Gene

KWMTBOMO06807  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012106

Annotation

PREDICTED:_tyrosine-protein_phosphatase_Lar_isoform_X1_[Plutella_xylostella]

Location

Bomo_Chr11(-):15509876-15516494      View in EpiBrowser

Full name

Tyrosine-protein phosphatase Lar      

Alternative Name

Protein-tyrosine-phosphate phosphohydrolase
dLAR

Location in the cell

Extracellular   Reliability : 3.268

CDS

ATGGATAAACCAGCTGGATTAATTTCCTCATTGGTGGTTTGCATTCTGCTACTGCAAGGGCTAGTCGAAAGTGCGCCATCATCTGACGCTCATCTCTTTCCACCTCCTCCAATTGCATATGTCGCTCGGGGAGGCACCGTAACATTAAAATGCTCCGCAACCGGCTCCCCGACCCCTACGATTAGATGGAAGAAAGGATCAGAATGGCTGACTCCCGAAGACAATACAGTGTCAAAGCATGTTCTGACACTAACAAACGTTACAGAAGAAGGTAAATACACATGTGTCTTTAAAACGGGAGAGCTTGTTTCTTCAGTGACGACCGCTGTTAAAATCAGACCATTACCACGCACACCGCACAGCGTCCATATGTCAGACGTCACGGACACCAGCGCTCAGTTGGAATGGTCGTATTCCTACATCCCAGGGACAGACGATCCAACTCATTACCACTTGCTTTTGAAACCTAAGCAACAAAACATTGAACCTCAGGATATAACAACAGGGACGAGAACAAGTTTCGAACTGACAAACTTGACTCCGGCAACCGAATATCAAGTTCAGGTCATTGCAGCTGGTACTGTCGGTAAAGGACCCGCCACAGAACCAGTTTTCTTTACTACCAAATTTTAA

Protein

MDKPAGLISSLVVCILLLQGLVESAPSSDAHLFPPPPIAYVARGGTVTLKCSATGSPTPTIRWKKGSEWLTPEDNTVSKHVLTLTNVTEEGKYTCVFKTGELVSSVTTAVKIRPLPRTPHSVHMSDVTDTSAQLEWSYSYIPGTDDPTHYHLLLKPKQQNIEPQDITTGTRTSFELTNLTPATEYQVQVIAAGTVGKGPATEPVFFTTKF

Description

Possible cell adhesion receptor (Probable). It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) (PubMed:2554325). It controls motor axon guidance (PubMed:8598047). In the developing eye, has a role in normal axonal targeting of the R7 photoreceptor, where it negatively regulates bdl (PubMed:24174674). Inhibits bdl cell adhesion activity in vitro; this effect is independent of its PTPase function (PubMed:24174674).

Catalytic Activity

H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate

Similarity

Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.

Keywords

3D-structure   Cell adhesion   Complete proteome   Disulfide bond   Glycoprotein   Heparin-binding   Hydrolase   Immunoglobulin domain   Membrane   Neurogenesis   Phosphoprotein   Protein phosphatase   Receptor   Reference proteome   Repeat   Signal   Transmembrane   Transmembrane helix  

Feature

chain  Tyrosine-protein phosphatase Lar

Uniprot

H9JRE6   A0A212ET51   A0A1B0A8A2   A0A195BU66   A0A195F635   A0A151IC73   + More
A0A158NJY1   A0A2H1W025   A0A195EJ36   B4IN44   A0A1B0BHE1   A0A194R538   A0A310SFZ7   A0A1B0G0C1   A0A3S2P2E0   A0A1A9V1C7   A0A1B6LMQ6   A0A026VZB6   A0A0M9AAH8   A0A3L8DRD2   A0A194PER9   E0V9F8   A0A182GI36   E2B1N6   B0X1M9   A0A0L0C2Q5   A0A1A9WX66   A0A1I8MPV9   A0A0P8XW02   A0A0P8Y3Z8   A0A0P8XG08   A0A0P9A4T0   A0A0N8NZ76   A0A0P9BNX7   B3ML69   A0A0P8XF82   A0A0P9BNY8   A0A2A3EPX0   A0A0A1WP55   A0A0P8XFK7   E2BS15   A0A034W7Z9   A0A034W6H2   A0A1I8NX70   A0A1I8NX96   A0A1I8NX65   A0A1D2ND36   D6WFC0   A0A182P152   A0A182KAD5   A0A139WLZ0   F4WXQ1   A0A1A9X874   A0A1Y1MEI9   A0A182R1N6   A0A2M4ATV6   Q17AI9   A0A0T6B9R3   M9PG93   M9PDF7   A0A0R1DTR4   A0A0R1DVT1   B4PB20   A0A0R1DVC6   A0A0R1DQC6   A0A0R1DVI0   A0A0Q9X675   A0A0R1DPG7   M9NCY3   A0A0Q9X679   A0A182XH68   A0A0Q9XFR8   A0A1W4V7C4   A0A0Q9XJC1   A0A0Q9XG67   A0A1W4UUY1   B4KIB2   A0A1W4V887   A0A0J9R4Q9   A0A1W4V7B8   A0A1W4V6V6   A0A1W4V6W3   M9PDR3   A0A0Q5VXV8   A0A1W4UUX7   A0A0Q5VJF1   A0A0J9R470   A8DZ18   A0A0J9R504   A0A0Q9XHM4   A0A0Q5VW78   A0A0J9TRP5   P16621   A0A0J9R500   A0A087ZS62   A0A0Q5VZ03   A0A0Q5VJR8   M9PD76   A0A0Q5VKK9   B4QA19  

