Silkworm Genome Informatics Database

Gene

KWMTBOMO06863

Pre Gene Modal

BGIBMGA012084

Annotation

PREDICTED:_adenylate_cyclase_type_2-like_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr11(-):17819875-17859825 View in EpiBrowser

Full name

Adenylate cyclase

Location in the cell

PlasmaMembrane Reliability : 3.972

CDS

ATGAGTGAAAGAGAAGAGGAGGGAACGGAATTGGAACTAGAGGCATTATACAGAAGATACTGTGTCCGACTCAAACACGCGCTATTTGTGTCAGCACTGTGTGTTACATTAGCGTGCTGCGTCACATTGCTGACGATCGTCTGCATTCAGCATTCACAAGAACTGTCAACTCAAGTGAAGGCCATCACGACTCTCTCGGTCATAACCTTCGTGCTCACCATAGTTCTGTGCTTGGAGTTGCTGCCGGCTGCAGCAGAGTGTGAGACCTTGGCGCTATCAGGCTCGTTACTTGTGACAGTATGCCTTGGGGCTGGTACTCTTGTAGCAACCAATCACGCACCGCTGCCTCTCTTTGCTTTGATTTTGATGGTGCACACGATGATGCCCATAGCTAGAACGATAGCGTTGGTTATCTCTGCTGTCCTGACGGTCGCCTACGCGGCTTTGGCGGTTGGGGTGCGTCCCGAGACCGAAGTGCATTTTTATCATCAGTTGGTGTGCGAGTTAGCGCTTCTGCTCTCCGCGAGTGGGATCGGAATGTACTACCGCGCGCTGACCGAGAGGGCGCACCGGAATACCTTCGCCGGCACCAGGACTTGTCTTGAACAGCGCGTGAAGTTGGAGTGCGAGAGGGAGCAGCAGGAACGACTGCTTCTCTCCGTCATACCAGCGTATATTGCTGCTGAGAGAAGAGGGGGAAATTTGGCTACTGCGGTACGAATTTCAGTTAACGATTTACAGAGAAGAGGGGGAAATTTGGCTACTGCGGTACGAATTTCAGTTAACGATTTACAGAGCAGAGGGGGAAATTTGGAGATGAGCTGA

Protein

MSEREEEGTELELEALYRRYCVRLKHALFVSALCVTLACCVTLLTIVCIQHSQELSTQVKAITTLSVITFVLTIVLCLELLPAAAECETLALSGSLLVTVCLGAGTLVATNHAPLPLFALILMVHTMMPIARTIALVISAVLTVAYAALAVGVRPETEVHFYHQLVCELALLLSASGIGMYYRALTERAHRNTFAGTRTCLEQRVKLECEREQQERLLLSVIPAYIAAERRGGNLATAVRISVNDLQRRGGNLATAVRISVNDLQSRGGNLEMS

Description

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.

Catalytic Activity

ATP = 3',5'-cyclic AMP + diphosphate

Cofactor

Mg(2+)

Similarity

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Uniprot

A0A2A4JUB5 A0A3S2NW72 A0A194Q9S2 V5IB33 A0A1W4X9X4 U4TU54 + More
U4U157 N6UJN3 A0A139WLU2 A0A1Y1L8L2 A0A1Y1L9N5 A0A1B6C545 B0WDM2 A0A0P6J1E0 Q16XH3 A0A1S4FKZ8 A0A023EWT6 A0A1J1J7C2

EC Number

4.6.1.1

Pubmed

26354079 23537049 18362917 19820115 28004739 26999592 + More
17510324 24945155

EMBL

NWSH01000605 PCG75366.1 RSAL01000138 RVE46181.1 KQ459252 KPJ02159.1 + More
GALX01000135 JAB68331.1 KB630170 ERL83448.1 KB630664 KB632363 ERL83770.1 ERL93534.1 APGK01021376 APGK01021377 APGK01021378 APGK01021379 APGK01021380 APGK01021381 APGK01021382 APGK01021383 APGK01021384 APGK01021385 KB740317 ENN80881.1 KQ971319 KYB28863.1 GEZM01065935 JAV68285.1 GEZM01065934 JAV68286.1 GEDC01028889 JAS08409.1 DS231899 EDS44721.1 GDUN01000044 JAN95875.1 CH477538 EAT39337.1 GAPW01000036 JAC13562.1 CVRI01000070 CRL07366.1

Proteomes

UP000218220 UP000283053 UP000053268 UP000192223 UP000030742 UP000019118 + More
UP000007266 UP000002320 UP000008820 UP000183832

Pfam

PF16214 AC_N + More
PF00211 Guanylate_cyc

Interpro

IPR032628   AC_N        + More
IPR029787   Nucleotide_cyclase
IPR001054   A/G_cyclase
IPR018297   A/G_cyclase_CS
IPR030672   Adcy

SUPFAM

SSF55073 SSF55073

Gene 3D

3.30.70.1230

ProteinModelPortal

A0A2A4JUB5 A0A3S2NW72 A0A194Q9S2 V5IB33 A0A1W4X9X4 U4TU54 + More
U4U157 N6UJN3 A0A139WLU2 A0A1Y1L8L2 A0A1Y1L9N5 A0A1B6C545 B0WDM2 A0A0P6J1E0 Q16XH3 A0A1S4FKZ8 A0A023EWT6 A0A1J1J7C2

KEGG

101737606 K08042 adenylate cyclase 2 [EC:4.6.1.1] | (RefSeq) adenylate cyclase type 2-like

PATHWAY

00230    Purine metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04213    Longevity regulating pathway - multiple species - Bombyx mori (domestic silkworm)

GO

GO:0016021 GO:0009190 GO:0016849 GO:0000166 GO:0035556 GO:0006171 GO:0007189 GO:0004016 GO:0046872 GO:0005887 GO:0005524 GO:0005886

Length:

274

Number of predicted TMHs:

5

Exp number of AAs in TMHs:

107.55301

Exp number, first 60 AAs:

22.83531

Total prob of N-in:

0.88954

POSSIBLE N-term signal

sequence

inside

1 - 26

TMhelix

27 - 49

outside

50 - 58

TMhelix

59 - 81

inside

82 - 87

TMhelix

88 - 110

outside

111 - 129

TMhelix

130 - 152

inside

153 - 158

TMhelix

159 - 181

outside

182 - 274

Pi

18.665223

Theta

19.37228

Tajima's D

-1.074628

CLR

2.505474

CSRT

0.126943652817359

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics