Gene

KWMTBOMO06832

Pre Gene Modal

BGIBMGA012057

Annotation

PREDICTED:_solute_carrier_family_35_member_B3_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr11(+):16468202-16472851      View in EpiBrowser

Full name

Adenosine 3'-phospho 5'-phosphosulfate transporter 2      

Alternative Name

PAPS transporter 2
Solute carrier family 35 member B3 homolog
dPAPST2
Solute carrier family 35 member B3

Location in the cell

PlasmaMembrane   Reliability : 4.954

CDS

ATGGAAACGTCATCAGATAAAATGAATTCTGTGAAGGAAACCTTCATAAGGATAGATGATGAGAACAGCAGAACATCAAAAACAGAAATCAATATATTATGCTTTGACATAACAAATTACAGTCAATTAACTCAGTTCCTGTGTTGTTCGATATTCGTTTTTATATTCTATTTAGCTTATGGATACTTCTTAGAATTAATATTTGCAAAACCGGAAGTGAAGCCAGTCAGTTTGTATATAACCTTAGTGCAATTTATGATTACTATGTTGTTGAGTTATGGAGAATCATGGATAAGAAATCCTATCAAAAGGAAAGTTCCACTAAAAACGTATGCAGTTTTAGCTGCATTGACATTAGGAACAATGTCATTTTCGAATTTAGCTTTAAGTTATTTGAACTATCCAACTCAATTGATATTCAAGAGCTGTAAACTTATACCAGTTATGATTGGTAGTATTATCATAATGAGAAAACGTTATTCGTTTTTGGATTATGTAGCGGCAATTGTTATGTGTGTAGGACTGACTATGTTTACTCTGGCTGACTCCAGCACATCACCGAATTTCGATTTGATTGGCGTTCTAGTTATATCCTTAGCATTACTATGCGACGCAATAATCGGAAACGTACAAGAGAAAGCAATGAAACAGTACCAAGCTTCAAATAACGAAGTTGTTTTCTATTCATATGCGATTGCATGTGTTTACCTTGTCTGTATTACTGGATTCAGTGGTATACTAGTTGACGGATTTGCTTATTGTGCTGAGACACCAGTTGAAATGTACCGGAACATATTTCTTCTAAGTCTGAGCGGCTATATGGGTCTGCAAGCGGTGTTGACGCTGGTGAGGATATGCGGTGCGACGGTCGCCGTTACCGTCACCACGATGAGGAAAGCTCTCTCGATAATCATATCGTTCTTGTTGTTCAGCAAGCCTTTTGTCTTCCAGTACGTTTGGTCGGGATCTTTGGTGGTTTTAGCCATTTACATAAATCACTACAGTAAAAAGCATCCCCACTACGTACCGGCCTCACTGTCTAGTTGCTGGCAACAAATAAGGAACTATTACGATTCAGAATACAGATATCTTAAGATGAAAACTAAAATGTACACCGATACGGTGTAA

Protein

METSSDKMNSVKETFIRIDDENSRTSKTEINILCFDITNYSQLTQFLCCSIFVFIFYLAYGYFLELIFAKPEVKPVSLYITLVQFMITMLLSYGESWIRNPIKRKVPLKTYAVLAALTLGTMSFSNLALSYLNYPTQLIFKSCKLIPVMIGSIIIMRKRYSFLDYVAAIVMCVGLTMFTLADSSTSPNFDLIGVLVISLALLCDAIIGNVQEKAMKQYQASNNEVVFYSYAIACVYLVCITGFSGILVDGFAYCAETPVEMYRNIFLLSLSGYMGLQAVLTLVRICGATVAVTVTTMRKALSIIISFLLFSKPFVFQYVWSGSLVVLAIYINHYSKKHPHYVPASLSSCWQQIRNYYDSEYRYLKMKTKMYTDTV

Description

Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Essential for viability. Involved in glycosaminoglycan synthesis and the subsequent signaling. May be involved in hh and dpp signaling by controlling the sulfation of heparan sulfate (HS) (By similarity).
Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Essential for viability. Involved in glycosaminoglycan synthesis and the subsequent signaling. May be involved in hh and dpp signaling by controlling the sulfation of heparan sulfate (HS).
Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Compensates for the insufficient expression of SLC35B2/PAPST1 during the synthesis of sulfated glycoconjugates in the colon (By similarity).

Biophysicochemical Properties

2.3 uM for PAPS

Similarity

Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.

