Silkworm Genome Informatics Database

Gene

KWMTBOMO06614

Pre Gene Modal

BGIBMGA011683

Annotation

Sodium/potassium-transporting_ATPase_subunit_alpha_[Papilio_xuthus]

Location

Bomo_Chr11(+):11689053-11690500 View in EpiBrowser

Full name

Sodium/potassium-transporting ATPase subunit alpha

Alternative Name

Sodium pump subunit alpha

Location in the cell

Extracellular Reliability : 1.936

CDS

ATGCAGACAATAATTTTTGTGATCGGTATCATTGTTGCGAATATTCCTGAAGGCTTACAACCTACAGTAACAGCTTCGCTAACGTTAACGGCTCAGCTAATGGTGAAGAAGCAATGTCTTGTTAAGAACTTAGATGCGATAGAGGCTTTAGGAGCATGCACTACCATTTGCTCGGATAAAACTGGTACTTTAACTCAGAACAAGATGTGTGTACATCACATTTGGATGTGGAACCAAACATACAATGTGTCAAAGATAGTTTTCCAGAGTTTGACGATATGTGGAGCTCTCTGTAGTACCGCTAGCATTCAAAGTGATGGTAATATAAGCGGCGATGCCTCAGAAAAAGCTATTTTAAATTTTTTGATGGAGCACGACAATCCAATGACCATTCGTGATAATTTTCCTAAAGTCGCAGAAATACCTTTTAATTCTGCAAATAAGTACCAAGCCAGCGTATGTCTTAACAAATATGATTCAAAATTTGTAGTACTAATGAAAGGAGCACCTGAATATATAGCCAATCGATGTGCTACCATCGCCCTAAAAACAGGAAATACCTCATTAACAACGGAAATGATGAAAGTGGTAGAATTAGCTACTGAAAAACTGGCCAACAGCGGTGAGAGGGTGTTAGCATTTGCTGATTTAACATTGAATACGAAAGAATTTCCAATTGACTTTGAATTTGACATAGATAATATTAATTTTCCACTGGACAAACTACGATTTTTAGGACTTTTAGGACTTATGGATCCTCCTAGACAAGAGGCAAGTTTGAAGTAG

Protein

MQTIIFVIGIIVANIPEGLQPTVTASLTLTAQLMVKKQCLVKNLDAIEALGACTTICSDKTGTLTQNKMCVHHIWMWNQTYNVSKIVFQSLTICGALCSTASIQSDGNISGDASEKAILNFLMEHDNPMTIRDNFPKVAEIPFNSANKYQASVCLNKYDSKFVVLMKGAPEYIANRCATIALKTGNTSLTTEMMKVVELATEKLANSGERVLAFADLTLNTKEFPIDFEFDIDNINFPLDKLRFLGLLGLMDPPRQEASLK

Catalytic Activity

ATP + H2O + K(+)(out) + Na(+)(in) = ADP + H(+) + K(+)(in) + Na(+)(out) + phosphate

Subunit

The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.

Similarity

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.

Keywords

ATP-binding Cell membrane Direct protein sequencing Ion transport Magnesium Membrane Metal-binding Nucleotide-binding Phosphoprotein Potassium Potassium transport Sodium Sodium transport Translocase Transmembrane Transmembrane helix Transport

Feature

chain Sodium/potassium-transporting ATPase subunit alpha

Uniprot

A0A2H1X0Q4 A0A2A4JVG5 A0A194PVC9 A0A3S2L7T1 A0A194QNU1 A0A212FJH3 + More
A0A0L7LLV5 A0A3B3C748 A0A3B3C542 A0A3B3DJ94 A0A0S7EVS2 A0A2A6D3E5 A0A0S7F4F7 A0A077D1P7 A0A146Z6G7 A0A3P9HTK2 A0A3Q0S5D9 A0A077D5K3 A0A3P8UIA1 A8VUU1 W5MZI4 A0A093IWW3 I6SBF7 A0A3P9JAD5 A0A146RXH2 A0A146RWM0 J9ZVP5 I4AZ64 P05025 C6YYS9 A0A1I7RVE5 A0A146Z633 A0A2H4TJD7 C6YYT2 E2DV11 A0A091PGQ2 A0A1T4J336 A0A0P7X449 A0A077D328 I4AZ66 I4AZ95 A0A1T4J318 A0A0B4PKQ8 A0A0B4PLG0 C6YYS4 A0A3Q1IRH7 A0A093GA23 I6QED3 I4AZC7 C6YYS5 A0A077D2Y0 A0A0B4PL97 C6YYT3 A0A0A7A7P1 A0A2H2IJ96 A0A091FW86 A0A1T4J322 A8VUY5 A0A1T4J328 C6YYT5 B6C823 B6C821 E2DV18 A0A2H4TJG0 I4AZ59 B6C833 C6YYT4 B6C806 A0A3Q2DJP5 A0A3P8SRR3 A0A077D4W0 A0A077CZZ0 A0A3Q1G984 A0A093EG36 A0A164WKM6 F6LGU8 A0A159UTH1 A0A164WJT9 I4AZB4 A0A3Q1CJ40 A0A172R0I6 A0A3Q2DI97 A0A3Q4MRU1 K9MFB1 I4AZ81 A0A172R0I3 A0A146Q8B1 L7P4N9 A0A172R0I9 L7P4M9 A0A1B6FCR8 A0A172R0J9 A0A3S2MGA5 L7P5I7 C6YYU4 C6YYS6 A0A172R0J0 B6C817 B6C810 B6C813

EC Number

7.2.2.13

Pubmed

26354079 22118469 26227816 29451363 18806794 17554307 + More
24487278 23142926 24947209 22531610 2993905 3008150 21909270 29122650 20805492 21490010 27029337 25186727 23321709

EMBL

ODYU01012538 SOQ58909.1 NWSH01000601 PCG75400.1 KQ459590 KPI97351.1 + More
RSAL01000097 RVE47665.1 KQ461190 KPJ07193.1 AGBW02008266 OWR53886.1 JTDY01000701 KOB76166.1 GBYX01472542 GBYX01472530 GBYX01472503 GBYX01472490 JAO09151.1 ABKE03000003 PDM84919.1 GBYX01472539 GBYX01472522 GBYX01472493 GBYX01472483 JAO09161.1 KF935928 AIL26358.1 GCES01024474 JAR61849.1 KF935847 AIL26277.1 EU184744 ABW38135.1 AHAT01034984 AHAT01034985 KK564131 KFW03259.1 JQ885970 AFM73920.1 GCES01113576 JAQ72746.1 GCES01113577 JAQ72745.1 JX508624 AB759891 AFS60173.1 BAN17690.1 JX090933 AFM10183.1 X02810 EF646435 ABV59042.1 GCES01024473 JAR61850.1 MG250924 ATY93814.1 EF646438 ABV59045.1 GU245203 ADN93769.1 KK658884 KFQ06840.1 LT795110 SJX66706.1 JARO02002942 KPP71523.1 KF935915 AIL26345.1 JX090935 JX090973 AFM10185.1 AFM10223.1 JX090934 JX090964 AFM10184.1 AFM10214.1 LT795077 SJX66683.1 KJ434888 AIS74971.1 KJ434807 AIS74890.1 EF646430 ABV59037.1 KL215658 KFV66013.1 JN180941 AFK29493.1 JX090996 AFM10246.1 EF646431 ABV59038.1 KF935840 AIL26270.1 KJ434881 AIS74964.1 EF646439 ABV59046.1 KF649219 AHB86586.1 KL447417 KFO73311.1 LT795078 SJX66684.1 EU184754 ABW38145.1 LT795083 SJX66689.1 EF646441 ABV59048.1 EF646405 ABV57440.1 EF646403 ABV57438.1 GU245210 ADN93776.1 MG250941 ATY93831.1 JX090928 AFM10178.1 EF646415 ABV57450.1 EF646440 ABV59047.1 EF646388 ABV57423.1 KF935916 AIL26346.1 KF935839 KF935907 AIL26269.1 KL243832 KFV13486.1 KU976212 AMS36800.1 HQ995989 AEE80911.1 KU976197 AMS36785.1 KU976182 AMS36770.1 JX090983 AFM10233.1 KT318960 ANE06785.1 JQ279339 AFV15610.1 JX090950 AFM10200.1 KT318963 ANE06788.1 GCES01134068 JAQ52254.1 JN882407 JN882408 JN882409 JN882410 JN882411 JN882412 JN882413 JN882414 JN882415 JN882416 JN882417 JN882418 JN882419 JN882420 JN882421 JN882422 JN882423 JN882424 JN882425 JN882426 JN882427 JN882428 JN882429 JN882430 JN882431 JN882434 JN882435 JN882436 JN882437 JN882438 JN882439 JN882440 KT318961 AFK91637.1 AFK91638.1 AFK91639.1 AFK91640.1 AFK91641.1 AFK91642.1 AFK91643.1 AFK91644.1 AFK91645.1 AFK91646.1 AFK91647.1 AFK91648.1 AFK91649.1 AFK91650.1 AFK91651.1 AFK91652.1 AFK91653.1 AFK91654.1 AFK91655.1 AFK91656.1 AFK91657.1 AFK91658.1 AFK91659.1 AFK91660.1 AFK91661.1 AFK91664.1 AFK91665.1 AFK91666.1 AFK91667.1 AFK91668.1 AFK91669.1 AFK91670.1 ANE06786.1 KT318959 KT318965 KT318966 ANE06784.1 ANE06790.1 ANE06791.1 JN882406 JN882432 JN882433 KT318950 KT318951 KT318952 KT318953 KT318954 KT318955 KT318956 KT318957 KT318958 AFK91636.1 AFK91662.1 AFK91663.1 ANE06775.1 ANE06776.1 ANE06777.1 ANE06778.1 ANE06779.1 ANE06780.1 ANE06781.1 ANE06782.1 ANE06783.1 GECZ01021753 JAS48016.1 KT318967 ANE06792.1 CM012438 RVE75278.1 JN882377 AFK91635.1 EF646450 ABV59057.1 EF646432 ABV59039.1 KT318962 ANE06787.1 EF646399 ABV57434.1 EF646392 ABV57427.1 EF646395 ABV57430.1

Proteomes

UP000218220 UP000053268 UP000283053 UP000053240 UP000007151 UP000037510 + More
UP000261560 UP000232936 UP000265200 UP000261340 UP000265120 UP000018468 UP000095284 UP000034805 UP000265040 UP000053875 UP000005237 UP000053760 UP000265020 UP000265080 UP000257200 UP000257160 UP000261580

PRIDE

P05025

Pfam

PF00690 Cation_ATPase_N + More
PF00689 Cation_ATPase_C

Interpro

IPR023214   HAD_sf        + More
IPR036412   HAD-like_sf
IPR023299   ATPase_P-typ_cyto_dom_N
IPR023298   ATPase_P-typ_TM_dom_sf
IPR006068   ATPase_P-typ_cation-transptr_C
IPR008250   ATPase_P-typ_transduc_dom_A_sf
IPR001757   P_typ_ATPase
IPR004014   ATPase_P-typ_cation-transptr_N
IPR018303   ATPase_P-typ_P_site
IPR005775   P-type_ATPase_IIC

SUPFAM

SSF81665   SSF81665        + More
SSF81660   SSF81660
SSF81653   SSF81653
SSF56784   SSF56784

Gene 3D

3.40.1110.10 3.40.50.1000

CDD

cd02608 P-type_ATPase_Na-K_like

ProteinModelPortal

A0A2H1X0Q4 A0A2A4JVG5 A0A194PVC9 A0A3S2L7T1 A0A194QNU1 A0A212FJH3 + More
A0A0L7LLV5 A0A3B3C748 A0A3B3C542 A0A3B3DJ94 A0A0S7EVS2 A0A2A6D3E5 A0A0S7F4F7 A0A077D1P7 A0A146Z6G7 A0A3P9HTK2 A0A3Q0S5D9 A0A077D5K3 A0A3P8UIA1 A8VUU1 W5MZI4 A0A093IWW3 I6SBF7 A0A3P9JAD5 A0A146RXH2 A0A146RWM0 J9ZVP5 I4AZ64 P05025 C6YYS9 A0A1I7RVE5 A0A146Z633 A0A2H4TJD7 C6YYT2 E2DV11 A0A091PGQ2 A0A1T4J336 A0A0P7X449 A0A077D328 I4AZ66 I4AZ95 A0A1T4J318 A0A0B4PKQ8 A0A0B4PLG0 C6YYS4 A0A3Q1IRH7 A0A093GA23 I6QED3 I4AZC7 C6YYS5 A0A077D2Y0 A0A0B4PL97 C6YYT3 A0A0A7A7P1 A0A2H2IJ96 A0A091FW86 A0A1T4J322 A8VUY5 A0A1T4J328 C6YYT5 B6C823 B6C821 E2DV18 A0A2H4TJG0 I4AZ59 B6C833 C6YYT4 B6C806 A0A3Q2DJP5 A0A3P8SRR3 A0A077D4W0 A0A077CZZ0 A0A3Q1G984 A0A093EG36 A0A164WKM6 F6LGU8 A0A159UTH1 A0A164WJT9 I4AZB4 A0A3Q1CJ40 A0A172R0I6 A0A3Q2DI97 A0A3Q4MRU1 K9MFB1 I4AZ81 A0A172R0I3 A0A146Q8B1 L7P4N9 A0A172R0I9 L7P4M9 A0A1B6FCR8 A0A172R0J9 A0A3S2MGA5 L7P5I7 C6YYU4 C6YYS6 A0A172R0J0 B6C817 B6C810 B6C813

PDB

5Y0B E-value=3.08548e-44, Score=447

KEGG

101741364 K01539 sodium/potassium-transporting ATPase subunit alpha [EC:7.2.2.13] | (RefSeq) sodium/potassium-

GO

GO:0016021 GO:0005524 GO:0008556 GO:0046872 GO:0000166 GO:0006813 GO:0006814 GO:0005886 GO:0000003 GO:0006937 GO:0001508 GO:0005391 GO:0016787 GO:0004003 GO:0006289 GO:0006367 GO:0006811 GO:0016020 GO:0005634 GO:0006260

Subcellular location

Membrane
Cell membrane

SignalP

Position: 1 - 18, Likelihood: 0.713415

Length:

261

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.86347

Exp number, first 60 AAs:

1.80162

Total prob of N-in:

0.09271

outside

1 - 261

Pi

146.416774

Theta

151.828449

Tajima's D

-0.112053

CLR

0.622056

CSRT

0.342382880855957

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics