Silkworm Genome Informatics Database

Gene

KWMTBOMO06631

Pre Gene Modal

BGIBMGA011694

Annotation

cAMP-dependent_protein_kinase_R1_[Bombyx_mori]

Location

Bomo_Chr11(+):11897322-11908426 View in EpiBrowser

Full name

cAMP-dependent protein kinase type I regulatory subunit + More
cAMP-dependent protein kinase regulatory subunit

Alternative Name

N4 subunit of protein kinase A

Location in the cell

Cytoplasmic Reliability : 2.422

CDS

ATGGAAGAAGAACAATGTTTACATGAATGTGAAGACTATATTCAAACTCATAACATTCAATTGTTGCTGAAAGATTGCATCGTTCAGTTATGTGTAAACAAGCCTGAAAATCCTGTATCGTTTTTACGTCAACATTTCCAGAAATTAGAACGAGAACAGGTCAAAGCTGCAGCAGCTGCAGCTGCTGCTTCTGAGGGTGAAGCAGATGGTGAACTCTCACCCCTACCTGTACCAGGGGGACAACTACCAAGGAGACGCGGGGGTATAAGTGCAGAGCCCGTAACCGAAGAAGATGCTACTAGTTATGTTAAAAAGGTGGTGCCAAAAGATTACAAAACAATGGGTGCCTTATCACGCGCTATTGCATCAAATGTATTGTTTACACATTTGGATGAATCTGAGAGGGCTGATATGTTTGATGCTATGTTTCCTGTCCAATGTCTTCCTGGTGAAACTGTTATTCGACAAGGGGATGAAGGCGACAACTTTTATATTATTGACTCAGGAGAGGTTGAGGTTCTCGTGAACGGCGAACCGGTGACTACGATTGGTGAAGGGGGTAGCTTTGGAGAATTAGCTTTAATTTATGGTACACCGCGAGCCGCCACGGTTCGCGCTCGCACCTCCCTTAAGTTGTGGGGACTGGATCGTGACTCTTACCGTCGAATTCTCATGGGCTCTACTATTAGGAAACGAAGAATGTACGACGAGTTCCTCTCAAGAGTCTCTATATTAGAGAGCTTAGAAAAGTGGGAACGACTCACGGTGGCTGATGCATTAGAGCCTGTATCCTTTAACGACAGCGAAACCATTGTTCGTCAAGGTGAACCCGGAAACGATTTCTACATCATAGTTGAAGGCACGGCGGTGGTACTGCAACAAAGAGGCGCGGGAGGCGAGGCAGTGGAAGTGGGGCGGCTAGGCCCTTCAGACTACTTCGGCGAGATCGCGTTGCTGCTGGACCGGCCGCGAGCCGCCACCGTGCGCGCTCACGGCCCGCTCAAATGCGTCAAGCTCGACCGTGCCAGATTTGAAAGAGTTCTTGGTCTCTGTGCCGACATTCTCAAGAGAAACATCGCCCAATACAACAGCTTTGTATCGCTTTCGGTATAA

Protein

MEEEQCLHECEDYIQTHNIQLLLKDCIVQLCVNKPENPVSFLRQHFQKLEREQVKAAAAAAAASEGEADGELSPLPVPGGQLPRRRGGISAEPVTEEDATSYVKKVVPKDYKTMGALSRAIASNVLFTHLDESERADMFDAMFPVQCLPGETVIRQGDEGDNFYIIDSGEVEVLVNGEPVTTIGEGGSFGELALIYGTPRAATVRARTSLKLWGLDRDSYRRILMGSTIRKRRMYDEFLSRVSILESLEKWERLTVADALEPVSFNDSETIVRQGEPGNDFYIIVEGTAVVLQQRGAGGEAVEVGRLGPSDYFGEIALLLDRPRAATVRAHGPLKCVKLDRARFERVLGLCADILKRNIAQYNSFVSLSV

Subunit

Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer.
The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules.

Similarity

Belongs to the cAMP-dependent kinase regulatory chain family.

