Silkworm Genome Informatics Database

Gene

KWMTBOMO06860

Pre Gene Modal

BGIBMGA012086

Annotation

PREDICTED:_adenylate_cyclase_type_2-like_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr11(-):17717288-17741476 View in EpiBrowser

Full name

Adenylate cyclase

Location in the cell

Nuclear Reliability : 2.122

CDS

ATGCTGAAAATGGCGGACGCGTGCGTCGACACGTCGAAGCAGACACGCTTCCACAAGATGCACGTGCAGAGGCACAACAACGTCAGCATACTGTACGCCGACATCGTGAACTTCACGCCGTTGTCGGAACGACTCAGCGCATCGGACCTGGTGAAGACTCTGAACGAACTATTCGGGAGGTTCGATCAAATTGCACAGGAAAATCAGTGTATGAGAATCAAGATCTTGGGTGATTGCTACTACTGCGTCTCCGGCTTGCCAGTTTCAAGACCTAACCATGCTTTCAACTGCGTCAATATGGGCCTACAAATGATTGACGCTATCAGATTCGTCCGTGAAGCGACAGGCTTTAACGTGGACATGCGCATCGGAATCCATACTGGGAACGTCCTTTGCGGCGTGTTGGGACTTCGGAAGTGGCAGTTCGACGTTTGGAGCGATGACGTCACGTTGGCGAATCACATGGAATCCGGCGGTATTGCCGGGCGTGTGCACATTACGAAAGCAACGATGCTCCAGCTAGGTGGAAAATTTGAAGTCGAACCAGGAGACGGTGCGTCGCGTGAGGGTTACCTCGCTGATCACAAAGTGGAAACGTACCTTATTGTTCCTCCGAAGAAGCCTTCGGAAAACGGTCGCCTCTCCATATGCACGGTAGACCGCAAAGCCAGTATTGTTTCATCGTTGTACCAAGAAACGTCACCGACGAGAGCGAAGGACAACATTAGTCCGGTACCCTCGCAGCACAGCTTCGTTGAAGACAGCGTCAAAGTTCTCAGATCAGAGTCGATGAGAGTGGAGCCAGCGCGAACGGAGTCCATTAGAATTGTCGGTGACCTGAGCCGAAGAGCTTCGGTAAGAGTGGACGGTCCAAAATCAGTGGCCTTTGAAAGTGGTCATGTGGCGACCAGCTCTGGTGAAGGCCTCAGCAATGGAAGCGCGGTTGCTATTAAGCCAAAGAGTCGAAGTGGTTCCATTATTGGAGCCATCAGCCCTATCATGGGAACTGCTACTCCCGGGATCCCTTCGCGATCTCGTCCTTCGAGTAGAATGACAAAATACGTAGAATGTTGGGGAGCGGACAAACCTTTCGCTAACATAACTGATTCTACTCTAGCGAAAAACATTGGAATCTCTAGCTTAGCAATGATCGAACAGAACTTACTGCCTCAGCGTACCAATTGTTGTGACTGCAGCAACAACACCGAAGGCATAAACCGTGTGACGCTCTGGTTCAAGAACAGCAATCAGGAACGACAATATAGGAACCAATCGGACACGCAGTTCAAGTATAACATCGCCTGCGCATCGCTACTGTTCACGTTATTGGCATTCACCCAACTACTCACCGTACCGAAGTAA

Protein

MLKMADACVDTSKQTRFHKMHVQRHNNVSILYADIVNFTPLSERLSASDLVKTLNELFGRFDQIAQENQCMRIKILGDCYYCVSGLPVSRPNHAFNCVNMGLQMIDAIRFVREATGFNVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGIAGRVHITKATMLQLGGKFEVEPGDGASREGYLADHKVETYLIVPPKKPSENGRLSICTVDRKASIVSSLYQETSPTRAKDNISPVPSQHSFVEDSVKVLRSESMRVEPARTESIRIVGDLSRRASVRVDGPKSVAFESGHVATSSGEGLSNGSAVAIKPKSRSGSIIGAISPIMGTATPGIPSRSRPSSRMTKYVECWGADKPFANITDSTLAKNIGISSLAMIEQNLLPQRTNCCDCSNNTEGINRVTLWFKNSNQERQYRNQSDTQFKYNIACASLLFTLLAFTQLLTVPK

Description

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.

Catalytic Activity

ATP = 3',5'-cyclic AMP + diphosphate

Cofactor

Mg(2+)

Similarity

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Uniprot

H9JRC6 A0A194QPJ7 A0A194QFB6 A0A212F2P4 A0A2A4JBA4 A0A1B0D560 + More
A0A195BKA9 A0A1B0CDA1

EC Number

4.6.1.1

Pubmed

19121390 26354079 22118469

EMBL

BABH01016117 BABH01016118 BABH01016119 BABH01016120 KQ461185 KPJ07458.1 + More
KQ459252 KPJ02161.1 AGBW02010694 OWR48015.1 NWSH01002149 PCG69046.1 AJVK01003319 AJVK01003320 KQ976455 KYM85050.1 AJWK01007607 AJWK01007608 AJWK01007609 AJWK01007610

Proteomes

UP000005204 UP000053240 UP000053268 UP000007151 UP000218220 UP000092462 + More
UP000078540 UP000092461

PRIDE

H9JRC6

Pfam

PF00211 Guanylate_cyc + More
PF16214 AC_N

Interpro

IPR018297   A/G_cyclase_CS        + More
IPR001054   A/G_cyclase
IPR029787   Nucleotide_cyclase
IPR030672   Adcy
IPR032628   AC_N

SUPFAM

SSF55073 SSF55073

Gene 3D

3.30.70.1230

ProteinModelPortal

H9JRC6 A0A194QPJ7 A0A194QFB6 A0A212F2P4 A0A2A4JBA4 A0A1B0D560 + More
A0A195BKA9 A0A1B0CDA1

PDB

3MAA E-value=5.59485e-76, Score=724

KEGG

101737606 K08042 adenylate cyclase 2 [EC:4.6.1.1] | (RefSeq) adenylate cyclase type 2-like

GO

GO:0016021 GO:0035556 GO:0000166 GO:0009190 GO:0016849 GO:0006171 GO:0046872 GO:0004016 GO:0005524 GO:0005886 GO:0006313 GO:0003824 GO:0004713 GO:0043565 GO:0016567 GO:0016020 GO:0005634 GO:0006260

Length:

453

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

19.0148

Exp number, first 60 AAs:

0.01131

Total prob of N-in:

0.53835

inside

1 - 428

TMhelix

429 - 451

outside

452 - 453

Pi

28.671031

Theta

28.290429

Tajima's D

-0.656443

CLR

1.200267

CSRT

0.212289385530723

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics