Gene

KWMTBOMO06740  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012134

Annotation

PREDICTED:_uncharacterized_protein_LOC101735671_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr11(-):13515880-13528372      View in EpiBrowser

Full name

E3 ubiquitin-protein ligase      

Location in the cell

Nuclear   Reliability : 2.282

CDS

ATGTCGCAGAATCTGGTCACACAATCGCAGCTTACATTAGACTCGGAAAGTCGAAAGTCCGTAGTCCTGAATTCGCTACTGGAGACTGACCATTATGAGAGCATCATCAAAGACCTGACGTGCAAAAGATGCTCAAAATACATGAAGCCGCCTATTCACCTCTGCGTGGACGGACACAGTATCTGCGGTCCTTGTTATGACAAAAGCTATCAATGTCACGTGTGCAAAAAAGAATTTTCACCGATCCGTTCCGCCGTGCTGGAGTCGTTGGCAAACAAAGTCTTGTTCCCGTGCACGAATGCGGGATGCCCAAAACACGCCACGCTCCCGCTACTGGAGAAGCACACTCCGCACTGCCAGTTCAGAATCATAAACTGCTTTATGGCTAGAGTATACGGTGAGTGCACGTGGGAGGGGCGCGCGGGCGACTGGATGGACCACTGCTTCTCGGAACATAAACAAAAGGTCACTGACCTGCCCTTCATCACTGTCAAAGACAAATGGGACGCTAAGAGGACAGAGCCGATCCTAAACTATTTCCTGCTAAGATGCTTCGAAAAAGTTTTTAATGTTTACCAGATCTATGATAAAAGAGGAGGTCGAATGATGTGGACAGTGCTCGTAAACGATGACAATGCAGAGAAATTTTATTTCGAAATCGACATCTTCCTTCCAAATCTACCGAGCAAAAGGATCGTGTACCGACGCCCCTGTAAATGCGAGAAGGACGCTGATTTCCTGGAACACACACAGAACGTGTACATTCCCGTTGAAAACGTTTTCTCTATGCTCGATGACAGCGAAGCCTTGAATTTCATTGTTAGAATCGGTGAAGTAGAAAATTTACCTCTGCTCGATACACCGACAGATAGCGAGAGCCGTATTCTTCTGAACCACGAAGATCATAAATAA

Protein

MSQNLVTQSQLTLDSESRKSVVLNSLLETDHYESIIKDLTCKRCSKYMKPPIHLCVDGHSICGPCYDKSYQCHVCKKEFSPIRSAVLESLANKVLFPCTNAGCPKHATLPLLEKHTPHCQFRIINCFMARVYGECTWEGRAGDWMDHCFSEHKQKVTDLPFITVKDKWDAKRTEPILNYFLLRCFEKVFNVYQIYDKRGGRMMWTVLVNDDNAEKFYFEIDIFLPNLPSKRIVYRRPCKCEKDADFLEHTQNVYIPVENVFSMLDDSEALNFIVRIGEVENLPLLDTPTDSESRILLNHEDHK

Description

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Catalytic Activity

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Similarity

Belongs to the SINA (Seven in absentia) family.
Belongs to the eIF-2B alpha/beta/delta subunits family.

Uniprot

H9JRH4   A0A194PFA0   A0A0N1IEK6   A0A212FC73   A0A2H1WI24   A0A2A4K4C3   + More
A0A2A4K3L4   A0A2A4K3N6   A0A2A4K2L6   A0A1S4FBP6   Q178N6   A0A1S4G471   Q1DGT7   B0X888   A0A182M2G9   A0A182W5Q5   A0A182RHN8   A0A182R0S6   A0A084VQD2   A0A182J359   A0A182YCV2   A0A182UP81   A0A182N8I5   A0A182TUG8   A0A182FJ00   A0A182XJZ9   Q7QF99   A0A182IAX9   A0A1B0D8Y9   A0A1B0CHF1   T1PC13   A0A1I8ND94   A0A1I8Q1U1   B4L1M7   W8BDB3   A0A0M4EIM2   A0A1A9Z212   A0A1A9XZY6   A0A1A9VD56   A0A182KLC8   A0A0A1XRW6   A0A034V5G1   A0A034V863   Q29HR3   A0A1B0B403   B4GYG0   A0A0K8UQ93   A0A0K8UPG7   A0A1B0FAC1   A0A3B0JXW5   A0A0R3P4Z5   B4N1V3   B3MWG9   B4I9Y9   A0A0P9BV27   Q9W4W4   B4R3T9   B4MG75   B3NTW1   A0A1W4VF65   B4JL29   B4Q0X0   Q8MTX6   A0A1W4XAW8   A0A0R3P416   A0A139WEW0   A0A1Y1LLZ1   D6W9Y6   V5GSR3   O76862   D6WQJ0   A0A1W4XCK0   A0A1W4XCS1   A0A2J7QN57   A0A1W4WN84   A0A2P8Z4M8   A0A1E1WES9  

EC Number

2.3.2.27

Pubmed

19121390    26354079    22118469    17510324    24438588    25244985    + More
12364791    25315136    17994087    24495485    20966253    25830018    25348373    15632085    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    17550304    12351680    18362917    19820115    28004739    29403074   

EMBL

BABH01016455    KQ459606    KPI91698.1    KQ460499    KPJ14278.1    AGBW02009213    + More
OWR51330.1    ODYU01008479    SOQ52114.1    NWSH01000197    PCG78502.1    PCG78498.1    PCG78504.1    PCG78501.1    CH477361    EAT42654.1    CH900425    EAT32367.1    DS232478    EDS42357.1    AXCM01001073    AXCN02002231    ATLV01015189    KE525003    KFB40176.1    AAAB01008846    EAA06700.5    APCN01001358    AJVK01012846    AJWK01012309    AJWK01012310    KA646229    AFP60858.1    CH933810    EDW07663.2    GAMC01018788    GAMC01018786    JAB87769.1    CP012528    ALC48778.1    GBXI01000238    JAD14054.1    GAKP01021228    JAC37724.1    GAKP01021229    JAC37723.1    CH379064    EAL31695.1    JXJN01008138    JXJN01008139    CH479197    EDW27816.1    GDHF01023593    JAI28721.1    GDHF01023715    JAI28599.1    CCAG010006092    OUUW01000011    SPP86905.1    KRT06464.1    CH963925    EDW78342.1    CH902625    EDV34954.1    CH480825    EDW44020.1    KPU75371.1    AE014298    BT044595    AAF45811.2    ACI31295.1    CM000366    EDX16951.1    CH940672    EDW57398.2    CH954180    EDV45669.1    CH916370    EDW00282.1    CM000162    EDX01337.2    AY047979    AAL08361.1    KRT06463.1    KQ971354    KYB26391.1    GEZM01051860    GEZM01051859    GEZM01051858    GEZM01051857    JAV74659.1    KQ971312    EEZ98089.2    GALX01001247    JAB67219.1    AL023874    CAA19647.1    EFA06066.2    NEVH01013199    PNF30025.1    PYGN01000196    PSN51458.1    GDQN01005556    JAT85498.1   

Proteomes

UP000005204    UP000053268    UP000053240    UP000007151    UP000218220    UP000008820    + More
UP000002320    UP000075883    UP000075920    UP000075900    UP000075886    UP000030765    UP000075880    UP000076408    UP000075903    UP000075884    UP000075902    UP000069272    UP000076407    UP000007062    UP000075840    UP000092462    UP000092461    UP000095301    UP000095300    UP000009192    UP000092553    UP000092445    UP000092443    UP000078200    UP000075882    UP000001819    UP000092460    UP000008744    UP000092444    UP000268350    UP000007798    UP000007801    UP000001292    UP000000803    UP000000304    UP000008792    UP000008711    UP000192221    UP000001070    UP000002282    UP000192223    UP000007266    UP000235965    UP000245037   

PRIDE

H9JRH4    Q9W4W4    O76862   

Pfam

PF03145   Sina        + More
PF01008   IF-2B
PF13445   zf-RING_UBOX

Interpro

IPR008974   TRAF-like        + More
IPR018121   7-in-absentia-prot_TRAF-dom       
IPR013083   Znf_RING/FYVE/PHD       
IPR004162   SINA-like       
IPR013010   Znf_SIAH       
IPR001841   Znf_RING       
IPR037171   NagB/RpiA_transferase-like       
IPR000649   IF-2B-related       
IPR027370   Znf-RING_LisH       

SUPFAM

SSF49599   SSF49599        + More
SSF100950   SSF100950       

Gene 3D

3.30.40.10     2.60.210.10    

ProteinModelPortal

H9JRH4   A0A194PFA0   A0A0N1IEK6   A0A212FC73   A0A2H1WI24   A0A2A4K4C3   + More
A0A2A4K3L4   A0A2A4K3N6   A0A2A4K2L6   A0A1S4FBP6   Q178N6   A0A1S4G471   Q1DGT7   B0X888   A0A182M2G9   A0A182W5Q5   A0A182RHN8   A0A182R0S6   A0A084VQD2   A0A182J359   A0A182YCV2   A0A182UP81   A0A182N8I5   A0A182TUG8   A0A182FJ00   A0A182XJZ9   Q7QF99   A0A182IAX9   A0A1B0D8Y9   A0A1B0CHF1   T1PC13   A0A1I8ND94   A0A1I8Q1U1   B4L1M7   W8BDB3   A0A0M4EIM2   A0A1A9Z212   A0A1A9XZY6   A0A1A9VD56   A0A182KLC8   A0A0A1XRW6   A0A034V5G1   A0A034V863   Q29HR3   A0A1B0B403   B4GYG0   A0A0K8UQ93   A0A0K8UPG7   A0A1B0FAC1   A0A3B0JXW5   A0A0R3P4Z5   B4N1V3   B3MWG9   B4I9Y9   A0A0P9BV27   Q9W4W4   B4R3T9   B4MG75   B3NTW1   A0A1W4VF65   B4JL29   B4Q0X0   Q8MTX6   A0A1W4XAW8   A0A0R3P416   A0A139WEW0   A0A1Y1LLZ1   D6W9Y6   V5GSR3   O76862   D6WQJ0   A0A1W4XCK0   A0A1W4XCS1   A0A2J7QN57   A0A1W4WN84   A0A2P8Z4M8   A0A1E1WES9  

PDB

4CA1     E-value=0.000568495,     Score=101

KEGG

101735671    K04506 E3 ubiquitin-protein ligase SIAH1 [EC:2.3.2.27] | (RefSeq) cysteine and histidine-rich protei

PATHWAY

04013    MAPK signaling pathway - fly - Bombyx mori (domestic silkworm)
04120    Ubiquitin mediated proteolysis - Bombyx mori (domestic silkworm)
04310    Wnt signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0016567   GO:0005634   GO:0006511   GO:0046872   GO:0007275   GO:0016874   GO:0008270   GO:0043161   GO:0031624   GO:0061630   GO:0004842   GO:0005515   GO:0016020   GO:0006260  

PANTHER

PTHR45877  

Length:

303

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01319

Exp number, first 60 AAs:

0

Total prob of N-in:

0.04953

outside

1  -  303

 

 

Pi

173.406131

Theta

165.551043

Tajima's D

-0.385769

CLR

1.787581

CSRT

0.270486475676216

Interpretation

Uncertain