Keywords

Alternative splicing cAMP cAMP-binding Complete proteome Disulfide bond Nucleotide-binding Phosphoprotein Reference proteome Repeat Acetylation

Feature

chain cAMP-dependent protein kinase type I regulatory subunit
splice variant In isoform 3.

Uniprot

A5HMG0 H9JQ88 A0A212FDB7 A0A2A4JJG7 A0A194QUE1 A0A194PVM2 + More
U5EKQ2 V5GNL5 A0A1W4XVF2 A0A151I9B1 A0A195BSW6 A0A195EWA7 E2C7R5 A0A158NNW5 E2AEL2 A0A151WK01 A0A026WQN0 A0A2A3E7G6 D6WDE6 A0A0L7QSG0 A0A0V0G6G1 A0A2M4CT86 A0A2M4AGW4 A0A069DTM3 F4WV86 A0A2M3Z727 A0A023FB30 A0A154PP25 A7UU99 A0A0P4VRE0 A0A2M4BRK4 R4G5J1 A0A1S4EJE7 A0A0K8TRG1 A0A2A4JKD2 A0A0A1X165 W8C2E9 A0A0K8VF90 A0A034VHL6 A0A1L8DM06 R4WD01 A0A0A9W0D4 A0A1Q3FUY3 T1DPJ5 A0A0L0CNS6 T1PCT7 A0A1B6CNM3 A0A1B6FXY8 A0A1I8PLB9 A0A0P9AK35 A0A1L8ED02 A0A0J9RYY1 A0A0R1E0E6 A0A0N8P0W0 A0A0Q5UCI6 P16905 A0A1W4UNZ6 B4GUN6 A0A0J9RZ66 A0A0R1DYT5 A0A0Q5UKR3 M9MRY3 B4N3W7 A0A3B0J5D4 Q2M150 A0A1W4UNR8 A0A310SAP6 A0A0Q9X1V6 B4LB63 B4J0Z0 A0A0Q9WHJ0 A0A2H8TKP4 J9JL27 A0A0P4WXA6 A0A3S2NMZ8 A0A0P4WG84 T1JGV4 A0A0K0PWD6 A0A0P5LUR3 C3Y8X8 P31319 A0A0P5Z9J4 A0A2D0Q782 A0A210QYF7 H2V080 A0A3B4THC1 A0A3N0XTU2 W5UDM9 A0A087TNX1 A0A3B4DRN2 A0A3Q3D5H4 H3AWD6 A0A3Q3VNH8 H9GJR9 K7F9E7 A0A2U9CS69 A0A0P6JFX6 A0A3Q7SUA9 F1Q3L1 M3Z2G1

Pubmed

19121390 22118469 26354079 20798317 21347285 24508170 + More
30249741 18362917 19820115 26334808 21719571 25474469 12364791 14747013 17210077 27129103 26369729 25830018 24495485 25348373 23691247 25401762 26108605 25315136 17994087 22936249 17550304 3215511 10731132 12537572 12537569 12537568 12537573 12537574 16110336 17569856 17569867 26109357 26109356 15632085 18563158 1310865 23127152 28812685 21551351 9215903 21881562 17381049 16341006

