Gene

KWMTBOMO06879  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012075

Annotation

PREDICTED:_glycine_cleavage_system_H_protein?_mitochondrial-like_isoform_X2_[Papilio_machaon]

Location

Bomo_Chr11(+):18220913-18222502      View in EpiBrowser

Full name

Glycine cleavage system H protein       + More
Glycine cleavage system H protein, mitochondrial      

Alternative Name

Protein pumpless

Location in the cell

Nuclear   Reliability : 1.893

CDS

ATGGCAATACAGAGATGCTTATTACAAATAGTGAAAACTTACAAATTAAGGCATCATTTACAGTCAAACATCAGACAAACATACTGTATGTTATGCCTGAAGTACAGCACAGGTGGATCATCAAGGAAATATACTGATAGACATGAATGGGTTACAATAGACAAAGATATAGGTACAGTTGGGGTTAGCGAATATGCCCAAGAATCTCTTGGTGATGTTGTTTTTGCACAGCTGCCAGACCCCGGAACAGACCTTAAAGCTGGTGATGAGTGCGGTGCCTTAGAAAGTGTGAAAGCTGCTAGTGAAATCTATTCTCCATTATCTGGTACTGTTACGGAGAAAAATAAAGATGTAGAAGACAAACCCGCACTAATAAATACATCTTGTTATGACAAAGGATGGTTGTTTAGGTTGAAAATAATTAAGCAAAGCGAGATAAATGATCTCATGACTGAAGAAGAGTACAAGAAATTTTTGGAAACAGATGCTGAGAAACCAGAATAA

Protein

MAIQRCLLQIVKTYKLRHHLQSNIRQTYCMLCLKYSTGGSSRKYTDRHEWVTIDKDIGTVGVSEYAQESLGDVVFAQLPDPGTDLKAGDECGALESVKAASEIYSPLSGTVTEKNKDVEDKPALINTSCYDKGWLFRLKIIKQSEINDLMTEEEYKKFLETDAEKPE

Description

The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity).

Cofactor

(R)-lipoate

Subunit

The glycine cleavage system is composed of four proteins: P, T, L and H.

Similarity

Belongs to the GcvH family.

Keywords

Complete proteome   Lipoyl   Mitochondrion   Reference proteome   Transit peptide  

Feature

chain  Glycine cleavage system H protein, mitochondrial

Uniprot

H9JRB5   S4PAH8   A0A194QPL1   A0A2Z5UM28   A0A194QFA1   A0A0L7LTG1   + More
A0A2A4K1Z9   I4DKF6   A0A2H1V4A7   A0A1I8NYC4   A0A1L8EDH4   A0A2M4DPE1   A0A1A9WTF4   T1DNG6   A0A182K926   A0A182X4D8   A0A2M4AIJ8   A0A2M4DNF6   A0A182WBU4   B0XAY4   A0A182Y7Y8   A0A182QSW9   A0A084WMP1   A0A2M3Z8X8   A0A182MGP4   A0A2M3ZL46   A0A2M4C1S6   A0A2M4C1V5   A0A2M4C1R6   W5JCV0   A0A182NIU5   A0A1Q3FCT0   A0A034W7C5   A0A0K8V0H6   A0A1B0DIS6   A0A182LKJ3   Q7PI72   A0A182I4D6   A0A0A1WMZ9   A0A182TW96   A0A0A1XI15   A0A0A1X597   A0A1Q3FD15   A0A182JFM6   A0A1I8MN24   A0A1B0CS70   A0A182V7Y1   A0A1L8E2K4   B4KUM5   A0A226F2Z4   A0A0L0CQS4   A0A182PRX5   Q0IE94   B4N529   A0A2W1BKD3   Q17PI9   A0A1A9VYN2   A0A2A4JPE5   J3JVI8   D3TM64   A0A0M3QWI2   U5EVI3   B4LHB5   A0A1B0B569   A0A3B0JY29   A0A2H1VKC6   A0A182GLF3   Q2LYP9   A0A131Z7I5   B4H5Z2   A0A194QYE4   W8CBG2   A0A1W4V9I0   A0A1J1IUW5   T1J4Y5   A0A224YX98   A0A131XBX6   L7M6I6   B3M6S0   A0A194PLJ9   B4J126   A0A182FFF6   E2BX40   A0A026VUE0   A0A2J7RP67   R4WKC4   E2AWJ4   C9W1H0   A0A182RSA4   B4IAL9   B4QJQ4   H9J2X8   Q9U616   A0A023G6D0   E0W0W4   A0A0B4J2U2   A0A1W4WMW5   A0A1D2NCT7   A0A232F3J0   B3NIX7  

Pubmed

19121390    23622113    26354079    26227816    22651552    25244985    + More
24438588    20920257    23761445    25348373    20966253    12364791    14747013    17210077    25830018    25315136    17994087    26108605    17510324    28756777    22516182    20353571    26483478    15632085    26830274    24495485    28797301    28049606    25576852    20798317    24508170    23691247    20650005    24029695    22936249    10556053    10731132    12537572    12537569    20566863    20075255    27289101    28648823   

EMBL

BABH01016071    GAIX01003259    JAA89301.1    KQ461185    KPJ07473.1    AP017502    + More
BBB06797.1    KQ459252    KPJ02146.1    JTDY01000138    KOB78644.1    NWSH01000295    PCG77662.1    AK401774    BAM18396.1    ODYU01000597    SOQ35667.1    GFDG01002114    JAV16685.1    GGFL01014790    MBW78968.1    GAMD01002900    JAA98690.1    GGFK01007289    MBW40610.1    GGFL01014891    MBW79069.1    DS232603    EDS43954.1    AXCN02000477    ATLV01024498    KE525352    KFB51485.1    GGFM01004201    MBW24952.1    AXCM01002601    GGFM01008387    MBW29138.1    GGFJ01010112    MBW59253.1    GGFJ01010113    MBW59254.1    GGFJ01010111    MBW59252.1    ADMH02001752    ETN61173.1    GFDL01009661    JAV25384.1    GAKP01008907    JAC50045.1    GDHF01019887    JAI32427.1    AJVK01063079    AAAB01008960    EAA44254.4    APCN01002303    GBXI01013873    JAD00419.1    GBXI01003671    JAD10621.1    GBXI01007783    JAD06509.1    GFDL01009652    JAV25393.1    AJWK01025711    GFDF01001114    JAV12970.1    CH933809    EDW18253.1    LNIX01000001    OXA64159.1    JRES01000036    KNC34708.1    CH477955    EAT34816.1    CH964101    EDW79468.1    KZ150031    PZC74731.1    CH477191    EAT48628.1    NWSH01000836    PCG73935.1    BT127256    AEE62218.1    EZ422516    ADD18792.1    CP012525    ALC44193.1    GANO01003393    JAB56478.1    CH940647    EDW70628.1    JXJN01008626    OUUW01000009    SPP85332.1    ODYU01003024    SOQ41273.1    JXUM01072026    KQ562697    KXJ75313.1    CH379069    EAL29812.1    GEDV01001772    JAP86785.1    CH479212    EDW33209.1    KQ460953    KPJ10319.1    GAMC01004821    JAC01735.1    CVRI01000058    CRL02934.1    JH431850    GFPF01008075    MAA19221.1    GEFH01003908    JAP64673.1    GACK01006266    JAA58768.1    CH902618    EDV39756.1    KQ459599    KPI94311.1    CH916366    EDV96881.1    GL451202    EFN79759.1    KK111147    EZA46469.1    NEVH01002140    PNF42630.1    AK418025    BAN21240.1    GL443346    EFN62158.1    EZ406118    ACX53917.1    CH480826    EDW44332.1    CM000363    CM002912    EDX11354.1    KMZ00960.1    BABH01031223    AF203725    AE014296    AY075433    GBBM01005632    JAC29786.1    DS235862    EEB19270.1    AAZX01005267    LJIJ01000088    ODN03051.1    NNAY01001139    OXU25013.1    CH954178    EDV52623.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000037510    UP000218220    UP000095300    + More
UP000091820    UP000075881    UP000076407    UP000075920    UP000002320    UP000076408    UP000075886    UP000030765    UP000075883    UP000000673    UP000075884    UP000092462    UP000075882    UP000007062    UP000075840    UP000075902    UP000075880    UP000095301    UP000092461    UP000075903    UP000009192    UP000198287    UP000037069    UP000075885    UP000008820    UP000007798    UP000078200    UP000092553    UP000008792    UP000092460    UP000268350    UP000069940    UP000249989    UP000001819    UP000008744    UP000192221    UP000183832    UP000007801    UP000001070    UP000069272    UP000008237    UP000053097    UP000235965    UP000000311    UP000075900    UP000001292    UP000000304    UP000000803    UP000009046    UP000002358    UP000192223    UP000094527    UP000215335    UP000008711   

PRIDE

H9JRB5    H9J2X8    Q9U616   

Pfam

PF01597   GCV_H

Interpro

IPR011053   Single_hybrid_motif        + More
IPR017453   GCV_H_sub       
IPR002930   GCV_H       
IPR033753   GCV_H/Fam206       
IPR003016   2-oxoA_DH_lipoyl-BS       
IPR000089   Biotin_lipoyl       

SUPFAM

SSF51230   SSF51230       

CDD

cd06848  GCS_H

ProteinModelPortal

H9JRB5   S4PAH8   A0A194QPL1   A0A2Z5UM28   A0A194QFA1   A0A0L7LTG1   + More
A0A2A4K1Z9   I4DKF6   A0A2H1V4A7   A0A1I8NYC4   A0A1L8EDH4   A0A2M4DPE1   A0A1A9WTF4   T1DNG6   A0A182K926   A0A182X4D8   A0A2M4AIJ8   A0A2M4DNF6   A0A182WBU4   B0XAY4   A0A182Y7Y8   A0A182QSW9   A0A084WMP1   A0A2M3Z8X8   A0A182MGP4   A0A2M3ZL46   A0A2M4C1S6   A0A2M4C1V5   A0A2M4C1R6   W5JCV0   A0A182NIU5   A0A1Q3FCT0   A0A034W7C5   A0A0K8V0H6   A0A1B0DIS6   A0A182LKJ3   Q7PI72   A0A182I4D6   A0A0A1WMZ9   A0A182TW96   A0A0A1XI15   A0A0A1X597   A0A1Q3FD15   A0A182JFM6   A0A1I8MN24   A0A1B0CS70   A0A182V7Y1   A0A1L8E2K4   B4KUM5   A0A226F2Z4   A0A0L0CQS4   A0A182PRX5   Q0IE94   B4N529   A0A2W1BKD3   Q17PI9   A0A1A9VYN2   A0A2A4JPE5   J3JVI8   D3TM64   A0A0M3QWI2   U5EVI3   B4LHB5   A0A1B0B569   A0A3B0JY29   A0A2H1VKC6   A0A182GLF3   Q2LYP9   A0A131Z7I5   B4H5Z2   A0A194QYE4   W8CBG2   A0A1W4V9I0   A0A1J1IUW5   T1J4Y5   A0A224YX98   A0A131XBX6   L7M6I6   B3M6S0   A0A194PLJ9   B4J126   A0A182FFF6   E2BX40   A0A026VUE0   A0A2J7RP67   R4WKC4   E2AWJ4   C9W1H0   A0A182RSA4   B4IAL9   B4QJQ4   H9J2X8   Q9U616   A0A023G6D0   E0W0W4   A0A0B4J2U2   A0A1W4WMW5   A0A1D2NCT7   A0A232F3J0   B3NIX7  

PDB

2EDG     E-value=5.70235e-36,     Score=373

KEGG

101737703    K02437 glycine cleavage system H protein | (RefSeq) glycine cleavage system H protein, mitochondrial

PATHWAY

00260    Glycine, serine and threonine metabolism - Bombyx mori (domestic silkworm)
00630    Glyoxylate and dicarboxylate metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01200    Carbon metabolism - Bombyx mori (domestic silkworm)

GO

GO:0005739   GO:0005960   GO:0019464   GO:0016021   GO:0006546   GO:0005215   GO:0016020   GO:0022891   GO:0043565   GO:0016567   GO:0005634   GO:0006260  

PANTHER

PTHR11715  

Subcellular location

Mitochondrion  

Length:

167

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00055

Exp number, first 60 AAs:

0.00055

Total prob of N-in:

0.12792

outside

1  -  167

 

 

Pi

14.463874

Theta

15.585574

Tajima's D

-0.884854

CLR

0.695412

CSRT

0.16079196040198

Interpretation

Uncertain