Gene

KWMTBOMO06629  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA011693

Annotation

PREDICTED:_xylosyltransferase_oxt_[Amyelois_transitella]

Location

Bomo_Chr11(+):11877652-11886134      View in EpiBrowser

Full name

Xylosyltransferase oxt      

Alternative Name

Imaginal disk type I
Peptide O-xylosyltransferase

Location in the cell

Nuclear   Reliability : 2.49

CDS

ATGTTAAGGTTCAGTGACGACGAAGATCTCCCAACAAACTTAAAAAAAAATAAACCTGGTTCTATTTTAAGAGTTGAGGAGCTGGATTTTATACCTGCATGTGAAATTAAAAGTAGAGAAGCTATATCTGCCATACACAGAGCCAAAACACAGCTGTGTAAACAACAGATACTCAACAAAACTTGCCTTATACAAGAAAGTAATTTTTATCCAGAAAAACTAACAAACGTTTGCCCACACAATGAAAAGTCTTATGGTACATATCTTGGATGTTTCGTTGATGAAAAGAAGATGAGATTGCTTTCCGGATTTTATGGAAATTATGTGAGCACAAATTCACCAAATTCATGTTTAGATATATGTGTTCAAGCTGGGTTTCCATATGCTGGTGTTCAATATGGATCTGAATGCTTTTGTGGAGATACAGACCCTCCTGATAATGCTAAACTCTCTGATGATGCCTGTGATATGAAGTGTCCCGCAAATCCCTCAGAAACCTGTGGTGGATATTTTACTATGAACATTTTCGAAACTGGATTAACAAAGTTCCAGCCTCAAATACCGGACACGTCGAATGACAAAGAGGAATCCGTGAGAATAATTTTTCTATTAACATTAAACGGCCGCGCTGTAAGACAAGTTAATAGACTAATAAATGCACTGTACAAAAGGAATCATTATTTTTACATACATGTCGATAAGCGTCAAGACTACCTCCATAGAAAATTATCTGTTTTAGAAACTCATTTTCCGAATATTAAAATGTCCAAAAAAAGATTTTCAACAATATGGGGCGGCGCATCATTACTTACCATGCTCCTGACATCTATGAAAGATATTCTTGCACTAAATTGGAATTGGGACTTTGTTATAAACTTAAGTGAAAGTGATTTTCCAATAAAGTCCTTAGAAAATTTAGAGAAGTTCCTATCAGTAAATAAAGGTTTCAATTTTGTTAAATCCCATGGTCGGGAGGTACAAAGATTTATAAAAAAACAAGGATTAGATAAAACATTTATTGAATGTGATACGCACATGTGGCGTGTTGGTGAAAGAAAACTTCCCCGTGGAATAGTAATAGACGGCGGCAGTGATTGGATAGCACTCTCTCCTAATTTCGTTTCCTATGTTGCAAATGAAAAAGATGAACTTTTGTCTGGCTTAGAAATAATTTTTCAACATACGCTTTTACCTGCAGAGTCATTTTTTCACACTGTACTTCGCAATTCACGTTTTTGTAATACGTACGTGGATAACAATCTACATGTAACCAATTGGAAAAGAAAATTAGGCTGCAAATGTCAGTACAAGCATGTAGTAGATTGGTGTGGATGTTCACCTAATGATTTTAAAACTGAAGACTGGCCTAGGATTCAAAACACACAGGATCGTCAACTCTTTTTTGCAAGAAAATTTGAGCCAATTATTAATCAAGAAATTATAAACAGAGTTGAACAGTATATAGGTTTTAAGGATCACTTAAAAATTCAAAATTTGGAAAGCTATTGGCAAAGTATATATAATGTGGATGATTTGACGGCAAGCAGTGATGATACACTTTTATCACACGCCGAAAGCATTATTCGTCATAATGCTAAAATTCTTGCTGAAGAAGGTTGTATAATTGAACCAGATATAGTGATTGAAATCACATCATATAATTATGCAGATGTATATAAAGGAAATTTAATACTTCATAAAATTTATCATAATAACGTAGAGTTGTCAATGGAAACATGGTACAAACCAAAGAAGAACTTGCAACTAAATTTTGAAAATCGTTACGTTGACAATATAAAACAATTCAAAGTTAGTTCTGATTATGATCAAAAAGAAATGATTTTCAGAAACCTTGCTGGTATTTTGGGTCCACTGTCTGAACCAACGTTGTCTTATAAATTTTCTACAAATACACTGTTAGAAAAAAGGACTGAAAACTTAACAATAGTTTGGCTTGACCCTGCCGGGATCATAGCAGATCTAACAGATATTCATGTGGATGAGAATAATTTAACAAACTTCATTAAACCCAATTTTAGAACTCCTCTATTACCTGGAGTGTGGAAGGTTGGTATGTTTGAGCAAAGCTATCTATTAGCTAGCACGAAATTTCTCGTCACTCCATTGCAATACTTCGGCGGTAAAGAAATTTCGAATCAAGAAGTATCCATACTTCACGGTGGCTCACAAAATTCTTACCACAATTTTTCGCACATTAAATTAGAAAATTTTGTACCAGATCAGGAATCTGCTATATTGTCACAAAAAATATCACAAGCAAATGTTAGAAGAACAAAACAAGACTTAAAAGATTGGATAGATGCATTAAGTTACGAATTTTATAATGTATTAGGATCATGTGTAAAGTCTAGTACGAATTTTAAAGAAAAAATAAAATGTGGAATTCACATACTTGAATACTGTGAATCAACCCATTGGAGCTCCTTAACACCAGACCCGAAAGGATCGATAGGAAAACTTAATAAACTTTCAGGACGATTAGATAGGATATGA

Protein

MLRFSDDEDLPTNLKKNKPGSILRVEELDFIPACEIKSREAISAIHRAKTQLCKQQILNKTCLIQESNFYPEKLTNVCPHNEKSYGTYLGCFVDEKKMRLLSGFYGNYVSTNSPNSCLDICVQAGFPYAGVQYGSECFCGDTDPPDNAKLSDDACDMKCPANPSETCGGYFTMNIFETGLTKFQPQIPDTSNDKEESVRIIFLLTLNGRAVRQVNRLINALYKRNHYFYIHVDKRQDYLHRKLSVLETHFPNIKMSKKRFSTIWGGASLLTMLLTSMKDILALNWNWDFVINLSESDFPIKSLENLEKFLSVNKGFNFVKSHGREVQRFIKKQGLDKTFIECDTHMWRVGERKLPRGIVIDGGSDWIALSPNFVSYVANEKDELLSGLEIIFQHTLLPAESFFHTVLRNSRFCNTYVDNNLHVTNWKRKLGCKCQYKHVVDWCGCSPNDFKTEDWPRIQNTQDRQLFFARKFEPIINQEIINRVEQYIGFKDHLKIQNLESYWQSIYNVDDLTASSDDTLLSHAESIIRHNAKILAEEGCIIEPDIVIEITSYNYADVYKGNLILHKIYHNNVELSMETWYKPKKNLQLNFENRYVDNIKQFKVSSDYDQKEMIFRNLAGILGPLSEPTLSYKFSTNTLLEKRTENLTIVWLDPAGIIADLTDIHVDENNLTNFIKPNFRTPLLPGVWKVGMFEQSYLLASTKFLVTPLQYFGGKEISNQEVSILHGGSQNSYHNFSHIKLENFVPDQESAILSQKISQANVRRTKQDLKDWIDALSYEFYNVLGSCVKSSTNFKEKIKCGIHILEYCESTHWSSLTPDPKGSIGKLNKLSGRLDRI

Description

Catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes.

Catalytic Activity

L-seryl-[protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP

Similarity

Belongs to the glycosyltransferase 14 family. XylT subfamily.

Keywords

Complete proteome   Disulfide bond   Endoplasmic reticulum   Glycoprotein   Glycosyltransferase   Golgi apparatus   Magnesium   Manganese   Membrane   Metal-binding   Reference proteome   Signal-anchor   Transferase   Transmembrane   Transmembrane helix  

Feature

chain  Xylosyltransferase oxt

Uniprot

A0A2H1VNZ3   A0A2A4JLF1   A0A194Q1U1   H9JQ87   A0A212FDG0   A0A194QNS1   + More
A0A0L7LLH2   A0A067RAY7   A0A2J7RKT5   A0A1B6CJW1   A0A1Y1LE34   A0A1W4WZH1   D7EJH3   A0A0L0CEF8   A0A1I8NTG4   A0A1B0CFL8   A0A023F1M5   A0A1L8E2J2   A0A146M8I4   A0A1W4X0J2   A0A0K8W078   A0A1A9ZMS0   W8C4M3   A0A034V6I6   A0A1A9XTV7   A0A1L8E1S2   A0A1B0BVC3   A0A1A9UVT9   A0A1I8MRA7   A0A1B0G6B3   B4LBW6   A0A2J7RKU1   A0A1W4VQK2   B4QN38   B4PDH0   Q2KT98   N6T0N0   A0A3B0K4K0   Q7KVA1   Q2KT99   B3NBG2   A0A0M5J3Q6   B4J0I5   B4KV08   Q5QQ53   B3M6N0   Q2KTA1   B4N301   A0A1S4FGE5   A0A0P6K152   Q172E6   A0A182SMI8   A0A2S2P7C4   A0A1J1J4J8   A0A1W7R8K2   Q2KT96   Q2KTA2   Q5TRC6   A0A182JLI1   A0A182XMH0   J9JW08   A0A2S2QY12   A0A2C9H5T7   A0A182TMS0   Q2KTA0   A0A182I2A0   A0A182Y7V1   A0A182R2A5   A0A2H8TI18   A0A182LRE1   A0A026VUQ6   A0A3L8DRI3   A0A182K8C7   T1HNX7   A0A182FD67   A0A182GXF2   A0A0T6B1C8   A0A084WDG1   A0A2M4BCA1   A0A2M4BCE2   A0A182WL74   A0A151INK5   A0A2M4AJE0   A0A2M4AJX4   W5JHG0   A0A232FH38   E2C867   A0A195B454   A0A151X1N7   E9IE24   A0A195E5R8   A0A158NFT2   K7IUC5   F4W496   A0A2A3ENU4   A0A088AAQ9   A0A0J7KU38   A0A182NJI0   A0A182QK58   Q2KT95  

EC Number

2.4.2.26

Pubmed

26354079    19121390    22118469    26227816    24845553    28004739    + More
18362917    19820115    26108605    25474469    26823975    24495485    25348373    25315136    17994087    22936249    17550304    23537049    11929872    10731132    12537572    12537569    15632085    17510324    26999592    12364791    25244985    24508170    30249741    26483478    24438588    20920257    23761445    28648823    20798317    21282665    21347285    20075255    21719571   

EMBL

ODYU01003588    SOQ42550.1    NWSH01001177    PCG72240.1    KQ459590    KPI97370.1    + More
BABH01012006    BABH01012007    AGBW02009074    OWR51737.1    KQ461190    KPJ07173.1    JTDY01000694    KOB76189.1    KK852815    KDR15812.1    NEVH01002708    PNF41440.1    GEDC01023588    JAS13710.1    GEZM01063142    JAV69277.1    DS497704    EFA12734.1    JRES01000493    KNC30793.1    AJWK01010179    GBBI01003509    JAC15203.1    GFDF01001359    JAV12725.1    GDHC01002565    JAQ16064.1    GDHF01007820    JAI44494.1    GAMC01009501    JAB97054.1    GAKP01020021    JAC38931.1    GFDF01001470    JAV12614.1    JXJN01021204    CCAG010000598    CH940647    EDW69766.1    PNF41441.1    CM000363    CM002912    EDX08920.1    KMY97071.1    CM000159    EDW93950.1    AM229414    CAJ76260.1    APGK01049767    APGK01049768    KB741156    ENN73634.1    OUUW01000012    SPP87632.1    AJ430595    AE014296    AY069660    U32626    AM229413    CH480817    CAJ76259.1    EDW50181.1    CH954178    EDV50284.1    CP012525    ALC43906.1    CH916366    EDV96821.1    CH933809    EDW18319.2    AJ866722    CH379069    CH902618    EDV38680.2    AM229411    CAJ76257.1    CH964062    EDW78740.1    GDUN01000096    JAN95823.1    CH477439    EAT40893.1    GGMR01012701    MBY25320.1    CVRI01000070    CRL07323.1    GEHC01000182    JAV47463.1    AM229416    CAJ76262.1    AM229410    CAJ76256.1    AAAB01008960    EAL39938.2    ABLF02034196    GGMS01013371    MBY82574.1    AM229412    CAJ76258.1    APCN01000134    GFXV01001884    MBW13689.1    AXCM01002279    KK107847    EZA47482.1    QOIP01000005    RLU23044.1    ACPB03013520    JXUM01095113    JXUM01095114    LJIG01016206    KRT81296.1    ATLV01022999    KE525339    KFB48255.1    GGFJ01001538    MBW50679.1    GGFJ01001574    MBW50715.1    KQ976932    KYN07041.1    GGFK01007582    MBW40903.1    GGFK01007597    MBW40918.1    ADMH02001182    ETN63807.1    NNAY01000211    OXU30002.1    GL453568    EFN75870.1    KQ976625    KYM79055.1    KQ982585    KYQ54323.1    GL762556    EFZ21172.1    KQ979609    KYN20194.1    ADTU01001537    ADTU01001538    AAZX01003953    GL887491    EGI71092.1    KZ288210    PBC32922.1    LBMM01003107    KMQ93957.1    AXCN02000445    AM229417    CAJ76263.1   

Proteomes

UP000218220    UP000053268    UP000005204    UP000007151    UP000053240    UP000037510    + More
UP000027135    UP000235965    UP000192223    UP000007266    UP000037069    UP000095300    UP000092461    UP000092445    UP000092443    UP000092460    UP000078200    UP000095301    UP000092444    UP000008792    UP000192221    UP000000304    UP000002282    UP000019118    UP000268350    UP000000803    UP000001292    UP000008711    UP000092553    UP000001070    UP000009192    UP000001819    UP000007801    UP000007798    UP000008820    UP000075901    UP000183832    UP000007062    UP000075880    UP000076407    UP000007819    UP000075903    UP000075902    UP000075840    UP000076408    UP000075900    UP000075883    UP000053097    UP000279307    UP000075881    UP000015103    UP000069272    UP000069940    UP000030765    UP000075920    UP000078542    UP000000673    UP000215335    UP000008237    UP000078540    UP000075809    UP000078492    UP000005205    UP000002358    UP000007755    UP000242457    UP000005203    UP000036403    UP000075884    UP000075886   

PRIDE

H9JQ87    Q7KVA1    Q5QQ53   

Pfam

PF01822   WSC        + More
PF12529   Xylo_C
PF02485   Branch

Interpro

IPR002889   WSC_carb-bd        + More
IPR024448   XylT       
IPR003406   Glyco_trans_14       

ProteinModelPortal

A0A2H1VNZ3   A0A2A4JLF1   A0A194Q1U1   H9JQ87   A0A212FDG0   A0A194QNS1   + More
A0A0L7LLH2   A0A067RAY7   A0A2J7RKT5   A0A1B6CJW1   A0A1Y1LE34   A0A1W4WZH1   D7EJH3   A0A0L0CEF8   A0A1I8NTG4   A0A1B0CFL8   A0A023F1M5   A0A1L8E2J2   A0A146M8I4   A0A1W4X0J2   A0A0K8W078   A0A1A9ZMS0   W8C4M3   A0A034V6I6   A0A1A9XTV7   A0A1L8E1S2   A0A1B0BVC3   A0A1A9UVT9   A0A1I8MRA7   A0A1B0G6B3   B4LBW6   A0A2J7RKU1   A0A1W4VQK2   B4QN38   B4PDH0   Q2KT98   N6T0N0   A0A3B0K4K0   Q7KVA1   Q2KT99   B3NBG2   A0A0M5J3Q6   B4J0I5   B4KV08   Q5QQ53   B3M6N0   Q2KTA1   B4N301   A0A1S4FGE5   A0A0P6K152   Q172E6   A0A182SMI8   A0A2S2P7C4   A0A1J1J4J8   A0A1W7R8K2   Q2KT96   Q2KTA2   Q5TRC6   A0A182JLI1   A0A182XMH0   J9JW08   A0A2S2QY12   A0A2C9H5T7   A0A182TMS0   Q2KTA0   A0A182I2A0   A0A182Y7V1   A0A182R2A5   A0A2H8TI18   A0A182LRE1   A0A026VUQ6   A0A3L8DRI3   A0A182K8C7   T1HNX7   A0A182FD67   A0A182GXF2   A0A0T6B1C8   A0A084WDG1   A0A2M4BCA1   A0A2M4BCE2   A0A182WL74   A0A151INK5   A0A2M4AJE0   A0A2M4AJX4   W5JHG0   A0A232FH38   E2C867   A0A195B454   A0A151X1N7   E9IE24   A0A195E5R8   A0A158NFT2   K7IUC5   F4W496   A0A2A3ENU4   A0A088AAQ9   A0A0J7KU38   A0A182NJI0   A0A182QK58   Q2KT95  

PDB

6EJ8     E-value=5.54511e-141,     Score=1287

KEGG

101739145    K00771 protein xylosyltransferase [EC:2.4.2.26] | (RefSeq) xylosyltransferase oxt

PATHWAY

00532    Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate - Bombyx mori (domestic silk
00534    Glycosaminoglycan biosynthesis - heparan sulfate / heparin - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0008375   GO:0030158   GO:0016021   GO:0006024   GO:0016020   GO:0042732   GO:0015012   GO:0030204   GO:0050650   GO:0030206   GO:0046872   GO:0005789   GO:0000139   GO:0030201   GO:0004970   GO:0005234   GO:0006811   GO:0005634   GO:0006260  

Subcellular location

Endoplasmic reticulum membrane  
Golgi apparatus membrane  

Length:

837

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.180410000000001

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00853

outside

1  -  837

 

 

Pi

27.771159

Theta

44.636412

Tajima's D

-2.274756

CLR

1126.170086

CSRT

0.00314984250787461

Interpretation

Uncertain