Gene

KWMTBOMO06859

Pre Gene Modal

BGIBMGA012087

Annotation

PREDICTED:_adenylate_cyclase_type_2-like_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr11(-):17691380-17716186      View in EpiBrowser

Full name

Adenylate cyclase       + More
Adenylate cyclase type 2      

Alternative Name

ATP pyrophosphate-lyase 2
Adenylyl cyclase 76E

Location in the cell

PlasmaMembrane   Reliability : 4.13

CDS

ATGACTCCTTTAACTTCCAGGGGCATAGTTCTGTACGCGTCGTTCGGTCCAACGTTTGTAACGTTGATGGTATTCGTGTATTTGTCTTGGTATGATGATAATCTCTTCAAGAGAGGCCTCCGTCCGCTCTCGGATGTACCGATCATGGACGACTTATACGCCGACACATGCACAAAGCCTGGACAGGTTGTAGCCAGCAATCGCTTCATAAGGCTAACGATGTTCCTTGTGTCCGTCGCACTGATCGGAGCCTGTGCGGTTATCAATTTGTTCCAAACATACGTATTCGAAGACGATTCAATCGAATTAACGAATGCGACTGAAAACCGAAACATATCGGAGGAATTCAACATCAGCGCTGCACCGGTCGAAGAATTGGCGAGGTTGAATCAATTCGATTCGGCGCCGAGCTACGTGTACAGCTCGGTGTTCACTCTGGCTTCCATCTCGGTGTTCCTTCGGATCGGCTACGTGCTCAAGCTGCTGATGATGTGCATCACCCTCGCCGCTCACATCACGCTGTTCGTCTCCGCCGAGGTCTTCAGCGAATATTTTAGCGGGGACATGGAGTATGAGTTCTCGATGTTCCCGTACGCCGCGAAGACAGGCATGATCCTCATATTCTTGGCGGTGCTGCTGCACATCCTCGACCGCCAGATAGAGTTCACCTCCCGCACTGACTTCCTCTGGAAAGACAAGTTGAAGTTCGAACAGGAGGAAGTCGAGACTATGAGAGGAATTAACAAGATTCTTCTTGAGAACATCCTACCGGCTCACGTCGCTGAGCATTTCCTCACGTCAGTCGCTTCAGAGGAGGACCTTTATCACGAGCGCTACTCGAGTATAGCGGTCATGTTCGCTTCGATACCGAACTACAAGGAGTTTTACGACGAGACCGACGTCAACAAGCAAGGGCTCGAGTGCCTGAGGCTGCTCAACGAAATCATATGCGACTTCGACAAGTTACTCTTAAAACCGAAATTCAGTTGTATAGAAAAGATAAAGACAATAGGAAGCACGTACATGATTGCGTCAGGGCTGAGTCCCGGGAAAGAAGAGCAGATCGATGCGAACACACGGGAGGAGCACACGGTCGCGATCCTGGTGGAGTTCGCGTTCGCGCTGATGACCATACTCGACCAGATCAACAGGGAGTCGTTCCAACGGTTTAAGCTCAGAATAGGACTAAGTCACGGGCCGGTGATAGCTGGGGTGGTGGGTGCCCAGAAGCCTCAGTACGATATATGGGGCAACACCGTGAACGTCGCATCGAGGATGGACTCCACCGGCATCATGGGAAAGATCCAAGTCACCGAGGACACTGCTAAAGTCCTAATGAACGCCGGATACAAATGCGAGTGTAGGGGACCGACATACGTGAAGGGCAAAGGGACTCTTGTGACGTACTTCGTGAAAACGCCTAATGTTGGTTAA

