Silkworm Genome Informatics Database

Gene

KWMTBOMO06803 Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012046

Annotation

PREDICTED:_large_subunit_GTPase_1_homolog_[Amyelois_transitella]

Location

Bomo_Chr11(+):15426525-15443680 View in EpiBrowser

Full name

Large subunit GTPase 1 homolog

Alternative Name

Nucleostemin-3

Location in the cell

Nuclear Reliability : 3.021

CDS

ATGGGCAAGAAGAATAAAGAGTCTCTTGGGAGAGCCCTCATCAAAGATAGATTCTCTAAAAATCGCAACAAAAAACATGTCGAAGACAATACCATGCTCCACACTACAGAGGTGAATGATGGATATGATTGGGGACGTTTGAATCTCCAGTCAGTGACTGCGGAGTCTTCACTCCAAGAATTTCTCTCCACAGCTGAACTGGCACAGAGAGAGTTCACTGCTGAGAAACTTAATCTAAAATATGTAAAATCTGTTCCTAGTGAAGTAGCCATTGTAACATCACAGCCTGATTTTGATGAGCCTCTCACTGTTCCACGAAGACCCCAGTGGAACCCTGGAGTAACAGCTGAAGAACAGCTCAACCGTGAGAGAGAAACATTCTTAGATTGGCGTCGGCATTTGAATGAACTTCAAGCTAAGCTTGGTGCAGCAGTGACACCTTATGAGAGGAACTTGGAACTTTGGAAGCAGTTATGGAGGACTTTAGAAAAATCTGATATTGTATTGATATTGTTAGATGCAAGGAATCCCTTATTATTTAGGTGTGTGGATCTAGAAAAGTATGCAAAAGAACAAAAATGCAAAAGTATATTATTGCTGAACAAAGCTGATCTTACAAGTGAATATGAAAGAAAGTGTTGGGCTGAATATTTCAATAAGGAGAACATTCGAATAGTCTTTTTTTCGGCCGCCAAAACTACGAATGAGCGCAAAATATCTGAATCCGAGAATGAAACAGTAAAAAATGAAAATAATTCCGACACAGATACGGCCAGTTCTGAAGATGAAGGTATTGAAGAAATTGATTTACTCCAAACTACGGAGGATGATATTGAATTGTTCAAGAAACAACTCAGTGAAATAGATAAGGCAGTATCAAATACAGCTGTAAAGTTAAATAGGATACAAGAAACATTAGATAAAGTACTTGAGAATTTAAAGCTTGGTAAATCTATAGAACTAACGACAAATGAAAATGACTCTAAAATTGATTTAGAAACAGTTGAAAATGATTCATTTGGAACTGAAATGCGAAATACACATGAAATATACGACAGAACTAAATTGTTGGAATTATTGAAGAGCATTGAGGTTGATAAGTTAAAAGATCCTCCTAGATTGAATGTCGGTATGATTGGTTACCCAAATGTGGGGAAATCTAGTACAGTTAATATACTTATGCAAACTAAGAAGGTAAGCGTGAGCTCAATGCCTGGTCACACACGGCACATACAATCGTTGATTCTTGACAATGACATTGAACTGTTAGACTGTCCCGGATTGGTGTTGCCCGCGTACGCCGTTGCACCAGATTTACTACTAACGGCCGTGTTGCCGATTGACCAGATGCGTTCCCACGACGCGGCGATGGCGAGACTGTGCCAGCTGGTGAGCAAGTTCACGTTCGAACAGAAGTACGGGCTGCTGTTGCCGCGGACCGACGACGCGGACGAACTCGACTACAAACAGATACTGACCGCGCACGCTTACAATCGCGGCTTTATGACGGCGGCGGGTCAGCCGGACCGGTCCAGGTCGGCGCGGCTGCTGCTCAAGGACGCCGCCAGCGGACGCCTCAGGTGGGAGCAGCTGCCGCCGGGATACCAGCCGGCTCCCCTCGAACAGCTCATAGAAGACAGGAGGAACGAGAAGAGGAAGCCCACGCCCATGGAAGCCAGGATGGTCGAGGGTTGGCGAAACAAGTCTGAAGAGATAGACAGCGCTTTCTTCGCTATGAAGAAAAGTACAGCGCACGTTAAAGGAAAACCTATTATCGGAGTTACCGGTGCTCAATCAGCAGAGAGACAGGTAACCAAACCGTGGAAGCAAGAGAAGAAACACGCCAACAAAAACAAACGAGAGAAGCTAAGAAGAGTATACGCCCATCTGGACGAACATTGA

