Silkworm Genome Informatics Database

Gene

KWMTBOMO06833

Pre Gene Modal

BGIBMGA012094

Annotation

PREDICTED:_tyrosine-protein_kinase_Src64B_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr11(-):16478066-16489921 View in EpiBrowser

Full name

Tyrosine-protein kinase + More
Tyrosine-protein kinase Src64B

Location in the cell

Cytoplasmic Reliability : 2.536

CDS

ATGGGTAACAAGTGTTGCAGCCGCCGACATGACGCCGAGAGACCTCCTGTGTACCCTCACAAGAATGAGCCCGGTTTCACAACGTGCCCCGTGTCTTTTGACACCCGGTACACTGGCGAGCCAAACACCAGGCAGCCGTCGCGACCTCCTGTTGACGTCGTAAGAACGACAACAAAATGCATATCAAACGGCGGTCGTCGAGTCGTAAAAGCCCTATGCGAGTATACGGCTCGAGCGGACTCCGACATCTCGTTTCACAAGGGCGACCGCATGGAAGTCCTCAACAGCTCGGAGCCGGATTGGTGGATGGTGTTCCATCTGACCACGAGGAGGGAAGGCCTGGTTCCAGTCAATTACGTCGCCGAAGAGAGTTCAGTGGAATGTGAAGACTGGTTCTTTCCTCACGTGTCGAGGAAGGAGGCCGACAAACTCCTCCTAGCCGAGAGCAACCCCCGCGGTACGTTCTTGGTCCGACCGGCGGAGCACAACCCTCACGGCTTCAGCTTAAGCGTCAAAGATTGGGAAGACGGAAGGGGCTACCACGTGAAACATTATAAAATAAAGCCGCTCGACAAAGGCGGTTTTTATATCGCCACAAACCAAACCTTCCCGAGCTTACCCGCTCTCGTCATGTCGTATACGAAAAATGCATTAGGGCTGTGTCACGTCCTGGCCCGGCCTTGTCCGAAGCCCGAGCCGCAGATCTGGGACCTCGGGCCCGAACTGCGGGACAAGTGGGAGATACCCAGGATGGAAATACAACTCATTAGGAAGCTCGGTCAAGGAAACTTCGGCGAAGTCTATTACGGGAAATGGAGGAATAATATTGAGGTCGCCGTGAAGACTCTTCGCGAGGGCACAATGTCGACTCAGGCCTTCCTGCAAGAGGCGGCGATCATGAAGAAGTTCCGGCACAACAAGCTGGTCGCCCTGTACGCCGTCTGCTCGCAGCAGGAGCCGGTCTACATCGTCCAGGAGTACATGAGCCGCGGCTCCTTACTGGAGTTCTTGAGGAACGGCGAAGGGAAGTTCCTCCAGTTCGAGGACCTAGTTTACATAGCGGCCCAGGTCGCCTCCGGTATGGAGTATCTCGAATCGAAAATGCTGATTCACAGAGACCTGGCCGCTCGGAACGTGCTCATCGGGGAGAACAATACCGCCAAAATATGCGACTTCGGTCTCGCCAGGGTCATAGAAGACAACGAATACTGCCCCAAGCAAGGCTCTAGGTTCCCAGTCAAATGGACAGCCCCCGAAGCTATAATATACGGGAAGTTCTCCATCAAAAGCGACGTCTGGTCGTACGGCATTCTCTTAATGGAGCTTTTCACATACGGGAAGATTCCGTACCCGGGATTGCACGGCAAGGACGTCATCGACAAAATCGAGATCGGCTACCGGATGCCGAAGCCGATAGACGTGTACCTGCCGGACGCCATATACGGGCTGATGCTGCAGTGCTGGGACGCGGTGCCTGAGAAGCGGCCCACCTTCGAGTTCCTCAATCATTACTTCGAATCGTTTACGGTGACCAGCGAGATGCCGTACAAGGAGGTACACGATTGA

Protein

MGNKCCSRRHDAERPPVYPHKNEPGFTTCPVSFDTRYTGEPNTRQPSRPPVDVVRTTTKCISNGGRRVVKALCEYTARADSDISFHKGDRMEVLNSSEPDWWMVFHLTTRREGLVPVNYVAEESSVECEDWFFPHVSRKEADKLLLAESNPRGTFLVRPAEHNPHGFSLSVKDWEDGRGYHVKHYKIKPLDKGGFYIATNQTFPSLPALVMSYTKNALGLCHVLARPCPKPEPQIWDLGPELRDKWEIPRMEIQLIRKLGQGNFGEVYYGKWRNNIEVAVKTLREGTMSTQAFLQEAAIMKKFRHNKLVALYAVCSQQEPVYIVQEYMSRGSLLEFLRNGEGKFLQFEDLVYIAAQVASGMEYLESKMLIHRDLAARNVLIGENNTAKICDFGLARVIEDNEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGKIPYPGLHGKDVIDKIEIGYRMPKPIDVYLPDAIYGLMLQCWDAVPEKRPTFEFLNHYFESFTVTSEMPYKEVHD

Description

May play a role in the development of neural tissue and smooth muscle.

