M4AF32   A0A2M4BYA8   A0A182FNY3   A0A0P4VNA4   A0A182J2G1   A0A182VAX2   W5J336   A0A182U7E3   A0A182XH14   A0A182KMV9   Q7Q2B0   A0A182I8D9   A0A182N6S9   A0A182XXL2   A0A0K8TNR5   A0A182M649   A0A182KFJ6   C3XZ66   A0A0P5YRK1   A0A1S3K3R9   A0A164PR99   A0A1D2NKE6   A0A232F000   A0A182Q3Z1   A0A182RY65   A0A1J1ISY9   A0A182VQG5   A0A0N8ECU1   A0A0P5AIU9   A0A0P4YNB4   A0A0P5MC31   A0A0P5BCN4   A0A0P4ZF56   E9HAP5   A0A0P5IEI8   A0A0P5ASX6   A0A0N8AJF2   A0A0P4ZB74   A0A2R7X246   A0A0P4YTZ2   A0A0N8BH29   V9L6Y5   A0A0P5WZX1   T1JGS3   R7UBE7   A0A131Z275   K4GK00  

PDB

6EPF     E-value=3.4886e-104,     Score=964

KEGG

732998    K02730 20S proteasome subunit alpha 1 [EC:3.4.25.1] | (RefSeq) proteasome subunit alpha type 6-A

PATHWAY

03050    Proteasome - Bombyx mori (domestic silkworm)

GO

GO:0005737   GO:0005634   GO:0004298   GO:0006511   GO:0019773   GO:0043161   GO:0005839   GO:0010499   GO:0004175   GO:0010498   GO:0051603   GO:0006418   GO:0016020   GO:0006260  

Subcellular location

Cytoplasm  
Nucleus  

Length:

246

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01992

Exp number, first 60 AAs:

0.00148

Total prob of N-in:

0.03609

outside

1  -  246

 

 

Pi

16.2283

Theta

19.112465

Tajima's D

-0.774893

CLR

1.174943

CSRT

0.186690665466727

Interpretation

Uncertain