Gene

KWMTBOMO06709

Pre Gene Modal

BGIBMGA011752

Annotation

PREDICTED:_dynein_intermediate_chain_3?_ciliary_[Bombyx_mori]

Location

Bomo_Chr11(-):12865917-12873649      View in EpiBrowser

Full name

Dynein intermediate chain 3, ciliary       + More
Dynein intermediate chain 2, axonemal      

Alternative Name

Axonemal dynein intermediate chain 2

Location in the cell

Cytoplasmic   Reliability : 1.73 Nuclear   Reliability : 1.766

CDS

ATGGAAAAACCAGAGAAAACTGAATTTGTTTATGAATACACAAGAAGAAGACGTGATTTTGGAAAACAAACATTATTCGAAGACTATGGACCAATTATGACGGTTAGCATTGTCAGCAATCAAGCTCTTTATAACAATTACATTCTCAGGAATCCCGTGCATGTCGGAATCCAAAATACCGGCACAATGTCCGAACACTGGGTTAATTCAGTCAGAGCTGAGTACACCAGTTCTGGTATAAATCACGTGGAAGGCGGATGGCCTAAAGATATAAACATGAACGACCCCGAAGCTGTTCAGCGCTACCGTCGTAAAATTGAAAAAGACGACGCATATATTCACGCTGTTATGCATTTAGGTCATGGTATGGAACACAACATACTTCAGAACAACGCTATAGATATGTTCGAGTCTTATTACTCTGATGTTCCCGAAATACCTCCGGTCGAGAAGAGTAGTTGTCACACTGTGAACGTCTACCGAGAGCCTGGAGCCAGGAGGCCCGTTCGGTCGTTGTCGTGGCAAGCCGACGGCGGAGCAAGATTTGCAGCTGCTCATGCTGACGTCGAATTAATGAGAAGCTGTCGAAGCTCACAGTTTTCTTACATTTGGGATATTGAGAATGCAAACGCCCCGGAATTGGTAATAAAGCCGCCACAGCCGTTATTAGATTTGCAGTACAACCCTCGCGACCAACATATTCTTGTAGGGGGGATGATGAACGGGCAGGTTGGTTGGTGGGATGTTCGGAAAGGCGGGGATCCAGCTGGCCTATGTCTTCCGCACGTAGCACATCGTGATATAGTTCGTAATGTTCTGTTTATCAACTCGAAAATCGGAGCAGAATTCTTCTCCTCGTCGCCCGACGGGGTTGTGAAATGGTGGGATACGCGAAATATGAGTGAACCGACTGATTCAATGATTATCGACATTGTAAAATCTGCAACAGACACGCAAAATATCGACAATGCCATCGGAATCTCAGCTCTTGAGTACGAACCAACAATACCAACTAGATTTATGGTTGGCACTGAAACTGGTTTGGTCATCGGAGGAAATCGTAAAGGAAAAAATCCCTTAGAAAAACTTCCCTCTAAATACGAAGCTCACTTGGGACCGGTTTACGCTCTTCAGAGAAACCCAACATTCCTCAAGAATTTCTTAACAGTGGGCGATTGGACAGCTCGGGTTTGGAGCGAGGATTGCAGGGAGTCCTCTATTTTGTGGACATATTCGCATCGCACGAACCTGACTGATGGCGCATGGAATCCCATTAGGTTTTCTTTAATGCTTGTGACTCAGTGGGACGGATGCCTGTCCTGTTGGGACTTGCTGAGGAGACGCAGCGCGCCCATTGTTACTGCGCAGCTTTGCGACGAGCCCTTACTGCGCCTTCGACCACACGAGGGGGGACTCCTGGTCGCTTGCGGTAGCAGCAAAGGCACTGTATACCTAGCAGAACTGTCACAAAATCTCGGAACAGCTGACAAGAACGACAAACAATTGTTGACACACATCTTCGACAGAGAAAATAAACGCGAACGTATACTTGAAGCACGTATGAGAGAGCTCAAGTTAAAAATGAGACAAGACCGCGACGGCGGGCCGCAGAACCAGGAGAACGACGCTTCGACAAACGACAGGGATTTAGAGGAAGCGACTGCCGAGTACGTGCAGACTATAAGCGACTTACAAGCTCAACAAAAGTCCCAATCCAATTAA

