Gene

KWMTBOMO06800  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012109

Annotation

PREDICTED:_RAB6-interacting_golgin_[Bombyx_mori]

Location

Bomo_Chr11(-):15407498-15408874      View in EpiBrowser

Full name

RAB6-interacting golgin      

Alternative Name

N-terminal kinase-like-binding protein 1
SCY1-like 1-binding protein 1

Location in the cell

Cytoplasmic   Reliability : 1.938 Nuclear   Reliability : 1.758

CDS

ATGGTGAACAAAAAGTTTTTCCAGCTCATCACTAAAACAATATGGACGAAACAGACAGAAGAAGAAGTAATGAAACTTGAGAAAATCAAGAAAGAACTACAAGTATTGGACAGTCAATTTTCACAGGATGTGTCAGTATTGAGGAAGAAAATAGATCAAGCCTGCTTAAGTTATGCTGATGCTGAGAAACAATACTTACGAGTTGAAAAAGAATTTCTTAATGCGAAGATTCTGCTGCAAAAAGAAAAGGAAAAAAAAGAGCTGCTCACAGAACATTTATGCGCCTTAATAACACACAACGAAATGAGGAAGGCTCAGAAACTTGAAACGCTCATGCTCGAACTTGCTAATGAAAAGAAAAATGAAATTAATGAAGCATTAACCCTCAATGACGATAATCCAGTTATAATCGATGGTGTTGATGAGAGGACAGGTAAGATGGTCGAAATTAATACCAATAAATCATAG

Protein

MVNKKFFQLITKTIWTKQTEEEVMKLEKIKKELQVLDSQFSQDVSVLRKKIDQACLSYADAEKQYLRVEKEFLNAKILLQKEKEKKELLTEHLCALITHNEMRKAQKLETLMLELANEKKNEINEALTLNDDNPVIIDGVDERTGKMVEINTNKS

Description

Required for centriole duplication probably through the interaction with Sas-6 (PubMed:29892014). During embryogenesis, maternally provided Gorab is required for centrosome duplication and nuclear division cycles of the syncytial embryos (PubMed:29892014). In femoral chordotonal organs, required for sensory cilia structural integrity and functionality necessary for motor coordination (PubMed:29892014). In male germline, has a role in cytokinesis which seems dependent on its localization to the Golgi (PubMed:29892014).

Subunit

Interacts with SCYL1 (By similarity). Interacts with RCHY1 and RAB6A/RAB6.
Interacts with RCHY1, RAB6A/RAB6 and SCYL1.
Interacts with Sas-6.

Similarity

Belongs to the GORAB family.
Belongs to the paired homeobox family.

Keywords

Alternative splicing   Coiled coil   Complete proteome   Cytoplasm   Dwarfism   Golgi apparatus   Polymorphism   Reference proteome   Cytoskeleton  

Feature

chain  RAB6-interacting golgin
splice variant  In isoform 3.
sequence variant  In dbSNP:rs913257.

Uniprot

A0A1E1W1X4   H9JRE9   S4PAV5   A0A2H1WZ63   A0A1E1WQW7   A0A2A4JXG0   + More
A0A194QVA9   A0A212EQ49   A0A194QAV2   A0A0L7L161   A0A3P8UH84   A0A1A8FD78   A0A0F8AKC5   A0A3Q3AR66   A0A3Q0EGY9   A0A146XRN3   A0A3Q2QA40   A0A3B4FCV6   A0A3P9CNY9   A0A3Q2X1P1   A0A3P8QRJ5   G3NN32   B4LE90   A0A3Q3KDA7   A0A1A8Q2B6   A0A3P8QT67   A0A1A8NUQ2   A0A146NSI4   A0A1A7Z829   A0A3Q4GG51   A0A1A8JKI1   K9IRX2   A0A1A8IS32   A0A1S3WE89   A0A3Q3MP05   A0A3P4S4X2   A0A1A8VDX7   G3NN25   A0A3Q0CLW7   A0A250YC84   A0A1A8BMN1   Q5T7V8-4   A0A024R923   A0A3B0K1W4   M1EP92   A0A1U7UW93   Q2LZH6   B4H6M1   B4J251   S9XPH2   H0VLH7   A0A3B3CA95   A0A1A8ECL0   A0A034VZM2   I3MV54   A0A1S2ZVL6   A0A3Q0CU05   A0A3Q2CVU5   A0A1Y1KHQ3   A0A3B3CB52   A0A3B3HX40   A0A2U9C1F8   A0A3P9IKG7   A0A091CM93   B1H222   F7CLZ6   M3YVW5   A0A3Q7SQX5   U6CVZ3   G1TEV0   A0A2Y9JXD8   A0A3Q1IQR9   A5PKK7   L8I7Q5   F1MBY2   A0A3Q7WJD4   A0A212CRN5   A0A3P8U571   A0A0Q3T1Z0   A0A2P4SI72   A0A3Q1AUI5   A0A0J9RX42   B3NHV6   B4QNU7   W5PQX5   B4HKS1   A0A3P8U577   Q8IQQ4   D2H9S3   A0A3Q1F0J9   M3X6F4   A0A1U7QRC0   A0A3Q7TCL6   B4KZ17   A0A3B4VGX6   A0A3B4VI05   A0A093HF07   A0A3B4ZZM8   A0A091WI15  