Protein

MTPLTSRGIVLYASFGPTFVTLMVFVYLSWYDDNLFKRGLRPLSDVPIMDDLYADTCTKPGQVVASNRFIRLTMFLVSVALIGACAVINLFQTYVFEDDSIELTNATENRNISEEFNISAAPVEELARLNQFDSAPSYVYSSVFTLASISVFLRIGYVLKLLMMCITLAAHITLFVSAEVFSEYFSGDMEYEFSMFPYAAKTGMILIFLAVLLHILDRQIEFTSRTDFLWKDKLKFEQEEVETMRGINKILLENILPAHVAEHFLTSVASEEDLYHERYSSIAVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKPKFSCIEKIKTIGSTYMIASGLSPGKEEQIDANTREEHTVAILVEFAFALMTILDQINRESFQRFKLRIGLSHGPVIAGVVGAQKPQYDIWGNTVNVASRMDSTGIMGKIQVTEDTAKVLMNAGYKCECRGPTYVKGKGTLVTYFVKTPNVG

Description

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.

Catalytic Activity

ATP = 3',5'-cyclic AMP + diphosphate

Cofactor

Mg(2+)

Similarity

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Keywords

ATP-binding   cAMP biosynthesis   Cell membrane   Complete proteome   Glycoprotein   Lyase   Magnesium   Manganese   Membrane   Metal-binding   Nucleotide-binding   Phosphoprotein   Reference proteome   Repeat   Transmembrane   Transmembrane helix  

Feature

chain  Adenylate cyclase

Uniprot

A0A2A4JBA4   A0A2H1VI21   A0A194QPJ7   A0A194QFB6   A0A3S2L5G5   A0A212F2P4   + More
A0A139WLU2   A0A2J7Q9L7   A0A0T6BAR7   N6TPL2   U4U0E1   E0VLV8   N6UGK2   A0A1Y1L8L2   A0A1Y1L9N5   A0A1B6C545   A0A067R9S1   A0A2H8TFS8   A0A0P6J1E0   X1WIW4   A0A2S2R7U8   A0A023EWT6   A0A182PVS6   A0A182G0I6   Q16XH3   A0A182J4D1   A0A2H8TR53   A0A0J7L387   A0A2M3ZKT8   A0A2M4AD36   A0A2M4ADH2   A0A182RBC5   A0A2M4AD52   A0A2M4AD02   T1P877   A0A1W4X9X4   A0A3L8DIC7   A0A2M4BA82   A0A0A1X1S9   A0A0C9QGC0   A0A034WKQ3   A0A182W3T2   A0A026VXX5   A0A182LUF7   Q7QDV4   A0A1W4W7F9   A0A0K8WC33   A0A182HX98   A0A182V3H5   A0A182WR88   A0A1W4VUU9   A0A158N9Z2   B4L0V5   E9IR76   A0A0K8UMI0   A0A1W4W6W7   A0A0K8V6N6   A0A1B0A696   A0A0Q9XD92   A0A232EVC5   A0A0A1XR15   B4MMI7   A0A0Q9XNK4   A0A0K8W1P4   B3M8S4   B3NE11   A0A0J9RZN3   A0A1I8N792   Q9VW60   A0A0C9RAS6   F4WC75   A0A0P8XW23   Q2LYW2   A0A3B0JA39   A0A0J9RYC0   A0A1B0AWD2   A0A0Q5U994   A0A1J1J7C2   E2BM54   B4LBK7   E2AC61   A0A1I8Q678   M9NDD2   B4IZL4   A0A3B0J5K8   A0A224XHA5   A0A1I8Q636   A0A0R3P562   A0A1I8Q662   A0A1I8Q651   A0A0Q9WKG2   B4PFV5   B4IIT0   A0A0R1EDX9   W8AQV4   A0A195FR18  

EC Number

4.6.1.1

Pubmed

26354079    22118469    18362917    19820115    23537049    20566863    + More
28004739    24845553    26999592    24945155    26483478    17510324    30249741    25830018    25348373    24508170    12364791    21347285    17994087    21282665    28648823    22936249    25315136    1739965    10731132    12537572    12537569    21719571    18057021    15632085    20798317    12537568    12537573    12537574    16110336    17569856    17569867    17550304    24495485   

