Gene

KWMTBOMO06626

Annotation

PREDICTED:_U6_snRNA_phosphodiesterase_[Plutella_xylostella]

Location

Bomo_Chr11(-):11844673-11847442      View in EpiBrowser

Full name

U6 snRNA phosphodiesterase      

Location in the cell

Nuclear   Reliability : 3.617

CDS

ATGTCTTGTCTGTCGTATATCAACGATTACGGATCTGATTCAACGAATAGTGACAGTGAAACTGAACAACATCTGTACAAAAGAGTGAAATTACCAGTTCCAGATCTCAGTCGTGTGCGAATAGTTTTAACTGAAGAAACACACATAGACGATCATCAAAAACATAAAGGCCGAAAACGTTCTTTTCCACATGTAAGAGGAAACTGGGCTACTTTCGTCTATGTGCAATATCCTAATGATGACTTTGTTAATAAATTGAGTAGAAAAGTATTAGATGCCTTAACAGAATCATCTCATACTTGGCATAAATGTGAAAATCTCCACATTACTTTATCAAAAACAGTTGTCCTTAATTATCATTGGATAGCACCATTTCACAATTCTTTAAAAAAAACTTTAACAAATATTAAATGTTTTGAACTTGAATTTGATGAGCTGCAAGTATTGTGCAATGAAGATAAATCTAGGACATTTGTTGTGTTGAAAACAAATCGTTTTAGTCATAAGCACTTTTTTGCTATAACTAAGAAGGTTGATGAAATATTGAGTGAATTTAAACTACCAAAATTTTATGATGAACCTTCTTTCCACATGAGCATACTTTGGACTAATGGGGATAAAGAGACAGAGACTAATGGTGCTCTTGACAAATTAAATCAAATCTTGACACCAGATTTTCAGGAATTAGCAAAAAATATTTTTATTGATAAAGTTTACTGTAAAAGCGGAAATAAGACATTTCAGTACCATTTACCATCAGATCGATAG

Protein

MSCLSYINDYGSDSTNSDSETEQHLYKRVKLPVPDLSRVRIVLTEETHIDDHQKHKGRKRSFPHVRGNWATFVYVQYPNDDFVNKLSRKVLDALTESSHTWHKCENLHITLSKTVVLNYHWIAPFHNSLKKTLTNIKCFELEFDELQVLCNEDKSRTFVVLKTNRFSHKHFFAITKKVDEILSEFKLPKFYDEPSFHMSILWTNGDKETETNGALDKLNQILTPDFQELAKNIFIDKVYCKSGNKTFQYHLPSDR

Description

Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA.
Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate.

Cofactor

Zn(2+)

Similarity

Belongs to the 2H phosphoesterase superfamily. USB1 family.
Belongs to the peptidase M10A family.

Keywords

Complete proteome   Hydrolase   Nuclease   Nucleus   Reference proteome   3D-structure   Alternative splicing   Polymorphism  

Feature

chain  U6 snRNA phosphodiesterase
splice variant  In isoform 3.
sequence variant  In dbSNP:rs35025252.

Uniprot

A0A2H1VP25   A0A194PVL7   A0A194QNT5   A0A212F5X0   A0A2A4JLF2   A0A3S2P4V3   + More
A0A1Y1LAA8   A0A1W4WWV0   L8IE31   W5NSK8   Q0II50   F7E331   A0A146LR70   A0A2K6DT55   G7Q194   A0A0A9W5M9   A0A0K8T016   A0A2K5LU96   A0A2K5WCV2   A0A2K5Y0R0   A0A096NIX9   G7NPV9   G1P970   A0A1U7QTA9   A0A2K6NZ53   A0A1S2ZJ59   A0A3Q7VEU7   A0A1U7U1T1   A0A151MSJ5   A0A2J8VZG7   F7F9N5   A0A0D9QXM2   A0A2I2YWK7   A0A340Y540   Q91W78   A0A0R4J0E0   M3VYZ4   A0A151MSJ7   K7BU00   A0A2R9CAG8   F6TF64   A0A383YXP5   A0A341BNB4   A0A2Y9LPJ2   L5KXC0   A0A384D2F4   A0A2K6U1Q8   A0A2Y9ERW4   F6TSW3   A0A2K5PYS5   A0A2Y9DBP5   A0A2U3VLG3   A0A2U4BDZ5   A0A1U7RLK3   A0A2K6G4P4   A0A2K5JF53   A0A1I8Q4D6   A0A2K5ESR1   A0A2K5JF38   A0A0K8WIV6   A0A024R6V6   Q9BQ65   W8BAF1   A0A2D0RGM5   A0A2D0RGL2   Q5I0I5   A0A2D0RGM1   A0A3Q7QH67   A0A182QX31   K9IZD0   A0A2K6N312   D2GTY3   W5LWP7   A0A3Q7RW66   B4JFE2   A0A1S3EWS7   A0A250XXB1   G1MFP5   G3I3J6   W5LWK0   A0A3Q7SVC9   A0A0K8V4Q3   A0A034WGQ5   L9KU30   A0A2J8VZJ9   A0A3B1JHC3   H2QB80   A0A2U3YQ15   A0A2J8MVQ0   A0A1I8M3B6   L5MIK6   A0A2J8VZM2   A0A3Q0S5S4   F1RFS6   S9X8T8   V9L8C2   U6DCX2   A0A2Y9KTD7   A0A182VRX7   A0A212DC28  

