Gene

KWMTBOMO06816

Pre Gene Modal

BGIBMGA012103

Annotation

PREDICTED:_exonuclease_1-like_[Amyelois_transitella]

Location

Bomo_Chr11(-):16020833-16025981      View in EpiBrowser

Full name

Exonuclease 1      

Alternative Name

Exonuclease I
Protein tosca

Location in the cell

Mitochondrial   Reliability : 1.175 Nuclear   Reliability : 1.168

CDS

ATGGGTATCACTGGTTTGATACCATTTATTGAAAAGGCTTCCCGCCGGACTGATGTTAGTGAATTCAGCGGTTGTACAGTTGCTATTGATTCTTATTGCTGGCTTCATAAAGGAGCTTTTGCATGTGCTGACAAGCTGGTGCGAGGAGAGGAGACTGACATGCATATAAAGTACTGTTTGAAATATGTGACAATGCTTCTGTCTAAGAACATAAAACCAATCTTAGTATTTGATGGACGACATCTCCCAGCTAAAGCAATGACAGAATCAAAAAGGCGAGAATCTCGAAACATTTCAAAGAAAAGAGCAGCAGAGCTTTTAAGTTTAGGAAAGATAGAAGAAGCCCGTTCATACCTGCGTCGTAGTGTCGATATCACTCACGCCATGGCACTGGATCTTATTAAGGAGTGCAGGAAAATGAATGTAGATTGTATTGTCGCTCCATACGAAGCAGACGCTCAGTTAGCCTACCTCAACATAAAGAACATAGCACAATTAGTGATAACTGAAGATTCTGATCTCATACTGTTTGGATGTACTAAGGTCCTCTTCAAAATGGATCTCCATGGTACAGGAACTTTGGTTGAAACATCGAAGTTGCCTCACGTAATGAAATGTCCGATACAACACTACACTTTTGACAAGTTCAGGAGGATGTGCATAATGTCTGGGTGTGATTACCTAGCCTCATTACCAGGCATAGGATTGGCTAAATCTAGACAATTCGTTGTTGCAACACAGGATCCAAATTTTGCTAATGCTTTAAGAAAACTGCCAAATTTTTTCAATCGGATGTCGTTGATCGTTACCGACGAATACAGAGAGAACTTCCTAAAAGCGGAAGCCACATTCAAACATCAGTACGTGTATGATCCTATTGAAAGGAAAATGCTGAGGCTGACTGAACCGGACGATGAAGGTACAGTTATGTTTTTGTATAGTTCTCTAAAGTCTTCAGCATTTCAAAGTCGTCGTGCTCTTAAAGGATAA

Protein

MGITGLIPFIEKASRRTDVSEFSGCTVAIDSYCWLHKGAFACADKLVRGEETDMHIKYCLKYVTMLLSKNIKPILVFDGRHLPAKAMTESKRRESRNISKKRAAELLSLGKIEEARSYLRRSVDITHAMALDLIKECRKMNVDCIVAPYEADAQLAYLNIKNIAQLVITEDSDLILFGCTKVLFKMDLHGTGTLVETSKLPHVMKCPIQHYTFDKFRRMCIMSGCDYLASLPGIGLAKSRQFVVATQDPNFANALRKLPNFFNRMSLIVTDEYRENFLKAEATFKHQYVYDPIERKMLRLTEPDDEGTVMFLYSSLKSSAFQSRRALKG

Description

5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for DNA mismatch repair (MMR) (By similarity).

Cofactor

Mg(2+)

Similarity

Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.

Keywords

Complete proteome   DNA damage   DNA excision   DNA repair   DNA-binding   Endonuclease   Excision nuclease   Exonuclease   Hydrolase   Magnesium   Metal-binding   Nuclease   Nucleus   Phosphoprotein   Reference proteome  