Protein

MEKPEKTEFVYEYTRRRRDFGKQTLFEDYGPIMTVSIVSNQALYNNYILRNPVHVGIQNTGTMSEHWVNSVRAEYTSSGINHVEGGWPKDINMNDPEAVQRYRRKIEKDDAYIHAVMHLGHGMEHNILQNNAIDMFESYYSDVPEIPPVEKSSCHTVNVYREPGARRPVRSLSWQADGGARFAAAHADVELMRSCRSSQFSYIWDIENANAPELVIKPPQPLLDLQYNPRDQHILVGGMMNGQVGWWDVRKGGDPAGLCLPHVAHRDIVRNVLFINSKIGAEFFSSSPDGVVKWWDTRNMSEPTDSMIIDIVKSATDTQNIDNAIGISALEYEPTIPTRFMVGTETGLVIGGNRKGKNPLEKLPSKYEAHLGPVYALQRNPTFLKNFLTVGDWTARVWSEDCRESSILWTYSHRTNLTDGAWNPIRFSLMLVTQWDGCLSCWDLLRRRSAPIVTAQLCDEPLLRLRPHEGGLLVACGSSKGTVYLAELSQNLGTADKNDKQLLTHIFDRENKRERILEARMRELKLKMRQDRDGGPQNQENDASTNDRDLEEATAEYVQTISDLQAQQKSQSN

Description

Part of the dynein complex of respiratory cilia.

Subunit

Consists of at least two heavy chains (alpha and beta), three intermediate chains and several light chains.
Consists of at least two heavy chains and a number of intermediate and light chains (Probable). Interacts with DNAAF2 (By similarity). Interacts with PIH1D3 (By similarity). Interacts with HEATR2; probably involved in outer arm dynein assembly (By similarity).
Consists of at least two heavy chains and a number of intermediate and light chains (Probable). Interacts with DNAAF2 (PubMed:19052621). Interacts with PIH1D3 (PubMed:24421334). Interacts with HEATR2; probably involved in outer arm dynein assembly (By similarity).
Consists of at least two heavy chains and a number of intermediate and light chains (Probable). Interacts with DNAAF2 (By similarity). Interacts with PIH1D3 (By similarity). Interacts with HEATR2; probably involved in outer arm dynein assembly (PubMed:25232951).

Similarity

Belongs to the dynein intermediate chain family.

Keywords

Cell projection   Cilium   Cytoplasm   Cytoskeleton   Dynein   Microtubule   Motor protein   Repeat   WD repeat   Complete proteome   Reference proteome   Alternative splicing   Ciliopathy   Kartagener syndrome   Polymorphism   Primary ciliary dyskinesia  

Feature

chain  Dynein intermediate chain 3, ciliary
splice variant  In isoform 2.
sequence variant  In dbSNP:rs28725418.

Uniprot

H9JQE6   A0A2H1W9I7   A0A194PF73   A0A194QZY6   A0A212FGV3   A0A2A4K9W5   + More
A0A212F7F5   A0A2W1BCK5   A0A2H1V4H2   H9J994   H9J995   A0A194QXZ9   A0A194PLU7   A0A2W1BBN8   A0A2A4JFG7   A0A2H1V2V5   A0A1B6H019   A0A0L7KHE8   A0A067QXI2   E0VIU6   A0A2A4JH19   D6WDC8   A0A2J7QWB5   N6T1P0   A0A210PH44   E2BG01   F6ZWA3   W4XTE9   A0A3B3SLU9   A0A195FJF9   E2B285   A0A158P2L6   Q2PEE4   A0A151NVX0   F1NQ70   A0A2D0S6C3   A0A3Q2UDN0   A0A3P8YL09   Q16960   F4W6B8   A0A3L8DB42   A0A151XCS7   A0A3Q2UDE2   A0A3B4DKT8   Q7QGH2   V4B996   A0A1Q3FTJ5   B0WLC7   A0A182Y5Y0   A0A182XC21   A0A182V9I7   A0A182LP72   A0A182HNC0   M3YS25   F6XSE5   A0A195DMF1   A0A182MUH2   A0A182WEV4   A0A182KAP0   A0A2J8Y006   A0A3M6V1K0   Q66HC9   A0A182MY67   A0A182R0Y4   A0A2C9JZT7   A2AC93   A0A1B0D579   A0A2C9JZU3   D2I1C9   F7CTV1   A0A2C9JZU0   U3DUT2   A0A1U7S529   A0A2P4SUI9   A0A182ITQ6   G1L3C6   A0A384CCJ3   A0A3Q7W7B6   B4J2I6   A0A3Q0CPX4   A0A0P6J3W2   A0A154PC68   H0VQ78   A0A1W4VTJ2   A0A026VZA0   B4KUS4   A0A1S2ZVB3   A0A2J8Y003   A0A2B4S8N7   B3RPX3   A0A0Q9XLF0   A0A2R9BTS3   A0A2J8KC38   A0A369S6F4   A0A0L8G036   A0A024R8N5   Q9GZS0   A0A091V6G3   G1SX48   G3SLK0  

Pubmed

19121390    26354079    22118469    28756777    26227816    24845553    + More
20566863    18362917    19820115    23537049    28812685    20798317    12481130    15114417    29240929    21347285    12203911    16141696    22293439    15592404    25069045    7579688    21719571    30249741    12364791    23254933    25244985    20966253    20431018    30382153    15489334    15562597    18547164    19468303    19052621    21183079    24421334    20010809    25243066    17994087    21993624    24508170    18719581    22722832    16136131    30042472    11181995    11153919    16625196    17974005    18950741    25232951    25186273   

EMBL

BABH01011924    BABH01011925    BABH01011926    ODYU01007193    SOQ49759.1    KQ459606    + More
KPI91673.1    KQ460883    KPJ11108.1    AGBW02008593    OWR52965.1    NWSH01000021    PCG80688.1    AGBW02009873    OWR49674.1    KZ150474    PZC70746.1    ODYU01000427    SOQ35174.1    BABH01004332    KQ461154    KPJ08451.1    KQ459599    KPI94411.1    PZC70747.1    NWSH01001606    PCG70721.1    SOQ35175.1    GECZ01001756    JAS68013.1    JTDY01009838    KOB62521.1    KK852855    KDR14924.1    DS235206    EEB13302.1    PCG70720.1    KQ971321    EEZ99548.1    NEVH01009765    PNF32875.1    APGK01055684    APGK01055685    KB741269    KB632330    ENN71438.1    ERL92589.1    NEDP02076708    OWF35787.1    GL448096    EFN85403.1    EAAA01002414    AAGJ04129498    KQ981523    KYN40397.1    GL445067    EFN60211.1    ADTU01006976    AB245510    BAE71137.1    AKHW03001796    KYO40938.1    AADN05000628    D28863    GL887707    EGI70253.1    QOIP01000010    RLU17333.1    KQ982297    KYQ58174.1    AAAB01008834    EAA05710.4    KB199905    ESP03921.1    GFDL01004302    JAV30743.1    DS231984    EDS30420.1    APCN01001903    AEYP01025432    AAMC01045484    KQ980724    KYN14063.1    AXCM01003863    NDHI03003284    PNJ87613.1    PNJ87614.1    RCHS01000292    RMX59689.1    BC081920    AXCN02002036    EF565270    AL663079    CH466558    AJVK01003394    AJVK01003395    GL193978    EFB21127.1    GAMS01005995    JAB17141.1    PPHD01022244    POI27789.1    ACTA01020198    CH916366    EDV97071.1    GEBF01005522    JAN98110.1    KQ434870    KZC09485.1    AAKN02047293    KK107670    EZA48184.1    CH933809    EDW19330.1    PNJ87615.1    LSMT01000143    PFX25746.1    DS985242    EDV28257.1    KRG06602.1    AJFE02042393    AJFE02042394    AJFE02042395    AACZ04070080    NBAG03000379    PNI32558.1    PNI32562.1    NOWV01000062    RDD42092.1    KQ425078    KOF69975.1    CH471099    EAW89149.1    AF250288    AF253097    AF253087    AF253088    AF253089    AF260782    AF253090    AF253091    AF253092    AF253093    AF253094    AF253095    AF253096    AJ295276    AC103809    BC039582    AL137526    KL410718    KFQ98673.1   

Proteomes

UP000005204    UP000053268    UP000053240    UP000007151    UP000218220    UP000037510    + More
UP000027135    UP000009046    UP000007266    UP000235965    UP000019118    UP000030742    UP000242188    UP000008237    UP000008144    UP000007110    UP000261540    UP000078541    UP000000311    UP000005205    UP000050525    UP000000539    UP000221080    UP000265140    UP000007755    UP000279307    UP000075809    UP000261440    UP000007062    UP000030746    UP000002320    UP000076408    UP000076407    UP000075903    UP000075882    UP000075840    UP000000715    UP000008143    UP000078492    UP000075883    UP000075920    UP000075881    UP000275408    UP000002494    UP000075884    UP000075886    UP000076420    UP000000589    UP000092462    UP000008225    UP000189705    UP000075880    UP000008912    UP000261680    UP000286642    UP000001070    UP000189706    UP000076502    UP000005447    UP000192221    UP000053097    UP000009192    UP000079721    UP000225706    UP000009022    UP000240080    UP000002277    UP000253843    UP000053454    UP000005640    UP000053283    UP000001811    UP000007646   

PRIDE

H9JQE6    H9J994    H9J995    Q66HC9    A2AC93    Q9GZS0    + More

Pfam

PF00658   PABP

Interpro

IPR036322   WD40_repeat_dom_sf        + More
IPR017986   WD40_repeat_dom       
IPR001680   WD40_repeat       
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR019775   WD40_repeat_CS       
IPR036053   PABP-dom       
IPR002004   PABP_HYD       

SUPFAM

SSF50978   SSF50978        + More
SSF63570   SSF63570       

Gene 3D

2.130.10.10    

ProteinModelPortal

H9JQE6   A0A2H1W9I7   A0A194PF73   A0A194QZY6   A0A212FGV3   A0A2A4K9W5   + More
A0A212F7F5   A0A2W1BCK5   A0A2H1V4H2   H9J994   H9J995   A0A194QXZ9   A0A194PLU7   A0A2W1BBN8   A0A2A4JFG7   A0A2H1V2V5   A0A1B6H019   A0A0L7KHE8   A0A067QXI2   E0VIU6   A0A2A4JH19   D6WDC8   A0A2J7QWB5   N6T1P0   A0A210PH44   E2BG01   F6ZWA3   W4XTE9   A0A3B3SLU9   A0A195FJF9   E2B285   A0A158P2L6   Q2PEE4   A0A151NVX0   F1NQ70   A0A2D0S6C3   A0A3Q2UDN0   A0A3P8YL09   Q16960   F4W6B8   A0A3L8DB42   A0A151XCS7   A0A3Q2UDE2   A0A3B4DKT8   Q7QGH2   V4B996   A0A1Q3FTJ5   B0WLC7   A0A182Y5Y0   A0A182XC21   A0A182V9I7   A0A182LP72   A0A182HNC0   M3YS25   F6XSE5   A0A195DMF1   A0A182MUH2   A0A182WEV4   A0A182KAP0   A0A2J8Y006   A0A3M6V1K0   Q66HC9   A0A182MY67   A0A182R0Y4   A0A2C9JZT7   A2AC93   A0A1B0D579   A0A2C9JZU3   D2I1C9   F7CTV1   A0A2C9JZU0   U3DUT2   A0A1U7S529   A0A2P4SUI9   A0A182ITQ6   G1L3C6   A0A384CCJ3   A0A3Q7W7B6   B4J2I6   A0A3Q0CPX4   A0A0P6J3W2   A0A154PC68   H0VQ78   A0A1W4VTJ2   A0A026VZA0   B4KUS4   A0A1S2ZVB3   A0A2J8Y003   A0A2B4S8N7   B3RPX3   A0A0Q9XLF0   A0A2R9BTS3   A0A2J8KC38   A0A369S6F4   A0A0L8G036   A0A024R8N5   Q9GZS0   A0A091V6G3   G1SX48   G3SLK0  

PDB

6F3A     E-value=2.04036e-12,     Score=177

KEGG

101745977    K11143 dynein intermediate chain 2, axonemal | (RefSeq) dynein intermediate chain 3, ciliary

GO

GO:0045503   GO:0007018   GO:0036158   GO:0003341   GO:0036157   GO:0045504   GO:0003723   GO:0003774   GO:0005929   GO:0030286   GO:0005737   GO:0005874   GO:0007368   GO:0036126   GO:0003777   GO:0009897   GO:0005858   GO:0005930   GO:0060271   GO:0005515   GO:0000166   GO:0003677   GO:0008242   GO:0016705   GO:0020037   GO:0006811   GO:0016020   GO:0005634   GO:0006260  

Subcellular location

  

Length:

573

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0447400000000001

Exp number, first 60 AAs:

0.0418

Total prob of N-in:

0.00293

outside

1  -  573

 

 

Pi

214.884634

Theta

147.555749

Tajima's D

0.704699

CLR

0.416346

CSRT

0.575621218939053

Interpretation

Uncertain