Gene

KWMTBOMO06880  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012077

Annotation

PREDICTED:_lysosomal_alpha-glucosidase-like_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr11(-):18224667-18253702      View in EpiBrowser

Full name

Cytosolic Fe-S cluster assembly factor NUBP1 homolog      

Location in the cell

Lysosomal   Reliability : 0.976

CDS

ATGCCTAAAATACCATATAAACCAGAAAAGTCTGGTGGAAATGACGATGACTACGAAATTGTTTCGTTCGATGATTTTTCCGACAAATCTCCGGGTTCGAAAACTGATTTATTAACTTTGAATGATAACATAAATTATCGTCTCTATTACGAAGCAGATAAACAATCAAAATATCTAGAAAACAATGGAGAATCATCCAAAGGTATTGACAGTCATACAGAAACGTCGCTGAATGGAGCAAGAAATGGATCATTCAGAAAATTATCAAATTCTTTTGTCCCATTCGGAAAATCCGGCGGGAAGACTCACACGCCGTTATTTAGCGGCGTTAAGTCTAAGAATGAAAATGAATCTTCATCTAGAGAACACAGATATCAACGATTTTCAGAAAATAGCACGTTTATGCAGAGAGTCTGCGATATGATGCCTGGAACTGGTTCAAGTGTACTAGCCATAATCTTGTTGTGCGGGTTGTCCCTTGCAAGTTATTGGGCAGTCGGCGGTACCATCGGTGGGTCCTGGGGCGAGGAGCATTACAAGAAACTATGGGAGAGAACGCATCCCGAAAATGTGAAGAAACCTCTATCACCCATGCCACATGACAAGCAGGTGATACCCGAATACAGGTACCACGACCACAACAACTTGAGCACCAAAAACAGAAGCAACGGAACTGAGGCTAAGAAGAAGGAATTCAGTAAGAAAAACGTGTACGTGGAACGTCCGGCCGCAGTCTTGCGCGAGCTATGCGCGCTCGTCGCGGACAATATGAAGTTCGACTGCTACCCTCAAGGCGACATCAATGAGGAGAACTGCGTCAAACGAGGTTGCTGCTGGAAGGTTACACAGATGAAGGGCGCTCCGTACTGCTACTACCCGTCGCAGTACGACACGTTCCGTTTCGTGAACATGACCGAGGACAAGCACTCCATGACCGTGTTCTACGAGAAGGCTCGACCCTCCGGTTATCCGGATGACTTTGAACTAGTCCGAATGGATTTTAAATACATGTCCGATGAAATTTTACAGATTAAGATATATGATGCGGAAAACAACCGATTCGAACCACCCTACCCAGAAATATCGATGGGCTCCAAGACCCTGACGGATATGAAATACAGAGTTGTCTTGGAAGGCTCGAAGATAGGGTTCAAAGTGATAAGGAATTCTGATGATGTTGTCATTTTCAACACCCAGGACGTGGGAGGGCTGATATTATCGGACAAGTTCCTTCAGATATCAGCAATACTTCCCACCGACCACGTGTTCGGCCTGGGAGAGAAGCGAGCGAGGTTCATGAACAACATGGACTGGCAGACCTTTGCCATATTCAACAGAGACAGGGCGCCCACGGAAGGGCTTAATTTGTATGGCACGCACCCTTTCTATCTGGCCGTGGAACAAAACGGACAAAGTCACGGGACGCTTCTACTCAATTCTAACGCTATGGACATAGTGCTGCAGCCGAGCCCCGGCATCACGTACCGCGCGACGGGCGGCGTGCTGCAGCTGTTCGTGCTGGCGGGCCCCAGCCCCGCGCTCGTCGCCCGCCAGTACACGGAGCTGGTGGGCAGGCCCTTCATGCCGCCCTACTGGTCCCTGGGCTTCCATCTGTGCAAGTTCAACTACGGGAACCTGAGCGTCATGGCGGACGTGTGGCAGAGGAACAGAGACGCTGGCATACCCTTTGACGTCCAGTGGAACGACATCGACTACATGACGCACAGCAACGACTTCACGCTGGACGCCGCCCGGTACGCGGGGCTGCCCGCTTTCGTGAAGAGGCTGCACTCCGAGGGCATGCACTACGTCATGATCTTTGATATTGGTATTGGAGCTTCAGAAAAGCCGGGCACGTATAAAGCCTACGACCGAGGCATAGAAATGGACATATTTGTGAAGAATTCTTCAAATCAACCGTTTATAGGAAGAGTCTGGAACAAAGGGTCCACGGTATATCCAGACTTCACTCATCCGAATTCGACTCCGTATTGGGTCGAAATGATGACGGACTTCCACAAACTCGTCCCGTACGACGGAGCGTGGATCGACATGAACGAGCCGTCGAACTTCGAGGACGGTCCCCTGCACGGCGCCTGCGCCCCCGAGCAGCTCCCGTACCGCCCGCGCACCGGCGACCCGCAGCTGCACACGCACACGCTGTGCATGGACGCCGCGCACCACGCCGGCCCGCACCGGCACTACCACGACCTGGTGGGGCTCATGCATGCCGTGGCCACCAACTTTGCCTTGCAAGAGATCAGAGGGAAGCGTCCGTTCATCATAAGCCGTGCGTCGTTCGTTGGACTGGGGAGGTACGCGGGCCACTGGAGCGGGGACATCAGCAGCCAGTGGCACGATATGAAGATGTCCATACCGGAGCTGCTGAGCTTCAGTCTGTTCGGAGTCCCCATGATGGGTGCCGACATCTGCGGCTTCAACGGCGACACCAACGTGGAGCTCTGCACGCGCTGGATGCAGCTCGGAGCCTTCTACCCCTTCTCGAGGAATCATAACACCGATACAGCCATTCCGCAAGACCCCGCGAGCCTGGGCCCGGCGGTGGTGCAGGCGAGCCGCGCCGCGCTGCGCACGCGCTACAAGCTGCTGCCCTACTACTACACGCTGTTCTGGCGCGCGCACGTGCTCGGCGACACCGTCGTGCGCCCGCTGCTCTTCGAATTTCCCGAGATGTCTGAGCTACATGACATCGACACCCAGTTCATGGTCGGGCCGCACGTGATGGTCGCGCCGGTGCTGGAGCCCGGCACGGACCGCGCCCGCGCCCTGTTCCCCGGCGCGCAGGGCTGGTACAGCCTGGCGACGGGCCGACACATCGCCACCAACGATTGGGCCGAAGTCTTGCACAACGACACTGTCTCTATTAAGGGCGGCGGCGTGGTGGTGCTGCAGGAGCCGGCGGCGCGCGGGCCCGTCAGCACCGGCTCGGCCCGCAGCGCGCCGCTGCAGCTGCTCGCGGCGCCCGACGCAGCCGCCGCCGCAAGCGGACGCCTCTACTGGGACGACGGCGACAGCCTGCACACCTACGAAGAGAAGAAATACAGTTACATAGAATTTTCACTGAACGGCACTGAAATCCAATCACATGTGAAATGGTGGGGATATGGAGTTCCGCTGTTCAACCAGCTGTCAATTCTCAATCAGCCCCCCGTCAAGCAAGTTCTGATCAACGGAATGCCGTGCGTGTCCCCCTGCTCGTTCACGTACTACAAGAAGAACAAAGTGTTGTCCATTATGATTAATTTGTCATTAGAGAAACCATTCAACGTCAGATGGTCATACGATGAGAAATATTTGAACAGGACCGGGGCATCGAGAAAAAATTGA