Keywords

Complete proteome   Developmental protein   Golgi apparatus   Membrane   Reference proteome   Transmembrane   Transmembrane helix   Transport   Glycoprotein   Phosphoprotein  

Feature

chain  Adenosine 3'-phospho 5'-phosphosulfate transporter 2

Uniprot

D2XRA6   Q2F658   A0A2A4JWN3   A0A3S2NGP5   H9JR97   A0A1E1WA90   + More
A0A212ERX1   A0A0L7L8N2   A0A194R3S0   A0A194PKX3   A0A0K8TQS0   A0A1Y1LDF0   A0A232FGK7   D6WH53   A0A2M4AKV7   K7J9A9   N6T0M2   A0A084WMH9   A0A2M4BRL8   A0A2M3Z4X2   W5J947   A0A1Q3FBK9   A0A2M4BRH8   A0A182NIY5   B0WKZ8   U4U9X4   A0A182ILV1   Q7Q5D4   A0A182URW5   A0A023ETA5   A0A182X956   A0A182I493   A0A182GE83   B4PJY7   A0A182TGT5   B4LBF8   Q9VVD9   A0A1W4VSK1   Q17CE7   A0A182QTK9   B4QNE6   A0A182RR65   A0A1B0B7S8   B3NDD6   A0A182MU49   B4HKA6   A0A182Y7V4   B4H5P1   A0A0R3P5S5   Q29EY2   A0A182WBY4   A0A1B6JGM3   A0A034V9Y8   B3M5H5   A0A182SJS2   A0A182K706   A0A3B0KFW5   B4N4X0   A0A1D2N287   A0A0K8VMZ2   W8BKZ8   A0A182NZT2   B4J0G6   R7UJB8   A0A0V0GBN0   A0A0L0CL30   A0A1I8MAJ6   A0A0A1X117   A0A1I8P623   A0A069DRV6   B4KV26   A0A1B6KRQ8   A0A2J7QBC8   A0A2S2P8I9   A0A164P2R6   A0A2R7WJU4   A0A0P6I6Q3   A0A2C9LTE5   E9H620   T1HPW5   A0A067R5L8   A0A2H8TPM1   A0A1A9VMZ9   A0A0P6AHT6   A0A1B0A2J2   A0A0B6ZVJ6   A0A1S3H0C6   A0A099ZIK7   A0A3P8VQG3   W5N6L6   A0A3B5KLF8   A0A1S3J8P5   A0A091I7L1   D4AAG3   Q922Q5   A0A146LSY8   A0A091MGF2   A0A2D0PQQ4   A0A0A9YSM8  

Pubmed

19121390    22118469    26227816    26354079    26369729    28004739    + More
28648823    18362917    19820115    20075255    23537049    24438588    20920257    23761445    12364791    24945155    26483478    17994087    17550304    16873373    10731132    12537572    12537569    18327897    17510324    22936249    25244985    15632085    25348373    27289101    24495485    23254933    26108605    25315136    25830018    26334808    15562597    21292972    24845553    24487278    21551351    15057822    16141072    15489334    26823975    25401762   

EMBL

GU244352    ADB08385.1    DQ311214    ABD36159.1    NWSH01000537    PCG75802.1    + More
RSAL01000045    RVE50624.1    BABH01016222    GDQN01007142    JAT83912.1    AGBW02012898    OWR44256.1    JTDY01002220    KOB71867.1    KQ460779    KPJ12337.1    KQ459606    KPI91755.1    GDAI01000899    JAI16704.1    GEZM01061560    JAV70370.1    NNAY01000233    OXU29825.1    KQ971330    EFA00972.1    GGFK01008041    MBW41362.1    APGK01049756    KB741156    ENN73619.1    ATLV01024459    KE525352    KFB51423.1    GGFJ01006482    MBW55623.1    GGFM01002794    MBW23545.1    ADMH02001836    ETN60977.1    GFDL01010081    JAV24964.1    GGFJ01006481    MBW55622.1    DS231978    EDS30138.1    KB631941    ERL87376.1    AAAB01008960    GAPW01001984    JAC11614.1    APCN01002286    JXUM01057598    KQ561962    KXJ77051.1    CM000159    EDW94756.2    CH940647    EDW69746.1    AB242867    AE014296    AY069640    CH477309    EAT44004.1    AXCN02000463    CM000363    CM002912    EDX10816.1    KMZ00187.1    JXJN01009712    CH954178    EDV51998.2    AXCM01003551    CH480815    EDW41847.1    CH479211    EDW33093.1    CH379070    KRT08497.1    GECU01009367    JAS98339.1    GAKP01020367    JAC38585.1    CH902618    EDV39585.1    OUUW01000009    SPP85219.1    CH964101    EDW79409.1    LJIJ01000285    ODM99368.1    GDHF01012065    JAI40249.1    GAMC01007118    JAB99437.1    CH916366    EDV96802.1    AMQN01008493    KB303236    ELU03367.1    GECL01000832    JAP05292.1    JRES01000254    KNC32956.1    GBXI01009696    JAD04596.1    GBGD01002086    JAC86803.1    CH933809    EDW18337.2    GEBQ01026053    JAT13924.1    NEVH01016301    PNF25893.1    GGMR01012889    MBY25508.1    LRGB01002722    KZS06460.1    KK854954    PTY19914.1    GDIQ01008627    JAN86110.1    GL732595    EFX72822.1    ACPB03001903    KK852729    KDR17582.1    GFXV01004135    MBW15940.1    GDIP01034394    JAM69321.1    HACG01025774    CEK72639.1    KL894251    KGL81647.1    AHAT01002330    KL218247    KFP03433.1    AABR07027364    AK076592    AK077208    AK141280    BC006881    GDHC01009079    JAQ09550.1    KK827143    KFP73587.1    GBHO01008400    GBHO01001380    GBHO01001379    JAG35204.1    JAG42224.1    JAG42225.1   

