Gene

KWMTBOMO06909  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA004645

Annotation

suppressor_of_profilin_2_[Bombyx_mori]

Location

Bomo_Chr11(-):19637200-19641625      View in EpiBrowser

Full name

Actin-related protein 2/3 complex subunit      

Location in the cell

Cytoplasmic   Reliability : 1.57 Extracellular   Reliability : 1.859

CDS

ATGGCACAAACGTTAACTTTTGGTGACTCATGCGCGCCGATAACATGTCATGCATGGAACAAGGATAGAAGTCAAATTGCATTCTCACCAAACAATAATGAAGTTCACATATACAAGAAGGAAGGAAATGACTGGAAGCAAACAAACAACCTTGTGGAACACGACCTTAGAGTGATGGGGATTGATTGGGCTCCCAACACCAACCGTATTGTTACGTGTTCTGTTGACCGTAATGCTTACGTCTGGACTCAAGGAGATGATGGGAAATGGGCAACTACTCTTGTTCTTCTGCGTATCAACCGAGCAGCGACTTGCGTGAAATGGTCTCCCATGGAGAACAAGTTTGCTGTCGGGTCAGGAGCTAGATTGATATCAATTTGCTATTTTGAGAAGGAAAATAATTGGTGGGTGTCTAAGCATATTAAGAAGCCCATTCGTTCGACTGTGACATCTATTGATTGGCATCCCAATAACATTTTGCTCGTCGCTGGCTCTGCTGACTTCAAAGTACGAGTCTTCTCTGCCTATATCAAGGATATCGAAGATCAGCCTGGACCGAATGTGTGGGGCTCTAAGTTGCCTTTAGGACAACTGTTAGCAGAGTTTCCCAATTCGCCTTCAGGTGGCGGTTGGGTCCACAGCGTTTCCTTCTCTGCGGACGGAAATAAAGTTGCCTGGGTCGCCCACGACAGCTCAATCAACGTAACCGACGCTACTAAAGGAAGGGCTGTCATAAAACTAAAGACTGAATACCTGCCATTCTTGGGATGCAGTTGGATCACCAACAATTCCCTGATAGTAGCAGGCCACAGCTGCATTCCGTTATTGTACTGCCACGACGGTGACGATATTAAGTATGTCGCCAAACTCGACAATACTCAGAGGAAGGAGTCTGGGGGACTGTCTGCTATGAAGAAGTTCCAGTCCTTGGATCGTCATGCTCGTATCGAGACCAGCGATACATTCTTGGACTCGATACACCAGAACGCTATCTCGTGCATCAATATTTACAAAGGAACTAAATCGCACACTAACAAGTTCAGTACTTCAGGTCTCGACGGCCAGCTCGTCATATGGGACTTGGACACTTTGGAGAGGTCATTTGAAGGAATCAAGATTGTCTAA

Protein

MAQTLTFGDSCAPITCHAWNKDRSQIAFSPNNNEVHIYKKEGNDWKQTNNLVEHDLRVMGIDWAPNTNRIVTCSVDRNAYVWTQGDDGKWATTLVLLRINRAATCVKWSPMENKFAVGSGARLISICYFEKENNWWVSKHIKKPIRSTVTSIDWHPNNILLVAGSADFKVRVFSAYIKDIEDQPGPNVWGSKLPLGQLLAEFPNSPSGGGWVHSVSFSADGNKVAWVAHDSSINVTDATKGRAVIKLKTEYLPFLGCSWITNNSLIVAGHSCIPLLYCHDGDDIKYVAKLDNTQRKESGGLSAMKKFQSLDRHARIETSDTFLDSIHQNAISCINIYKGTKSHTNKFSTSGLDGQLVIWDLDTLERSFEGIKIV

Description

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

Similarity

Belongs to the WD repeat ARPC1 family.

Uniprot

H9J555   Q5S745   I4DR44   A0A194QPJ2   I4DJI3   H9CTT0   + More
A0A2W1BX99   A0A2A4K6M0   W5VGT1   A0A0L7L3Y4   S4PI17   A0A212FLV7   A0A1Y1NLZ3   A0A023EQX7   A0A023ET38   A0A182GMS3   A0A1S4FGV6   A0A0K8TN71   Q171R5   A0A084VL09   A0A1Q3FXZ8   A0A182P8B0   A0A182IN19   T1DNA3   A0A2M4A469   A0A1L8E5F0   A0A182JUM4   A0A2M4BRA3   W5J1U0   A0A2M3Z0W3   A0A2M4BRI4   A0A2M3Z0Q3   A0A182F1E1   A0A182I7A7   A0A182Q2Y5   A0A182SM36   A0A182VBK3   A0A182XNP8   A0A182LMV0   Q7PWN2   A0A182U2L1   A0A182MZ76   A0A182Y0B2   U5ETL0   A0A182VUD6   A0A2J7QGZ0   A0A182RSJ6   A0A182MID2   A0A067QYD7   A0A1B0DH83   A0A1A9Z442   A0A0T6B9N5   D3TPI0   A0A1A9UYR4   A0A1A9YJV9   A0A0A1WMR5   J3JZG0   A0A1I8PPU9   A0A0L0CJN3   A0A0K8UMT1   A0A034WWR4   A0A1A9WXD7   W8C4D9   A0A1I8MC28   A0A1W4XH64   A0A1J1II70   A0A1L8ECK8   B4GX11   Q29K75   A0A336M9E9   A0A336M8T0   B3MN25   A0A1W4UV62   B4HXA3   B4Q569   O97182   B4P3Q6   B3NAD0   A0A0M5J984   B4MVR3   E2RZJ2   A0A1B6CGM3   A0A0P4VST6   A0A1B6JJC6   B4KIY1   T1HKR3   B4JCX5   A0A3B0JJK2   A0A1B6M8N3   A0A0P4WLJ6   A0A0V0GCJ0   B4M8L5   A0A069DSY9   E0VQZ3   E9HDB8   A0A3R7N738   A0A0N8E7K5   A0A0P5E8Q3   R4WDR2   A0A0L7QX55  

Pubmed

19121390    22651552    26354079    28756777    26227816    23622113    + More
22118469    28004739    24945155    26483478    26369729    17510324    24438588    20920257    23761445    20966253    12364791    14747013    17210077    25244985    24845553    20353571    25830018    22516182    23537049    26108605    25348373    24495485    25315136    17994087    15632085    23185243    18057021    22936249    10886416    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    17550304    27129103    26334808    20566863    21292972    23691247   

EMBL

BABH01040712    AY763110    AAV65755.1    AK404933    BAM20384.1    KQ461185    + More
KPJ07453.1    AK401451    KQ459252    BAM18073.1    KPJ02166.1    JQ364941    ODYU01000452    AFD50557.1    SOQ35262.1    KZ149906    PZC78275.1    NWSH01000092    PCG79666.1    KF670139    AHH80647.1    JTDY01003110    KOB70130.1    GAIX01005585    JAA86975.1    AGBW02007696    OWR54722.1    GEZM01003101    JAV96917.1    GAPW01002063    JAC11535.1    GAPW01002064    JAC11534.1    JXUM01075043    KQ562865    KXJ74977.1    GDAI01002228    JAI15375.1    CH477447    EAT40752.1    ATLV01014395    KE524970    KFB38653.1    GFDL01002606    JAV32439.1    GAMD01003065    JAA98525.1    GGFK01002220    MBW35541.1    GFDF01000107    JAV13977.1    GGFJ01006474    MBW55615.1    ADMH02002157    ETN58217.1    GGFM01001370    MBW22121.1    GGFJ01006473    MBW55614.1    GGFM01001361    MBW22112.1    APCN01003375    AXCN02002069    AAAB01008984    EAA14867.2    GANO01001866    JAB58005.1    NEVH01014359    PNF27847.1    AXCM01000345    KK852879    KDR14465.1    AJVK01060758    LJIG01009020    KRT83915.1    CCAG010006778    EZ423332    ADD19608.1    GBXI01014321    JAC99970.1    APGK01055683    BT128642    KB741269    KB632330    AEE63599.1    ENN71437.1    ERL92590.1    JRES01000300    KNC32618.1    GDHF01024327    JAI27987.1    GAKP01000292    JAC58660.1    GAMC01005584    JAC00972.1    CVRI01000048    CRK98750.1    GFDG01002434    JAV16365.1    CH479195    EDW27338.1    CH379061    EAL33302.1    KRT04886.1    UFQT01000742    SSX26865.1    UFQT01000716    SSX26732.1    CH902620    EDV32003.1    KPU73731.1    CH480818    EDW51683.1    CM000361    CM002910    EDX04975.1    KMY90166.1    AE014134    AY058778    AJ133649    AAF53339.1    AAL14007.1    CAB38634.1    CM000157    EDW88357.1    CH954177    EDV58632.1    CP012523    ALC39544.1    CH963857    EDW75783.1    AB568464    BAJ23428.1    GEDC01025248    GEDC01024694    JAS12050.1    JAS12604.1    GDKW01000384    JAI56211.1    GECU01008467    JAS99239.1    CH933807    EDW13494.1    ACPB03015801    CH916368    EDW03214.1    OUUW01000006    SPP82537.1    GEBQ01007763    JAT32214.1    GDRN01037180    JAI67309.1    GECL01001021    JAP05103.1    CH940654    EDW57541.1    GBGD01001824    JAC87065.1    DS235442    EEB15799.1    GL732623    EFX70226.1    QCYY01001308    ROT78974.1    GDIQ01054028    JAN40709.1    GDIP01145135    LRGB01001899    JAJ78267.1    KZS10082.1    AK417903    BAN21118.1    KQ414705    KOC63146.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000218220    UP000037510    UP000007151    + More
UP000069940    UP000249989    UP000008820    UP000030765    UP000075885    UP000075880    UP000075881    UP000000673    UP000069272    UP000075840    UP000075886    UP000075901    UP000075903    UP000076407    UP000075882    UP000007062    UP000075902    UP000075884    UP000076408    UP000075920    UP000235965    UP000075900    UP000075883    UP000027135    UP000092462    UP000092445    UP000092444    UP000078200    UP000092443    UP000019118    UP000030742    UP000095300    UP000037069    UP000091820    UP000095301    UP000192223    UP000183832    UP000008744    UP000001819    UP000007801    UP000192221    UP000001292    UP000000304    UP000000803    UP000002282    UP000008711    UP000092553    UP000007798    UP000009192    UP000015103    UP000001070    UP000268350    UP000008792    UP000009046    UP000000305    UP000283509    UP000076858    UP000053825   

PRIDE

H9J555    Q5S745   

Pfam

PF00400   WD40        + More
PF07676   PD40
PF12894   ANAPC4_WD40

Interpro

IPR017383   ARPC1        + More
IPR030140   ARC1A       
IPR036322   WD40_repeat_dom_sf       
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR017986   WD40_repeat_dom       
IPR001680   WD40_repeat       
IPR019775   WD40_repeat_CS       
IPR011659   PD40       
IPR024977   Apc4_WD40_dom       

SUPFAM

SSF50978   SSF50978       

Gene 3D

2.130.10.10    

ProteinModelPortal

H9J555   Q5S745   I4DR44   A0A194QPJ2   I4DJI3   H9CTT0   + More
A0A2W1BX99   A0A2A4K6M0   W5VGT1   A0A0L7L3Y4   S4PI17   A0A212FLV7   A0A1Y1NLZ3   A0A023EQX7   A0A023ET38   A0A182GMS3   A0A1S4FGV6   A0A0K8TN71   Q171R5   A0A084VL09   A0A1Q3FXZ8   A0A182P8B0   A0A182IN19   T1DNA3   A0A2M4A469   A0A1L8E5F0   A0A182JUM4   A0A2M4BRA3   W5J1U0   A0A2M3Z0W3   A0A2M4BRI4   A0A2M3Z0Q3   A0A182F1E1   A0A182I7A7   A0A182Q2Y5   A0A182SM36   A0A182VBK3   A0A182XNP8   A0A182LMV0   Q7PWN2   A0A182U2L1   A0A182MZ76   A0A182Y0B2   U5ETL0   A0A182VUD6   A0A2J7QGZ0   A0A182RSJ6   A0A182MID2   A0A067QYD7   A0A1B0DH83   A0A1A9Z442   A0A0T6B9N5   D3TPI0   A0A1A9UYR4   A0A1A9YJV9   A0A0A1WMR5   J3JZG0   A0A1I8PPU9   A0A0L0CJN3   A0A0K8UMT1   A0A034WWR4   A0A1A9WXD7   W8C4D9   A0A1I8MC28   A0A1W4XH64   A0A1J1II70   A0A1L8ECK8   B4GX11   Q29K75   A0A336M9E9   A0A336M8T0   B3MN25   A0A1W4UV62   B4HXA3   B4Q569   O97182   B4P3Q6   B3NAD0   A0A0M5J984   B4MVR3   E2RZJ2   A0A1B6CGM3   A0A0P4VST6   A0A1B6JJC6   B4KIY1   T1HKR3   B4JCX5   A0A3B0JJK2   A0A1B6M8N3   A0A0P4WLJ6   A0A0V0GCJ0   B4M8L5   A0A069DSY9   E0VQZ3   E9HDB8   A0A3R7N738   A0A0N8E7K5   A0A0P5E8Q3   R4WDR2   A0A0L7QX55  

PDB

6DEC     E-value=3.03199e-118,     Score=1087

KEGG

692691    K05757 actin related protein 2/3 complex, subunit 1A/1B | (RefSeq) Sop2; suppressor of profilin 2

PATHWAY

04144    Endocytosis - Bombyx mori (domestic silkworm)

GO

GO:0005885   GO:0005737   GO:0003779   GO:0034314   GO:0051015   GO:0030037   GO:0030589   GO:0033627   GO:0001745   GO:0051491   GO:0007409   GO:0008407   GO:0007413   GO:0006886   GO:0005200   GO:0030029   GO:0000902   GO:0015629   GO:0030833   GO:0005515   GO:0043565   GO:0043401   GO:0006418   GO:0016020   GO:0005634   GO:0006260  

PANTHER

PTHR10709:SF11   PTHR10709  

Length:

374

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.03944

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00704

outside

1  -  374

 

 

Pi

28.90864

Theta

25.970824

Tajima's D

0.494045

CLR

1.571118

CSRT

0.517674116294185

Interpretation

Uncertain