Protein

MPKIPYKPEKSGGNDDDYEIVSFDDFSDKSPGSKTDLLTLNDNINYRLYYEADKQSKYLENNGESSKGIDSHTETSLNGARNGSFRKLSNSFVPFGKSGGKTHTPLFSGVKSKNENESSSREHRYQRFSENSTFMQRVCDMMPGTGSSVLAIILLCGLSLASYWAVGGTIGGSWGEEHYKKLWERTHPENVKKPLSPMPHDKQVIPEYRYHDHNNLSTKNRSNGTEAKKKEFSKKNVYVERPAAVLRELCALVADNMKFDCYPQGDINEENCVKRGCCWKVTQMKGAPYCYYPSQYDTFRFVNMTEDKHSMTVFYEKARPSGYPDDFELVRMDFKYMSDEILQIKIYDAENNRFEPPYPEISMGSKTLTDMKYRVVLEGSKIGFKVIRNSDDVVIFNTQDVGGLILSDKFLQISAILPTDHVFGLGEKRARFMNNMDWQTFAIFNRDRAPTEGLNLYGTHPFYLAVEQNGQSHGTLLLNSNAMDIVLQPSPGITYRATGGVLQLFVLAGPSPALVARQYTELVGRPFMPPYWSLGFHLCKFNYGNLSVMADVWQRNRDAGIPFDVQWNDIDYMTHSNDFTLDAARYAGLPAFVKRLHSEGMHYVMIFDIGIGASEKPGTYKAYDRGIEMDIFVKNSSNQPFIGRVWNKGSTVYPDFTHPNSTPYWVEMMTDFHKLVPYDGAWIDMNEPSNFEDGPLHGACAPEQLPYRPRTGDPQLHTHTLCMDAAHHAGPHRHYHDLVGLMHAVATNFALQEIRGKRPFIISRASFVGLGRYAGHWSGDISSQWHDMKMSIPELLSFSLFGVPMMGADICGFNGDTNVELCTRWMQLGAFYPFSRNHNTDTAIPQDPASLGPAVVQASRAALRTRYKLLPYYYTLFWRAHVLGDTVVRPLLFEFPEMSELHDIDTQFMVGPHVMVAPVLEPGTDRARALFPGAQGWYSLATGRHIATNDWAEVLHNDTVSIKGGGVVVLQEPAARGPVSTGSARSAPLQLLAAPDAAAAASGRLYWDDGDSLHTYEEKKYSYIEFSLNGTEIQSHVKWWGYGVPLFNQLSILNQPPVKQVLINGMPCVSPCSFTYYKKNKVLSIMINLSLEKPFNVRWSYDEKYLNRTGASRKN

Description

Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.

Cofactor

[4Fe-4S] cluster

Subunit

Heterotetramer of 2 NUBP1 and 2 NUBP2 chains.

Similarity

Belongs to the glycosyl hydrolase 31 family.
Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.

Uniprot

H9JRB7   A0A2A4K069   A0A3S2NXS9   A0A212F808   A0A194QAX6   A0A194QQ36   + More
A0A067R6F4   D6WDN8   A0A1Y1L9Q9   A0A1W4X0K2   A0A1W4WPS6   A0A1W4X0S9   A0A1W4WPS7   A0A1W4WZI1   N6UEN5   U4URX8   A0A154PP69   A0A1B6F1T2   E2BEF1   A0A232EPJ9   A0A088AP40   E9INW4   A0A195CTJ7   E9H648   E2A599   A0A0L7R0H2   A0A2H8TF00   A0A2A3E141   A0A0J7L2F7   A0A0P5WPA1   A0A0P5WQY7   A0A151WZI2   A0A0P5XJE2   A0A0N8CYY9   A0A158NT86   A0A0P5WK62   A0A0P5VR91   A0A0P5Y9E2   A0A0P5SLI1   A0A0P5YQP4   A0A0P5VMU5   A0A0P5EBP1   A0A0P6A4I4   A0A0P5BFG8   A0A0P5UZ20   A0A0P5SCL6   A0A0P5VQY0   A0A0N8CE76   A0A0P5TGZ7   A0A0P5XVY9   A0A0N8D313   A0A0P5TQQ9   A0A0P5SYE4   A0A0P5ECX5   A0A0N8E534   A0A0P5VH76   A0A0P5EKD1   A0A0P5AQD2   A0A0P5HER8   A0A0P5KSM1   A0A0N7ZS03   A0A0N7ZSQ9   A0A195E332   A0A1S6J0W8   A0A0P5V4A1   A0A195BSZ9   J9JP90   A0A0N8A1L5   A0A151JVQ8   A0A0P5CX84   A0A0P5KGJ0   A0A0P5PRM3   A0A0N8A9J0   A0A0P5K557   A0A0P5NCV0   K7IPK3   F4WH36   A0A0P5KBP7   A0A0N8E9A8   A0A0P6HR96   A0A0P6GG39   A0A0N8B239   A0A0P5QVL2   A0A0P5QH45   A0A1B6EMJ2   A0A0N8AEN9   A0A0P5WH59   A0A0P6AQT6   A0A0P5VMH1   A0A0P6B2W6   A0A0P4YCU2   A0A3L8D368   A0A1B6D5E9   A0A0P4W3H6  

Pubmed

19121390    22118469    26354079    24845553    18362917    19820115    + More
28004739    23537049    20798317    28648823    21282665    21292972    21347285    27414796    20075255    21719571    30249741   

EMBL

BABH01016069    BABH01016070    BABH01016071    NWSH01000295    PCG77661.1    RSAL01000107    + More
RVE47283.1    AGBW02009812    OWR49877.1    KQ459252    KPJ02145.1    KQ461185    KPJ07474.1    KK852855    KDR14932.1    KQ971322    EEZ99945.2    GEZM01061536    GEZM01061535    JAV70402.1    APGK01038392    KB740954    ENN77102.1    KB632338    ERL92906.1    KQ435007    KZC13685.1    GECZ01025718    JAS44051.1    GL447768    EFN85996.1    NNAY01002918    OXU20309.1    GL764397    EFZ17773.1    KQ977329    KYN03454.1    GL732596    EFX72744.1    GL436894    EFN71395.1    KQ414670    KOC64342.1    GFXV01000854    MBW12659.1    KZ288483    PBC25244.1    LBMM01001148    KMQ96823.1    GDIP01083482    JAM20233.1    GDIP01083481    JAM20234.1    KQ982636    KYQ53310.1    GDIP01083483    JAM20232.1    GDIP01085135    JAM18580.1    ADTU01025716    GDIP01085134    JAM18581.1    GDIP01096642    JAM07073.1    GDIP01061188    JAM42527.1    GDIP01138273    JAL65441.1    GDIP01055037    JAM48678.1    GDIP01097885    JAM05830.1    GDIP01143678    JAJ79724.1    GDIP01047332    JAM56383.1    GDIP01200426    JAJ22976.1    GDIP01109532    JAL94182.1    GDIP01141480    GDIP01140440    JAL62234.1    GDIP01113691    GDIP01096643    JAM07072.1    GDIP01140439    JAL63275.1    GDIP01126376    JAL77338.1    GDIP01231777    GDIP01218312    GDIP01209165    GDIP01200425    GDIP01199064    GDIP01139380    GDIP01133237    GDIP01131987    GDIP01130632    GDIP01125223    GDIP01122927    GDIP01086434    GDIP01066637    GDIP01063940    GDIP01050894    GDIP01045944    GDIP01044448    JAM37078.1    GDIP01240574    GDIP01239481    GDIP01219724    GDIP01198027    GDIP01196017    GDIP01160969    GDIP01157071    GDIP01156027    GDIP01124220    GDIP01109530    GDIP01094379    GDIP01089736    GDIP01087533    GDIP01073743    GDIP01072636    GDIP01071336    GDIP01052155    GDIQ01067196    JAM29972.1    JAN27541.1    GDIP01122928    JAL80786.1    GDIP01138274    JAL65440.1    GDIP01143679    JAJ79723.1    GDIQ01060996    JAN33741.1    GDIP01115035    JAL88679.1    GDIP01240575    GDIP01239482    GDIP01220876    GDIP01219723    GDIP01198028    GDIP01165672    GDIP01164972    GDIP01158579    GDIP01157070    GDIP01156026    GDIP01145730    GDIQ01167853    GDIQ01152507    GDIP01124219    GDIP01109531    GDIP01094378    GDIP01087532    GDIP01073744    GDIP01072637    GDIP01071337    GDIP01052156    GDIQ01067245    LRGB01000642    JAJ64823.1    JAK83872.1    KZS17340.1    GDIP01230519    GDIP01200424    GDIP01199063    GDIP01197178    GDIP01167170    GDIP01158024    GDIP01139381    GDIP01133238    GDIP01130631    GDIP01125222    GDIP01122926    GDIP01086435    GDIP01063941    GDIP01044447    GDIP01040391    JAJ22978.1    GDIQ01230834    JAK20891.1    GDIQ01179790    JAK71935.1    GDIP01218313    JAJ05089.1    GDIP01216265    JAJ07137.1    KQ979701    KYN19575.1    KU764423    AQS60670.1    GDIP01104626    JAL99088.1    KQ976409    KYM90922.1    ABLF02032902    GDIP01191417    JAJ31985.1    KQ981686    KYN37953.1    GDIP01164171    JAJ59231.1    GDIQ01186042    JAK65683.1    GDIQ01145461    JAL06265.1    GDIP01169217    JAJ54185.1    GDIQ01189102    JAK62623.1    GDIQ01147069    JAL04657.1    GL888148    EGI66515.1    GDIQ01187649    JAK64076.1    GDIQ01049204    JAN45533.1    GDIQ01016544    JAN78193.1    GDIQ01053707    JAN41030.1    GDIQ01220347    JAK31378.1    GDIQ01129314    JAL22412.1    GDIQ01117236    JAL34490.1    GECZ01030630    GECZ01023675    JAS39139.1    JAS46094.1    GDIP01154825    JAJ68577.1    GDIP01099273    JAM04442.1    GDIP01039597    JAM64118.1    GDIP01099274    JAM04441.1    GDIP01021205    JAM82510.1    GDIP01232918    JAI90483.1    QOIP01000014    RLU14947.1    GEDC01016377    JAS20921.1    GDRN01075433    JAI63060.1   

Proteomes

UP000005204    UP000218220    UP000283053    UP000007151    UP000053268    UP000053240    + More
UP000027135    UP000007266    UP000192223    UP000019118    UP000030742    UP000076502    UP000008237    UP000215335    UP000005203    UP000078542    UP000000305    UP000000311    UP000053825    UP000242457    UP000036403    UP000075809    UP000005205    UP000076858    UP000078492    UP000078540    UP000007819    UP000078541    UP000002358    UP000007755    UP000279307   

PRIDE

H9JRB7    A0A088AP40    E9INW4    E2A599    F4WH36   

Pfam

PF13802   Gal_mutarotas_2        + More
PF16863   NtCtMGAM_N
PF00088   Trefoil
PF01055   Glyco_hydro_31
PF17137   DUF5110
PF10609   ParA

Interpro

IPR030459   Glyco_hydro_31_CS        + More
IPR011013   Gal_mutarotase_sf_dom       
IPR000322   Glyco_hydro_31       
IPR025887   Glyco_hydro_31_N_dom       
IPR017853   Glycoside_hydrolase_SF       
IPR000519   P_trefoil_dom       
IPR031727   Gal_mutarotase_N       
IPR013780   Glyco_hydro_b       
IPR030458   Glyco_hydro_31_AS       
IPR017957   P_trefoil_CS       
IPR033403   DUF5110       
IPR033756   YlxH/NBP35       
IPR000808   Mrp_CS       
IPR028601   NUBP1/Nbp35       
IPR027417   P-loop_NTPase       
IPR019591   Mrp/NBP35_ATP-bd       

SUPFAM

SSF51445   SSF51445        + More
SSF74650   SSF74650       
SSF52540   SSF52540       

Gene 3D

2.60.40.1180    

CDD

cd00111  Trefoil
cd02037  MRP-like

ProteinModelPortal

H9JRB7   A0A2A4K069   A0A3S2NXS9   A0A212F808   A0A194QAX6   A0A194QQ36   + More
A0A067R6F4   D6WDN8   A0A1Y1L9Q9   A0A1W4X0K2   A0A1W4WPS6   A0A1W4X0S9   A0A1W4WPS7   A0A1W4WZI1   N6UEN5   U4URX8   A0A154PP69   A0A1B6F1T2   E2BEF1   A0A232EPJ9   A0A088AP40   E9INW4   A0A195CTJ7   E9H648   E2A599   A0A0L7R0H2   A0A2H8TF00   A0A2A3E141   A0A0J7L2F7   A0A0P5WPA1   A0A0P5WQY7   A0A151WZI2   A0A0P5XJE2   A0A0N8CYY9   A0A158NT86   A0A0P5WK62   A0A0P5VR91   A0A0P5Y9E2   A0A0P5SLI1   A0A0P5YQP4   A0A0P5VMU5   A0A0P5EBP1   A0A0P6A4I4   A0A0P5BFG8   A0A0P5UZ20   A0A0P5SCL6   A0A0P5VQY0   A0A0N8CE76   A0A0P5TGZ7   A0A0P5XVY9   A0A0N8D313   A0A0P5TQQ9   A0A0P5SYE4   A0A0P5ECX5   A0A0N8E534   A0A0P5VH76   A0A0P5EKD1   A0A0P5AQD2   A0A0P5HER8   A0A0P5KSM1   A0A0N7ZS03   A0A0N7ZSQ9   A0A195E332   A0A1S6J0W8   A0A0P5V4A1   A0A195BSZ9   J9JP90   A0A0N8A1L5   A0A151JVQ8   A0A0P5CX84   A0A0P5KGJ0   A0A0P5PRM3   A0A0N8A9J0   A0A0P5K557   A0A0P5NCV0   K7IPK3   F4WH36   A0A0P5KBP7   A0A0N8E9A8   A0A0P6HR96   A0A0P6GG39   A0A0N8B239   A0A0P5QVL2   A0A0P5QH45   A0A1B6EMJ2   A0A0N8AEN9   A0A0P5WH59   A0A0P6AQT6   A0A0P5VMH1   A0A0P6B2W6   A0A0P4YCU2   A0A3L8D368   A0A1B6D5E9   A0A0P4W3H6  

PDB

5NN8     E-value=0,     Score=1686

KEGG

101736905    K12316 lysosomal alpha-glucosidase [EC:3.2.1.20] | (RefSeq) lysosomal alpha-glucosidase-like

PATHWAY

00052    Galactose metabolism - Bombyx mori (domestic silkworm)
00500    Starch and sucrose metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04142    Lysosome - Bombyx mori (domestic silkworm)

GO

GO:0004553   GO:0030246   GO:0005975   GO:0016021   GO:0016226   GO:0005524   GO:0051539   GO:0005737   GO:0046872   GO:0016798   GO:0008152   GO:0003824   GO:0022891   GO:0043565   GO:0016567   GO:0016020   GO:0005634   GO:0006260  

Subcellular location

Cytoplasm  

Length:

1115

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

19.6402699999999

Exp number, first 60 AAs:

0

Total prob of N-in:

0.86889

inside

1  -  143

TMhelix

144  -  166

outside

167  -  1115

 

 

Pi

16.441109

Theta

16.881454

Tajima's D

-0.923188

CLR

1.311788

CSRT

0.150042497875106

Interpretation

Uncertain