EC Number

3.1.4.-

Pubmed

26354079    22118469    28004739    22751099    20809919    19892987    + More
26823975    22002653    25401762    17431167    25319552    21993624    25362486    22293439    18464734    16141072    15489334    19468303    17975172    22722832    25243066    23258410    17495919    11181995    14702039    15616553    20004881    20503306    22899009    23190533    24495485    20010809    17994087    28087693    21804562    29704459    25348373    23385571    25329095    16136131    25315136    23149746    24402279    29294181   

EMBL

ODYU01003588    SOQ42547.1    KQ459590    KPI97367.1    KQ461190    KPJ07177.1    + More
AGBW02010125    OWR49123.1    NWSH01001177    PCG72242.1    RSAL01000414    RVE41831.1    GEZM01062320    JAV69828.1    JH881589    ELR53412.1    AMGL01027930    BC122807    GDHC01008298    GDHC01007400    JAQ10331.1    JAQ11229.1    CM001295    EHH60432.1    GBHO01043454    JAG00150.1    GBRD01006957    JAG58864.1    AQIA01043035    AHZZ02018797    AHZZ02018798    JSUE03026294    JSUE03026295    JU336397    JU472843    JV045352    CM001272    AFE80150.1    AFH29647.1    AFI35423.1    EHH31711.1    AAPE02069114    AKHW03005169    KYO27487.1    NDHI03003406    PNJ62932.1    AQIB01137321    CABD030101248    AK135527    AK160901    AK168683    BC016418    AC165414    AANG04002512    KYO27486.1    GABC01010570    GABF01003301    GABD01005551    GABE01011003    NBAG03000242    JAA00768.1    JAA18844.1    JAA27549.1    JAA33736.1    PNI63608.1    AJFE02083779    AJFE02083780    AJFE02083781    GAMT01009349    GAMS01010386    GAMR01010776    GAMQ01000183    GAMP01008688    JAB02512.1    JAB12750.1    JAB23156.1    JAB41668.1    JAB44067.1    KB030537    ELK15433.1    GDHF01001218    JAI51096.1    CH471092    EAW82964.1    AK023216    AK301494    AK303121    AC010543    AC012182    BC004415    BC006291    BC007774    BC010099    BC021554    GAMC01012547    JAB94008.1    BC088280    AXCN02002238    GABZ01007461    JAA46064.1    GL192338    EFB22239.1    CH916369    EDV93423.1    GFFV01003939    JAV36006.1    ACTA01016790    JH001191    RAZU01000121    EGW12718.1    RLQ71457.1    GDHF01032308    GDHF01018729    JAI20006.1    JAI33585.1    GAKP01005638    GAKP01005637    GAKP01005636    JAC53315.1    KB320660    ELW66208.1    PNJ62928.1    AACZ04057490    PNI63610.1    PNI63607.1    KB098932    ELK38464.1    PNJ62933.1    AEMK02000040    KB016731    EPY84773.1    JW875551    AFP08068.1    HAAF01008143    CCP79967.1    MKHE01000004    OWK15776.1   

Proteomes

UP000053268    UP000053240    UP000007151    UP000218220    UP000283053    UP000192223    + More
UP000002356    UP000009136    UP000002281    UP000233120    UP000009130    UP000233060    UP000233100    UP000233140    UP000028761    UP000006718    UP000001074    UP000189706    UP000233200    UP000079721    UP000286642    UP000189704    UP000050525    UP000002279    UP000029965    UP000001519    UP000265300    UP000000589    UP000011712    UP000240080    UP000008225    UP000261681    UP000252040    UP000248483    UP000010552    UP000261680    UP000233220    UP000248484    UP000002280    UP000233040    UP000248480    UP000245340    UP000245320    UP000189705    UP000233160    UP000233080    UP000095300    UP000233020    UP000005640    UP000221080    UP000002494    UP000286641    UP000075886    UP000233180    UP000018468    UP000001070    UP000081671    UP000008912    UP000001075    UP000273346    UP000286640    UP000011518    UP000018467    UP000002277    UP000245341    UP000095301    UP000261340    UP000008227    UP000248482    UP000075920   

PRIDE

Q0II50    Q91W78    Q9BQ65    Q5I0I5    G3I3J6   

Pfam

PF09749   HVSL        + More
PF11857   DUF3377
PF00413   Peptidase_M10
PF00045   Hemopexin
PF01471   PG_binding_1

Interpro

IPR027521   Usb1        + More
IPR009097   cNuc_Pdiesterase       
IPR000571   Znf_CCCH       
IPR028729   MMP15       
IPR036365   PGBD-like_sf       
IPR006026   Peptidase_Metallo       
IPR018487   Hemopexin-like_repeat       
IPR000585   Hemopexin-like_dom       
IPR021805   Pept_M10A_metallopeptidase_C       
IPR024079   MetalloPept_cat_dom_sf       
IPR018486   Hemopexin_CS       
IPR033739   M10A_MMP       
IPR021190   Pept_M10A       
IPR036375   Hemopexin-like_dom_sf       
IPR021158   Pept_M10A_Zn_BS       
IPR001818   Pept_M10_metallopeptidase       
IPR002477   Peptidoglycan-bd-like       

SUPFAM

SSF55144   SSF55144        + More
SSF50923   SSF50923       
SSF47090   SSF47090       

Gene 3D

2.110.10.10     3.40.390.10    

CDD

cd04278  ZnMc_MMP
cd00094  HX

ProteinModelPortal

A0A2H1VP25   A0A194PVL7   A0A194QNT5   A0A212F5X0   A0A2A4JLF2   A0A3S2P4V3   + More
A0A1Y1LAA8   A0A1W4WWV0   L8IE31   W5NSK8   Q0II50   F7E331   A0A146LR70   A0A2K6DT55   G7Q194   A0A0A9W5M9   A0A0K8T016   A0A2K5LU96   A0A2K5WCV2   A0A2K5Y0R0   A0A096NIX9   G7NPV9   G1P970   A0A1U7QTA9   A0A2K6NZ53   A0A1S2ZJ59   A0A3Q7VEU7   A0A1U7U1T1   A0A151MSJ5   A0A2J8VZG7   F7F9N5   A0A0D9QXM2   A0A2I2YWK7   A0A340Y540   Q91W78   A0A0R4J0E0   M3VYZ4   A0A151MSJ7   K7BU00   A0A2R9CAG8   F6TF64   A0A383YXP5   A0A341BNB4   A0A2Y9LPJ2   L5KXC0   A0A384D2F4   A0A2K6U1Q8   A0A2Y9ERW4   F6TSW3   A0A2K5PYS5   A0A2Y9DBP5   A0A2U3VLG3   A0A2U4BDZ5   A0A1U7RLK3   A0A2K6G4P4   A0A2K5JF53   A0A1I8Q4D6   A0A2K5ESR1   A0A2K5JF38   A0A0K8WIV6   A0A024R6V6   Q9BQ65   W8BAF1   A0A2D0RGM5   A0A2D0RGL2   Q5I0I5   A0A2D0RGM1   A0A3Q7QH67   A0A182QX31   K9IZD0   A0A2K6N312   D2GTY3   W5LWP7   A0A3Q7RW66   B4JFE2   A0A1S3EWS7   A0A250XXB1   G1MFP5   G3I3J6   W5LWK0   A0A3Q7SVC9   A0A0K8V4Q3   A0A034WGQ5   L9KU30   A0A2J8VZJ9   A0A3B1JHC3   H2QB80   A0A2U3YQ15   A0A2J8MVQ0   A0A1I8M3B6   L5MIK6   A0A2J8VZM2   A0A3Q0S5S4   F1RFS6   S9X8T8   V9L8C2   U6DCX2   A0A2Y9KTD7   A0A182VRX7   A0A212DC28  

PDB

4H7W     E-value=3.70175e-28,     Score=308

KEGG

101740070    K23093 U6 snRNA phosphodiesterase [EC:3.1.4.-] | (RefSeq) U6 snRNA phosphodiesterase

GO

GO:0005634   GO:1990838   GO:0034477   GO:0046872   GO:0045171   GO:0008380   GO:0000175   GO:0004518   GO:0030223   GO:0043484   GO:0008270   GO:0005887   GO:0031012   GO:0004222   GO:0005216   GO:0006811   GO:0016020   GO:0004970   GO:0005234   GO:0006260  

PANTHER

PTHR13522   PTHR10201:SF25  

Subcellular location

Nucleus  

Length:

255

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00753

Exp number, first 60 AAs:

0

Total prob of N-in:

0.06175

outside

1  -  255

 

 

Pi

120.223984

Theta

138.957278

Tajima's D

-0.497192

CLR

110.633775

CSRT

0.249787510624469

Interpretation

Uncertain