EMBL

EF540759 ABQ11379.1 BABH01012004 AGBW02009074 OWR51739.1 NWSH01001177 + More
PCG72235.1 KQ461190 KPJ07171.1 KQ459590 KPI97372.1 GANO01001719 JAB58152.1 GALX01002747 JAB65719.1 KQ978303 KYM95333.1 KQ976417 KYM89763.1 KQ981953 KYN32431.1 GL453395 EFN76048.1 ADTU01021857 ADTU01021858 GL438870 EFN68135.1 KQ983031 KYQ48137.1 KK107128 QOIP01000006 EZA58352.1 RLU21685.1 KZ288345 PBC27648.1 KQ971321 EEZ99469.1 KQ414766 KOC61401.1 GECL01002800 JAP03324.1 GGFL01004359 MBW68537.1 GGFK01006705 MBW40026.1 GBGD01001857 JAC87032.1 GL888384 EGI61852.1 GGFM01003553 MBW24304.1 GBBI01000584 JAC18128.1 KQ435007 KZC13619.1 AAAB01008960 EDO63877.1 GDKW01000988 JAI55607.1 GGFJ01006493 MBW55634.1 ACPB03013600 ACPB03013601 ACPB03013602 ACPB03013603 ACPB03013604 ACPB03013605 ACPB03013606 ACPB03013607 ACPB03013608 GAHY01000510 JAA77000.1 GDAI01000644 JAI16959.1 PCG72236.1 GBXI01009198 JAD05094.1 GAMC01006574 JAB99981.1 GDHF01016929 GDHF01014786 JAI35385.1 JAI37528.1 GAKP01017899 GAKP01017895 JAC41053.1 GFDF01006595 JAV07489.1 AK417288 BAN20503.1 GBHO01042315 GBRD01016796 GBRD01009651 JAG01289.1 JAG49031.1 GFDL01003749 JAV31296.1 GAMD01003294 JAA98296.1 JRES01000234 KNC33104.1 KA646570 KA646571 AFP61200.1 GEDC01022290 JAS15008.1 GECZ01014725 JAS55044.1 CH902618 KPU78219.1 GFDG01002273 JAV16526.1 CM002912 KMZ00877.1 CM000159 KRK02238.1 KPU78220.1 CH954178 KQS44333.1 X16963 X16964 X16970 X16971 X16966 X16968 AE014296 AY058709 AY122131 BT001678 CH479191 EDW26319.1 KMZ00883.1 KRK02240.1 KQS44338.1 ADV37583.1 ADV37584.1 ADV37585.1 CH964095 EDW79322.1 OUUW01000002 SPP76875.1 CH379069 EAL30726.3 KQ762207 OAD56044.1 KRF99046.1 CH940647 EDW68627.1 CH916366 EDV95811.1 KRF83930.1 GFXV01002814 MBW14619.1 ABLF02016814 ABLF02016815 ABLF02022395 ABLF02022397 ABLF02025626 ABLF02025627 ABLF02025631 ABLF02059700 ABLF02060050 ABLF02066672 GDIP01250667 JAI72734.1 RSAL01000227 RVE43949.1 GDRN01050451 JAI66469.1 JH432212 KT203799 AKQ77108.1 GDIQ01254608 GDIQ01247453 GDIQ01210562 GDIQ01189474 JAK62251.1 GG666492 EEN63034.1 X62382 GDIP01048659 JAM55056.1 NEDP02001221 OWF53732.1 RJVU01060737 ROJ44602.1 JT411969 AHH39679.1 KK116101 KFM66810.1 AFYH01079130 AFYH01079131 AFYH01079132 AFYH01079133 AFYH01079134 AFYH01079135 AFYH01079136 AFYH01079137 AFYH01079138 AFYH01079139 AAWZ02022354 AAWZ02022355 AGCU01017821 AGCU01017822 AGCU01017823 AGCU01017824 AGCU01017825 AGCU01017826 AGCU01017827 AGCU01017828 AGCU01017829 AGCU01017830 CP026260 AWP17462.1 GEBF01001951 JAO01682.1 AAEX03004357 AAEX03004358 AAEX03004359 AAEX03004360 AEYP01088969 AEYP01088970 AEYP01088971 AEYP01088972 AEYP01088973 AEYP01088974

Proteomes

UP000005204 UP000007151 UP000218220 UP000053240 UP000053268 UP000192223 + More
UP000078542 UP000078540 UP000078541 UP000008237 UP000005205 UP000000311 UP000075809 UP000053097 UP000279307 UP000242457 UP000007266 UP000053825 UP000007755 UP000076502 UP000007062 UP000015103 UP000079169 UP000037069 UP000095301 UP000095300 UP000007801 UP000002282 UP000008711 UP000000803 UP000192221 UP000008744 UP000007798 UP000268350 UP000001819 UP000008792 UP000001070 UP000007819 UP000283053 UP000001554 UP000221080 UP000242188 UP000005226 UP000261420 UP000054359 UP000261440 UP000264820 UP000008672 UP000261620 UP000001646 UP000007267 UP000246464 UP000286640 UP000002254 UP000000715

PRIDE

A5HMG0 H9JQ88 P16905 P31319

Pfam

PF00027   cNMP_binding        + More
PF02197   RIIa
PF03564   DUF1759

Interpro

IPR000595   cNMP-bd_dom        + More
IPR003117   cAMP_dep_PK_reg_su_I/II_a/b
IPR018488   cNMP-bd_CS
IPR012198   cAMP_dep_PK_reg_su
IPR014710   RmlC-like_jellyroll
IPR018490   cNMP-bd-like
IPR005312   DUF1759

SUPFAM

SSF51206 SSF51206

Gene 3D

2.60.120.10

CDD

cd00038 CAP_ED

ProteinModelPortal

A5HMG0 H9JQ88 A0A212FDB7 A0A2A4JJG7 A0A194QUE1 A0A194PVM2 + More
U5EKQ2 V5GNL5 A0A1W4XVF2 A0A151I9B1 A0A195BSW6 A0A195EWA7 E2C7R5 A0A158NNW5 E2AEL2 A0A151WK01 A0A026WQN0 A0A2A3E7G6 D6WDE6 A0A0L7QSG0 A0A0V0G6G1 A0A2M4CT86 A0A2M4AGW4 A0A069DTM3 F4WV86 A0A2M3Z727 A0A023FB30 A0A154PP25 A7UU99 A0A0P4VRE0 A0A2M4BRK4 R4G5J1 A0A1S4EJE7 A0A0K8TRG1 A0A2A4JKD2 A0A0A1X165 W8C2E9 A0A0K8VF90 A0A034VHL6 A0A1L8DM06 R4WD01 A0A0A9W0D4 A0A1Q3FUY3 T1DPJ5 A0A0L0CNS6 T1PCT7 A0A1B6CNM3 A0A1B6FXY8 A0A1I8PLB9 A0A0P9AK35 A0A1L8ED02 A0A0J9RYY1 A0A0R1E0E6 A0A0N8P0W0 A0A0Q5UCI6 P16905 A0A1W4UNZ6 B4GUN6 A0A0J9RZ66 A0A0R1DYT5 A0A0Q5UKR3 M9MRY3 B4N3W7 A0A3B0J5D4 Q2M150 A0A1W4UNR8 A0A310SAP6 A0A0Q9X1V6 B4LB63 B4J0Z0 A0A0Q9WHJ0 A0A2H8TKP4 J9JL27 A0A0P4WXA6 A0A3S2NMZ8 A0A0P4WG84 T1JGV4 A0A0K0PWD6 A0A0P5LUR3 C3Y8X8 P31319 A0A0P5Z9J4 A0A2D0Q782 A0A210QYF7 H2V080 A0A3B4THC1 A0A3N0XTU2 W5UDM9 A0A087TNX1 A0A3B4DRN2 A0A3Q3D5H4 H3AWD6 A0A3Q3VNH8 H9GJR9 K7F9E7 A0A2U9CS69 A0A0P6JFX6 A0A3Q7SUA9 F1Q3L1 M3Z2G1

PDB

4DIN E-value=6.32334e-149, Score=1352

KEGG

100101201 K04739 cAMP-dependent protein kinase regulator | (RefSeq) cAMP-dependent protein kinase R1

GO

GO:0005952 GO:0016301 GO:0008603 GO:0030552 GO:0019934 GO:0005829 GO:0047555 GO:0004691 GO:0045471 GO:0005737 GO:0019933 GO:0007015 GO:0007274 GO:0008103 GO:0008355 GO:2000253 GO:0007591 GO:0007419 GO:0034236 GO:0031625 GO:0031588 GO:0001772 GO:0001707 GO:0019904 GO:2000480 GO:0004862 GO:0098978 GO:0031594 GO:0044853 GO:0060038 GO:0005930 GO:0046007 GO:0045214 GO:0098685 GO:0098693 GO:0098686 GO:0007611 GO:0050804 GO:0001932 GO:0008026 GO:0005524 GO:0005234 GO:0006811 GO:0016020 GO:0005634 GO:0006260

Length:

370

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0015

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00953

outside

1 - 370

Pi

171.732909

Theta

170.393439

Tajima's D

0.029792

CLR

0.66447

CSRT

0.378631068446578

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics