Gene

KWMTBOMO06780  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012118

Annotation

PREDICTED:_U1_small_nuclear_ribonucleoprotein_A_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr11(-):14828703-14831191      View in EpiBrowser

Full name

U1 small nuclear ribonucleoprotein A      

Alternative Name

Sex determination protein snf

Location in the cell

Mitochondrial   Reliability : 1.645 Nuclear   Reliability : 1.982

CDS

ATGACAATGGATATAAGACCCAACCATACCATTTATATCAATAATCTCAATGAAAAGATTAAAAAAGAAGAATTAAAGAAGTCACTTTATGCAATATTTTCACAATTTGGTCAAATATTGGATATAGTAGCAATGAAAACCTTAAAAATGCGTGGTCAAGCATTTGTTATTTTCAAGGAAATTTCAAGTGCCACTGTTGCTTTGCGGAGCATGCAAGGATTTCCATTCTATGATAAACCAATGAGAATTCAGTATTCAAAAATTGATAGTGATATAATAGCAAAAAGTAAAGGAACATTTCAAGAACGACCTAAACGTCCAAAGCTACCTAAAGGTACTGATGATGGGAAGAAAAAGAAAAACAAAGATCCTAGCAGACTTATTGGGCATGGTATCCCTGGTGCTGGTATCCTAAACAATGTTAATGCGGAACAACCTCCCAACCAAATTCTGTTCTTGACAAACCTTCCAGATGAAACTTCAGAGATGATGTTATCAATGTTGTTCAATCAGTTCCCAGGCTTTAAGGAGGTTCGTCTTGTGCCAAACAGGCATGATATCGCTTTTGTTGAATTCGGAAATGAAATGCAATCTGCAGCAGCCAAAGAAGCATTACAAGGATTCAAAATAACACCAACACATGCAATGAAGATTACTTTTGCTAAGAAATAG

Protein

MTMDIRPNHTIYINNLNEKIKKEELKKSLYAIFSQFGQILDIVAMKTLKMRGQAFVIFKEISSATVALRSMQGFPFYDKPMRIQYSKIDSDIIAKSKGTFQERPKRPKLPKGTDDGKKKKNKDPSRLIGHGIPGAGILNNVNAEQPPNQILFLTNLPDETSEMMLSMLFNQFPGFKEVRLVPNRHDIAFVEFGNEMQSAAAKEALQGFKITPTHAMKITFAKK

Description

Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP (By similarity). Plays a role in regulating sex-lethal splicing.

Subunit

Belongs to the spliceosome where it is associated with snRNP U1. Interacts with the SMN complex.

Similarity

Belongs to the RRM U1 A/B'' family.

Keywords

3D-structure   Complete proteome   mRNA processing   mRNA splicing   Nucleus   Reference proteome   Repeat   Ribonucleoprotein   RNA-binding   Spliceosome  

Feature

chain  U1 small nuclear ribonucleoprotein A

Uniprot

H9JRF8   A0A2A4J5K2   A0A2H1V9Y9   L7R9W5   A0A1E1W7V2   S4P0Z9   + More
A0A212F812   Q3HR40   A0A026VTW3   A0A182PDA7   Q7PYY3   A0A182YNI7   A0A0N0U768   A0A182LNU9   A0A182WX77   A0A182UTB9   A0A182TZX9   A0A182HN27   E2C3U3   A0A195C7L5   A0A182RQN4   A0A151JBB9   A0A195EX61   A0A158NMT8   A0A151WUQ6   A0A023EIS8   A0A182MXK8   A0A1W4XIL8   A0A182M0A1   A0A182QQX1   A0A182WEL1   A0A2A3EE87   D6WG78   A0A1L8DH55   A0A1Y1NE16   K7IWY9   A0A232EUJ9   A0A1Q3EY32   A0A2M4AX10   W5JHK5   A0A182FBE2   A0A1B0DH24   B0XIL2   A0A084WQ23   A0A1J1IV90   G9FRH2   U5EZF2   A0A194QVA4   C1BQ46   Q16H40   C6ZQZ6   C1C334   A0A224Z4L3   D3PJS0   C1C2H3   A0A164W5T0   A0A0P6J5P7   C1BTN6   E9HAA5   A0A131Z047   T1IP18   A0A0P6BBM5   B3MRQ8   A0A0M5JDD1   A0A194QAV9   A0A1W4VK01   B4PZS0   A0A0P5LMQ3   B3NV27   A0A131XLP2   A0A2S2NTK3   C4WV94   B4I0R3   P43332   R7UUX4   A0A0P5IDF6   A0A1D2N284   A0A3B3X697   A0A183J0F7   A0A1S3WV66   V4A4Z3   A0A091GFN5   A0A212DDH7   A0A3Q3N2A3   A0A3Q2CDD3   A0A3S1ABF7   A0A099YY56   A0A3P8WI67   A0A3Q2UTT6   A0A3Q4MAN9   A0A3P9CJC6   A0A3P8Q472   A0A091ICM3   A0A1S2ZWU0   A0A093C967   A0A093F5D6   A0A091MDD8   A0A093R8T8   A0A087R8B0   A0A091R9P7  

Pubmed

19121390    23622113    22118469    24508170    30249741    12364791    + More
14747013    17210077    25244985    20966253    20798317    21347285    24945155    26483478    18362917    19820115    28004739    20075255    28648823    20920257    23761445    24438588    26354079    17510324    20496585    28797301    21292972    26830274    17994087    17550304    28049606    1386424    7926776    10731132    12537572    12537569    18621711    23254933    27289101    29294181    24487278    25186727   

EMBL

BABH01016368    NWSH01003235    PCG66710.1    ODYU01001443    SOQ37649.1    JX112897    + More
AGC00413.1    GDQN01008011    JAT83043.1    GAIX01009121    JAA83439.1    AGBW02009812    OWR49863.1    DQ202313    ABA43713.1    KK108051    QOIP01000001    EZA46961.1    RLU27406.1    AAAB01008986    EAA00418.2    KQ435710    KOX79928.1    APCN01001831    GL452364    EFN77329.1    KQ978231    KYM96156.1    KQ979147    KYN22451.1    KQ981940    KYN32736.1    ADTU01020803    KQ982729    KYQ51583.1    JXUM01037414    GAPW01004240    KQ561128    JAC09358.1    KXJ79627.1    AXCM01002192    AXCN02001066    KZ288271    PBC29784.1    KQ971320    EFA00191.1    GFDF01008306    JAV05778.1    GEZM01005442    GEZM01005441    JAV96172.1    AAZX01012980    NNAY01002117    OXU22030.1    GFDL01014818    JAV20227.1    GGFK01012003    MBW45324.1    ADMH02001501    ETN62289.1    AJVK01015316    DS233329    EDS29436.1    ATLV01025159    KE525370    KFB52317.1    CVRI01000057    CRL02449.1    JN191600    AEV40671.1    GANO01000906    JAB58965.1    KQ461185    KPJ07486.1    BT076725    ACO11149.1    CH478208    CH477258    EAT33559.1    EAT45781.1    EZ114947    ACU31000.1    BT081263    ACO15687.1    GFPF01012979    MAA24125.1    BT121876    ADD38806.1    BT081052    ACO15476.1    LRGB01001348    KZS12975.1    GDIQ01022923    JAN71814.1    BT077965    HACA01012862    ACO12389.1    CDW30223.1    GL732611    EFX71329.1    GEDV01003748    JAP84809.1    JH431236    GDIP01017427    JAM86288.1    CH902622    EDV34463.2    CP012528    ALC48356.1    KQ459252    KPJ02130.1    CM000162    EDX01137.1    GDIQ01167583    JAK84142.1    CH954180    EDV45875.1    GEFH01001104    JAP67477.1    GGMR01007866    MBY20485.1    ABLF02033703    AK341414    BAH71814.1    CH480819    EDW53094.1    M89775    L29521    AE014298    AY061491    AMQN01006060    AMQN01006061    KB297495    ELU10438.1    GDIQ01216270    JAK35455.1    LJIJ01000284    ODM99393.1    UZAM01012615    VDP22688.1    KB202199    ESO91782.1    KL447392    KFO72947.1    MKHE01000004    OWK16303.1    RQTK01000109    RUS87500.1    KL886513    KGL73858.1    KL218527    KFP06339.1    KL458477    KFV10958.1    KK617526    KFV49421.1    KL330320    KFP57764.1    KL225110    KFW67444.1    KL226203    KFM09714.1    KK812568    KFQ36573.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053097    UP000279307    UP000075885    + More
UP000007062    UP000076408    UP000053105    UP000075882    UP000076407    UP000075903    UP000075902    UP000075840    UP000008237    UP000078542    UP000075900    UP000078492    UP000078541    UP000005205    UP000075809    UP000069940    UP000249989    UP000075884    UP000192223    UP000075883    UP000075886    UP000075920    UP000242457    UP000007266    UP000002358    UP000215335    UP000000673    UP000069272    UP000092462    UP000002320    UP000030765    UP000183832    UP000053240    UP000008820    UP000076858    UP000000305    UP000007801    UP000092553    UP000053268    UP000192221    UP000002282    UP000008711    UP000007819    UP000001292    UP000000803    UP000014760    UP000094527    UP000261480    UP000050793    UP000079721    UP000030746    UP000053760    UP000261660    UP000265020    UP000271974    UP000053641    UP000265120    UP000264840    UP000261580    UP000265160    UP000265100    UP000054308    UP000054081    UP000053286   

PRIDE

H9JRF8    Q3HR40    P43332   

Pfam

PF00076   RRM_1

Interpro

IPR000504   RRM_dom        + More
IPR012677   Nucleotide-bd_a/b_plait_sf       
IPR035979   RBD_domain_sf       
IPR034407   U1A_RRM1       
IPR034409   U1A_RRM2       
IPR034564   U2B''_RRM1       
IPR034562   U2B''_RRM2       

SUPFAM

SSF54928   SSF54928       

Gene 3D

3.30.70.330    

CDD

cd12477  RRM1_U1A
cd12480  RRM2_U1A
cd12478  RRM1_U2B
cd12481  RRM2_U2B

ProteinModelPortal

H9JRF8   A0A2A4J5K2   A0A2H1V9Y9   L7R9W5   A0A1E1W7V2   S4P0Z9   + More
A0A212F812   Q3HR40   A0A026VTW3   A0A182PDA7   Q7PYY3   A0A182YNI7   A0A0N0U768   A0A182LNU9   A0A182WX77   A0A182UTB9   A0A182TZX9   A0A182HN27   E2C3U3   A0A195C7L5   A0A182RQN4   A0A151JBB9   A0A195EX61   A0A158NMT8   A0A151WUQ6   A0A023EIS8   A0A182MXK8   A0A1W4XIL8   A0A182M0A1   A0A182QQX1   A0A182WEL1   A0A2A3EE87   D6WG78   A0A1L8DH55   A0A1Y1NE16   K7IWY9   A0A232EUJ9   A0A1Q3EY32   A0A2M4AX10   W5JHK5   A0A182FBE2   A0A1B0DH24   B0XIL2   A0A084WQ23   A0A1J1IV90   G9FRH2   U5EZF2   A0A194QVA4   C1BQ46   Q16H40   C6ZQZ6   C1C334   A0A224Z4L3   D3PJS0   C1C2H3   A0A164W5T0   A0A0P6J5P7   C1BTN6   E9HAA5   A0A131Z047   T1IP18   A0A0P6BBM5   B3MRQ8   A0A0M5JDD1   A0A194QAV9   A0A1W4VK01   B4PZS0   A0A0P5LMQ3   B3NV27   A0A131XLP2   A0A2S2NTK3   C4WV94   B4I0R3   P43332   R7UUX4   A0A0P5IDF6   A0A1D2N284   A0A3B3X697   A0A183J0F7   A0A1S3WV66   V4A4Z3   A0A091GFN5   A0A212DDH7   A0A3Q3N2A3   A0A3Q2CDD3   A0A3S1ABF7   A0A099YY56   A0A3P8WI67   A0A3Q2UTT6   A0A3Q4MAN9   A0A3P9CJC6   A0A3P8Q472   A0A091ICM3   A0A1S2ZWU0   A0A093C967   A0A093F5D6   A0A091MDD8   A0A093R8T8   A0A087R8B0   A0A091R9P7  

PDB

6QX9     E-value=6.88513e-66,     Score=633

KEGG

692785    no KO assigned | (RefSeq) SNF; U1 small nuclear ribonucleoprotein A

GO

GO:0003723   GO:0000398   GO:0030619   GO:0005685   GO:0030620   GO:0048477   GO:0042802   GO:0030532   GO:0097158   GO:0070868   GO:0000381   GO:0008266   GO:0035614   GO:0003729   GO:1990904   GO:0071013   GO:0019099   GO:0032991   GO:0071011   GO:0008380   GO:0005686   GO:0005681   GO:0005634   GO:0007539   GO:0000166   GO:0003676   GO:0005524   GO:0005515   GO:0006355   GO:0043565   GO:0016567   GO:0016020   GO:0006260  

Subcellular location

Nucleus  

Length:

223

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.60298

Exp number, first 60 AAs:

1.10886

Total prob of N-in:

0.32814

outside

1  -  223

 

 

Pi

23.258718

Theta

23.046429

Tajima's D

0.119342

CLR

0.154039

CSRT

0.407629618519074

Interpretation

Uncertain