Pubmed

19121390    23622113    26354079    22118469    26227816    24487278    + More
25835551    25186727    17994087    28087693    14702039    16710414    15489334    15781263    18997784    18669648    11181995    23236062    15632085    23149746    21993624    29451363    25348373    28004739    17554307    19892987    22751099    19393038    22936249    20809919    10731132    12537572    12537569    29892014    20010809    17975172   

EMBL

GDQN01010054    JAT81000.1    BABH01016305    GAIX01008535    JAA84025.1    ODYU01012169    + More
SOQ58341.1    GDQN01001737    JAT89317.1    NWSH01000397    PCG76697.1    KQ461185    KPJ07491.1    AGBW02013309    OWR43620.1    KQ459252    KPJ02125.1    JTDY01003743    KOB69061.1    HAEB01010229    SBQ56756.1    KQ041921    KKF21148.1    GCES01041582    JAR44741.1    CH940647    EDW69046.1    HAEH01009624    SBR87636.1    HAEI01000675    SBR72786.1    GCES01151614    JAQ34708.1    HADY01000249    SBP38734.1    HAEE01000417    SBR20433.1    GABZ01002065    JAA51460.1    HAED01013707    SBR00152.1    CYRY02045999    VCX41532.1    HAEJ01018392    SBS58849.1    GFFW01003540    JAV41248.1    HADZ01003965    SBP67906.1    AF143889    AK021814    AL162399    BC047476    BC064945    CH471067    EAW90879.1    OUUW01000012    SPP87313.1    JP010628    AER99225.1    CH379069    EAL29531.2    CH479214    EDW33449.1    CH916366    EDV97002.1    KB016393    EPY89569.1    AAKN02037455    HAEA01014339    SBQ42819.1    GAKP01011939    JAC47013.1    AGTP01015042    GEZM01086971    GEZM01086970    JAV58936.1    CP026254    AWP10447.1    KN125372    KFO18538.1    BC086370    BC160825    AEYP01041805    AEYP01041806    AEYP01041807    HAAF01002810    CCP74636.1    AAGW02000062    AAGW02000063    AAGW02000064    BC142523    JH881963    ELR51569.1    MKHE01000014    OWK08681.1    LMAW01003023    KQK74606.1    PPHD01046044    POI23806.1    CM002912    KMZ00227.1    CH954178    EDV51971.1    CM000363    EDX10849.1    AMGL01021393    CH480815    EDW41876.1    AE014296    AY070587    AAL48058.1    GL192609    EFB23832.1    AANG04002195    CH933809    EDW17814.1    KK625593    KFV53188.1    KK735494    KFR14458.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000007151    UP000053268    UP000037510    + More
UP000265120    UP000264800    UP000189704    UP000265000    UP000261460    UP000265160    UP000264840    UP000265100    UP000007635    UP000008792    UP000261600    UP000261580    UP000079721    UP000261640    UP000189706    UP000005640    UP000268350    UP000001819    UP000008744    UP000001070    UP000005447    UP000261560    UP000005215    UP000265020    UP000001038    UP000246464    UP000265200    UP000028990    UP000002494    UP000002281    UP000000715    UP000286640    UP000001811    UP000248482    UP000265040    UP000009136    UP000286642    UP000265080    UP000051836    UP000257160    UP000008711    UP000000304    UP000002356    UP000001292    UP000000803    UP000257200    UP000011712    UP000009192    UP000261420    UP000261400    UP000053605   

PRIDE

H9JRE9    Q5T7V8    B1H222    A5PKK7    Q8IQQ4    B4KZ17    + More

Pfam

PF04949   Transcrip_act        + More
PF03826   OAR
PF00046   Homeodomain

Interpro

IPR007033   GORAB        + More
IPR017970   Homeobox_CS       
IPR003654   OAR_dom       
IPR001356   Homeobox_dom       
IPR009057   Homeobox-like_sf       

SUPFAM

SSF46689   SSF46689       

CDD

cd00086  homeodomain

ProteinModelPortal

A0A1E1W1X4   H9JRE9   S4PAV5   A0A2H1WZ63   A0A1E1WQW7   A0A2A4JXG0   + More
A0A194QVA9   A0A212EQ49   A0A194QAV2   A0A0L7L161   A0A3P8UH84   A0A1A8FD78   A0A0F8AKC5   A0A3Q3AR66   A0A3Q0EGY9   A0A146XRN3   A0A3Q2QA40   A0A3B4FCV6   A0A3P9CNY9   A0A3Q2X1P1   A0A3P8QRJ5   G3NN32   B4LE90   A0A3Q3KDA7   A0A1A8Q2B6   A0A3P8QT67   A0A1A8NUQ2   A0A146NSI4   A0A1A7Z829   A0A3Q4GG51   A0A1A8JKI1   K9IRX2   A0A1A8IS32   A0A1S3WE89   A0A3Q3MP05   A0A3P4S4X2   A0A1A8VDX7   G3NN25   A0A3Q0CLW7   A0A250YC84   A0A1A8BMN1   Q5T7V8-4   A0A024R923   A0A3B0K1W4   M1EP92   A0A1U7UW93   Q2LZH6   B4H6M1   B4J251   S9XPH2   H0VLH7   A0A3B3CA95   A0A1A8ECL0   A0A034VZM2   I3MV54   A0A1S2ZVL6   A0A3Q0CU05   A0A3Q2CVU5   A0A1Y1KHQ3   A0A3B3CB52   A0A3B3HX40   A0A2U9C1F8   A0A3P9IKG7   A0A091CM93   B1H222   F7CLZ6   M3YVW5   A0A3Q7SQX5   U6CVZ3   G1TEV0   A0A2Y9JXD8   A0A3Q1IQR9   A5PKK7   L8I7Q5   F1MBY2   A0A3Q7WJD4   A0A212CRN5   A0A3P8U571   A0A0Q3T1Z0   A0A2P4SI72   A0A3Q1AUI5   A0A0J9RX42   B3NHV6   B4QNU7   W5PQX5   B4HKS1   A0A3P8U577   Q8IQQ4   D2H9S3   A0A3Q1F0J9   M3X6F4   A0A1U7QRC0   A0A3Q7TCL6   B4KZ17   A0A3B4VGX6   A0A3B4VI05   A0A093HF07   A0A3B4ZZM8   A0A091WI15  

KEGG

101739937    K19748 RAB6-interacting golgin | (RefSeq) RAB6-interacting golgin

GO

GO:0032467   GO:0045724   GO:0005813   GO:0005802   GO:0005814   GO:0046601   GO:0005794   GO:0005730   GO:0005829   GO:0031069   GO:0005737   GO:0005654   GO:0005634   GO:1905515   GO:1901622   GO:0043565   GO:0006355   GO:0007275  

PANTHER

PTHR21470  

Subcellular location

Cytoplasm  
Golgi apparatus  
Nucleus  
Cytoskeleton   Co-localizes with the centriole in interphase and mitosis (PubMed:29892014). Mostly found in the Golgi, with a small amount detected in centrosomes (PubMed:29892014).   With evidence from 3 publications.
Microtubule organizing center   Co-localizes with the centriole in interphase and mitosis (PubMed:29892014). Mostly found in the Golgi, with a small amount detected in centrosomes (PubMed:29892014).   With evidence from 3 publications.
Centrosome   Co-localizes with the centriole in interphase and mitosis (PubMed:29892014). Mostly found in the Golgi, with a small amount detected in centrosomes (PubMed:29892014).   With evidence from 3 publications.
Centriole   Co-localizes with the centriole in interphase and mitosis (PubMed:29892014). Mostly found in the Golgi, with a small amount detected in centrosomes (PubMed:29892014).   With evidence from 3 publications.
trans-Golgi network   Co-localizes with the centriole in interphase and mitosis (PubMed:29892014). Mostly found in the Golgi, with a small amount detected in centrosomes (PubMed:29892014).   With evidence from 3 publications.

Length:

155

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0

Exp number, first 60 AAs:

0

Total prob of N-in:

0.12633

outside

1  -  155

 

 

Pi

26.712587

Theta

22.58457

Tajima's D

0.793306

CLR

2.658665

CSRT

0.608569571521424

Interpretation

Uncertain