Silkworm Genome Informatics Database

Gene

KWMTBOMO06915

Pre Gene Modal

BGIBMGA014476

Annotation

PREDICTED:_histone-lysine_N-methyltransferase_E(z)_[Bombyx_mori]

Location

Bomo_Chr11(+):19681616-19689324 View in EpiBrowser

Full name

Histone-lysine N-methyltransferase E(z)

Alternative Name

Lysine N-methyltransferase 6
Protein enhancer of zeste

Location in the cell

Nuclear Reliability : 3.834

CDS

ATGTCGGGCGACCCGCTGTGTCCGCCGCCCGAGTGCACGCCCAACGTGGACGGGCCGCTCGCCGAGCCCGTGCCGCGCGACCAGACCATGCACTCCTTCCACGCGCTCTTCTGTCGACGCTGCTTCAAGTACGACTGCTTCCTGCACCGACTACAAGCGTGCCACCCGCGGCCCAACCTGTCGAAGCGCAAGGGACCCGACCTCAAGCCCTTCTCCGAGCCGTGCGGGCCCAACTGCTACATGCTGCTGGACGGGATGCGCGAGCGGCTGGCGCGCGAGCAGGCGGCCGGCGGACACGACTCGCCCAACGACGCCTCCTCCGAGGACAGCAACGACAGCAACCGCTTCCACAAGGGCAGCCACAGCAACTCCGGCGGCGGCGCGTGGGGCGCGGGCGGACACAAGCAGCACGCGGAGTCGCCGGCCGAGCCCGCCTACAGCGCGCTGGGGCTGTCGCTGGGCGCGGCGGAGTGGACGGGGTCGGACGTGTCGCTGCACCGCGCGCTGCACAAGGTGTTCCCGCACAACTACTGCGCGCAGGCCCAGCTCATGCTGTCCAAGACGTGCCAGCAGGTGTGGTGGCGGCGGCAGCGCGGCGGCGGCCAGGAGCCGGGCGCGGCCGTGGACCTCACGCCGCCGCGCAAGAAGAAGAAGAAGCACCGGCTGTGGTCCGTGCACTGCCGCAAGATACAACTCAAGAAGGACTCCGCCTCGCACCACGTGTACAACTACACGCCGTGCGACCACCCCAGCCAGCCGTGCGACAGCCTGTGCCCGTGCCTGCAGTCGCAGAACTTCTGCGAGAAGTTCTGTCAGTGCAGCAGCGACTGTCAGAACCGGTTCCCGGGGTGCCGCTGCAAGGCGCAGTGCAACACGAAGCAGTGCCCGTGCTACCTCGGCGTGCGCGAGTGCGACCCCGACCTCTGCACCGCGTGCGGCGCCGACGCCTCCCCGCTGCACGCCGCGCCCGTCTACTGCAAGAACGTGTCCGTGCAGAGAGGCCTGCACAAACACCTGCTGCTGGCTCCCAGCGACGTGGCGGGCTGGGGGATCTTCCTCAAGGAAGCCGCGCACAAGAACGAGTTCATCTCCGAGTACTGCGGGGAGATCATATCGCAGGACGAAGCCGACCGCCGCGGGAAGGTCTACGACAAGTACATGTGCTCCTTCCTCTTCAACCTCAACAACGATTTTGTCGTGGATGCGACACGTAAAGGTAACAAGATTCGTTTCGCGAACCACTCGATCAACCCGAACTGTTACGCGAAGGTCATGATGGTGAATGGTGACCATCGCATTGGTATCTTCGCTAAACGGGCGATCCAGCCTGGAGAAGAACTGTTCTTTGATTATAGATATGGACCTACTGAGCAATTGAAATTCGTAGGAATCGAGAGAGAGATGGAGTTCTTATGA

Protein

MSGDPLCPPPECTPNVDGPLAEPVPRDQTMHSFHALFCRRCFKYDCFLHRLQACHPRPNLSKRKGPDLKPFSEPCGPNCYMLLDGMRERLAREQAAGGHDSPNDASSEDSNDSNRFHKGSHSNSGGGAWGAGGHKQHAESPAEPAYSALGLSLGAAEWTGSDVSLHRALHKVFPHNYCAQAQLMLSKTCQQVWWRRQRGGGQEPGAAVDLTPPRKKKKKHRLWSVHCRKIQLKKDSASHHVYNYTPCDHPSQPCDSLCPCLQSQNFCEKFCQCSSDCQNRFPGCRCKAQCNTKQCPCYLGVRECDPDLCTACGADASPLHAAPVYCKNVSVQRGLHKHLLLAPSDVAGWGIFLKEAAHKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSINPNCYAKVMMVNGDHRIGIFAKRAIQPGEELFFDYRYGPTEQLKFVGIEREMEFL

Catalytic Activity

L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine

Subunit

Component of the Esc/E(z) complex, composed of Caf1, esc, E(z), Su(z)12, and possibly pho. The Esc/E(z) complex may also associate with Pcl and Rpd3 during early embryogenesis. This complex is distinct from the PRC1 complex, which contains many other PcG proteins like Pc, Ph, Psc, Su(z)2. The two complexes however cooperate and interact together during the first 3 hours of development to establish PcG silencing. Interacts with corto in vitro.