EMBL

NWSH01002149    PCG69046.1    ODYU01002683    SOQ40497.1    KQ461185    KPJ07458.1    + More
KQ459252    KPJ02161.1    RSAL01000138    RVE46178.1    AGBW02010694    OWR48015.1    KQ971319    KYB28863.1    NEVH01016348    PNF25264.1    LJIG01002518    KRT84422.1    APGK01012948    KB738878    ENN82454.1    KB631824    ERL86547.1    DS235281    EEB14364.1    APGK01021374    KB740317    ENN80880.1    GEZM01065935    JAV68285.1    GEZM01065934    JAV68286.1    GEDC01028889    JAS08409.1    KK852609    KDR20323.1    GFXV01001106    MBW12911.1    GDUN01000044    JAN95875.1    ABLF02032196    ABLF02032202    ABLF02032203    ABLF02032204    ABLF02065533    GGMS01016845    MBY86048.1    GAPW01000036    JAC13562.1    JXUM01001407    JXUM01001408    JXUM01001409    JXUM01001410    CH477538    EAT39337.1    GFXV01003923    MBW15728.1    LBMM01000981    KMQ97116.1    GGFM01008362    MBW29113.1    GGFK01005349    MBW38670.1    GGFK01005510    MBW38831.1    GGFK01005394    MBW38715.1    GGFK01005344    MBW38665.1    KA644876    AFP59505.1    QOIP01000007    RLU20194.1    GGFJ01000795    MBW49936.1    GBXI01009506    JAD04786.1    GBYB01013578    JAG83345.1    GAKP01004589    JAC54363.1    KK107589    EZA48638.1    AXCM01000637    AAAB01008849    EAA07148.4    GDHF01003695    JAI48619.1    APCN01005160    ADTU01009912    ADTU01009913    ADTU01009914    ADTU01009915    ADTU01009916    CH933809    EDW19205.1    GL765099    EFZ16929.1    GDHF01024432    JAI27882.1    GDHF01017773    JAI34541.1    KRG06543.1    NNAY01002030    OXU22268.1    GBXI01000895    JAD13397.1    CH963847    EDW73332.2    KRG06542.1    GDHF01007574    JAI44740.1    CH902618    EDV41075.2    CH954178    EDV52435.1    CM002912    KMZ00650.1    AF093454    AE014296    AY119547    AAC62509.1    AAF49089.3    AAM50201.1    GBYB01013579    JAG83346.1    GL888070    EGI68055.1    KPU78905.1    KPU78906.1    CH379069    EAL29747.2    OUUW01000002    SPP77273.1    KMZ00649.1    JXJN01004648    KQS44276.1    CVRI01000070    CRL07366.1    GL449158    EFN83180.1    CH940647    EDW70817.1    GL438422    EFN68977.1    AFH04509.1    CH916366    EDV97789.1    SPP77274.1    GFTR01008464    JAW07962.1    KRT08330.1    KRF85130.1    CM000159    EDW95252.1    CH480844    EDW49851.1    CH891887    KRK05338.1    GAMC01018133    JAB88422.1    KQ981305    KYN42871.1   

Proteomes

UP000218220    UP000053240    UP000053268    UP000283053    UP000007151    UP000007266    + More
UP000235965    UP000019118    UP000030742    UP000009046    UP000027135    UP000007819    UP000075885    UP000069940    UP000008820    UP000075880    UP000036403    UP000075900    UP000192223    UP000279307    UP000075920    UP000053097    UP000075883    UP000007062    UP000192221    UP000075840    UP000075903    UP000076407    UP000005205    UP000009192    UP000092445    UP000215335    UP000007798    UP000007801    UP000008711    UP000095301    UP000000803    UP000007755    UP000001819    UP000268350    UP000092460    UP000183832    UP000008237    UP000008792    UP000000311    UP000095300    UP000001070    UP000002282    UP000001292    UP000078541   

PRIDE

Q9VW60    M9NDD2   

Pfam

PF00211   Guanylate_cyc        + More
PF16214   AC_N

Interpro

IPR018297   A/G_cyclase_CS        + More
IPR001054   A/G_cyclase       
IPR029787   Nucleotide_cyclase       
IPR032628   AC_N       
IPR030672   Adcy       

SUPFAM

SSF55073   SSF55073       

Gene 3D

3.30.70.1230    

ProteinModelPortal

A0A2A4JBA4   A0A2H1VI21   A0A194QPJ7   A0A194QFB6   A0A3S2L5G5   A0A212F2P4   + More
A0A139WLU2   A0A2J7Q9L7   A0A0T6BAR7   N6TPL2   U4U0E1   E0VLV8   N6UGK2   A0A1Y1L8L2   A0A1Y1L9N5   A0A1B6C545   A0A067R9S1   A0A2H8TFS8   A0A0P6J1E0   X1WIW4   A0A2S2R7U8   A0A023EWT6   A0A182PVS6   A0A182G0I6   Q16XH3   A0A182J4D1   A0A2H8TR53   A0A0J7L387   A0A2M3ZKT8   A0A2M4AD36   A0A2M4ADH2   A0A182RBC5   A0A2M4AD52   A0A2M4AD02   T1P877   A0A1W4X9X4   A0A3L8DIC7   A0A2M4BA82   A0A0A1X1S9   A0A0C9QGC0   A0A034WKQ3   A0A182W3T2   A0A026VXX5   A0A182LUF7   Q7QDV4   A0A1W4W7F9   A0A0K8WC33   A0A182HX98   A0A182V3H5   A0A182WR88   A0A1W4VUU9   A0A158N9Z2   B4L0V5   E9IR76   A0A0K8UMI0   A0A1W4W6W7   A0A0K8V6N6   A0A1B0A696   A0A0Q9XD92   A0A232EVC5   A0A0A1XR15   B4MMI7   A0A0Q9XNK4   A0A0K8W1P4   B3M8S4   B3NE11   A0A0J9RZN3   A0A1I8N792   Q9VW60   A0A0C9RAS6   F4WC75   A0A0P8XW23   Q2LYW2   A0A3B0JA39   A0A0J9RYC0   A0A1B0AWD2   A0A0Q5U994   A0A1J1J7C2   E2BM54   B4LBK7   E2AC61   A0A1I8Q678   M9NDD2   B4IZL4   A0A3B0J5K8   A0A224XHA5   A0A1I8Q636   A0A0R3P562   A0A1I8Q662   A0A1I8Q651   A0A0Q9WKG2   B4PFV5   B4IIT0   A0A0R1EDX9   W8AQV4   A0A195FR18  

PDB

3MAA     E-value=1.58962e-75,     Score=720

KEGG

101737606    K08042 adenylate cyclase 2 [EC:4.6.1.1] | (RefSeq) adenylate cyclase type 2-like

GO

GO:0000166   GO:0035556   GO:0016021   GO:0009190   GO:0016849   GO:0016829   GO:0006171   GO:0007189   GO:0004016   GO:0046872   GO:0005887   GO:0005524   GO:0005886   GO:0002165   GO:0040015   GO:0042594   GO:0004383   GO:0006313   GO:0003824   GO:0004713   GO:0043565   GO:0016567   GO:0016020   GO:0005634   GO:0006260  

Subcellular location

Membrane  
Cell membrane  

Length:

477

Number of predicted TMHs:

4

Exp number of AAs in TMHs:

104.67531

Exp number, first 60 AAs:

22.21517

Total prob of N-in:

0.44453

POSSIBLE N-term signal

sequence

inside

1  -  8

TMhelix

9  -  31

outside

32  -  68

TMhelix

69  -  91

inside

92  -  155

TMhelix

156  -  178

outside

179  -  192

TMhelix

193  -  215

inside

216  -  477

 

 

Pi

16.098257

Theta

18.3388

Tajima's D

-1.191078

CLR

15.274837

CSRT

0.104444777761112

Interpretation

Uncertain