Catalytic Activity

ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]

Similarity

Belongs to the protein kinase superfamily. Tyr protein kinase family.
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.

Keywords

ATP-binding Complete proteome Developmental protein Kinase Nucleotide-binding Phosphoprotein Proto-oncogene Reference proteome SH2 domain SH3 domain Transferase Tyrosine-protein kinase

Feature

chain Tyrosine-protein kinase Src64B

Uniprot

A0A2A4JUW5 A0A2A4JVG0 H9JRD4 A0A212ERZ7 A0A194PEH4 A0A194R3F6 + More
A0A0L7L919 A0A084WMI0 W5JAG1 A0A1Q3G073 A0A182MD62 A0A182QU87 A0A0K8VLV5 W8B4I4 A0A034V3V1 A0A182V1T8 A0A182UFX5 Q7Q5D3 A0A182J610 Q17CE8 A0A0A1WLL3 A0A1I8MNN6 A0A1J1IN93 A0A1S4F874 A0A3B0JC04 Q29EB5 B4H1S6 A0A1W4VNP7 A0A1I8Q8J8 B4HU86 B3NC61 B4QR05 M9MSK3 B4PI98 P00528 A0A0Q9VZD8 B4MFY6 B4IZ80 A0A0R3P952 B4KX98 A0A1A9X352 A0A1A9UXP5 A0A1A9XXA5 B4MMY8 A0A1A9ZWJ9 A0A1W4VAL7 X2JCI2 B3M9I4 A0A1Q3G0A3 A0A3B0JXY4 A0A3B0JQ36 A0A182GE84 A0A0C9S1N2 A0A0C9RZ52 E2B6N7 A0A182T948 A0A195E5N9 F4W469 A0A151X1X9 E2AGB2 A0A1B6DBV7 A0A310S576 A0A2J7QBD3 A0A158NF94 A0A195CLJ5 A0A2J7QBD7 A0A195ET97 A0A0C9QIX9 A0A026W269 A0A3L8DPV5 A0A0L7QSY0 A0A1Y1MNH6 A0A067RF36 A0A1B0AZ14 A0A0N0BIX5 E9I9W3 A0A2A3EBZ5 A0A195B436 A0A154PDP5 A0A1B6F6I2 A0A2S2QXI1 A0A2H8TTJ2 J9JNW3 A0A224XAP3 A0A2S2NKV7 D6WH54 A0A023F4P5 T1I1G4 A0A088A505 A0A0J7L1N8 A0A0A9W1P4 A0A1B6M227 A0A0T6B3B8 E0VM96 B0WKZ9 A0A1D2MCK7 A0A0N8DE06 A0A0N8AZW3 A0A0P5WRF2 A0A0P5X2C5

EC Number

2.7.10.2

Pubmed

19121390 22118469 26354079 26227816 24438588 20920257 + More
23761445 24495485 25348373 12364791 14747013 17210077 17510324 25830018 25315136 15632085 17994087 22936249 10731132 12537568 12537572 12537573 12537574 16110336 17569856 17569867 26109357 26109356 17550304 2996778 12537569 6317185 9731193 18057021 26483478 20798317 21719571 21347285 24508170 30249741 28004739 24845553 21282665 18362917 19820115 25474469 25401762 20566863 27289101

EMBL

NWSH01000537 PCG75801.1 PCG75799.1 BABH01016221 BABH01016222 AGBW02012898 + More
OWR44255.1 KQ459606 KPI91756.1 KQ460779 KPJ12338.1 JTDY01002220 KOB71865.1 ATLV01024459 KE525352 KFB51424.1 ADMH02001836 ETN60976.1 GFDL01001834 JAV33211.1 AXCM01008822 AXCN02000463 GDHF01032063 GDHF01025214 GDHF01018527 GDHF01012486 JAI20251.1 JAI27100.1 JAI33787.1 JAI39828.1 GAMC01018351 GAMC01018350 GAMC01018349 JAB88206.1 GAKP01022133 GAKP01022131 GAKP01022130 GAKP01022129 JAC36822.1 AAAB01008960 EAA11388.2 CH477309 EAT44003.1 GBXI01014358 GBXI01005471 JAC99933.1 JAD08821.1 CVRI01000056 CRL01691.1 OUUW01000002 SPP77582.1 CH379070 EAL30146.1 CH479203 EDW30278.1 CH480817 EDW50507.1 CH954178 EDV50949.1 CM000363 CM002912 EDX09242.1 KMY97648.1 AE014296 ADV37488.1 CM000159 EDW93440.1 M11917 AY051781 K01043 AJ002919 CH940669 KRF78195.1 EDW58247.1 CH916366 CH916865 EDV95602.1 EDW04576.1 KRT08678.1 CH933809 EDW17556.1 CH963847 EDW73544.1 AHN57962.1 CH902618 EDV38990.1 KPU77803.1 GFDL01001835 JAV33210.1 SPP77581.1 SPP77580.1 JXUM01057599 JXUM01057600 KQ561962 KXJ77052.1 GBYB01014691 JAG84458.1 GBYB01014690 JAG84457.1 GL446000 EFN88621.1 KQ979609 KYN20164.1 GL887491 EGI71065.1 KQ982585 KYQ54295.1 GL439266 EFN67603.1 GEDC01016649 GEDC01014176 JAS20649.1 JAS23122.1 KQ771134 OAD52547.1 NEVH01016301 PNF25896.1 ADTU01001526 ADTU01001527 KQ977642 KYN00944.1 PNF25895.1 KQ981979 KYN31475.1 GBYB01014693 JAG84460.1 KK107538 EZA49129.1 QOIP01000005 RLU22454.1 KQ414755 KOC61730.1 GEZM01029673 GEZM01029672 JAV85995.1 KK852729 KDR17588.1 JXJN01006116 KQ435727 KOX78091.1 GL761846 EFZ22631.1 KZ288303 PBC28812.1 KQ976625 KYM79027.1 KQ434870 KZC09514.1 GECZ01030960 GECZ01023941 GECZ01023642 GECZ01014541 JAS38809.1 JAS45828.1 JAS46127.1 JAS55228.1 GGMS01013017 MBY82220.1 GFXV01002789 GFXV01005741 MBW14594.1 MBW17546.1 ABLF02040183 GFTR01006969 JAW09457.1 GGMR01005129 MBY17748.1 KQ971330 EEZ99753.2 GBBI01002330 JAC16382.1 ACPB03006877 LBMM01001290 KMQ96571.1 GBHO01041871 GBHO01041870 JAG01733.1 JAG01734.1 GEBQ01012640 GEBQ01009978 GEBQ01002389 JAT27337.1 JAT29999.1 JAT37588.1 LJIG01016022 KRT81848.1 DS235303 EEB14502.1 DS231978 EDS30139.1 LJIJ01001816 ODM90737.1 GDIP01042999 LRGB01001581 JAM60716.1 KZS11042.1 GDIQ01226555 GDIQ01036940 JAK25170.1 GDIP01083298 JAM20417.1 GDIP01078849 JAM24866.1

Proteomes

UP000218220 UP000005204 UP000007151 UP000053268 UP000053240 UP000037510 + More
UP000030765 UP000000673 UP000075883 UP000075886 UP000075903 UP000075902 UP000007062 UP000075880 UP000008820 UP000095301 UP000183832 UP000268350 UP000001819 UP000008744 UP000192221 UP000095300 UP000001292 UP000008711 UP000000304 UP000000803 UP000002282 UP000008792 UP000001070 UP000009192 UP000091820 UP000078200 UP000092443 UP000007798 UP000092445 UP000007801 UP000069940 UP000249989 UP000008237 UP000075901 UP000078492 UP000007755 UP000075809 UP000000311 UP000235965 UP000005205 UP000078542 UP000078541 UP000053097 UP000279307 UP000053825 UP000027135 UP000092460 UP000053105 UP000242457 UP000078540 UP000076502 UP000007819 UP000007266 UP000015103 UP000005203 UP000036403 UP000009046 UP000002320 UP000094527 UP000076858

PRIDE

H9JRD4 M9MSK3 P00528 X2JCI2

Pfam

PF00017   SH2        + More
PF00018   SH3_1
PF07714   Pkinase_Tyr
PF10545   MADF_DNA_bdg

Interpro

IPR036860   SH2_dom_sf        + More
IPR020635   Tyr_kinase_cat_dom
IPR008266   Tyr_kinase_AS
IPR000719   Prot_kinase_dom
IPR000980   SH2
IPR001452   SH3_domain
IPR036028   SH3-like_dom_sf
IPR011009   Kinase-like_dom_sf
IPR001245   Ser-Thr/Tyr_kinase_cat_dom
IPR017441   Protein_kinase_ATP_BS
IPR006578   MADF-dom

SUPFAM

SSF55550   SSF55550        + More
SSF50044   SSF50044
SSF56112   SSF56112

Gene 3D

3.30.505.10

ProteinModelPortal

A0A2A4JUW5 A0A2A4JVG0 H9JRD4 A0A212ERZ7 A0A194PEH4 A0A194R3F6 + More
A0A0L7L919 A0A084WMI0 W5JAG1 A0A1Q3G073 A0A182MD62 A0A182QU87 A0A0K8VLV5 W8B4I4 A0A034V3V1 A0A182V1T8 A0A182UFX5 Q7Q5D3 A0A182J610 Q17CE8 A0A0A1WLL3 A0A1I8MNN6 A0A1J1IN93 A0A1S4F874 A0A3B0JC04 Q29EB5 B4H1S6 A0A1W4VNP7 A0A1I8Q8J8 B4HU86 B3NC61 B4QR05 M9MSK3 B4PI98 P00528 A0A0Q9VZD8 B4MFY6 B4IZ80 A0A0R3P952 B4KX98 A0A1A9X352 A0A1A9UXP5 A0A1A9XXA5 B4MMY8 A0A1A9ZWJ9 A0A1W4VAL7 X2JCI2 B3M9I4 A0A1Q3G0A3 A0A3B0JXY4 A0A3B0JQ36 A0A182GE84 A0A0C9S1N2 A0A0C9RZ52 E2B6N7 A0A182T948 A0A195E5N9 F4W469 A0A151X1X9 E2AGB2 A0A1B6DBV7 A0A310S576 A0A2J7QBD3 A0A158NF94 A0A195CLJ5 A0A2J7QBD7 A0A195ET97 A0A0C9QIX9 A0A026W269 A0A3L8DPV5 A0A0L7QSY0 A0A1Y1MNH6 A0A067RF36 A0A1B0AZ14 A0A0N0BIX5 E9I9W3 A0A2A3EBZ5 A0A195B436 A0A154PDP5 A0A1B6F6I2 A0A2S2QXI1 A0A2H8TTJ2 J9JNW3 A0A224XAP3 A0A2S2NKV7 D6WH54 A0A023F4P5 T1I1G4 A0A088A505 A0A0J7L1N8 A0A0A9W1P4 A0A1B6M227 A0A0T6B3B8 E0VM96 B0WKZ9 A0A1D2MCK7 A0A0N8DE06 A0A0N8AZW3 A0A0P5WRF2 A0A0P5X2C5

PDB

2H8H E-value=1.71532e-143, Score=1307

KEGG

101739984 K05704 tyrosine-protein kinase Src [EC:2.7.10.2] | (RefSeq) tyrosine-protein kinase Src64B

PATHWAY

04013    MAPK signaling pathway - fly - Bombyx mori (domestic silkworm)
04137    Mitophagy - animal - Bombyx mori (domestic silkworm)
04144    Endocytosis - Bombyx mori (domestic silkworm)

GO

GO:0005524 GO:0004715 GO:0030154 GO:0031234 GO:0005102 GO:0038083 GO:0007169 GO:0018108 GO:0036058 GO:0090136 GO:0005886 GO:0048167 GO:0007349 GO:0007300 GO:0030708 GO:0030717 GO:0007301 GO:0007616 GO:0007411 GO:0008302 GO:0007293 GO:0048477 GO:0034332 GO:0045743 GO:0016319 GO:0005829 GO:0007435 GO:0030036 GO:0045742 GO:0120176 GO:0045172 GO:0030723 GO:0008064 GO:0007424 GO:0008335 GO:0030046 GO:0045886 GO:0000185 GO:0045874 GO:0004713 GO:0004672 GO:0006468 GO:0005515 GO:0043565 GO:0016567 GO:0016020 GO:0005634 GO:0006260

Length:

521

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.16682

Exp number, first 60 AAs:

0

Total prob of N-in:

0.01994

outside

1 - 521

Pi

19.15826

Theta

16.841685

Tajima's D

-1.330197

CLR

1.119516

CSRT

0.0808959552022399

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics