Gene

KWMTBOMO06784  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012038

Annotation

putative_o-sialoglycoprotein_endopeptidase_[Danaus_plexippus]

Location

Bomo_Chr11(+):14865782-14869060      View in EpiBrowser

Full name

Probable tRNA N6-adenosine threonylcarbamoyltransferase      

Alternative Name

t(6)A37 threonylcarbamoyladenosine biosynthesis protein
tRNA threonylcarbamoyladenosine biosynthesis protein
t(6)A37 threonylcarbamoyladenosine biosynthesis protein CSON001408
tRNA threonylcarbamoyladenosine biosynthesis protein CSON001408
t(6)A37 threonylcarbamoyladenosine biosynthesis protein CSON001875
tRNA threonylcarbamoyladenosine biosynthesis protein CSON001875
t(6)A37 threonylcarbamoyladenosine biosynthesis protein 5573005
tRNA threonylcarbamoyladenosine biosynthesis protein 5573005
t(6)A37 threonylcarbamoyladenosine biosynthesis protein 6042337
tRNA threonylcarbamoyladenosine biosynthesis protein 6042337
t(6)A37 threonylcarbamoyladenosine biosynthesis protein 1270132
tRNA threonylcarbamoyladenosine biosynthesis protein 1270132
t(6)A37 threonylcarbamoyladenosine biosynthesis protein osgep_2
tRNA threonylcarbamoyladenosine biosynthesis protein osgep_2
t(6)A37 threonylcarbamoyladenosine biosynthesis protein 8238097
tRNA threonylcarbamoyladenosine biosynthesis protein 8238097
t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEP
tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP
O-sialoglycoprotein endopeptidase
t(6)A37 threonylcarbamoyladenosine biosynthesis protein ACYPI004911
tRNA threonylcarbamoyladenosine biosynthesis protein ACYPI004911
t(6)A37 threonylcarbamoyladenosine biosynthesis protein osgep
tRNA threonylcarbamoyladenosine biosynthesis protein osgep
t(6)A37 threonylcarbamoyladenosine biosynthesis protein LOC106176207
tRNA threonylcarbamoyladenosine biosynthesis protein LOC106176207
t(6)A37 threonylcarbamoyladenosine biosynthesis protein CG4933_0
tRNA threonylcarbamoyladenosine biosynthesis protein CG4933_0
N6-L-threonylcarbamoyladenine synthase
t(6)A37 threonylcarbamoyladenosine biosynthesis protein LOC108737171
tRNA threonylcarbamoyladenosine biosynthesis protein LOC108737171
t(6)A37 threonylcarbamoyladenosine biosynthesis protein LOC106576589
tRNA threonylcarbamoyladenosine biosynthesis protein LOC106576589

Location in the cell

Cytoplasmic   Reliability : 3.014

CDS

ATGGTAGTAGCAATAGGATTTGAGGGAAGTGCAAACAAACTGGGAATTGGTATAGTTAAAGATGGAGAAATCTTGGCCAATTGCAGAAGAACGTACATAACCCCACCCGGTGAAGGGTTTCTTCCTAGAGAAACTGCGGAGCATCATCAACAAAACATTCATGAAGTATTGCAAGAAGCTTTGGACCAGTCTGGTCTCAATCCAGATGAAATTGACGTTGTCTGTTATACCAAAGGACCTGGTATGGGGGCGCCATTGATGGTGTGTGCAATTGTTGCCAGAACATGTGCTAAACTATGGAAAAAACCTATTTACGGTGTAAATCATTGTATTGGACATATAGAAATGGGAAGGTTGATAACCAAAGCAAATAATCCAACAGTGCTATATGTGAGTGGAGGGAATACACAAATTATAGCATATTCAAGAAAAAGATACAGGATATTTGGTGAAACTATTGATATAGCTGTTGGCAACTGCTTAGATAGGTTTGCTAGAGTTTTGAAATTGTCTAATGCTCCAAGTCCAGGTTATAACATAGAACAAGCTGCTAAAAAAGGAAAAAAGTATTTGCCCTTACCATATTGTGTTAAAGGAATGGACGTAAGTTTTTCTGGTATCCTATCGTACATGGAGGATAAAATTGACGAATTATTGAAAGAATATACTCCGGAAGACTTATGTTATTCTTTGCAAGAAACTGTTTTTGCAATGCTAGTGGAGATCACTGAACGAGCTATGGCTCACTGCGGTTCTGATGAGGTATTAATAGTAGGTGGAGTTGGGTGCAATGAGCGACTTCAAGAGATGATGGGAGTAATGTGTCATGAACGAGAGGCTAAGATATTTGCTACCGATGAGAGATTTTGCATAGATAATGGAGTGATGATAGCATATGCTGGTGCCCTTGCTCATGCTTCTGGCACTCGCATGGATTTCAAAGATGCAACAATTACACAAAGATATAGGACAGATGATGTTCTTGTTACGTGGCGAGATGATTAA

Protein

MVVAIGFEGSANKLGIGIVKDGEILANCRRTYITPPGEGFLPRETAEHHQQNIHEVLQEALDQSGLNPDEIDVVCYTKGPGMGAPLMVCAIVARTCAKLWKKPIYGVNHCIGHIEMGRLITKANNPTVLYVSGGNTQIIAYSRKRYRIFGETIDIAVGNCLDRFARVLKLSNAPSPGYNIEQAAKKGKKYLPLPYCVKGMDVSFSGILSYMEDKIDELLKEYTPEDLCYSLQETVFAMLVEITERAMAHCGSDEVLIVGGVGCNERLQEMMGVMCHEREAKIFATDERFCIDNGVMIAYAGALAHASGTRMDFKDATITQRYRTDDVLVTWRDD

Description

Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Osgep likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.

Catalytic Activity

adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA

Cofactor

a divalent metal cation

Subunit

Component of the EKC/KEOPS complex; the whole complex dimerizes.
Component of the EKC/KEOPS complex composed of at least TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes.
Component of the EKC/KEOPS complex composed of at least tp53rk, tprkb, osgep and lage3; the whole complex dimerizes.

Similarity

Belongs to the KAE1 / TsaD family.

Keywords

Acyltransferase   Complete proteome   Cytoplasm   Metal-binding   Nucleus   Reference proteome   Transferase   tRNA processing  

Feature

chain  Probable tRNA N6-adenosine threonylcarbamoyltransferase

Uniprot

A0A3S2TIX0   A0A212F800   A0A2A4J5L9   A0A2H1VA26   S4PF58   A0A194QQ51   + More
A0A336L7E3   A0A336L8H4   A0A1L8DTJ2   D6WGD4   A0A1B6LLM1   N6URV1   A0A1B6IXS4   U4UYN0   A0A1B6FX76   Q17JQ2   A0A1Q3F2H3   Q17JQ4   A0A182G8M0   A0A1S4F082   J3JXV9   B0WRY1   A0A1B6E6R6   A0A182N996   A0A1Y1L519   A0A182TT82   Q7QIM5   A0A2J7QBB4   A0A182VIC0   A0A182L3L9   A0A182I6S2   A0A182WWJ1   E0VCY3   A0A131XE09   W8C880   A0A1I8JUP0   A0A182QUX9   A0A3B3DUR2   A0A2M4BST6   A0A0K8R5M8   A0A182IR96   A0A182Y2C8   C4WVI6   A0A2P8XPS1   A0A2M4BST1   W5JPN9   A0A2M4ANZ2   A0A2M3Z9Y1   A0A3B4YWS2   A0A3Q4MCJ4   A0A3Q3JJ62   A0A2U9B1H6   A0A3P8TVH2   A0A182SXW4   A0A182PII1   I3K266   A0A1S3JUE1   A0A3Q3JCH8   A0A182JP77   Q5RHZ6   A0A3P8QCK5   A0A3B4H8Y6   A0A3Q3BRA2   A0A3P9C9B6   Q4SY05   A0A3B4UVE1   A0A131Z5L4   A0A067R3I0   A0A3B4YJJ8   A0A034VQT7   A0A224YIZ2   L7MF93   A0A1L8I071   A0A3Q2XSL8   A0A0S7MDV1   A0A3P9AJ18   A0A2D0T2K0   E3TBP5   A0A1E1XQA4   A0A0K8V745   A0A146N6M5   A0A232FHF2   A0A154PDK5   A0A087XE15   A0A3P9PGV7   A0A3Q1IID3   Q7SYR1   A0A1W4WZ88   A0A3B3U9G9   A0A146XJ08   A0A3B3R4S0   A0A1S3N1L8   A0A147AIE0   A0A3Q3T2J8   A0A1J1J4I1   A0A3Q2EIG5   A0A3B5R332   Q0V9I9   G3MH93   A0A0N7ZDA9  

EC Number

2.3.1.234

Pubmed

22118469    23622113    26354079    18362917    19820115    23537049    + More
17510324    26483478    22516182    28004739    12364791    14747013    17210077    20966253    20566863    28049606    24495485    29451363    25244985    29403074    20920257    23761445    25186727    23594743    29346415    28805828    15496914    26830274    24845553    25348373    28797301    25576852    27762356    25069045    20634964    29209593    28648823    29240929    23542700    20431018    22216098   

EMBL

RSAL01000107    RVE47286.1    AGBW02009812    OWR49860.1    NWSH01003235    PCG66713.1    + More
ODYU01001443    SOQ37646.1    GAIX01004202    JAA88358.1    KQ461185    KPJ07489.1    UFQS01001209    UFQT01001209    SSX09785.1    SSX29508.1    UFQS01001301    UFQT01001301    SSX10185.1    SSX29906.1    GFDF01004357    JAV09727.1    KQ971329    EFA01122.1    GEBQ01015336    JAT24641.1    APGK01019136    KB740092    ENN81462.1    GECU01015955    JAS91751.1    KB632429    ERL95430.1    GECZ01014974    JAS54795.1    CH477231    EAT46922.1    GFDL01013316    JAV21729.1    EAT46920.1    JXUM01008040    KQ560252    KXJ83547.1    BT128081    AEE63042.1    DS232062    EDS33591.1    GEDC01028342    GEDC01017293    GEDC01003675    JAS08956.1    JAS20005.1    JAS33623.1    GEZM01066418    JAV67898.1    AAAB01008807    EAA04730.2    NEVH01016301    PNF25867.1    APCN01003693    DS235068    EEB11239.1    GEFH01004705    JAP63876.1    GAMC01000082    JAC06474.1    AXCN02000558    GGFJ01007006    MBW56147.1    GADI01007336    JAA66472.1    ABLF02038097    AK341535    BAH71906.1    PYGN01001569    PSN33990.1    GGFJ01007005    MBW56146.1    ADMH02000528    ETN66096.1    GGFK01009174    MBW42495.1    GGFM01004583    MBW25334.1    CP026244    AWO97792.1    AERX01022926    AERX01022927    BX323558    BC093366    BC164136    CAAE01012247    CAF94477.1    GEDV01002497    JAP86060.1    KK852729    KDR17566.1    GAKP01014128    JAC44824.1    GFPF01004553    MAA15699.1    GACK01003175    JAA61859.1    CM004466    OCU01558.1    GBYX01067356    JAO99900.1    GU587770    ADO27731.1    GFAA01001970    JAU01465.1    GDHF01017592    GDHF01009827    JAI34722.1    JAI42487.1    GCES01158818    JAQ27504.1    NNAY01000242    OXU29767.1    KQ434870    KZC09464.1    AYCK01014076    BC054300    GCES01044293    JAR42030.1    GCES01007939    JAR78384.1    CVRI01000070    CRL07317.1    AAMC01032139    AAMC01032140    AAMC01032141    BC121530    AAI21531.1    JO841244    AEO32861.1    GDRN01047212    JAI66736.1   

Proteomes

UP000283053    UP000007151    UP000218220    UP000053240    UP000007266    UP000019118    + More
UP000030742    UP000008820    UP000069940    UP000249989    UP000002320    UP000075884    UP000075902    UP000007062    UP000235965    UP000075903    UP000075882    UP000075840    UP000076407    UP000009046    UP000075900    UP000075886    UP000261560    UP000075880    UP000076408    UP000007819    UP000245037    UP000000673    UP000261400    UP000261580    UP000261600    UP000246464    UP000265080    UP000075901    UP000075885    UP000005207    UP000085678    UP000075881    UP000000437    UP000265100    UP000261460    UP000264840    UP000265160    UP000007303    UP000261420    UP000027135    UP000261360    UP000186698    UP000264820    UP000265140    UP000221080    UP000215335    UP000076502    UP000028760    UP000242638    UP000265040    UP000192223    UP000261500    UP000265000    UP000261540    UP000087266    UP000261640    UP000183832    UP000265020    UP000002852    UP000008143   

PRIDE

Q5RHZ6    Q7SYR1   

Pfam

PF00814   Peptidase_M22        + More
PF15008   DUF4518
PF04893   Yip1

Interpro

IPR034680   Kae1/OSGEP        + More
IPR000905   Gcp-like_dom       
IPR017860   Peptidase_M22_CS       
IPR017861   KAE1/TsaD       
IPR026698   UPF_C3orf38       
IPR006977   Yip1       

ProteinModelPortal

A0A3S2TIX0   A0A212F800   A0A2A4J5L9   A0A2H1VA26   S4PF58   A0A194QQ51   + More
A0A336L7E3   A0A336L8H4   A0A1L8DTJ2   D6WGD4   A0A1B6LLM1   N6URV1   A0A1B6IXS4   U4UYN0   A0A1B6FX76   Q17JQ2   A0A1Q3F2H3   Q17JQ4   A0A182G8M0   A0A1S4F082   J3JXV9   B0WRY1   A0A1B6E6R6   A0A182N996   A0A1Y1L519   A0A182TT82   Q7QIM5   A0A2J7QBB4   A0A182VIC0   A0A182L3L9   A0A182I6S2   A0A182WWJ1   E0VCY3   A0A131XE09   W8C880   A0A1I8JUP0   A0A182QUX9   A0A3B3DUR2   A0A2M4BST6   A0A0K8R5M8   A0A182IR96   A0A182Y2C8   C4WVI6   A0A2P8XPS1   A0A2M4BST1   W5JPN9   A0A2M4ANZ2   A0A2M3Z9Y1   A0A3B4YWS2   A0A3Q4MCJ4   A0A3Q3JJ62   A0A2U9B1H6   A0A3P8TVH2   A0A182SXW4   A0A182PII1   I3K266   A0A1S3JUE1   A0A3Q3JCH8   A0A182JP77   Q5RHZ6   A0A3P8QCK5   A0A3B4H8Y6   A0A3Q3BRA2   A0A3P9C9B6   Q4SY05   A0A3B4UVE1   A0A131Z5L4   A0A067R3I0   A0A3B4YJJ8   A0A034VQT7   A0A224YIZ2   L7MF93   A0A1L8I071   A0A3Q2XSL8   A0A0S7MDV1   A0A3P9AJ18   A0A2D0T2K0   E3TBP5   A0A1E1XQA4   A0A0K8V745   A0A146N6M5   A0A232FHF2   A0A154PDK5   A0A087XE15   A0A3P9PGV7   A0A3Q1IID3   Q7SYR1   A0A1W4WZ88   A0A3B3U9G9   A0A146XJ08   A0A3B3R4S0   A0A1S3N1L8   A0A147AIE0   A0A3Q3T2J8   A0A1J1J4I1   A0A3Q2EIG5   A0A3B5R332   Q0V9I9   G3MH93   A0A0N7ZDA9  

PDB

2VWB     E-value=3.31405e-90,     Score=845

KEGG

101744341    K01409 N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234] | (RefSeq) probable tRNA N6-adenosine t

GO

GO:0061711   GO:0002949   GO:0005634   GO:0046872   GO:0005737   GO:0000408   GO:0016021   GO:0016787  

PANTHER

PTHR11735   PTHR11735:SF14  

Subcellular location

Cytoplasm  
Nucleus  

Length:

334

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.08563

Exp number, first 60 AAs:

0.00048

Total prob of N-in:

0.00472

outside

1  -  334

 

 

Pi

15.210799

Theta

12.848247

Tajima's D

-0.53261

CLR

2.734817

CSRT

0.233338333083346

Interpretation

Uncertain