Silkworm Genome Informatics Database

Gene

KWMTBOMO06610 Validated by peptides from experiments

Pre Gene Modal

BGIBMGA011681

Annotation

PREDICTED:_type_I_phosphatidylinositol_4?5-bisphosphate_4-phosphatase-A_[Papilio_machaon]

Location

Bomo_Chr11(+):11625273-11634921 View in EpiBrowser

Full name

Phosphatidylinositol-4,5-bisphosphate 4-phosphatase

Location in the cell

Extracellular Reliability : 1.961 PlasmaMembrane Reliability : 1.343

CDS

ATGGGGGACAGCCAAAGTGAAAATCAAGCTTTGCTGAGAATTGAAGAGGTCGCATGTGATGATGTGAGCACAATCTCCCCAATTGGGCCCGATGAGTTGCCTCCGCCATATCAACAAGTAGGGATGCCTATGGTCTCTTGCCGAGTGTGCCAAGCACTGATTGACATTCGTGGGAAAAAAGAGCAACATGTAGTGAAATGTTCAGAATGCAAAGAAGCTACGCCTATAAAGAATGCTCCGCCAGGCAAGAAGTATGTTCGGTGCCCTTGCAATTGCCTACTAATTTGCAAGTCATCTTCGCAACGTATAGCTTGTCCTCGTGCTGATTGCAAGAGGATTATCAACCTAGCACCATCACCAGTTACTCCACCTGTGCCCACTCTGCCCGGCATGGATAGAGTAATCTGTGCACATTGTCAAGACACATTCTTGAAAGCCACAATGGGGGACAGCCAAAGTGAAAATCAAGCTTTGCTGAGAATTGAAGAGGTCGCATGTGATGATGTGAGCACAATCTCCCCAATTGGGCCCGATGAGTTGCCTCCGCCATATCAACAAGTAGGGATGCCTATGGTCTCTTGCCGAGTGTGCCAAGCACTGATTGACATTCGTGGGAAAAAAGAGCAACATGTAGTGAAATGTTCAGAATGCAAAGAAGCTACGCCTATAAAGAATGCTCCGCCAGGCAAGAAGTATGTTCGGTGCCCTTGCAATTGCCTACTAATTTGCAAGTCATCTTCGCAACGTATAGCTTGTCCTCGTGCTGATTGCAAGAGGATTATCAACCTAGCACCATCACCAGTTACTCCACCTGTGCCCACTCTGCCCGGCATGGATAGAGTAATCTGTGCACATTGTCAAGACACATTCTTGTATCAATCTCTGAAGAACATGCCTGTTCGGTGTCCTCACTGTCGGAAGGTATCATTTGTTCGTTCACCATCCGGCGGTTCCAAAGCTCGAGTTAAAGGTATTATATTTGCTGTTCTGGCTGTAATTTTCCTTATCATTGCTTTGGGTGTCACCCTTGGCACATTGTCTGCGGCAAAAGCTCACGGCGGCGGAATCTTTGTGGCTTATGTGGGAGCGTTCCTGGTCTCCGTCATATTGGCCAGTCGTGCCGTCTACTACTTCAGGATGAAAGAGAGTTCCATCGAAGGAACGATGTAA

Protein

MGDSQSENQALLRIEEVACDDVSTISPIGPDELPPPYQQVGMPMVSCRVCQALIDIRGKKEQHVVKCSECKEATPIKNAPPGKKYVRCPCNCLLICKSSSQRIACPRADCKRIINLAPSPVTPPVPTLPGMDRVICAHCQDTFLKATMGDSQSENQALLRIEEVACDDVSTISPIGPDELPPPYQQVGMPMVSCRVCQALIDIRGKKEQHVVKCSECKEATPIKNAPPGKKYVRCPCNCLLICKSSSQRIACPRADCKRIINLAPSPVTPPVPTLPGMDRVICAHCQDTFLYQSLKNMPVRCPHCRKVSFVRSPSGGSKARVKGIIFAVLAVIFLIIALGVTLGTLSAAKAHGGGIFVAYVGAFLVSVILASRAVYYFRMKESSIEGTM

Description

Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate.

Catalytic Activity

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate

Uniprot

A0A195BXM7 A0A195EST2

EC Number

3.1.3.78

EMBL

KQ976398 KYM92701.1 KQ981979 KYN31310.1

Proteomes

UP000078540 UP000078541

Pfam

PF09788 Tmemb_55A

Interpro

IPR019178 PtdIns-P2-Ptase

ProteinModelPortal

A0A195BXM7 A0A195EST2

KEGG

101741980 K13084 phosphatidylinositol-4,5-bisphosphate 4-phosphatase [EC:3.1.3.78] | (RefSeq) type 1 phosphati

GO

GO:0016021 GO:0034597 GO:0005765 GO:0046856 GO:0031902 GO:0005524 GO:0016787 GO:0004003 GO:0006289 GO:0006367 GO:0006811 GO:0016020 GO:0005634 GO:0006260

PANTHER

PTHR21014

Subcellular location

Late endosome membrane
Lysosome membrane

Length:

389

Number of predicted TMHs:

2

Exp number of AAs in TMHs:

44.471

Exp number, first 60 AAs:

0.0025

Total prob of N-in:

0.79880

inside

1 - 323

TMhelix

324 - 346

outside

347 - 355

TMhelix

356 - 378

inside

379 - 389

Pi

187.795557

Theta

144.05667

Tajima's D

-0.99088

CLR

0

CSRT

0.142592870356482

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics

Multiple alignment of Orthologues

Gene Tree