Protein

MGKKNKESLGRALIKDRFSKNRNKKHVEDNTMLHTTEVNDGYDWGRLNLQSVTAESSLQEFLSTAELAQREFTAEKLNLKYVKSVPSEVAIVTSQPDFDEPLTVPRRPQWNPGVTAEEQLNRERETFLDWRRHLNELQAKLGAAVTPYERNLELWKQLWRTLEKSDIVLILLDARNPLLFRCVDLEKYAKEQKCKSILLLNKADLTSEYERKCWAEYFNKENIRIVFFSAAKTTNERKISESENETVKNENNSDTDTASSEDEGIEEIDLLQTTEDDIELFKKQLSEIDKAVSNTAVKLNRIQETLDKVLENLKLGKSIELTTNENDSKIDLETVENDSFGTEMRNTHEIYDRTKLLELLKSIEVDKLKDPPRLNVGMIGYPNVGKSSTVNILMQTKKVSVSSMPGHTRHIQSLILDNDIELLDCPGLVLPAYAVAPDLLLTAVLPIDQMRSHDAAMARLCQLVSKFTFEQKYGLLLPRTDDADELDYKQILTAHAYNRGFMTAAGQPDRSRSARLLLKDAASGRLRWEQLPPGYQPAPLEQLIEDRRNEKRKPTPMEARMVEGWRNKSEEIDSAFFAMKKSTAHVKGKPIIGVTGAQSAERQVTKPWKQEKKHANKNKREKLRRVYAHLDEH

Description

GTPase required for the nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of Nmd3 from the 60S ribosomal subunit after export into the cytoplasm. Regulator of body size; acts in serotonergic neurons to regulate insulin signaling and thus exerts global growth control.
GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (By similarity).

Similarity

Belongs to the TRAFAC class YlqF/YawG GTPase family. LSG1 subfamily.

Keywords

Complete proteome Cytoplasm Developmental protein Growth regulation GTP-binding Hydrolase Nucleotide-binding Phosphoprotein Protein transport Reference proteome Transport Nucleus

Feature

chain Large subunit GTPase 1 homolog

Uniprot

H9JR86 A0A2A4JZ51 A0A194Q9M6 A0A3S2M3P2 A0A194R915 S4PIL5 + More
A0A212EKA9 A0A1W4W3Z7 A0A087ZNN8 A0A310SCB9 A0A2A3ESU6 A0A151IGF4 D6WNM0 A0A0T6AWR5 A0A0N0BE47 Q177U6 A0A3L8DST5 A0A0L7RCK0 A0A1Y1KNS8 K7IW95 A0A026WBI6 A0A158P3H5 A0A195BC90 A0A2M4BHE4 A0A182GCR1 A0A232EX62 A0A2M4BHI6 A0A182FPN6 E2AQ07 A0A0A1XL09 B4GTL1 A0A2M4AB78 A0A2M4AB65 B4NCU5 Q29J05 A0A1I8P9X9 A0A2M3Z6V9 A0A1Q3F3N2 A0A0A9WJ77 B3P9I3 A0A182JPA6 A0A1Q3F2M3 A0A182P9B7 W5JR94 B4I9E5 A0A182WF66 X2JA43 Q9W590 A0A1I8N343 A0A034V9S0 A0A084WBD2 A0A0K8UXE2 B4JLG5 A0A182QVH5 B4M3D9 A0A1W4VF35 A0A2M3Z6M6 A0A182LPG2 A0A182XC93 A0A182MT11 A0A182HNJ4 A0A182UP39 A0A154P928 B4L413 A0A3B4E288 A0A1B0D7Y3 A0A182R8P3 A0A0L0BYQ0 E2C7C6 G3TAC7 B3MRG8 A0A067R8Q0 E9IXY6 A0A182J2Z2 A0A3P4PGE4 M3X0K0 A0A182MXZ4 A0A1S3H623 A0A1B0FGV9 A0A195FVY5 G3TS01 M3XXA4 B4PXP7 A0A0R4IIR9 A0A195DCL2 A0A0C9Q9E6 A0A2M4BIU9 Q6NY89 A0A1B0A039 A0A1J1HHS7 A0A182YPE6 T1PBV2 A0A2Y9FB65 A0A1U7TJA1 B0WM37 A0A2K5CC04 A0A2M4BJ59 A0A2D0RVV9 A0A384B6P9

EC Number

3.6.1.-

Pubmed

19121390 26354079 23622113 22118469 18362917 19820115 + More
17510324 30249741 28004739 20075255 24508170 21347285 26483478 28648823 20798317 25830018 17994087 15632085 25401762 26823975 20920257 23761445 10731132 12537568 12537572 12537573 12537574 16110336 17569856 17569867 10731137 12537569 18628395 18327897 25315136 25348373 24438588 20966253 26108605 24845553 21282665 17975172 26383154 17550304 23594743 25244985

EMBL

BABH01016301 BABH01016302 NWSH01000397 PCG76690.1 KQ459252 KPJ02109.1 + More
RSAL01000045 RVE50608.1 KQ460779 KPJ12361.1 GAIX01005350 JAA87210.1 AGBW02014303 OWR41910.1 KQ769179 OAD52903.1 KZ288186 PBC34767.1 KQ977726 KYN00306.1 KQ971342 EFA03822.1 LJIG01022637 KRT79505.1 KQ435847 KOX71122.1 CH477371 EAT42422.1 QOIP01000005 RLU22949.1 KQ414616 KOC68471.1 GEZM01081146 GEZM01081145 JAV61850.1 KK107293 EZA53318.1 ADTU01001327 KQ976519 KYM82181.1 GGFJ01003339 MBW52480.1 JXUM01056326 KQ561906 KXJ77207.1 NNAY01001770 OXU22964.1 GGFJ01003343 MBW52484.1 GL441645 EFN64494.1 GBXI01002616 JAD11676.1 CH479190 EDW25881.1 GGFK01004723 MBW38044.1 GGFK01004712 MBW38033.1 CH964239 EDW82654.1 CH379063 EAL32497.1 GGFM01003506 MBW24257.1 GFDL01012881 JAV22164.1 GBHO01037056 GBRD01016337 GDHC01001415 JAG06548.1 JAG49489.1 JAQ17214.1 CH954183 EDV45479.1 GFDL01013239 JAV21806.1 ADMH02000409 ETN66656.1 CH480825 EDW43826.1 AE014298 AHN59250.1 AL035632 AY047556 GAKP01019708 JAC39244.1 ATLV01022344 KE525331 KFB47526.1 GDHF01021073 JAI31241.1 CH916370 EDW00418.1 AXCN02001648 CH940651 EDW65314.1 GGFM01003426 MBW24177.1 AXCM01000254 APCN01001937 KQ434829 KZC07728.1 CH933810 EDW07291.1 AJVK01033328 JRES01001143 KNC25172.1 GL453369 EFN76113.1 CH902622 EDV34373.2 KK852665 KDR18965.1 GL766836 EFZ14558.1 CYRY02031983 VCX09067.1 AANG04001815 CCAG010015881 KQ981264 KYN44004.1 AEYP01017440 AEYP01017441 CM000162 EDX00900.2 CU694233 KQ980989 KYN10577.1 GBYB01011003 JAG80770.1 GGFJ01003839 MBW52980.1 BC066695 CVRI01000004 CRK87557.1 KA646247 AFP60876.1 DS231994 EDS30865.1 GGFJ01003946 MBW53087.1

Proteomes

UP000005204 UP000218220 UP000053268 UP000283053 UP000053240 UP000007151 + More
UP000192223 UP000005203 UP000242457 UP000078542 UP000007266 UP000053105 UP000008820 UP000279307 UP000053825 UP000002358 UP000053097 UP000005205 UP000078540 UP000069940 UP000249989 UP000215335 UP000069272 UP000000311 UP000008744 UP000007798 UP000001819 UP000095300 UP000008711 UP000075881 UP000075885 UP000000673 UP000001292 UP000075920 UP000000803 UP000095301 UP000030765 UP000001070 UP000075886 UP000008792 UP000192221 UP000075882 UP000076407 UP000075883 UP000075840 UP000075903 UP000076502 UP000009192 UP000261440 UP000092462 UP000075900 UP000037069 UP000008237 UP000007646 UP000007801 UP000027135 UP000075880 UP000011712 UP000075884 UP000085678 UP000092444 UP000078541 UP000000715 UP000002282 UP000000437 UP000078492 UP000092445 UP000183832 UP000076408 UP000248484 UP000189704 UP000002320 UP000233020 UP000221080 UP000261681

PRIDE

H9JR86 X2JA43 Q9W590 Q6NY89

Pfam

PF01926   MMR_HSR1        + More
PF00018   SH3_1
PF01249   Ribosomal_S21e
PF00787   PX
PF10456   BAR_3_WASP_bdg

Interpro

IPR027417   P-loop_NTPase        + More
IPR030378   G_CP_dom
IPR006073   GTP_binding_domain
IPR023179   GTP-bd_ortho_bundle_sf
IPR018247   EF_Hand_1_Ca_BS
IPR001452   SH3_domain
IPR001683   Phox
IPR036871   PX_dom_sf
IPR027267   AH/BAR_dom_sf
IPR001931   Ribosomal_S21e
IPR019497   Sorting_nexin_WASP-bd-dom
IPR038579   Ribosomal_S21e_sf
IPR018279   Ribosomal_S21e_CS
IPR036028   SH3-like_dom_sf

SUPFAM

SSF52540   SSF52540        + More
SSF50044   SSF50044
SSF64268   SSF64268

Gene 3D

1.10.1580.10 1.20.1270.60 3.30.1230.20 3.30.1520.10

ProteinModelPortal

H9JR86 A0A2A4JZ51 A0A194Q9M6 A0A3S2M3P2 A0A194R915 S4PIL5 + More
A0A212EKA9 A0A1W4W3Z7 A0A087ZNN8 A0A310SCB9 A0A2A3ESU6 A0A151IGF4 D6WNM0 A0A0T6AWR5 A0A0N0BE47 Q177U6 A0A3L8DST5 A0A0L7RCK0 A0A1Y1KNS8 K7IW95 A0A026WBI6 A0A158P3H5 A0A195BC90 A0A2M4BHE4 A0A182GCR1 A0A232EX62 A0A2M4BHI6 A0A182FPN6 E2AQ07 A0A0A1XL09 B4GTL1 A0A2M4AB78 A0A2M4AB65 B4NCU5 Q29J05 A0A1I8P9X9 A0A2M3Z6V9 A0A1Q3F3N2 A0A0A9WJ77 B3P9I3 A0A182JPA6 A0A1Q3F2M3 A0A182P9B7 W5JR94 B4I9E5 A0A182WF66 X2JA43 Q9W590 A0A1I8N343 A0A034V9S0 A0A084WBD2 A0A0K8UXE2 B4JLG5 A0A182QVH5 B4M3D9 A0A1W4VF35 A0A2M3Z6M6 A0A182LPG2 A0A182XC93 A0A182MT11 A0A182HNJ4 A0A182UP39 A0A154P928 B4L413 A0A3B4E288 A0A1B0D7Y3 A0A182R8P3 A0A0L0BYQ0 E2C7C6 G3TAC7 B3MRG8 A0A067R8Q0 E9IXY6 A0A182J2Z2 A0A3P4PGE4 M3X0K0 A0A182MXZ4 A0A1S3H623 A0A1B0FGV9 A0A195FVY5 G3TS01 M3XXA4 B4PXP7 A0A0R4IIR9 A0A195DCL2 A0A0C9Q9E6 A0A2M4BIU9 Q6NY89 A0A1B0A039 A0A1J1HHS7 A0A182YPE6 T1PBV2 A0A2Y9FB65 A0A1U7TJA1 B0WM37 A0A2K5CC04 A0A2M4BJ59 A0A2D0RVV9 A0A384B6P9

PDB

6N8O E-value=2.10401e-42, Score=436

KEGG

101742911 K14539 large subunit GTPase 1 [EC:3.6.1.-] | (RefSeq) large subunit GTPase 1 homolog

PATHWAY

03008 Ribosome biogenesis in eukaryotes - Bombyx mori (domestic silkworm)

GO

GO:0005525 GO:0005829 GO:0005737 GO:0003924 GO:0046626 GO:0000054 GO:0007275 GO:0015030 GO:0051168 GO:0005783 GO:0040008 GO:0016787 GO:0015031 GO:0035091 GO:0005840 GO:0003735 GO:0006412 GO:0008168 GO:0009452 GO:0004930 GO:0006355 GO:0043565 GO:0016567 GO:0016020 GO:0005634 GO:0006260

Subcellular location

Cytoplasm
Nucleus

Length:

633

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02803

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00067

outside

1 - 633

Pi

19.743923

Theta

19.588475

Tajima's D

-0.849754

CLR

1.95559

CSRT

0.168591570421479

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics