Gene

KWMTBOMO06922

Pre Gene Modal

BGIBMGA004639

Annotation

PREDICTED:_frizzled-2-like_[Bombyx_mori]

Location

Bomo_Chr11(-):19766357-19800847      View in EpiBrowser

Full name

Frizzled-8       + More
Frizzled-5      

Location in the cell

PlasmaMembrane   Reliability : 3.524

CDS

ATGTGGGCAGCGGGCGTGGCGGCGTGCGCGCTGCTGGCCGCCGCCGGAGCCCTGCAGCAGCCGCGCTGTCAGGACATCACCATCCCCATGTGCCGCGGCATCGGCTACAACCTCACTTCCTTCCCCAACGCGCTGGACCACGACACGCAGGAAGAAGCCGGACTAGAGGTTCACCAATATTGGCCCCTCGTCGAGATCAAGTGCTCGTCGGACCTAAAGTTCTTCCTGTGCTCCGTGTACACGCCGATCTGCATCGAGGACTACGCGAAGCCGCTGCCGGCGTGTCGCAGCGTGTGCGAGCGCGCGCGGGCCGGCTGCGCGCCGCTCATGCAGCAGTACGGGTTCCCGTGGCCCGAGCGCATGGCGTGCGAGCAGCTGCCGCGCGCCGGCGACCCCGACCAGCTGTGCATGGAGGAGACGGAGCGCGCGCACGAGCCCGAGCCGCCCCGCCCGCCGCCCCGCAAGCCCGCCAAGAACAACTGCAAGGATCCAAAAAACTGCGGCGGCGCGGCGGCTGCGGGCGCCGGCGACGCGGCCGAGTGCGAGTGCGCGTGCCGCCCGCCGCTGCTCGCCGCGCCCAACACCAGCGCCGCGCCCGGCCTGCGCCCCCCCGCCTGTCTGCAGCCCTGCCGCGGCGCCTTCTTCACCGCCGACGAAAAACACTTCGCGGCCGTCTGGGTGGCGCTGTGGAGCGGCCTCTGCGCCGCCTCCACGCTCATGACGCTCACCACCTTCCTGATCGACTCGCAGCGGTTTAAGTACCCGGAGCGCCCCATCGTGTACTTGTCGGCCTGCTACTTCATGGTGTCGCTGGGCTACCTGGCGCGCCTGGCGCTGGGGCACGACGAGATCGCGTGCGACGGGCCGGCGCTCAAGGTGTCCGCCAGCGGACCCAGCGCGTGCACGCTCGTCTTCATCTTGGTCTATTTCTTCGGAATGGCGTCGTCGATCTGGTGGGTGGTGCTGTCCTTCGCGTGGTTCCTCGCCGCCGGACTCAAGTGGGGCAATGAAGCCATCGCCGGTTACGCACAGTACTACCACCTGGCCGCGTGGCTCGTACCGGCTGCGAAGACGGTCGCCGTGCTGCTGGCCGGCGCCGTTGACGGCGACCCGGTGGCCGGGATCTGTTCAGTCGGCAACTCTTCTCCGGAAAATCTCAAGAAATTCGTGCTGGCGCCGCTGGTCGTGTACTTCGGTCTGGGCGCGACGTTCCTGCTCGCCGGGTTCGTGTCGCTGTTCCGCATCCGGTCGGTGATCAAGCGGCAGGGCGGCGTGGGCGCGGGCTCCAAGGCGGACAAGCTGGAGAAGCTGATGATCCGCATCGGCGTGTTCAGCGTGCTGTACGCGGTGCCGGCGGGCGCGGTGCTGGCGTGCCTGGCGTACGAGGCGGCGGGGCACGCGGGCTGGCTGCGGCGCGCCGCGTGCGGCTCCCGCTGCGGGCCGGCGCCGCTGTACGCCGCGCTCATGCTCAAGTACTTCATGGCGCTGGCGGTGGGCATCACGTCGGGCGTGTGGATCTGGTCGGGCAAGACGCTGGACTCGTGGCGCCGCGTGTGGGCGGGCGGGCGGCGCGTGCCCCCGCCCTCGCAGCGCGCGCTCGTCAAGGGCGCCGTGTGA

Protein

MWAAGVAACALLAAAGALQQPRCQDITIPMCRGIGYNLTSFPNALDHDTQEEAGLEVHQYWPLVEIKCSSDLKFFLCSVYTPICIEDYAKPLPACRSVCERARAGCAPLMQQYGFPWPERMACEQLPRAGDPDQLCMEETERAHEPEPPRPPPRKPAKNNCKDPKNCGGAAAAGAGDAAECECACRPPLLAAPNTSAAPGLRPPACLQPCRGAFFTADEKHFAAVWVALWSGLCAASTLMTLTTFLIDSQRFKYPERPIVYLSACYFMVSLGYLARLALGHDEIACDGPALKVSASGPSACTLVFILVYFFGMASSIWWVVLSFAWFLAAGLKWGNEAIAGYAQYYHLAAWLVPAAKTVAVLLAGAVDGDPVAGICSVGNSSPENLKKFVLAPLVVYFGLGATFLLAGFVSLFRIRSVIKRQGGVGAGSKADKLEKLMIRIGVFSVLYAVPAGAVLACLAYEAAGHAGWLRRAACGSRCGPAPLYAALMLKYFMALAVGITSGVWIWSGKTLDSWRRVWAGGRRVPPPSQRALVKGAV

Description

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activation by Wnt8, Wnt5A or Wnt3A induces expression of beta-catenin target genes. Displays an axis-inducing activity.
Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).

Subunit

Interacts with lypd6 and the interaction is strongly enhanced by wnt3a (PubMed:23987510).

Similarity

Belongs to the G-protein coupled receptor Fz/Smo family.

Keywords

Cell membrane   Developmental protein   Disulfide bond   G-protein coupled receptor   Glycoprotein   Membrane   Receptor   Signal   Transducer   Transmembrane   Transmembrane helix   Wnt signaling pathway   Golgi apparatus  

Feature

chain  Frizzled-8

Uniprot

A0A212FLT4   A0A2H1V370   A0A1L8DK48   A0A182H9U6   A0A1S4FER6   Q174W8   + More
B0XF00   A0A1B0D459   A0A182YIP9   D6WG76   A0A2P8XU91   A0A0A9X185   A0A1B6C5G0   T1HKP7   U4URZ2   N6T4T2   A0A0L7QT69   A0A1Q3F425   A0A1Q3F4C5   A0A1Q3F402   A0A2J7R9R2   A0A224X9S1   A0A336MTN4   A0A336LSY3   A0A1Y1K6Z8   K7JBY1   A0A2R7WR03   A0A154PC89   A0A1A9X0F7   A0A067RPY7   E0VGL1   A0A143VP63   A0A1S3KHK3   A0A193PMF2   A0A147A2P6   A0A194Q9T8   A0A3N0Z9R6   A0A3B4D8K0   H3B9V4   A0A2D0R765   A0A3P8VZI9   A0A2P4SHJ0   A0A0F8C7W7   A0A1L8EX74   A0A3Q2VUY7   A0A3P9N8F6   W5LUP7   B3DIG4   D1LX20   W4Z465   Q9W6E2   A0A1L8FVD0   A0A087YPZ1   A0A1V4L046   F6QAW3   O93274   A0A3Q2HVX2   A0A3B3X1I2   G3NBP6   A0A3B3TKC7   A0A1A8CC31   A0A3P8RSQ2   Q2WC00   A0A2I4DCZ9   A0A3Q1CWG3   A0A3Q3SQ36   A0A3B4B9X8   A0A3Q3G2M5   A0A3B4YN81   W5U7U1   A0A2S2P2Z4   M3ZGK7   A0A3Q4G1N3   A0A3Q1HHE2   A0A3B4U8Y5   A0A2U9CCF7   A0A2I0LXL0   A0A146P5Q0   A0A3P8UTE2   A0A3B3SLN2   A0A0Q3M2V1   B7ZQV9   A0A287BDT2   A0A3B4FT02   A0A3Q1FTC3   A0A3P8QQD2   A0A3P9CS68   A0A3Q2ECT1   A0A2H8TH98   A0A3B5BG11   F6VM33   B7ZPB7   P58421   A0A1L8EPX2   A0A3B5MXP3   A0A3L8Q5P4   A0A3B4EPW2   F7AS02   A0A3Q3EVM8  

Pubmed

22118469    26483478    17510324    25244985    18362917    19820115    + More
29403074    25401762    26823975    23537049    28004739    20075255    24845553    20566863    27346542    26354079    9215903    24487278    25835551    27762356    25329095    23594743    20431018    9651509    9636083    10097073    23987510    19892987    16722215    16396908    25463417    23127152    23542700    25186727    23371554    29240929    11335120    30282656   

EMBL

AGBW02007696    OWR54705.1    ODYU01000452    SOQ35277.1    GFDF01007337    JAV06747.1    + More
JXUM01004841    KQ560182    KXJ83965.1    CH477405    EAT41596.2    DS232885    EDS26348.1    AJVK01003115    KQ971320    EFA01325.1    PYGN01001337    PSN35572.1    GBHO01032739    GDHC01013891    JAG10865.1    JAQ04738.1    GEDC01028823    GEDC01020202    JAS08475.1    JAS17096.1    ACPB03015808    KB632338    ERL92926.1    APGK01043959    KB741019    ENN75149.1    KQ414755    KOC61754.1    GFDL01012723    JAV22322.1    GFDL01012707    JAV22338.1    GFDL01012764    JAV22281.1    NEVH01006580    PNF37566.1    GFTR01007340    JAW09086.1    UFQS01002678    UFQT01002678    SSX14523.1    SSX33924.1    UFQT01000098    SSX19833.1    GEZM01093585    GEZM01093584    JAV56238.1    AAZX01009892    KK855322    PTY22006.1    KQ434870    KZC09539.1    KK852538    KDR21799.1    DS235149    EEB12517.1    LN849083    CRI73785.1    LC138024    BAV17685.1    GCES01013535    JAR72788.1    KQ459252    KPJ02184.1    RJVU01002418    ROL55062.1    AFYH01069935    PPHD01048218    POI23543.1    KQ042628    KKF12960.1    CM004482    OCT63879.1    FQ377896    BC163118    BC163120    AAI63118.1    GU075997    ACY92526.1    AAGJ04009227    AF117387    AAD25357.1    CM004476    OCT75534.1    AYCK01002502    LSYS01000429    OPJ90213.1    AAMC01066237    AF017177    AF033110    HADZ01012364    SBP76305.1    AM084899    CAJ29888.1    JT407661    AHH38066.1    GGMR01011218    MBY23837.1    CP026256    AWP13456.1    AKCR02000066    PKK22172.1    GCES01147227    JAQ39095.1    LMAW01002801    KQK76912.1    BC169947    BC169949    CM004477    AAI69947.1    OCT73890.1    AEMK02000074    GFXV01001688    MBW13493.1    AAMC01042393    BC169396    BC169398    AAI69396.1    AF300716    CM004483    OCT61360.1    QUSF01006046    RLV62647.1   

Proteomes

UP000007151    UP000069940    UP000249989    UP000008820    UP000002320    UP000092462    + More
UP000076408    UP000007266    UP000245037    UP000015103    UP000030742    UP000019118    UP000053825    UP000235965    UP000002358    UP000076502    UP000091820    UP000027135    UP000009046    UP000085678    UP000053268    UP000261440    UP000008672    UP000221080    UP000265120    UP000186698    UP000264840    UP000242638    UP000018467    UP000000437    UP000007110    UP000028760    UP000190648    UP000008143    UP000002281    UP000261480    UP000007635    UP000261500    UP000265080    UP000192220    UP000257160    UP000261640    UP000261520    UP000261660    UP000261360    UP000002852    UP000261580    UP000265040    UP000261420    UP000246464    UP000053872    UP000265000    UP000261540    UP000051836    UP000008227    UP000261460    UP000257200    UP000265100    UP000265160    UP000265020    UP000261400    UP000261380    UP000276834    UP000264800   

PRIDE

P58421   

Pfam

PF01534   Frizzled        + More
PF01392   Fz

Interpro

IPR020067   Frizzled_dom        + More
IPR000539   Frizzled/Smoothened_TM       
IPR015526   Frizzled/SFRP       
IPR017981   GPCR_2-like       
IPR036790   Frizzled_dom_sf       
IPR041776   FZ8_CRD       
IPR037441   FZ5_CRD       

SUPFAM

SSF63501   SSF63501       

Gene 3D

1.10.2000.10    

CDD

cd07461  CRD_FZ8
cd07460  CRD_FZ5

ProteinModelPortal

A0A212FLT4   A0A2H1V370   A0A1L8DK48   A0A182H9U6   A0A1S4FER6   Q174W8   + More
B0XF00   A0A1B0D459   A0A182YIP9   D6WG76   A0A2P8XU91   A0A0A9X185   A0A1B6C5G0   T1HKP7   U4URZ2   N6T4T2   A0A0L7QT69   A0A1Q3F425   A0A1Q3F4C5   A0A1Q3F402   A0A2J7R9R2   A0A224X9S1   A0A336MTN4   A0A336LSY3   A0A1Y1K6Z8   K7JBY1   A0A2R7WR03   A0A154PC89   A0A1A9X0F7   A0A067RPY7   E0VGL1   A0A143VP63   A0A1S3KHK3   A0A193PMF2   A0A147A2P6   A0A194Q9T8   A0A3N0Z9R6   A0A3B4D8K0   H3B9V4   A0A2D0R765   A0A3P8VZI9   A0A2P4SHJ0   A0A0F8C7W7   A0A1L8EX74   A0A3Q2VUY7   A0A3P9N8F6   W5LUP7   B3DIG4   D1LX20   W4Z465   Q9W6E2   A0A1L8FVD0   A0A087YPZ1   A0A1V4L046   F6QAW3   O93274   A0A3Q2HVX2   A0A3B3X1I2   G3NBP6   A0A3B3TKC7   A0A1A8CC31   A0A3P8RSQ2   Q2WC00   A0A2I4DCZ9   A0A3Q1CWG3   A0A3Q3SQ36   A0A3B4B9X8   A0A3Q3G2M5   A0A3B4YN81   W5U7U1   A0A2S2P2Z4   M3ZGK7   A0A3Q4G1N3   A0A3Q1HHE2   A0A3B4U8Y5   A0A2U9CCF7   A0A2I0LXL0   A0A146P5Q0   A0A3P8UTE2   A0A3B3SLN2   A0A0Q3M2V1   B7ZQV9   A0A287BDT2   A0A3B4FT02   A0A3Q1FTC3   A0A3P8QQD2   A0A3P9CS68   A0A3Q2ECT1   A0A2H8TH98   A0A3B5BG11   F6VM33   B7ZPB7   P58421   A0A1L8EPX2   A0A3B5MXP3   A0A3L8Q5P4   A0A3B4EPW2   F7AS02   A0A3Q3EVM8  

PDB

6BD4     E-value=4.15667e-80,     Score=760

KEGG

101740097    K02375 frizzled 5/8 | (RefSeq) frizzled-2-like

PATHWAY

04150    mTOR signaling pathway - Bombyx mori (domestic silkworm)
04310    Wnt signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0007275   GO:0016021   GO:0004888   GO:0016055   GO:0007166   GO:0005886   GO:0035567   GO:0017147   GO:0042813   GO:0060070   GO:0090090   GO:0043010   GO:0048794   GO:0001889   GO:0051091   GO:0004930   GO:0045595   GO:0000139   GO:0042127   GO:0048666   GO:0021531   GO:0060898   GO:0021879   GO:0021529   GO:0016020   GO:0005515   GO:0043565   GO:0043401   GO:0006418   GO:0005634   GO:0006260  

PANTHER

PTHR11309  

Subcellular location

Membrane  
Cell membrane  
Golgi apparatus membrane   Localized at the plasma membrane and also found at the Golgi.   With evidence from 2 publications.

SignalP

Position:   1 - 17,         Likelihood:  0.982823

 

 

Length:

538

Number of predicted TMHs:

7

Exp number of AAs in TMHs:

160.58461

Exp number, first 60 AAs:

0.910589999999999

Total prob of N-in:

0.13468

outside

1  -  223

TMhelix

224  -  246

inside

247  -  257

TMhelix

258  -  280

outside

281  -  301

TMhelix

302  -  324

inside

325  -  344

TMhelix

345  -  367

outside

368  -  390

TMhelix

391  -  413

inside

414  -  442

TMhelix

443  -  465

outside

466  -  484

TMhelix

485  -  507

inside

508  -  538

 

 

Pi

21.194689

Theta

20.448443

Tajima's D

0.137528

CLR

0.753708

CSRT

0.414179291035448

Interpretation

Uncertain