Feature

chain  Exonuclease 1

Uniprot

H9JRE3   A0A2A4J8I6   A0A194R3G9   A0A2H1VZ86   A0A194PEI8   A0A1Q3EVI7   + More
A0A1Q3EVH7   A0A1Q3EVI6   A0A1S4FCU8   Q177A6   A0A182GRP3   A0A182FSS4   A0A182TPT1   A0A182K160   W5J497   A0A182UW22   A0A182Y8T0   A0A182PP82   A0A182W3F5   A0A182KZK4   A0A182XIJ4   A0A182M264   A0A182TA54   A0A084WA06   A0A182RZK4   Q7PQB9   A0A212EI36   B4LSK1   A0A1W4VMS0   B4MZN1   B4P9W4   B3MM41   A0A0M3QTD8   A0A0T6B2W6   K7IXT7   B4JBY6   Q29LT2   B4G7G0   B4I5J1   B3NLB5   Q24558   A0A0J9R3L8   A0A232F2L0   A0A182QVU5   B4KJQ3   A0A310SJI8   A0A1B6HE61   W8C750   A0A154NX69   A0A182NGF0   T1HD04   A0A1B0DIG3   A0A195BM21   A0A195DG79   A0A023F307   A0A336LMH7   A0A158NKL2   A0A195FB10   A0A2S2PEI0   A0A0A9Y086   A0A146LHP4   A0A2H8TR37   A0A1I8MG48   A0A026W2G0   A0A0K8URD9   B0W3C7   A0A1A9ZQA4   A0A1B0G531   N6TSV2   A0A1B6EBA7   A0A224X834   U4TWP5   A0A1B0BY14   A0A0L0BS72   A0A1A9XCX3   A0A1A9UDX7   A0A2A3EBV6   A0A1B6MAT9   E2ATI8   A0A1A9W9Z0   J9JKZ2   A0A034W2S5   F4WWE4   A0A182HYN4   A0A151IEK2   A0A1W4XIT1   A0A1I8NNZ8   A0A2R7W3Q9   A0A0A1XG15   A0A0A1X711   A0A2C9JGD7   E2BXB3   A0A0C9RNG8   T1EE23   A0A1J1J6E3   D7EK58   V3Z9S6   A0A0P6CR89   T1J9L4   A0A0P5SVF3  

EC Number

3.1.-.-

Pubmed

19121390    26354079    17510324    26483478    20920257    23761445    + More
25244985    20966253    24438588    12364791    22118469    17994087    17550304    20075255    15632085    8812111    10731132    12537572    12537569    18327897    22936249    28648823    24495485    25474469    21347285    25401762    26823975    25315136    24508170    23537049    26108605    20798317    25348373    21719571    25830018    15562597    23254933    18362917    19820115   

EMBL

BABH01016273    NWSH01002489    PCG68179.1    KQ460779    KPJ12353.1    ODYU01005213    + More
SOQ45852.1    KQ459606    KPI91771.1    GFDL01015725    JAV19320.1    GFDL01015735    JAV19310.1    GFDL01015733    JAV19312.1    CH477379    EAT42243.1    JXUM01016808    KQ560466    KXJ82279.1    ADMH02002125    ETN58706.1    AXCM01001884    ATLV01021992    KE525327    KFB47050.1    AAAB01008898    EAA09057.6    AGBW02014707    OWR41149.1    CH940649    EDW64823.1    CH963920    EDW77816.1    CM000158    EDW90305.1    CH902620    EDV30856.1    CP012523    ALC38709.1    LJIG01016064    KRT81722.1    CH916368    EDW04089.1    CH379060    EAL33963.1    CH479180    EDW29293.1    CH480822    EDW55647.1    CH954179    EDV54765.2    X89021    X89022    AE014134    AY051794    BT058042    CM002910    KMY90857.1    NNAY01001235    OXU24657.1    AXCN02001612    CH933807    EDW11498.1    KQ762400    OAD55893.1    GECU01034728    JAS72978.1    GAMC01000762    JAC05794.1    KQ434777    KZC04259.1    ACPB03008823    AJVK01062504    KQ976439    KYM86774.1    KQ980886    KYN11898.1    GBBI01002972    JAC15740.1    UFQS01000022    UFQT01000022    SSW97585.1    SSX17971.1    ADTU01018880    ADTU01018881    KQ981693    KYN37810.1    GGMR01015238    MBY27857.1    GBHO01018040    JAG25564.1    GDHC01011018    JAQ07611.1    GFXV01004257    MBW16062.1    KK107467    EZA50275.1    GDHF01023231    JAI29083.1    DS231831    EDS31270.1    CCAG010011372    APGK01020355    KB740193    ENN81118.1    GEDC01002087    JAS35211.1    GFTR01007889    JAW08537.1    KB631669    ERL85232.1    JXJN01022467    JRES01001454    KNC22853.1    KZ288309    PBC28666.1    GEBQ01006950    JAT33027.1    GL442602    EFN63252.1    ABLF02035429    GAKP01010330    JAC48622.1    GL888406    EGI61486.1    APCN01005391    KQ977862    KYM99279.1    KK854273    PTY14068.1    GBXI01003973    JAD10319.1    GBXI01007395    JAD06897.1    GL451230    EFN79696.1    GBYB01009925    GBYB01009929    JAG79692.1    JAG79696.1    AMQM01000745    KB096742    ESO01888.1    CVRI01000069    CRL07046.1    KQ971466    EFA13005.2    KB202849    ESO87703.1    GDIQ01089177    JAN05560.1    JH431976    GDIP01134734    JAL68980.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000008820    UP000069940    + More
UP000249989    UP000069272    UP000075902    UP000075881    UP000000673    UP000075903    UP000076408    UP000075885    UP000075920    UP000075882    UP000076407    UP000075883    UP000075901    UP000030765    UP000075900    UP000007062    UP000007151    UP000008792    UP000192221    UP000007798    UP000002282    UP000007801    UP000092553    UP000002358    UP000001070    UP000001819    UP000008744    UP000001292    UP000008711    UP000000803    UP000215335    UP000075886    UP000009192    UP000076502    UP000075884    UP000015103    UP000092462    UP000078540    UP000078492    UP000005205    UP000078541    UP000095301    UP000053097    UP000002320    UP000092445    UP000092444    UP000019118    UP000030742    UP000092460    UP000037069    UP000092443    UP000078200    UP000242457    UP000000311    UP000091820    UP000007819    UP000007755    UP000075840    UP000078542    UP000192223    UP000095300    UP000076420    UP000008237    UP000015101    UP000183832    UP000007266    UP000030746   

PRIDE

H9JRE3    Q24558   

Pfam

PF00867   XPG_I        + More
PF00752   XPG_N
PF00067   p450

Interpro

IPR008918   HhH2        + More
IPR006085   XPG_DNA_repair_N       
IPR019974   XPG_CS       
IPR006084   XPG/Rad2       
IPR032641   Exo1       
IPR036279   5-3_exonuclease_C_sf       
IPR006086   XPG-I_dom       
IPR029060   PIN-like_dom_sf       
IPR037315   EXO1_H3TH       
IPR036396   Cyt_P450_sf       
IPR002401   Cyt_P450_E_grp-I       
IPR001128   Cyt_P450       
IPR017972   Cyt_P450_CS       

SUPFAM

SSF88723   SSF88723        + More
SSF47807   SSF47807       
SSF48264   SSF48264       

Gene 3D

1.10.630.10    

CDD

cd09908  H3TH_EXO1

ProteinModelPortal

H9JRE3   A0A2A4J8I6   A0A194R3G9   A0A2H1VZ86   A0A194PEI8   A0A1Q3EVI7   + More
A0A1Q3EVH7   A0A1Q3EVI6   A0A1S4FCU8   Q177A6   A0A182GRP3   A0A182FSS4   A0A182TPT1   A0A182K160   W5J497   A0A182UW22   A0A182Y8T0   A0A182PP82   A0A182W3F5   A0A182KZK4   A0A182XIJ4   A0A182M264   A0A182TA54   A0A084WA06   A0A182RZK4   Q7PQB9   A0A212EI36   B4LSK1   A0A1W4VMS0   B4MZN1   B4P9W4   B3MM41   A0A0M3QTD8   A0A0T6B2W6   K7IXT7   B4JBY6   Q29LT2   B4G7G0   B4I5J1   B3NLB5   Q24558   A0A0J9R3L8   A0A232F2L0   A0A182QVU5   B4KJQ3   A0A310SJI8   A0A1B6HE61   W8C750   A0A154NX69   A0A182NGF0   T1HD04   A0A1B0DIG3   A0A195BM21   A0A195DG79   A0A023F307   A0A336LMH7   A0A158NKL2   A0A195FB10   A0A2S2PEI0   A0A0A9Y086   A0A146LHP4   A0A2H8TR37   A0A1I8MG48   A0A026W2G0   A0A0K8URD9   B0W3C7   A0A1A9ZQA4   A0A1B0G531   N6TSV2   A0A1B6EBA7   A0A224X834   U4TWP5   A0A1B0BY14   A0A0L0BS72   A0A1A9XCX3   A0A1A9UDX7   A0A2A3EBV6   A0A1B6MAT9   E2ATI8   A0A1A9W9Z0   J9JKZ2   A0A034W2S5   F4WWE4   A0A182HYN4   A0A151IEK2   A0A1W4XIT1   A0A1I8NNZ8   A0A2R7W3Q9   A0A0A1XG15   A0A0A1X711   A0A2C9JGD7   E2BXB3   A0A0C9RNG8   T1EE23   A0A1J1J6E3   D7EK58   V3Z9S6   A0A0P6CR89   T1J9L4   A0A0P5SVF3  

PDB

5V0E     E-value=2.94104e-79,     Score=750

KEGG

101741887    K10746 exonuclease 1 [EC:3.1.-.-] | (RefSeq) exonuclease 1

PATHWAY

03430    Mismatch repair - Bombyx mori (domestic silkworm)

GO

GO:0006281   GO:0005634   GO:0035312   GO:0003677   GO:0006310   GO:0017108   GO:0006298   GO:0048256   GO:0051908   GO:0046872   GO:0045145   GO:0008409   GO:0016021   GO:0016705   GO:0005506   GO:0020037   GO:0016788   GO:0004518   GO:0003824   GO:0043565   GO:0016567   GO:0016020   GO:0006260  

PANTHER

PTHR11081:SF8   PTHR11081   PTHR11081:SF53  

Subcellular location

Nucleus  

Length:

329

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01067

Exp number, first 60 AAs:

0.00051

Total prob of N-in:

0.00270

outside

1  -  329

 

 

Pi

25.516594

Theta

22.987429

Tajima's D

0.270284

CLR

1.211926

CSRT

0.450477476126194

Interpretation

Uncertain