Gene

KWMTBOMO06741  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012019

Annotation

putative_selenium-binding_protein_[Danaus_plexippus]

Location

Bomo_Chr11(+):13581422-13602585      View in EpiBrowser

Full name

Methanethiol oxidase      

Alternative Name

56 kDa selenium-binding protein
Selenium-binding protein 1

Location in the cell

Cytoplasmic   Reliability : 2.857

CDS

ATGTCTTGTTGTAAAGGACCAGGGTATGCGTCACCATTAGACGCATTTAATAATGGACCGAGGGAAGAACTTCTTTACGTGGTCTGCGTTCGGCCAAACAAAAACAAACAGGACTATCTTGCAACAGTGGACGTTGATTCTAAATCCGCAACATACGGCCAGGTCATTCACCGCACCTACACGGGAGTAACAGGAGACGAACTGCATCACAGCGGCTGGAATGTGTGTTCGAGTTGCCATGACAACGCGGCACTGAAGCGAGACCTTCTCATAATGCCGGGATTGCATTCCTGCAATGTCTACGCCGTTGACGTCGGGACCGATCCTAGGAAGCCTCGATTGCATAAGGTAATCGACGGCTCAAAGATGAGGTCATTCAACTGCAGTTTCCCGCACACGACGCACTGCCTGGCAACCGGCGAAATTATGATCTCAACGATGGGAGATGAAAACGAAAACGGAAAGGGGGATTTTGTGCTCATCGACTCGAAGACTTTGGAAGTGACAGGAACGTGGACTAAGGGGAAAAATCATGCTAAATTTGGCTACGATTTTTGGTATCAACCATACCATGATGTTATGATTTCCTCAGAATGGGGTACCCCGAAATATTTTAAAAGCGGATTTCACGCAGAAGATATATCCGACCCCGAGCGATATGGTACAAAGTTAAATGTTTATAAATGGTCAACGCGCGAACTACAACAAGTTATAGATCTGGGCAGCGAGGGTTGTGCTCCGTTGGAAATCAGATTTCTTCATGATCCGAAATCCGCCCAAGGATTTGTCGGGTGTGCAGTCCAGGCCAATGTTTACAGATTCTACAAAACTGCCGAAGGAACTTGGAAAGCAGATAAAGTCATCGACATACCGGCTAAAAAAGTTTTCAAAGATGGAGTCGAGTCGGAACTTAACGGTTTAATATCTGACATTCTTTTATCATTGGACGACAAGTATTTATATTTCTCGTGCTGGCTACACGGTGATGTTTATCAGTATGACATATCGAATCCGGAGCACCCAAAGTTAATAAGTCGTGTGCATCTCGGAGGAAAAGTTGCTTCGGAAGGTTTGAAAATCCTGGACAAGGAAGAGTTGAAGAATTCTGAAAAACCGATAACAGTCAAAGGCAAGATCCTCCAAGGTGGACCACAAATGTTGCAACTATCATTGGATGGAAAACGCTTGTATGTCTCGTCGTCGCTATACTCACCTTGGGATAAACAAGTTTACCCTAAAATGGCTGAAGAGGGTGGGTGGTTAGTAAAGTTAGACGTGGATACTGTGAATGGAGGCATGAAGTTGGATCCGGATTTCCTCGTAGACTTCGGGGCCGAACCGGACGGGCCGGCGTTGCCGCACGAAATGAGATACCCCGGCGGAGACTGCACTTCAGACATTTGGTTGACAGATGACTAA

Protein

MSCCKGPGYASPLDAFNNGPREELLYVVCVRPNKNKQDYLATVDVDSKSATYGQVIHRTYTGVTGDELHHSGWNVCSSCHDNAALKRDLLIMPGLHSCNVYAVDVGTDPRKPRLHKVIDGSKMRSFNCSFPHTTHCLATGEIMISTMGDENENGKGDFVLIDSKTLEVTGTWTKGKNHAKFGYDFWYQPYHDVMISSEWGTPKYFKSGFHAEDISDPERYGTKLNVYKWSTRELQQVIDLGSEGCAPLEIRFLHDPKSAQGFVGCAVQANVYRFYKTAEGTWKADKVIDIPAKKVFKDGVESELNGLISDILLSLDDKYLYFSCWLHGDVYQYDISNPEHPKLISRVHLGGKVASEGLKILDKEELKNSEKPITVKGKILQGGPQMLQLSLDGKRLYVSSSLYSPWDKQVYPKMAEEGGWLVKLDVDTVNGGMKLDPDFLVDFGAEPDGPALPHEMRYPGGDCTSDIWLTDD

Description

Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria (PubMed:29255262). Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity).

Catalytic Activity

H2O + methanethiol + O2 = formaldehyde + H(+) + H2O2 + hydrogen sulfide

Biophysicochemical Properties

5 nM for methanethiol

Subunit

Interacts with USP33.

Similarity

Belongs to the selenium-binding protein family.

Keywords

Acetylation   Complete proteome   Cytoplasm   Membrane   Nucleus   Oxidoreductase   Phosphoprotein   Protein transport   Reference proteome   Selenium   Transport  

Feature

chain  Methanethiol oxidase

Uniprot

H9JR59   A0A1E1WDC0   A0A386KRV0   A0A2A4K2L7   A0A212F5P4   A0A2H1WN87   + More
A0A0N1PJD3   A0A194PG70   A0A067QJN9   D6WGB6   A0A2J7PJN2   A0A2J7PJK8   A0A1Y1K1C0   S4P912   W8BJV9   V5I9B5   E0VL34   A0A1B6CU85   W5JE39   A0A2M4BLT5   A0A0A1X3Y6   A0A2S2QB06   A0A2M4ADU0   A0A182FUC0   A0A1B6H0Q8   A0A0K8VD18   A0A034W1Z1   A0A2H8U0V5   J9K000   B4K8H8   A0A182W2G2   A0A336MLL8   A0A336MSM8   B4PPW3   A0A1B6IVT8   A0A0M4ES54   A0A182MUN9   A0A1Y1L5E7   A0A182Y5X1   A0A1S4F087   Q5U137   Q9VFZ4   A0A182PU92   A0A182GED0   A0A1A9WTR5   Q17JR3   J3JTD9   B5DXU8   A0A023EV95   A0A182QJJ0   A0A182XC31   A0A1A9XNS1   A0A182LP81   A0A2S2P3J2   A0A182RQZ5   A0A182MY63   A0A1B0BB37   A0A182HNC9   A0A1L8DCZ9   B3LWN6   A0A1L8DCK3   B4JEW1   B4R1W7   U4U5P1   B4N9Z4   N6TVU9   A0A182JVG8   A0A1W4UJ61   A0A1B0A1H6   B4M3U0   A0A1A9VPT5   B4M3T8   A0A3B0KVC6   A0A182IQV4   B3P187   B3LWN4   A0A084VRL8   T1PF27   A0A0L0BVE7   A0A1Q3FIW6   A0A1L8EDZ5   A0A1I8MEM1   A0A1L8EDS9   B0X2S7   A0A0T6B6R8   U5EVV0   K7IX17   W5MPL7   A0A1I8Q0Q3   A0A076FKV6   A0A0A9X941   A0A1W4X823   A0A3L8DTE8   Q7K537   P17563   H1A455   A0A1J1I5A8   D3TMB9   A0A182VGD7   I3IZ52  

EC Number

1.8.3.4

Pubmed

19121390    22118469    26354079    24845553    18362917    19820115    + More
28004739    23622113    24495485    20566863    20920257    23761445    25830018    25348373    17994087    17550304    25244985    17510324    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26483478    22516182    15632085    24945155    20966253    18057021    23537049    24438588    26108605    25315136    20075255    25401762    26823975    30249741    2225343    15489334    15378723    21183079    29255262    20360741    20353571    25186727   

EMBL

BABH01016448    BABH01016449    BABH01016450    GDQN01006081    JAT84973.1    MH712737    + More
AYD88369.1    NWSH01000197    PCG78495.1    AGBW02010176    OWR49029.1    ODYU01009458    SOQ53914.1    KQ460499    KPJ14277.1    KQ459606    KPI91699.1    KK853282    KDR09028.1    KQ971329    EFA01143.1    NEVH01024946    PNF16519.1    PNF16520.1    GEZM01097309    JAV54278.1    GAIX01003939    JAA88621.1    GAMC01004955    JAC01601.1    GALX01003225    JAB65241.1    DS235269    EEB14090.1    GEDC01020403    JAS16895.1    ADMH02001793    ETN61079.1    GGFJ01004908    MBW54049.1    GBXI01008233    JAD06059.1    GGMS01005169    MBY74372.1    GGFK01005634    MBW38955.1    GECZ01030912    GECZ01001532    JAS38857.1    JAS68237.1    GDHF01015551    JAI36763.1    GAKP01010268    JAC48684.1    GFXV01007223    MBW19028.1    ABLF02032716    CH933806    EDW14377.2    UFQT01001257    SSX29723.1    UFQS01001778    UFQT01001778    SSX12312.1    SSX31763.1    CM000160    EDW97190.1    GECU01016649    JAS91057.1    CP012526    ALC47522.1    AXCM01003888    GEZM01063935    JAV68903.1    BT016055    AAV36940.1    AE014297    AAF54900.2    JXUM01057782    KQ561971    KXJ77029.1    CH477231    EAT46911.1    BT126495    AEE61459.1    CM000070    EDY67914.4    JXUM01044436    GAPW01001194    KQ561401    JAC12404.1    KXJ78701.1    AXCN02002036    GGMR01011424    MBY24043.1    JXJN01011291    APCN01001905    GFDF01009884    JAV04200.1    CH902617    EDV41630.1    EDV41632.1    GFDF01009883    JAV04201.1    CH916369    EDV93242.1    CM000364    EDX13119.1    KB632056    ERL88362.1    CH964232    EDW81749.1    APGK01059111    APGK01059112    APGK01059113    KB741292    ENN70422.1    CH940652    EDW59301.2    EDW59299.2    OUUW01000013    SPP87928.1    CH954181    EDV49276.1    EDV41628.1    ATLV01015746    KE525033    KFB40612.1    KA646493    AFP61122.1    JRES01001281    KNC23958.1    GFDL01007603    JAV27442.1    GFDG01001913    JAV16886.1    GFDG01001919    JAV16880.1    DS232298    EDS39401.1    LJIG01009448    KRT83060.1    GANO01000848    JAB59023.1    AAZX01000575    AHAT01028155    AHAT01028156    AHAT01028157    KF516652    AII16556.1    GBHO01028256    GBRD01001858    GDHC01006907    JAG15348.1    JAG63963.1    JAQ11722.1    QOIP01000004    RLU23720.1    AY051481    AAK92905.1    M32032    BC011202    ABQF01060944    CVRI01000040    CRK94772.1    EZ422571    ADD18847.1    AERX01046459   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053240    UP000053268    UP000027135    + More
UP000007266    UP000235965    UP000009046    UP000000673    UP000069272    UP000007819    UP000009192    UP000075920    UP000002282    UP000092553    UP000075883    UP000076408    UP000000803    UP000075885    UP000069940    UP000249989    UP000091820    UP000008820    UP000001819    UP000075886    UP000076407    UP000092443    UP000075882    UP000075900    UP000075884    UP000092460    UP000075840    UP000007801    UP000001070    UP000000304    UP000030742    UP000007798    UP000019118    UP000075881    UP000192221    UP000092445    UP000008792    UP000078200    UP000268350    UP000075880    UP000008711    UP000030765    UP000037069    UP000095301    UP000002320    UP000002358    UP000018468    UP000095300    UP000192223    UP000279307    UP000000589    UP000007754    UP000183832    UP000075903    UP000005207   

PRIDE

H9JR59    Q5U137    Q9VFZ4    Q7K537    P17563    I3IZ52    + More

Pfam

PF05694   SBP56

Interpro

IPR008826   Se-bd        + More
IPR011044   Quino_amine_DH_bsu       
IPR015943   WD40/YVTN_repeat-like_dom_sf       

SUPFAM

SSF50969   SSF50969       

Gene 3D

2.130.10.10    

ProteinModelPortal

H9JR59   A0A1E1WDC0   A0A386KRV0   A0A2A4K2L7   A0A212F5P4   A0A2H1WN87   + More
A0A0N1PJD3   A0A194PG70   A0A067QJN9   D6WGB6   A0A2J7PJN2   A0A2J7PJK8   A0A1Y1K1C0   S4P912   W8BJV9   V5I9B5   E0VL34   A0A1B6CU85   W5JE39   A0A2M4BLT5   A0A0A1X3Y6   A0A2S2QB06   A0A2M4ADU0   A0A182FUC0   A0A1B6H0Q8   A0A0K8VD18   A0A034W1Z1   A0A2H8U0V5   J9K000   B4K8H8   A0A182W2G2   A0A336MLL8   A0A336MSM8   B4PPW3   A0A1B6IVT8   A0A0M4ES54   A0A182MUN9   A0A1Y1L5E7   A0A182Y5X1   A0A1S4F087   Q5U137   Q9VFZ4   A0A182PU92   A0A182GED0   A0A1A9WTR5   Q17JR3   J3JTD9   B5DXU8   A0A023EV95   A0A182QJJ0   A0A182XC31   A0A1A9XNS1   A0A182LP81   A0A2S2P3J2   A0A182RQZ5   A0A182MY63   A0A1B0BB37   A0A182HNC9   A0A1L8DCZ9   B3LWN6   A0A1L8DCK3   B4JEW1   B4R1W7   U4U5P1   B4N9Z4   N6TVU9   A0A182JVG8   A0A1W4UJ61   A0A1B0A1H6   B4M3U0   A0A1A9VPT5   B4M3T8   A0A3B0KVC6   A0A182IQV4   B3P187   B3LWN4   A0A084VRL8   T1PF27   A0A0L0BVE7   A0A1Q3FIW6   A0A1L8EDZ5   A0A1I8MEM1   A0A1L8EDS9   B0X2S7   A0A0T6B6R8   U5EVV0   K7IX17   W5MPL7   A0A1I8Q0Q3   A0A076FKV6   A0A0A9X941   A0A1W4X823   A0A3L8DTE8   Q7K537   P17563   H1A455   A0A1J1I5A8   D3TMB9   A0A182VGD7   I3IZ52  

PDB

2ECE     E-value=1.90229e-70,     Score=676

KEGG

101735354    K17285 methanethiol oxidase [EC:1.8.3.4] | (RefSeq) selenium-binding protein 1

PATHWAY

00920    Sulfur metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0008430   GO:0016021   GO:0016020   GO:0018549   GO:0015031   GO:0005730   GO:0001650   GO:0050873   GO:0005829   GO:0005515   GO:0007275   GO:0004842   GO:0008270   GO:0016567   GO:0005634   GO:0006260  

PANTHER

PTHR23300  

Subcellular location

Nucleus   May associate with Golgi membrane (By similarity). May associate with the membrane of autophagosomes (By similarity).   With evidence from 3 publications.
Cytoplasm   May associate with Golgi membrane (By similarity). May associate with the membrane of autophagosomes (By similarity).   With evidence from 3 publications.
Cytosol   May associate with Golgi membrane (By similarity). May associate with the membrane of autophagosomes (By similarity).   With evidence from 3 publications.
Membrane   May associate with Golgi membrane (By similarity). May associate with the membrane of autophagosomes (By similarity).   With evidence from 3 publications.

Length:

472

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00272

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00347

outside

1  -  472

 

 

Pi

200.223183

Theta

175.580643

Tajima's D

-0.625886

CLR

19.623939

CSRT

0.210639468026599

Interpretation

Uncertain