Similarity

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily.

Keywords

Chromatin regulator Complete proteome Developmental protein Methyltransferase Nucleus Phosphoprotein Reference proteome Repressor S-adenosyl-L-methionine Transcription Transcription regulation Transferase

Feature

chain Histone-lysine N-methyltransferase E(z)

Uniprot

A0A194QPI2 A0A212FLU8 A0A2A4K7M2 A0A2H1V347 A0A194Q9J3 H9JY58 + More
A0A0H5AZZ1 A0A1W4X9U4 A0A1W4XKH6 E0VLU5 D6WFD9 K7JBX9 A0A0C9R7C3 A0A195ELD0 Q16JU6 A0A1S4FY93 Q16KH6 A0A1B0CNG9 A0A195BIX9 B0WI23 A0A182H9M9 A0A1Q3F2X2 A0A1B0FC38 A0A1A9VYH1 A0A1B0B9D4 A0A1A9WT88 A0A1I8MV92 A0A1I8P7Q2 A0A336LRU8 A0A1Q3F2Y1 A0A1L8DW20 A0A182QBS4 A0A0A1XMP7 A0A0K8UWS2 A0A034VYA0 A0A182K689 A0A1I8MV84 U5EZS4 A0A182MLZ4 W8C0W0 A0A1I8P7Q3 A0A0L0BTA4 A0A084W177 A0A1W4UV12 A0A182RJV1 A0A1L8DW01 P42124 A0A182J6X0 A0A0J9RT70 A0A0K8U5Q5 A0A034VXA1 B4PEF8 B4HLW0 Q7PTY9 B3NCL9 W8C0W7 A0A1W4UHH2 A0A182NQ93 M9PHZ5 A0A0R1E303 A0A0J9RSX3 B3M5C3 A0A0Q5U7R1 A0A182PUS1 A0A0M4EP09 A0A3B0JSM8 A0A0N8P116 A0A224L167 A0A224L0H8 A0A3B0J4V1 A0A182WAY0 A0A224L173 Q2LZJ3 B4H6P3 B4N6Q3 A0A3B0K017 A0A0R3P8I9 B4QP80 A0A146XPM0 A0A1Q3EU77

EC Number

2.1.1.43

Pubmed

26354079 22118469 19121390 26253405 20566863 18362917 + More
19820115 20075255 17510324 26483478 25315136 25830018 25348373 24495485 26108605 24438588 8413234 10731132 12537572 12537569 9012527 9566901 11124122 11581156 12408863 12408864 12533794 12697833 12771214 18327897 22936249 17994087 17550304 9087549 12364791 14747013 17210077 12537568 12537573 12537574 16110336 17569856 17569867 15632085

EMBL

KQ461185 KPJ07443.1 AGBW02007696 OWR54715.1 NWSH01000092 PCG79652.1 + More
ODYU01000452 SOQ35268.1 KQ459252 KPJ02173.1 BABH01042253 BABH01042254 BABH01042255 LC012934 BAR94240.1 DS235281 EEB14351.1 KQ971319 EFA00261.1 AAZX01015307 GBYB01008692 JAG78459.1 KQ978739 KYN28742.1 CH477990 EAT34568.1 CH477957 EAT34804.1 AJWK01020299 AJWK01020300 AJWK01020301 AJWK01020302 AJWK01020303 KQ976455 KYM85051.1 DS231941 EDS28105.1 JXUM01121146 KQ566467 KXJ70111.1 GFDL01013144 JAV21901.1 CCAG010016063 JXJN01010368 UFQT01000136 SSX20670.1 GFDL01013134 JAV21911.1 GFDF01003471 JAV10613.1 AXCN02001889 GBXI01002489 JAD11803.1 GDHF01021185 JAI31129.1 GAKP01011880 JAC47072.1 GANO01000248 JAB59623.1 AXCM01004513 GAMC01007239 JAB99316.1 JRES01001499 KNC22429.1 ATLV01019240 KE525266 KFB43971.1 GFDF01003472 JAV10612.1 U00180 AE014296 AY051785 AXCP01007913 CM002912 KMY98857.1 GDHF01030391 JAI21923.1 GAKP01011878 JAC47074.1 CM000159 EDW94024.1 CH480815 EDW40992.1 AAAB01007639 EAA03026.3 CH954178 EDV51316.1 GAMC01007234 JAB99321.1 AGB94376.1 KRK01623.1 KMY98858.1 CH902618 EDV40628.1 KQS43780.1 CP012525 ALC43780.1 OUUW01000002 SPP76699.1 KPU78668.1 LN864774 CRL92670.1 LN864773 CRL92669.1 SPP76697.1 LN864775 CRL92671.1 CH379069 EAL29514.1 CH479214 EDW33471.1 CH964161 EDW80042.2 SPP76698.1 KRT08102.1 CM000363 EDX09978.1 GCES01042807 JAR43516.1 GFDL01016239 JAV18806.1

Proteomes

UP000053240 UP000007151 UP000218220 UP000053268 UP000005204 UP000192223 + More
UP000009046 UP000007266 UP000002358 UP000078492 UP000008820 UP000092461 UP000078540 UP000002320 UP000069940 UP000249989 UP000092444 UP000078200 UP000092460 UP000091820 UP000095301 UP000095300 UP000075886 UP000075881 UP000075883 UP000037069 UP000030765 UP000192221 UP000075900 UP000000803 UP000075880 UP000002282 UP000001292 UP000007062 UP000008711 UP000075884 UP000007801 UP000075885 UP000092553 UP000268350 UP000075920 UP000001819 UP000008744 UP000007798 UP000000304

PRIDE

H9JY58 P42124

Pfam

PF18118   PRC2_HTH_1        + More
PF00856   SET
PF18264   preSET_CXC

Interpro

IPR041355   Pre-SET_CXC        + More
IPR001214   SET_dom
IPR009057   Homeobox-like_sf
IPR026489   CXC_dom
IPR001005   SANT/Myb
IPR033467   Tesmin/TSO1-like_CXC
IPR041343   PRC2_HTH_1

SUPFAM

SSF46689 SSF46689

CDD

cd00167 SANT

ProteinModelPortal

A0A194QPI2 A0A212FLU8 A0A2A4K7M2 A0A2H1V347 A0A194Q9J3 H9JY58 + More
A0A0H5AZZ1 A0A1W4X9U4 A0A1W4XKH6 E0VLU5 D6WFD9 K7JBX9 A0A0C9R7C3 A0A195ELD0 Q16JU6 A0A1S4FY93 Q16KH6 A0A1B0CNG9 A0A195BIX9 B0WI23 A0A182H9M9 A0A1Q3F2X2 A0A1B0FC38 A0A1A9VYH1 A0A1B0B9D4 A0A1A9WT88 A0A1I8MV92 A0A1I8P7Q2 A0A336LRU8 A0A1Q3F2Y1 A0A1L8DW20 A0A182QBS4 A0A0A1XMP7 A0A0K8UWS2 A0A034VYA0 A0A182K689 A0A1I8MV84 U5EZS4 A0A182MLZ4 W8C0W0 A0A1I8P7Q3 A0A0L0BTA4 A0A084W177 A0A1W4UV12 A0A182RJV1 A0A1L8DW01 P42124 A0A182J6X0 A0A0J9RT70 A0A0K8U5Q5 A0A034VXA1 B4PEF8 B4HLW0 Q7PTY9 B3NCL9 W8C0W7 A0A1W4UHH2 A0A182NQ93 M9PHZ5 A0A0R1E303 A0A0J9RSX3 B3M5C3 A0A0Q5U7R1 A0A182PUS1 A0A0M4EP09 A0A3B0JSM8 A0A0N8P116 A0A224L167 A0A224L0H8 A0A3B0J4V1 A0A182WAY0 A0A224L173 Q2LZJ3 B4H6P3 B4N6Q3 A0A3B0K017 A0A0R3P8I9 B4QP80 A0A146XPM0 A0A1Q3EU77

PDB

5WG6 E-value=4.43447e-163, Score=1475

KEGG

101745450 K11430 histone-lysine N-methyltransferase EZH2 [EC:2.1.1.43] | (RefSeq) E(Z); histone-lysine N-methy

PATHWAY

00310 Lysine degradation - Bombyx mori (domestic silkworm)

GO

GO:0018024 GO:0070734 GO:0003677 GO:0008168 GO:0000790 GO:0043565 GO:0016571 GO:0051567 GO:0042054 GO:0035098 GO:0006723 GO:0035097 GO:0045892 GO:0005634 GO:0016458 GO:0007411 GO:0022008 GO:0046976 GO:0003700 GO:0046974 GO:0031062 GO:1902692 GO:0035186 GO:0005515 GO:0004523 GO:0030833 GO:0043401 GO:0006418 GO:0016020 GO:0006260

Subcellular location

Nucleus

Length:

471

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00035

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00025

outside

1 - 471

Pi

18.744138

Theta

20.924024

Tajima's D

-1.245481

CLR

11.718584

CSRT

0.0966451677416129

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics