Gene

KWMTBOMO06585

Pre Gene Modal

BGIBMGA011669

Annotation

PREDICTED:_N-alpha-acetyltransferase_60_[Bombyx_mori]

Location

Bomo_Chr11(+):11104892-11115763      View in EpiBrowser

Full name

N-alpha-acetyltransferase 60      

Alternative Name

NatF catalytic subunit

Location in the cell

PlasmaMembrane   Reliability : 3.824

CDS

ATGGCTGGGTTTAGCTGGTATCTGTCTGAAGGCTTCCAAGTTATAATTGAGAAGTCTAAAGACAAGAAATGCTCTCTAAAAGATGTACAATTACGTTTCTTGTGCCCTGATGATTTAGAAGAGGTTAGGTCTCTGTGCAGAGACTGGTTTCCTATCGAATACCCGCAGTCTTGGTATGAAGACATCACATCCTCGGACAGGTTCTTCGCGCTCGCGGCAGTGTACAAGAACCAGATCATAGGTCTCATTGTTGCCGAAATAAAACCTTATTTAAAACTGAATGCCGAAGACAGAGGTATCTTGTCGAGATGGTTCGCTTCCAAGGATACATTAGTTGCTTATATATTGTCATTGGGAGTGGTGCGTTCGCACCGTCGTTCAGGGGTGGCAACGATGCTGCTCGATGTTCTGATCAACCACCTGTCGGGGCCGGTGCCCCAGCCGCCGCACGAACATCGAGTCAAGGCTATATTTCTGCACGTCCTCACGACCAACAACGAGGCTATACTGTTTTATGAACACAAAAGATTCCTTCTACACTCGTTTCTTCCGTACTACTACTCGATAAAGGGCCGTTGTAAAGACGGTTTCACATACGTGTACTATGTGAACGGGGGCCACGCGCCGTGGAGCCTCATCGACTACATGAAGTTCATGGCTCGGACAGCGTGGAGGGGCGGAGGCCTATATCCGTGGCTGTGGGGGAAACTGAGAGCGGCGCTCACTATAGCGTGGCACAGTTTTACGTCGTCTTCGAATACTGTAAAATTTAGGGGTGCGGTATACTGA

Protein

MAGFSWYLSEGFQVIIEKSKDKKCSLKDVQLRFLCPDDLEEVRSLCRDWFPIEYPQSWYEDITSSDRFFALAAVYKNQIIGLIVAEIKPYLKLNAEDRGILSRWFASKDTLVAYILSLGVVRSHRRSGVATMLLDVLINHLSGPVPQPPHEHRVKAIFLHVLTTNNEAILFYEHKRFLLHSFLPYYYSIKGRCKDGFTYVYYVNGGHAPWSLIDYMKFMARTAWRGGGLYPWLWGKLRAALTIAWHSFTSSSNTVKFRGAVY

Description

Displays alpha (N-terminal) acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase.
Isoform A: Shows histone acetyltransferase activity toward free histones.
Isoform B: Does not show histone acetyltransferase activity toward free histones.

Catalytic Activity

acetyl-CoA + N-terminal L-methionyl-[transmembrane protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein]
acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]

Similarity

Belongs to the acetyltransferase family. NAA60 subfamily.

Keywords

Acyltransferase   Alternative splicing   Chromatin regulator   Chromosome partition   Complete proteome   Reference proteome   Transferase  

Feature

chain  N-alpha-acetyltransferase 60
splice variant  In isoform B and isoform C.

Uniprot

H9JQ63   A0A2W1BRR9   A0A2H1VSZ3   A0A212EL51   A0A194QNZ0   A0A194PV85   + More
A0A0L7KYZ1   A0A1Y1L6H4   A0A139WK49   A0A0P6J6A3   A0A1Q3G351   A0A182JG47   A0A182XEX5   A0A1Y1L305   A0A2M3ZB36   A0A2M4BXH6   A0A2M4AU45   A0A2M4CKK6   A0A2M4CKE3   A0A2M4CKC5   A0A1Y9INA8   A0A1L8DCV4   A0A182H3N9   A0A023EJQ4   A0A067QKR8   U5EL81   A0A0J9RTX3   Q95SX8-2   B3NGL1   B4HLA1   A0A0K8TKZ5   B4PEC9   A0A1Y1L7W5   D6WGD7   A0A0A9XY07   B3MA74   A0A1W4U9U8   B4L0K6   A0A182T5X9   E2C870   A0A1S4GND8   B4LGA7   A0A1I8NF75   A0A0L7QRE9   A0A151X239   A0A2M4DSE6   B4J2P6   A0A195EU61   A0A182RX08   A0A2M3ZJ68   F4W499   A0A195B3J0   B4N4A1   A0A158NFW6   A0A151INW9   E9IE22   A0A182M1M3   A0A182N1Q6   A0A1B6BXA0   A0A026VUY1   B5DQ59   B4HAF6   A0A1I8QAL0   A0A0M9AB05   A0A2A3EM93   V9II72   A0A088AAN9   Q7PQ00   K7IR38   T1GN36   A0A1B6LDQ0   A0A182HP01   A0A1B0D7I0   A0A1B6IIX5   A0A1B6GW07   B4QNN5   A0A1Y1L5A3   Q95SX8   A0A224XW67   A0A069DRG7   A0A0J9UIB6   A0A0Q5U3R3   A0A0K8V4V0   A0A034WBA5   A0A195E5M6   E2A733   A0A0R1DUX1   Q95SX8-3   A0A0P8YG23   A0A0A1WUK0   A0A1W4UL81   A0A1A9YEB9   A0A1B0AVM4   A0A0Q9XLY8   A0A0T6ASX3   A0A0K8VZU5   A0A0Q9WJ68   B0WH57   J3JVU9   A0A0A1X4X6  

EC Number

2.3.1.259
2.3.1.48

Pubmed

19121390    28756777    22118469    26354079    26227816    28004739    + More
18362917    19820115    26999592    26483478    24945155    24845553    22936249    10731132    12537572    12537569    21981917    21750686    17994087    26369729    17550304    25401762    26823975    20798317    12364791    25315136    21719571    21347285    21282665    24508170    30249741    15632085    20075255    26334808    25348373    25830018    22516182   

EMBL

BABH01012076    KZ150049    PZC74453.1    ODYU01004271    SOQ43965.1    AGBW02014142    + More
OWR42197.1    KQ461190    KPJ07232.1    KQ459590    KPI97311.1    JTDY01004183    KOB68488.1    GEZM01068121    JAV67166.1    KQ971329    KYB28350.1    GDUN01000180    JAN95739.1    GFDL01000876    JAV34169.1    GEZM01068118    JAV67168.1    GGFM01004972    MBW25723.1    GGFJ01008636    MBW57777.1    GGFK01010998    MBW44319.1    GGFL01001597    MBW65775.1    GGFL01001595    MBW65773.1    GGFL01001596    MBW65774.1    GFDF01009940    JAV04144.1    JXUM01107731    KQ565169    KXJ71257.1    GAPW01004312    JAC09286.1    KK853239    KDR09509.1    GANO01001522    JAB58349.1    CM002912    KMY98744.1    AE014296    AY060437    BT001491    AAL25476.1    AAS65049.1    CH954178    EDV51247.1    CH480815    EDW40920.1    GDAI01002770    JAI14833.1    CM000159    EDW92967.1    GEZM01068119    JAV67167.1    EFA01153.1    GBHO01021469    GBRD01010193    GDHC01010432    GDHC01008823    GDHC01000313    JAG22135.1    JAG55631.1    JAQ08197.1    JAQ09806.1    JAQ18316.1    CH902618    EDV39088.1    CH933809    EDW18083.1    GL453568    EFN75873.1    AAAB01008900    CH940647    EDW69415.1    KQ414784    KOC61129.1    KQ982585    KYQ54326.1    GGFL01016299    MBW80477.1    CH916366    EDV96037.1    KQ981979    KYN31442.1    GGFM01007737    MBW28488.1    GL887491    EGI71095.1    KQ976625    KYM79058.1    CH964095    EDW78975.1    ADTU01001538    KQ976932    KYN07038.1    GL762556    EFZ21140.1    AXCM01001477    GEDC01031410    JAS05888.1    KK107847    QOIP01000005    EZA47485.1    RLU23041.1    CH379069    EDY73726.1    CH479240    EDW37554.1    KQ435711    KOX79479.1    KZ288210    PBC32923.1    JR046405    AEY60186.1    EAA09480.5    CAQQ02182124    CAQQ02182125    GEBQ01018162    JAT21815.1    APCN01002823    AJVK01026926    GECU01020845    JAS86861.1    GECZ01003194    JAS66575.1    CM000363    EDX09902.1    GEZM01068122    JAV67165.1    GFTR01004225    JAW12201.1    GBGD01002603    JAC86286.1    KMY98745.1    KQS43727.1    GDHF01018347    JAI33967.1    GAKP01007375    JAC51577.1    KQ979609    KYN20197.1    GL437252    EFN70765.1    KRK00845.1    KPU77885.1    GBXI01012097    JAD02195.1    JXJN01004319    KRG05950.1    LJIG01022892    KRT78193.1    GDHF01007958    JAI44356.1    KRF84386.1    DS231933    EDS27564.1    BT127367    AEE62329.1    GBXI01008554    JAD05738.1   

Proteomes

UP000005204    UP000007151    UP000053240    UP000053268    UP000037510    UP000007266    + More
UP000075880    UP000076407    UP000075902    UP000069940    UP000249989    UP000027135    UP000000803    UP000008711    UP000001292    UP000002282    UP000007801    UP000192221    UP000009192    UP000075901    UP000008237    UP000008792    UP000095301    UP000053825    UP000075809    UP000001070    UP000078541    UP000075900    UP000007755    UP000078540    UP000007798    UP000005205    UP000078542    UP000075883    UP000075884    UP000053097    UP000279307    UP000001819    UP000008744    UP000095300    UP000053105    UP000242457    UP000005203    UP000007062    UP000002358    UP000015102    UP000075840    UP000092462    UP000000304    UP000078492    UP000000311    UP000092443    UP000092460    UP000002320   

PRIDE

H9JQ63    Q95SX8   

Pfam

PF00583   Acetyltransf_1

Interpro

IPR000182   GNAT_dom        + More
IPR016181   Acyl_CoA_acyltransferase       

SUPFAM

SSF55729   SSF55729       

ProteinModelPortal

H9JQ63   A0A2W1BRR9   A0A2H1VSZ3   A0A212EL51   A0A194QNZ0   A0A194PV85   + More
A0A0L7KYZ1   A0A1Y1L6H4   A0A139WK49   A0A0P6J6A3   A0A1Q3G351   A0A182JG47   A0A182XEX5   A0A1Y1L305   A0A2M3ZB36   A0A2M4BXH6   A0A2M4AU45   A0A2M4CKK6   A0A2M4CKE3   A0A2M4CKC5   A0A1Y9INA8   A0A1L8DCV4   A0A182H3N9   A0A023EJQ4   A0A067QKR8   U5EL81   A0A0J9RTX3   Q95SX8-2   B3NGL1   B4HLA1   A0A0K8TKZ5   B4PEC9   A0A1Y1L7W5   D6WGD7   A0A0A9XY07   B3MA74   A0A1W4U9U8   B4L0K6   A0A182T5X9   E2C870   A0A1S4GND8   B4LGA7   A0A1I8NF75   A0A0L7QRE9   A0A151X239   A0A2M4DSE6   B4J2P6   A0A195EU61   A0A182RX08   A0A2M3ZJ68   F4W499   A0A195B3J0   B4N4A1   A0A158NFW6   A0A151INW9   E9IE22   A0A182M1M3   A0A182N1Q6   A0A1B6BXA0   A0A026VUY1   B5DQ59   B4HAF6   A0A1I8QAL0   A0A0M9AB05   A0A2A3EM93   V9II72   A0A088AAN9   Q7PQ00   K7IR38   T1GN36   A0A1B6LDQ0   A0A182HP01   A0A1B0D7I0   A0A1B6IIX5   A0A1B6GW07   B4QNN5   A0A1Y1L5A3   Q95SX8   A0A224XW67   A0A069DRG7   A0A0J9UIB6   A0A0Q5U3R3   A0A0K8V4V0   A0A034WBA5   A0A195E5M6   E2A733   A0A0R1DUX1   Q95SX8-3   A0A0P8YG23   A0A0A1WUK0   A0A1W4UL81   A0A1A9YEB9   A0A1B0AVM4   A0A0Q9XLY8   A0A0T6ASX3   A0A0K8VZU5   A0A0Q9WJ68   B0WH57   J3JVU9   A0A0A1X4X6  

PDB

5HH0     E-value=3.17029e-59,     Score=577

KEGG

101739089    K21121 N-alpha-acetyltransferase 60 [EC:2.3.1.259] | (RefSeq) N-alpha-acetyltransferase 60

GO

GO:0016740   GO:0000139   GO:0043967   GO:0004596   GO:0043966   GO:0017196   GO:0016021   GO:0016746   GO:0016573   GO:0005737   GO:0007059   GO:0004402   GO:0010485   GO:0008080   GO:0006397   GO:0016788   GO:0008094   GO:0000166   GO:0015299   GO:0006419   GO:0015923   GO:0005634   GO:0006260  

Length:

262

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.87222

Exp number, first 60 AAs:

0

Total prob of N-in:

0.02461

outside

1  -  262

 

 

Pi

284.832592

Theta

203.286907

Tajima's D

0.143818

CLR

0.203568

CSRT

0.411679416029199

Interpretation

Uncertain