Gene
KWMTBOMO06814
Pre Gene Modal
BGIBMGA012049
Annotation
PREDICTED:_tyrosine-protein_phosphatase_Lar_isoform_X5_[Papilio_xuthus]
Full name
Tyrosine-protein phosphatase Lar
+ More
Receptor-type tyrosine-protein phosphatase delta
Receptor-type tyrosine-protein phosphatase delta
Alternative Name
Protein-tyrosine-phosphate phosphohydrolase
dLAR
dLAR
Location in the cell
Nuclear Reliability : 2.346
Sequence
CDS
ATGTATCCCGAAAATACGACAACTGTTCGCGCGCGTCAAAAATCCTTCTTATATCTAACAGACGAAGAATCCGAAGATACCGAACCGCCATCAGAAGTGCCAGAATTACCAGAAGAACCACAAGTACAGGAAACGCCAGAGATCCCGCAAGCTCCGGATAGCTCAGGAATACCAGAAACGCCATCCATACCAGAAGAACCTCGGATACCGGAACCGCAAATACCAGATGAGGAAGAAACTGAAGAGCCATATATAACCGTAACACAGCATATACCGGGCAGTACTTATCCGATAGCCCCTCATCTACCAGGTGTACCGTACTTTGCGGTACCATATATTCCTGGGCCGCAACCAGAAGTTACACACACGGGATTTCCGCAAATACCACCACATTATCCACCTAGCTATCAAACTCCGCCCGGGTATCCGCAACCGCATCCCGGATACCCGCAACCGCCACCGGGATATCCGCAACCTCCACCGAGCTATCCGCAGCCACCGCAAGGCTATCCACAGACTCCGCCAGGCTACCCTCAATTACCACCTGGTTTTCCGATTCCGCCCGGATATCAGTTGCCACCTGGATTTGCATTACCGCCGGGGTACCCGCATTTACTACCCGGCTATCCGCAACTACCGCCAGGATATTCGCATTTTCCGGACGTGGTCACAGACTACAAACCACCTATCTTTGCACCACCAATCAACGACTCCGGAAATATCTATATCAGATATTTAACACATCCGCCTGAGATCACGATCCGGCCGAGGAACCTTCAAGTTCGAGCTAACAGCATCGCAGCGTTCTATTGCGCGGCACGAGGAGACCCGATACCTAACATACAGTGGCGCAAAAACGGAAAGAAAGTTTCCAACATGCAAACCCGCTACCAAGTATCGGGCATGGACGGAGCGGCCGGCCCCGGTGCCAACGGAGCTGTCCTTCGCATCGAACCAGTGCGGGCGCAACGCGACGACGCGACCTACGAGTGCGTTGCCGAGAACGGCGTTGGCGACGCTGTCACTGCCGTAGCTACGTTGACGGTGTTCGAAGTTGATAAAGTCCCGCCCGGTTTCCCGAGCATTTCGCCGCCCTCCACCATGATGGTCGTCGAGATTGGCCACACGGCTACCCTGCCCTGCCAAGCTACCGGGAACCCAACGCCCAAAATAAGATGGCTTCGGAACTCCTTGCCACTGGACGTCGCTTCGAATCCAAGATACGCTCTGCTCAACGATAAGATGCATGGCACACTGCAAATAGTGAAGAGTGAAGAGGATGACAATGGCAAATTTGAATGTATCGCGGAAAACTCGATTGGAACTGAATTCTCTAAGCCCACGGTTCTATACGTGAAAGTACGAAGAGTCGCACCCCAGTTTTCGATACCACCCCCTCCCCGCTCAGAAGTGATGCTCGGTGGAAACCTGACTTTGAAATGCGTTGCTTTCGGAGCACCGATGCCTACTGTTAAATGGAGGAAAGGATTAACGAAATGGTTGACCCCGGAGGATAATCCTCCTCTAGGGCTGAACAACCTTGAATTAAGAGACATCAGAGAATCTGCCAACTACACTTGCGAAGCAGCCAGCGTGCTTGGAGTCATTGAAGCCACAGCCGAAGTCAAAGTTCAATCATTACCTGGAGCCCCCACTGAAGTTAGACCTTCCGAAGTTACAGCGACCGCAGTTCGCCTGTCATGGACATATAACGGCCCAGAAGAACCCCAGTACTATGTCATACAGTACAAACCTAAAAACGCTCATCAGGCCTTCAGCGAGATATCTGGAGTGATCACCCAATACTACTCCGTTACGAATCTATCGCCTTACACTGAATACGAGATGTACGTCATTGCGGTCAACAACATCGGCAGGGGACCTCCGTCTTCACCGGCGGTCATCAGTACCGGAGAAACAGAGCCCGGTTCAGCGCCGAAGAATGTTCAAGTCCGTCCACTCAGCTCCAGCACGATGGTGATACAATGGGAAGAACCGGAGACGCCTAACGGTCAAGTCACCGGCTACAAGATATTTTACACTACGGATCCATCGCAACCTTTACAGTCTTGGCACTCTCATATGATGGACAACAGTCACTTGACAACGATAAGCGAGCTAACCCCACACACGGTGTACACGATAAGAGTGCAAGCGTATACATCCGTTGGACCCGGTCCGATATCTGCTCCAGTTCAAGTGAAAACCCAACAAGGAGTACCGTCGCAGCCATCGAACCTCGTTGCCACGGAAGCTGGTGAAACATCTGTGACTCTGTCGTGGAAACGACCAGCTCACGCCGGCGACAACATCGTCTCTTACGAACTCTATTGGAACGATACGTACGCTAAGGAGCATCATAAAAAACGCATCCCGATAACGGAGACATACACCCTGAACGGTCTGTATCCGAATACGTTGTACTACATCTGGCTAGCGGCGAGGTCTCAGCGAGGGGAAGGCGCCACCACACCCGCCATAGCCGTCAGAACCAAACAGTATGTGCCTGGTGAACCACAAGACGTCAAGGTGACAGCCATCAACTCAACCTCTATCCATGTTACGTGGAAGCCGCCACATGATAAAGATAAAAACGGAATCATCAGGGGCTATCATGTTCACGTCCAAGAAGTTAGAGAAGAAGGGAAAGGTCTTCTCAACGACCCCATGCGTTTCAATGTAATGGATGACACGACATTGGAACTGAACGTTTCTGGCCTCCAACCGGACACACGGTACAATGTTCAGGTTGCCGCGCTGACAAGGAAAGGAGACGGCGACCGGAGTCCACCAGTATCTGTCAAAACCCCTGGCGGAGTGCCAAACAGACCCACCGTTAGTCTAAAAATCCTGGAACGCGAACCAATAGTTTCTATCGAATTAGATTGGGCGAGACCTACACAGACATACGGAGACTTACTTGGATATCGATTACGATTCGGAATTAAAGATCAGCCGTTAGAGGAAATCAATTTCCCTGGTACCAAAGTGACGTCACATAGAATAAGTGATTTAGAACGAGGAGTTCAGTATGAGTTTAGAATAGCAGGAACAAATCAAATAGGCGTCGGACAAGAAACTATAAAGTACATGTTGACTCCAGAAGGTGCTCCTAAGGGACCTCCAACTAATGTTACATATCATTTCCAAACTCCCGATATCATAAGTATAACCTGGGAACCCCCTGTAAGAGCGGACAGAAGTGGCCAAATTAAGAAATATGACGTCCAATTTTATAAAAGAGGAGATCAGTCGTCATTATTAGAAAAAACCACTAACCAAACGAAGGCCGTATTCACGGGTCTGGAAGAGGACGCACATTACGTATTTAAGGTTCGTGCGTATACTGATCAGGGGCCTGGACCCTACAGCAAAGATATGACTGCTCATACCGAAAGAGATATCGGAAGAGCACCCATGTCCGTCAAAGCTGTCGCCACCTCAGAGTCAAGCGTCGAAGTATGGTGGGAAACATTCCGTTCCAGAAAGAAGATAATAGGCTATGTCTTATTTTATACTATGACGCCGGTTGAAGATTTGGACGAATGGCAACAAAAGAGTATACATGTAACACATTCGGCTGATTTGGAAAATCTGGAAACGTTTGCGGAGTATGCTATAGCAGTGGCTGCTAAAACAGCGGACGGATTGGGAAGGCTGTCGGAAAAGGTTACTGTTAAAGTTAAACCAGAAGAAGTGCCTTTACACCTAAGAGCTCAGGACGTGTCTACACATTCTATGACTCTGTCCTGGTCATCCCCGCTACGATTAAACCCTGTTAGTTATAAAATCTCGTACAATGCCATCAAAGAGTTCGTAGACTCGCTCGGTATGACACAGACTCAAGAGATACCTAGAAAAGAAATTATTGTTAAGCATAATAGAACATCATTTTCTATCAACGACTTGTCGCCTTTTACGACTTACAATGTAAACGTAAGCGCCATACCGAATGACGATTCGTATCGGCCGCCTAAAAAGATTACAGTGACGACGCAAATGGCCGCACCTAAGCCGATGGTCAAACCAGACTTCTATGGTGTTGTCGAAAACGAAATACTCGTAATTCTACCTCAAGCTTCCGAGGAATACGGACCTATCTCCCATTATTATTTAGTCGTAGTACCTGATGATAAGTTGCACAATCACAAGAATCCGGATCAGTTCCTAACAGACGACCTAATCAAGAATAACATGAGAACGGACGATGAAAACGCTCCCTACATTGCAGCCAAATTTTTACAGAGAAACATTTTGTATACCTTTCACCTCGGCAACGACGAACTGTACGAAGGATTTTTGAATAGAAAATTGAACCTGAACAAAAGGTATCGAGTGTTTGTAAGAGCAGTAGTAGACACACCTCAGAAACACTTGTATACATCAAGTCCATTTTCGGAATATCTGTCTTTGGATATGCGAGAAGCTCCTCCGGGTGAGGAACCTAGCAGACCAGATCCCAAGGATATTAATGGCGATCCTGAAATTCGAATAGAAGAGAACAGGAAAGAGGCGGGCATGGCGGCGGTCACCAGACCTTTGATGTCCGCCGATGTTGGTTTTGGTGCTCCATCTGACCCCGTGGAAATGAGACGATTAAACTTCCAGACACCCGCGATGATCTCTCATCCGCCTATTCCGATTTCTGAACTAGGCGAACACATTGATAGACTGAAAGCCAACGACAATATGAAATTCTCTCAAGAATATGAGAGTATCGAGCCAGGACAACAGTTTACTTGGGACCATTCTAACATGGAAGTTAACAAACCGAAGAATCGGTATGCTAATGTGATCGCGTACGACCACAGTCGAGTCATCCTTCAGCCCATCGATGGAATTCTAGGCAGTGATTACATTAATGCCAATTATTGCGACGGCTACCGCAAACATAACGCATACGTAGCTACTCAAGGGCCGCTGCAGGAAACTTTTGCGGATTTCTGGAGAATGTGTTGGGAGCTACGCACGTCCACGATTGTTATGATGACAAAATTGGAAGAGAGAACTAGAATAAAATGCGACCAATATTGGCCGAGCCGCGGCACTGAATCGTACGGCATGATGAGCGTTACCATTGCCGAAGTTCAAGAACTTTCGACTTATTCCATACGTACTTTCCAAGTATCTAGGAACGGATGCGCCGAACGTAGAGAAATCAAACAGCTACAGTTTACGGCTTGGCCGGATCACGGCGTTCCCGATCATCCTGCGCCCTTCCTCCAGTTTTTGAGACGCGTTCGTGCCTTGAATCCGCCCGAAGCCGGTCCGCTGGTCGTCCACTGTTCCGCCGGGGTGGGTCGTACGGGGTGCTTCATAGTCATTGACTCGATGCTTGAGAGAGCCCGACATGAGCGCACTGTCGATATATACGGGCACGTGACCTGTCTCCGCGCTCAACGTAACTACATGGTGCAAACCGAGGACCAATACATCTTCATTCACGACGCCTTACTGGAGGCGGTTATCTGCGGCGACACGGAAGTGCCGGCGCGCAATCTGCACGCTCACATCCAGAAGCTGATGCGAATCGACTCTATCGAGAACATAACGGGCATGGAATTAGAATTCAAGAAGCTGGCGAACATGAAGGCGGACTCCAGTAGGTTTGTCTCGGCCAGTTTGCCTTGCAACAAGCACAAGAACAGGCTAGTCCACATCTTGCCGTACGAGTCTAGTCGGGTCTGCCTGACGCCGCGCGATGGCTCCGATTACATCAACGCGTCGTTCGTTGACGGATACAGATACAGGGCGGCGTATATCGCCACGCAGGGCCCCCTACCGGACACCACCGACGACTTCTGGCGAATGCTTTGGGAGCACAACTCAACCATCATCGTGATGCTGACCAAACTGAAGGAAATGGGCCGGGAAAAATGTCACCAATATTGGCCGTCTGACCGCTCGGTGCGTTACCAGTGCTTCGTAGTGGATCCGATTGCCGAATACAACATGCCTCAATACATTTTGAGGGAATTTAAGGTCACGGATGCCCGGGACGGCGCCTCCAGGACGGTCAGACAGTTCCAGTTCACGGACTGGCCCGAACAAGGAGTGCCGAAAAGCGGAGAAGGCTTCATCGATTTCCTCGGACAAGTTCACAAGACCAAGGAACAATTCGGACAGGACGGACCTATAACTGTGCACTGCAGTGCGGGCGTCGGTCGCACGGGCGTGTTCATAACTCTGTCAACGGTGTTGGAGCGTATGCAGTATGAAGGCGTGGTGGATGTATTCCAGACGGTACGCACGCTCCGCACGCAGCGACCCGCCATCGTGCAGACTGAGGACCAGTACGAGTTCTGCTACCGCGCAGCCCTGGAGTATCTCGGCTCGTTCGATCACTACACCAACTGA
Protein
MYPENTTTVRARQKSFLYLTDEESEDTEPPSEVPELPEEPQVQETPEIPQAPDSSGIPETPSIPEEPRIPEPQIPDEEETEEPYITVTQHIPGSTYPIAPHLPGVPYFAVPYIPGPQPEVTHTGFPQIPPHYPPSYQTPPGYPQPHPGYPQPPPGYPQPPPSYPQPPQGYPQTPPGYPQLPPGFPIPPGYQLPPGFALPPGYPHLLPGYPQLPPGYSHFPDVVTDYKPPIFAPPINDSGNIYIRYLTHPPEITIRPRNLQVRANSIAAFYCAARGDPIPNIQWRKNGKKVSNMQTRYQVSGMDGAAGPGANGAVLRIEPVRAQRDDATYECVAENGVGDAVTAVATLTVFEVDKVPPGFPSISPPSTMMVVEIGHTATLPCQATGNPTPKIRWLRNSLPLDVASNPRYALLNDKMHGTLQIVKSEEDDNGKFECIAENSIGTEFSKPTVLYVKVRRVAPQFSIPPPPRSEVMLGGNLTLKCVAFGAPMPTVKWRKGLTKWLTPEDNPPLGLNNLELRDIRESANYTCEAASVLGVIEATAEVKVQSLPGAPTEVRPSEVTATAVRLSWTYNGPEEPQYYVIQYKPKNAHQAFSEISGVITQYYSVTNLSPYTEYEMYVIAVNNIGRGPPSSPAVISTGETEPGSAPKNVQVRPLSSSTMVIQWEEPETPNGQVTGYKIFYTTDPSQPLQSWHSHMMDNSHLTTISELTPHTVYTIRVQAYTSVGPGPISAPVQVKTQQGVPSQPSNLVATEAGETSVTLSWKRPAHAGDNIVSYELYWNDTYAKEHHKKRIPITETYTLNGLYPNTLYYIWLAARSQRGEGATTPAIAVRTKQYVPGEPQDVKVTAINSTSIHVTWKPPHDKDKNGIIRGYHVHVQEVREEGKGLLNDPMRFNVMDDTTLELNVSGLQPDTRYNVQVAALTRKGDGDRSPPVSVKTPGGVPNRPTVSLKILEREPIVSIELDWARPTQTYGDLLGYRLRFGIKDQPLEEINFPGTKVTSHRISDLERGVQYEFRIAGTNQIGVGQETIKYMLTPEGAPKGPPTNVTYHFQTPDIISITWEPPVRADRSGQIKKYDVQFYKRGDQSSLLEKTTNQTKAVFTGLEEDAHYVFKVRAYTDQGPGPYSKDMTAHTERDIGRAPMSVKAVATSESSVEVWWETFRSRKKIIGYVLFYTMTPVEDLDEWQQKSIHVTHSADLENLETFAEYAIAVAAKTADGLGRLSEKVTVKVKPEEVPLHLRAQDVSTHSMTLSWSSPLRLNPVSYKISYNAIKEFVDSLGMTQTQEIPRKEIIVKHNRTSFSINDLSPFTTYNVNVSAIPNDDSYRPPKKITVTTQMAAPKPMVKPDFYGVVENEILVILPQASEEYGPISHYYLVVVPDDKLHNHKNPDQFLTDDLIKNNMRTDDENAPYIAAKFLQRNILYTFHLGNDELYEGFLNRKLNLNKRYRVFVRAVVDTPQKHLYTSSPFSEYLSLDMREAPPGEEPSRPDPKDINGDPEIRIEENRKEAGMAAVTRPLMSADVGFGAPSDPVEMRRLNFQTPAMISHPPIPISELGEHIDRLKANDNMKFSQEYESIEPGQQFTWDHSNMEVNKPKNRYANVIAYDHSRVILQPIDGILGSDYINANYCDGYRKHNAYVATQGPLQETFADFWRMCWELRTSTIVMMTKLEERTRIKCDQYWPSRGTESYGMMSVTIAEVQELSTYSIRTFQVSRNGCAERREIKQLQFTAWPDHGVPDHPAPFLQFLRRVRALNPPEAGPLVVHCSAGVGRTGCFIVIDSMLERARHERTVDIYGHVTCLRAQRNYMVQTEDQYIFIHDALLEAVICGDTEVPARNLHAHIQKLMRIDSIENITGMELEFKKLANMKADSSRFVSASLPCNKHKNRLVHILPYESSRVCLTPRDGSDYINASFVDGYRYRAAYIATQGPLPDTTDDFWRMLWEHNSTIIVMLTKLKEMGREKCHQYWPSDRSVRYQCFVVDPIAEYNMPQYILREFKVTDARDGASRTVRQFQFTDWPEQGVPKSGEGFIDFLGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSTVLERMQYEGVVDVFQTVRTLRTQRPAIVQTEDQYEFCYRAALEYLGSFDHYTN
Summary
Description
Possible cell adhesion receptor (Probable). It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) (PubMed:2554325). It controls motor axon guidance (PubMed:8598047). In the developing eye, has a role in normal axonal targeting of the R7 photoreceptor, where it negatively regulates bdl (PubMed:24174674). Inhibits bdl cell adhesion activity in vitro; this effect is independent of its PTPase function (PubMed:24174674).
Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically (PubMed:25908590). Involved in pre-synaptic differentiation through interaction with SLITRK2 (PubMed:25989451).
Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically (PubMed:25908590). Involved in pre-synaptic differentiation through interaction with SLITRK2 (PubMed:25989451).
Catalytic Activity
H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate
Subunit
Interacts with PPFIA1, PPFIA2 and PPFIA3 (By similarity). Interacts (via extracellular domain) with SLITRK4 (via LRR 1 and 2 repeats) (PubMed:25989451). Interacts with SLITRK2; induces presynaptic differentiation (PubMed:25989451). Interacts (via the second immunoglobilin domain) with IL1RAPL1 (via the first immunoglobilin domain); induces pre- and postsynaptic differentiation of neurons and synapse formation. Isoform G, isoform H, isoform I, isoform J, and isoform K do not interact with IL1RAPL1 (PubMed:25908590, PubMed:21940441). Interacts (via the third immunoglobilin domain) with IL1RAP (via the first immunoglobilin domain); induces pre- and postsynaptic differentiation of neurons (PubMed:25908590).
Similarity
Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.
Keywords
3D-structure
Cell adhesion
Complete proteome
Disulfide bond
Glycoprotein
Heparin-binding
Hydrolase
Immunoglobulin domain
Membrane
Neurogenesis
Phosphoprotein
Protein phosphatase
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix
Alternative splicing
Feature
chain Tyrosine-protein phosphatase Lar
splice variant In isoform A and isoform B.
splice variant In isoform A and isoform B.
Uniprot
A0A2A4JAZ8
A0A0Q9X675
A0A0Q9X679
A0A0Q9WKV6
A0A1I8NX96
A0A0Q9W897
+ More
A0A1I8NX65 A0A1I8NX70 A0A0R1DTR4 A0A2A3EPX0 A0A1W4V6W3 A0A0J9R4Q9 A0A0Q5VXV8 A0A0R1DQC6 M9PG93 A0A0R3P0R2 A0A0P9A4T0 A0A1W4V887 A0A0Q5VW78 M9NCY3 A0A0J9R504 A0A0R3NVP0 M9PDR3 A0A0R1DVC6 A0A0N8NZ76 M9PDF7 A0A3B0JXY1 A0A1W4V7C4 A0A0J9R470 A0A0Q5VJF1 A0A0P8Y3Z8 A0A0R3NVV0 A0A3B0JUZ9 A0A0M9AAH8 A0A0M4EE71 A0A0Q9XHM4 B4KIB2 A0A0Q9XFR8 B4LVH6 B3NL41 A0A0Q5VZ03 A0A0Q9XJC1 P16621 B4PB20 A8DZ18 A0A0Q9XG67 A0A0R1DVT1 A0A0Q9W8C2 A0A1W4V6V6 A0A0Q9WFN3 A0A0Q5VKK9 A0A0R1DVI0 A0A0Q5VJR8 B4JR64 A0A1W4UUY1 A0A0R1DPG7 M9PD76 A0A0Q9W9I4 A0A0J9R500 A0A1W4V7B8 B4QA19 A0A1W4UUX7 A0A0J9TRP5 B3ML69 A0A0P9BNY8 B4MWA1 A0A0J9TRN8 A0A0P8XW02 B5DKB5 B4GJB3 A0A0P9BNX7 A0A3B0KJJ1 A0A3B0JV10 A0A0R3NVE0 A0A0R3P0K9 A0A0R3NV87 A0A0P8XFK7 A0A0P8XG08 A0A0P8XF82 A0A0R3NVB5 A0A0R3NVE1 A0A0R3P228 W5JND8 A0A087U595 A0A3Q1LUB1 A0A287B9S0 A0A1U7TGZ0 F1PH17 A0A3Q7SL22 A0A091IL26 A0A2R9AVC6 Q64487-9 A0A0A0AJF3 G1SE72 M3WV97 A0A3Q7X5D8 A0A2R9AQW8
A0A1I8NX65 A0A1I8NX70 A0A0R1DTR4 A0A2A3EPX0 A0A1W4V6W3 A0A0J9R4Q9 A0A0Q5VXV8 A0A0R1DQC6 M9PG93 A0A0R3P0R2 A0A0P9A4T0 A0A1W4V887 A0A0Q5VW78 M9NCY3 A0A0J9R504 A0A0R3NVP0 M9PDR3 A0A0R1DVC6 A0A0N8NZ76 M9PDF7 A0A3B0JXY1 A0A1W4V7C4 A0A0J9R470 A0A0Q5VJF1 A0A0P8Y3Z8 A0A0R3NVV0 A0A3B0JUZ9 A0A0M9AAH8 A0A0M4EE71 A0A0Q9XHM4 B4KIB2 A0A0Q9XFR8 B4LVH6 B3NL41 A0A0Q5VZ03 A0A0Q9XJC1 P16621 B4PB20 A8DZ18 A0A0Q9XG67 A0A0R1DVT1 A0A0Q9W8C2 A0A1W4V6V6 A0A0Q9WFN3 A0A0Q5VKK9 A0A0R1DVI0 A0A0Q5VJR8 B4JR64 A0A1W4UUY1 A0A0R1DPG7 M9PD76 A0A0Q9W9I4 A0A0J9R500 A0A1W4V7B8 B4QA19 A0A1W4UUX7 A0A0J9TRP5 B3ML69 A0A0P9BNY8 B4MWA1 A0A0J9TRN8 A0A0P8XW02 B5DKB5 B4GJB3 A0A0P9BNX7 A0A3B0KJJ1 A0A3B0JV10 A0A0R3NVE0 A0A0R3P0K9 A0A0R3NV87 A0A0P8XFK7 A0A0P8XG08 A0A0P8XF82 A0A0R3NVB5 A0A0R3NVE1 A0A0R3P228 W5JND8 A0A087U595 A0A3Q1LUB1 A0A287B9S0 A0A1U7TGZ0 F1PH17 A0A3Q7SL22 A0A091IL26 A0A2R9AVC6 Q64487-9 A0A0A0AJF3 G1SE72 M3WV97 A0A3Q7X5D8 A0A2R9AQW8
EC Number
3.1.3.48
Pubmed
17994087
17550304
22936249
10731132
12537568
12537572
+ More
12537573 12537574 16110336 17569856 17569867 15632085 2554325 8598047 12537569 18327897 24174674 21402080 18057021 23185243 20920257 23761445 19393038 16341006 22722832 8355697 11978849 19468303 7832766 21183079 21940441 25908590 25989451 21993624 17975172
12537573 12537574 16110336 17569856 17569867 15632085 2554325 8598047 12537569 18327897 24174674 21402080 18057021 23185243 20920257 23761445 19393038 16341006 22722832 8355697 11978849 19468303 7832766 21183079 21940441 25908590 25989451 21993624 17975172
EMBL
NWSH01002307
PCG68563.1
CH933807
KRG03743.1
KRG03744.1
CH940649
+ More
KRF81056.1 KRF81059.1 CM000158 KRJ99186.1 KZ288204 PBC33179.1 CM002910 KMY91068.1 CH954179 KQS61874.1 KRJ99182.1 AE014134 AGB93132.1 CH379062 KRT05061.1 CH902620 KPU73547.1 KQS61870.1 AFH03768.1 KMY91071.1 KRT05066.1 AGB93130.1 KRJ99184.1 KPU73548.1 AGB93131.1 OUUW01000010 SPP85923.1 KMY91069.1 KMY91072.1 KQS61869.1 KPU73551.1 KRT05068.1 SPP85925.1 KQ435714 KOX79189.1 CP012523 ALC40272.1 KRG03745.1 EDW13409.2 KRG03746.1 EDW63355.2 EDV54619.1 KQS61871.1 KRG03747.1 M27700 U36857 U36849 U36850 U36851 U36852 U36853 U36854 U36855 U36856 AY051985 EDW90449.1 AAN11057.2 KRG03742.1 KRJ99187.1 KRF81057.1 KRF81058.1 KRF81064.1 KRF81063.1 KQS61873.1 KRJ99185.1 KQS61872.1 CH916372 EDV99394.1 KRJ99181.1 KRJ99183.1 AGB93129.1 KRF81060.1 KRF81061.1 KRF81062.1 KRF81065.1 KMY91066.1 CM000361 EDX05549.1 KMY91064.1 KMY91070.1 EDV31687.1 KPU73552.1 CH963857 EDW75971.2 KMY91065.1 KMY91067.1 KPU73545.1 EDY70741.1 CH479184 EDW37427.1 KPU73543.1 SPP85926.1 SPP85924.1 KRT05064.1 KRT05069.1 KRT05070.1 KPU73546.1 KPU73550.1 KPU73544.1 KPU73549.1 KRT05067.1 KRT05060.1 KRT05063.1 KRT05065.1 KRT05062.1 ADMH02000562 ETN65882.1 KK118240 KFM72534.1 AEMK02000004 AAEX03007837 KK500601 KFP09389.1 AJFE02082354 AJFE02082355 AJFE02082356 AJFE02082357 AJFE02082358 AJFE02082359 AJFE02082360 AJFE02082361 AJFE02082362 AJFE02082363 D13903 D13905 D13904 AF326559 AF326560 AL844848 AL845517 AL929181 Z23051 KL871841 KGL93593.1 AAGW02032701 AAGW02032702 AAGW02032703 AAGW02032704 AAGW02032705 AAGW02032706 AAGW02032707 AAGW02032708 AANG04001055
KRF81056.1 KRF81059.1 CM000158 KRJ99186.1 KZ288204 PBC33179.1 CM002910 KMY91068.1 CH954179 KQS61874.1 KRJ99182.1 AE014134 AGB93132.1 CH379062 KRT05061.1 CH902620 KPU73547.1 KQS61870.1 AFH03768.1 KMY91071.1 KRT05066.1 AGB93130.1 KRJ99184.1 KPU73548.1 AGB93131.1 OUUW01000010 SPP85923.1 KMY91069.1 KMY91072.1 KQS61869.1 KPU73551.1 KRT05068.1 SPP85925.1 KQ435714 KOX79189.1 CP012523 ALC40272.1 KRG03745.1 EDW13409.2 KRG03746.1 EDW63355.2 EDV54619.1 KQS61871.1 KRG03747.1 M27700 U36857 U36849 U36850 U36851 U36852 U36853 U36854 U36855 U36856 AY051985 EDW90449.1 AAN11057.2 KRG03742.1 KRJ99187.1 KRF81057.1 KRF81058.1 KRF81064.1 KRF81063.1 KQS61873.1 KRJ99185.1 KQS61872.1 CH916372 EDV99394.1 KRJ99181.1 KRJ99183.1 AGB93129.1 KRF81060.1 KRF81061.1 KRF81062.1 KRF81065.1 KMY91066.1 CM000361 EDX05549.1 KMY91064.1 KMY91070.1 EDV31687.1 KPU73552.1 CH963857 EDW75971.2 KMY91065.1 KMY91067.1 KPU73545.1 EDY70741.1 CH479184 EDW37427.1 KPU73543.1 SPP85926.1 SPP85924.1 KRT05064.1 KRT05069.1 KRT05070.1 KPU73546.1 KPU73550.1 KPU73544.1 KPU73549.1 KRT05067.1 KRT05060.1 KRT05063.1 KRT05065.1 KRT05062.1 ADMH02000562 ETN65882.1 KK118240 KFM72534.1 AEMK02000004 AAEX03007837 KK500601 KFP09389.1 AJFE02082354 AJFE02082355 AJFE02082356 AJFE02082357 AJFE02082358 AJFE02082359 AJFE02082360 AJFE02082361 AJFE02082362 AJFE02082363 D13903 D13905 D13904 AF326559 AF326560 AL844848 AL845517 AL929181 Z23051 KL871841 KGL93593.1 AAGW02032701 AAGW02032702 AAGW02032703 AAGW02032704 AAGW02032705 AAGW02032706 AAGW02032707 AAGW02032708 AANG04001055
Proteomes
UP000218220
UP000009192
UP000008792
UP000095300
UP000002282
UP000242457
+ More
UP000192221 UP000008711 UP000000803 UP000001819 UP000007801 UP000268350 UP000053105 UP000092553 UP000001070 UP000000304 UP000007798 UP000008744 UP000000673 UP000054359 UP000009136 UP000008227 UP000189704 UP000002254 UP000286640 UP000053119 UP000240080 UP000000589 UP000053858 UP000001811 UP000011712 UP000286642
UP000192221 UP000008711 UP000000803 UP000001819 UP000007801 UP000268350 UP000053105 UP000092553 UP000001070 UP000000304 UP000007798 UP000008744 UP000000673 UP000054359 UP000009136 UP000008227 UP000189704 UP000002254 UP000286640 UP000053119 UP000240080 UP000000589 UP000053858 UP000001811 UP000011712 UP000286642
Interpro
IPR013783
Ig-like_fold
+ More
IPR003599 Ig_sub
IPR000387 TYR_PHOSPHATASE_dom
IPR003595 Tyr_Pase_cat
IPR036116 FN3_sf
IPR000242 PTPase_domain
IPR007110 Ig-like_dom
IPR003961 FN3_dom
IPR036179 Ig-like_dom_sf
IPR016130 Tyr_Pase_AS
IPR003598 Ig_sub2
IPR029021 Prot-tyrosine_phosphatase-like
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR000387 TYR_PHOSPHATASE_dom
IPR003595 Tyr_Pase_cat
IPR036116 FN3_sf
IPR000242 PTPase_domain
IPR007110 Ig-like_dom
IPR003961 FN3_dom
IPR036179 Ig-like_dom_sf
IPR016130 Tyr_Pase_AS
IPR003598 Ig_sub2
IPR029021 Prot-tyrosine_phosphatase-like
IPR013098 Ig_I-set
Gene 3D
CDD
ProteinModelPortal
A0A2A4JAZ8
A0A0Q9X675
A0A0Q9X679
A0A0Q9WKV6
A0A1I8NX96
A0A0Q9W897
+ More
A0A1I8NX65 A0A1I8NX70 A0A0R1DTR4 A0A2A3EPX0 A0A1W4V6W3 A0A0J9R4Q9 A0A0Q5VXV8 A0A0R1DQC6 M9PG93 A0A0R3P0R2 A0A0P9A4T0 A0A1W4V887 A0A0Q5VW78 M9NCY3 A0A0J9R504 A0A0R3NVP0 M9PDR3 A0A0R1DVC6 A0A0N8NZ76 M9PDF7 A0A3B0JXY1 A0A1W4V7C4 A0A0J9R470 A0A0Q5VJF1 A0A0P8Y3Z8 A0A0R3NVV0 A0A3B0JUZ9 A0A0M9AAH8 A0A0M4EE71 A0A0Q9XHM4 B4KIB2 A0A0Q9XFR8 B4LVH6 B3NL41 A0A0Q5VZ03 A0A0Q9XJC1 P16621 B4PB20 A8DZ18 A0A0Q9XG67 A0A0R1DVT1 A0A0Q9W8C2 A0A1W4V6V6 A0A0Q9WFN3 A0A0Q5VKK9 A0A0R1DVI0 A0A0Q5VJR8 B4JR64 A0A1W4UUY1 A0A0R1DPG7 M9PD76 A0A0Q9W9I4 A0A0J9R500 A0A1W4V7B8 B4QA19 A0A1W4UUX7 A0A0J9TRP5 B3ML69 A0A0P9BNY8 B4MWA1 A0A0J9TRN8 A0A0P8XW02 B5DKB5 B4GJB3 A0A0P9BNX7 A0A3B0KJJ1 A0A3B0JV10 A0A0R3NVE0 A0A0R3P0K9 A0A0R3NV87 A0A0P8XFK7 A0A0P8XG08 A0A0P8XF82 A0A0R3NVB5 A0A0R3NVE1 A0A0R3P228 W5JND8 A0A087U595 A0A3Q1LUB1 A0A287B9S0 A0A1U7TGZ0 F1PH17 A0A3Q7SL22 A0A091IL26 A0A2R9AVC6 Q64487-9 A0A0A0AJF3 G1SE72 M3WV97 A0A3Q7X5D8 A0A2R9AQW8
A0A1I8NX65 A0A1I8NX70 A0A0R1DTR4 A0A2A3EPX0 A0A1W4V6W3 A0A0J9R4Q9 A0A0Q5VXV8 A0A0R1DQC6 M9PG93 A0A0R3P0R2 A0A0P9A4T0 A0A1W4V887 A0A0Q5VW78 M9NCY3 A0A0J9R504 A0A0R3NVP0 M9PDR3 A0A0R1DVC6 A0A0N8NZ76 M9PDF7 A0A3B0JXY1 A0A1W4V7C4 A0A0J9R470 A0A0Q5VJF1 A0A0P8Y3Z8 A0A0R3NVV0 A0A3B0JUZ9 A0A0M9AAH8 A0A0M4EE71 A0A0Q9XHM4 B4KIB2 A0A0Q9XFR8 B4LVH6 B3NL41 A0A0Q5VZ03 A0A0Q9XJC1 P16621 B4PB20 A8DZ18 A0A0Q9XG67 A0A0R1DVT1 A0A0Q9W8C2 A0A1W4V6V6 A0A0Q9WFN3 A0A0Q5VKK9 A0A0R1DVI0 A0A0Q5VJR8 B4JR64 A0A1W4UUY1 A0A0R1DPG7 M9PD76 A0A0Q9W9I4 A0A0J9R500 A0A1W4V7B8 B4QA19 A0A1W4UUX7 A0A0J9TRP5 B3ML69 A0A0P9BNY8 B4MWA1 A0A0J9TRN8 A0A0P8XW02 B5DKB5 B4GJB3 A0A0P9BNX7 A0A3B0KJJ1 A0A3B0JV10 A0A0R3NVE0 A0A0R3P0K9 A0A0R3NV87 A0A0P8XFK7 A0A0P8XG08 A0A0P8XF82 A0A0R3NVB5 A0A0R3NVE1 A0A0R3P228 W5JND8 A0A087U595 A0A3Q1LUB1 A0A287B9S0 A0A1U7TGZ0 F1PH17 A0A3Q7SL22 A0A091IL26 A0A2R9AVC6 Q64487-9 A0A0A0AJF3 G1SE72 M3WV97 A0A3Q7X5D8 A0A2R9AQW8
PDB
2FH7
E-value=0,
Score=2593
Ontologies
GO
GO:0016021
GO:0004725
GO:0007399
GO:1903386
GO:0007412
GO:0048477
GO:0045467
GO:0048841
GO:0032093
GO:0007411
GO:0009925
GO:0120034
GO:0030424
GO:0008594
GO:0051491
GO:0007283
GO:0031290
GO:0008045
GO:0060269
GO:0031252
GO:0008201
GO:0048675
GO:0035335
GO:0007155
GO:0051124
GO:0005001
GO:0005925
GO:1905606
GO:0098978
GO:0099545
GO:0099560
GO:0006470
GO:0099056
GO:0050804
GO:0050775
GO:0097105
GO:0050839
GO:0050776
GO:0005102
GO:0007157
GO:0051965
GO:0098686
GO:0046426
GO:0030182
GO:0099151
GO:0098685
GO:0005515
GO:0016311
GO:0016791
GO:0043565
GO:0016567
GO:0016020
GO:0005634
GO:0006260
Topology
Subcellular location
Membrane
Length:
2118
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.03038
Exp number, first 60 AAs:
0
Total prob of N-in:
0.00036
outside
1 - 2118
Population Genetic Test Statistics
Pi
23.507605
Theta
22.610697
Tajima's D
0.107801
CLR
1.108046
CSRT
0.405429728513574
Interpretation
Uncertain