Proteomes

UP000218220    UP000283053    UP000005204    UP000007151    UP000037510    UP000053240    + More
UP000053268    UP000215335    UP000007266    UP000002358    UP000019118    UP000030765    UP000000673    UP000075884    UP000002320    UP000030742    UP000075880    UP000007062    UP000075903    UP000076407    UP000075840    UP000069940    UP000249989    UP000002282    UP000075902    UP000008792    UP000000803    UP000192221    UP000008820    UP000075886    UP000000304    UP000075900    UP000092460    UP000008711    UP000075883    UP000001292    UP000076408    UP000008744    UP000001819    UP000075920    UP000007801    UP000075901    UP000075881    UP000268350    UP000007798    UP000094527    UP000075885    UP000001070    UP000014760    UP000037069    UP000095301    UP000095300    UP000009192    UP000235965    UP000076858    UP000076420    UP000000305    UP000015103    UP000027135    UP000078200    UP000092445    UP000085678    UP000053641    UP000265120    UP000018468    UP000005226    UP000054308    UP000002494    UP000000589    UP000221080   

PRIDE

D2XRA6    Q2F658    H9JR97    Q9VVD9    Q17CE7    D4AAG3    + More
Q922Q5   

Pfam

PF08449   UAA

Interpro

IPR013657   UAA       

ProteinModelPortal

D2XRA6   Q2F658   A0A2A4JWN3   A0A3S2NGP5   H9JR97   A0A1E1WA90   + More
A0A212ERX1   A0A0L7L8N2   A0A194R3S0   A0A194PKX3   A0A0K8TQS0   A0A1Y1LDF0   A0A232FGK7   D6WH53   A0A2M4AKV7   K7J9A9   N6T0M2   A0A084WMH9   A0A2M4BRL8   A0A2M3Z4X2   W5J947   A0A1Q3FBK9   A0A2M4BRH8   A0A182NIY5   B0WKZ8   U4U9X4   A0A182ILV1   Q7Q5D4   A0A182URW5   A0A023ETA5   A0A182X956   A0A182I493   A0A182GE83   B4PJY7   A0A182TGT5   B4LBF8   Q9VVD9   A0A1W4VSK1   Q17CE7   A0A182QTK9   B4QNE6   A0A182RR65   A0A1B0B7S8   B3NDD6   A0A182MU49   B4HKA6   A0A182Y7V4   B4H5P1   A0A0R3P5S5   Q29EY2   A0A182WBY4   A0A1B6JGM3   A0A034V9Y8   B3M5H5   A0A182SJS2   A0A182K706   A0A3B0KFW5   B4N4X0   A0A1D2N287   A0A0K8VMZ2   W8BKZ8   A0A182NZT2   B4J0G6   R7UJB8   A0A0V0GBN0   A0A0L0CL30   A0A1I8MAJ6   A0A0A1X117   A0A1I8P623   A0A069DRV6   B4KV26   A0A1B6KRQ8   A0A2J7QBC8   A0A2S2P8I9   A0A164P2R6   A0A2R7WJU4   A0A0P6I6Q3   A0A2C9LTE5   E9H620   T1HPW5   A0A067R5L8   A0A2H8TPM1   A0A1A9VMZ9   A0A0P6AHT6   A0A1B0A2J2   A0A0B6ZVJ6   A0A1S3H0C6   A0A099ZIK7   A0A3P8VQG3   W5N6L6   A0A3B5KLF8   A0A1S3J8P5   A0A091I7L1   D4AAG3   Q922Q5   A0A146LSY8   A0A091MGF2   A0A2D0PQQ4   A0A0A9YSM8  

KEGG

692839    K15277 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3 | (R

GO

GO:0016021   GO:0055085   GO:0030173   GO:0046964   GO:0030176   GO:0022857   GO:0046963   GO:0007275   GO:0005794   GO:0000137   GO:0005783   GO:0015012   GO:0000139   GO:0005739  

Subcellular location

Golgi apparatus membrane  

Length:

375

Number of predicted TMHs:

9

Exp number of AAs in TMHs:

190.09027

Exp number, first 60 AAs:

16.13909

Total prob of N-in:

0.67991

POSSIBLE N-term signal

sequence

inside

1  -  45

TMhelix

46  -  68

outside

69  -  77

TMhelix

78  -  97

inside

98  -  109

TMhelix

110  -  132

outside

133  -  135

TMhelix

136  -  155

inside

156  -  161

TMhelix

162  -  181

outside

182  -  190

TMhelix

191  -  210

inside

211  -  230

TMhelix

231  -  253

outside

254  -  272

TMhelix

273  -  295

inside

296  -  307

TMhelix

308  -  330

outside

331  -  375

 

 

Pi

30.585376

Theta

27.254976

Tajima's D

0.414789

CLR

0

CSRT

0.500374981250937

Interpretation

Uncertain