EC Number

3.1.3.48

Pubmed

19121390    22118469    21347285    17994087    26354079    24508170    + More
30249741    20566863    26483478    20798317    26108605    25315136    18057021    25830018    25348373    27289101    18362917    19820115    21719571    28004739    17510324    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    17550304    22936249    2554325    8598047    12537569    18327897    24174674    21402080   

EMBL

BABH01016295    AGBW02012669    OWR44621.1    KQ976403    KYM92154.1    KQ981805    + More
KYN35529.1    KQ978064    KYM97687.1    ADTU01002015    ADTU01002016    ADTU01002017    ADTU01002018    ADTU01002019    ADTU01002020    ADTU01002021    ADTU01002022    ADTU01002023    ADTU01002024    ODYU01005213    SOQ45854.1    KQ978801    KYN28275.1    CH481513    EDW55890.1    JXJN01014297    JXJN01014298    KQ460779    KPJ12355.1    KQ760382    OAD60720.1    CCAG010016271    RSAL01000045    RVE50612.1    GEBQ01015049    JAT24928.1    KK107570    EZA48821.1    KQ435714    KOX79189.1    QOIP01000005    RLU22970.1    KQ459606    KPI91772.1    DS234992    EEB10014.1    JXUM01012059    JXUM01012060    JXUM01012061    KQ560344    KXJ82941.1    GL444953    EFN60392.1    DS232264    EDS38757.1    JRES01000979    KNC26541.1    CH902620    KPU73545.1    KPU73551.1    KPU73550.1    KPU73547.1    KPU73548.1    KPU73543.1    EDV31687.1    KPU73544.1    KPU73549.1    KPU73552.1    KZ288204    PBC33179.1    GBXI01013650    JAD00642.1    KPU73546.1    GL450107    EFN81531.1    GAKP01009044    JAC49908.1    GAKP01009045    JAC49907.1    LJIJ01000090    ODN02995.1    KQ971319    EFA00482.2    KYB28847.1    GL888427    EGI60979.1    GEZM01033883    JAV84073.1    GGFK01010697    MBW44018.1    CH477334    EAT43263.1    LJIG01002886    KRT84054.1    AE014134    AGB93132.1    AGB93131.1    CM000158    KRJ99186.1    KRJ99187.1    EDW90449.1    KRJ99184.1    KRJ99182.1    KRJ99185.1    CH933807    KRG03743.1    KRJ99181.1    KRJ99183.1    AFH03768.1    KRG03744.1    KRG03746.1    KRG03747.1    KRG03742.1    EDW13409.2    CM002910    KMY91068.1    AGB93130.1    CH954179    KQS61874.1    KQS61869.1    KMY91069.1    KMY91072.1    AAN11057.2    KMY91071.1    KRG03745.1    KQS61870.1    KMY91070.1    M27700    U36857    U36849    U36850    U36851    U36852    U36853    U36854    U36855    U36856    AY051985    KMY91066.1    KQS61871.1    KQS61872.1    AGB93129.1    KQS61873.1    CM000361    EDX05549.1    KMY91064.1   

Proteomes

UP000005204    UP000007151    UP000092445    UP000078540    UP000078541    UP000078542    + More
UP000005205    UP000078492    UP000001292    UP000092460    UP000053240    UP000092444    UP000283053    UP000078200    UP000053097    UP000053105    UP000279307    UP000053268    UP000009046    UP000069940    UP000249989    UP000000311    UP000002320    UP000037069    UP000091820    UP000095301    UP000007801    UP000242457    UP000008237    UP000095300    UP000094527    UP000007266    UP000075885    UP000075881    UP000007755    UP000092443    UP000075900    UP000008820    UP000000803    UP000002282    UP000009192    UP000076407    UP000192221    UP000008711    UP000005203    UP000000304   

PRIDE

H9JRE6    A8DZ18    P16621   

Pfam

PF00041   fn3        + More
PF07679   I-set
PF00102   Y_phosphatase

Interpro

IPR003598   Ig_sub2        + More
IPR036179   Ig-like_dom_sf       
IPR003961   FN3_dom       
IPR003599   Ig_sub       
IPR007110   Ig-like_dom       
IPR013783   Ig-like_fold       
IPR036116   FN3_sf       
IPR013098   Ig_I-set       
IPR029021   Prot-tyrosine_phosphatase-like       
IPR003595   Tyr_Pase_cat       
IPR016130   Tyr_Pase_AS       
IPR000387   TYR_PHOSPHATASE_dom       
IPR000242   PTPase_domain       

SUPFAM

SSF48726   SSF48726        + More
SSF49265   SSF49265       
SSF52799   SSF52799       

Gene 3D

2.60.40.10     3.90.190.10    

CDD

cd00063  FN3

ProteinModelPortal

H9JRE6   A0A212ET51   A0A1B0A8A2   A0A195BU66   A0A195F635   A0A151IC73   + More
A0A158NJY1   A0A2H1W025   A0A195EJ36   B4IN44   A0A1B0BHE1   A0A194R538   A0A310SFZ7   A0A1B0G0C1   A0A3S2P2E0   A0A1A9V1C7   A0A1B6LMQ6   A0A026VZB6   A0A0M9AAH8   A0A3L8DRD2   A0A194PER9   E0V9F8   A0A182GI36   E2B1N6   B0X1M9   A0A0L0C2Q5   A0A1A9WX66   A0A1I8MPV9   A0A0P8XW02   A0A0P8Y3Z8   A0A0P8XG08   A0A0P9A4T0   A0A0N8NZ76   A0A0P9BNX7   B3ML69   A0A0P8XF82   A0A0P9BNY8   A0A2A3EPX0   A0A0A1WP55   A0A0P8XFK7   E2BS15   A0A034W7Z9   A0A034W6H2   A0A1I8NX70   A0A1I8NX96   A0A1I8NX65   A0A1D2ND36   D6WFC0   A0A182P152   A0A182KAD5   A0A139WLZ0   F4WXQ1   A0A1A9X874   A0A1Y1MEI9   A0A182R1N6   A0A2M4ATV6   Q17AI9   A0A0T6B9R3   M9PG93   M9PDF7   A0A0R1DTR4   A0A0R1DVT1   B4PB20   A0A0R1DVC6   A0A0R1DQC6   A0A0R1DVI0   A0A0Q9X675   A0A0R1DPG7   M9NCY3   A0A0Q9X679   A0A182XH68   A0A0Q9XFR8   A0A1W4V7C4   A0A0Q9XJC1   A0A0Q9XG67   A0A1W4UUY1   B4KIB2   A0A1W4V887   A0A0J9R4Q9   A0A1W4V7B8   A0A1W4V6V6   A0A1W4V6W3   M9PDR3   A0A0Q5VXV8   A0A1W4UUX7   A0A0Q5VJF1   A0A0J9R470   A8DZ18   A0A0J9R504   A0A0Q9XHM4   A0A0Q5VW78   A0A0J9TRP5   P16621   A0A0J9R500   A0A087ZS62   A0A0Q5VZ03   A0A0Q5VJR8   M9PD76   A0A0Q5VKK9   B4QA19  

PDB

4YH7     E-value=6.47821e-21,     Score=245

KEGG

101742279    no KO assigned | (RefSeq) tyrosine-protein phosphatase Lar

GO

GO:0004725   GO:0016021   GO:0016787   GO:0050254   GO:0006470   GO:0008045   GO:0007399   GO:1903386   GO:0007412   GO:0048477   GO:0045467   GO:0048841   GO:0032093   GO:0007411   GO:0009925   GO:0120034   GO:0030424   GO:0008594   GO:0051491   GO:0007283   GO:0031290   GO:0060269   GO:0031252   GO:0008201   GO:0048675   GO:0035335   GO:0007155   GO:0051124   GO:0005001   GO:0005925   GO:0005515   GO:0007165   GO:0009452   GO:0004930   GO:0006355   GO:0043565   GO:0016567   GO:0016020   GO:0005634   GO:0006260  

Subcellular location

Membrane  

SignalP

Position:   1 - 24,         Likelihood:  0.997773

 

 

Length:

210

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

5.53240999999999

Exp number, first 60 AAs:

5.52757

Total prob of N-in:

0.28400

outside

1  -  210

 

 

Pi

13.458753

Theta

16.561996

Tajima's D

-0.945147

CLR

15.883075

CSRT

0.149842507874606

Interpretation

Uncertain