Gene

KWMTBOMO06582  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA011667

Annotation

Aprataxin_[Operophtera_brumata]

Location

Bomo_Chr11(+):11055422-11056246      View in EpiBrowser

Full name

Aprataxin       + More
Aprataxin-like protein      

Alternative Name

Forkhead-associated domain histidine triad-like protein

Location in the cell

Nuclear   Reliability : 2.32

CDS

ATGAGTAAGAGAAAAAATACTACTTCCAGTATACCTTCAAAAACACCAAAACATTGGTCTTTAGGACTCATTGCATCGATGAAAGACCCTAATTCAATTATAAAAAATACAGAAAAAGTTGTTGTTATAAAAGATAAGTATCCAAAAGCTAAAGTACATTACCTTGTATTACCTCATGAAGAAATCAATAGCATTTACAAATTAAATAAATCACACATCAGTTTACTTGAAGAATTTGGTAACATCTTTAAAGAATTAAAGGAAGAAAATGAATCTGAACTTAGAGCTGGTTTTCACGCAATACCTAGTATGCAGAGAATGCACATGCATGTTATTAGCACAGACATGATATCCACATCCCTCAAAACAAAAATACATTGGAATAGTTTCTGTACAAAGTTTTTTATTCCCTACGATGAATTACTTCAAGAACTAAAAGACATTGGTAACATAAGGAAGATTCCTTCAGAATTGCATACTTCACTAATGAAAACTCCACTGCAATGCAATCAATGTTCATTCAAACCAAAAAACATGCCTGAATTAAAAGATCATTTATTAAAACATCAACTTTTATAA

Protein

MSKRKNTTSSIPSKTPKHWSLGLIASMKDPNSIIKNTEKVVVIKDKYPKAKVHYLVLPHEEINSIYKLNKSHISLLEEFGNIFKELKEENESELRAGFHAIPSMQRMHMHVISTDMISTSLKTKIHWNSFCTKFFIPYDELLQELKDIGNIRKIPSELHTSLMKTPLQCNQCSFKPKNMPELKDHLLKHQLL

Description

DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (By similarity). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity).
DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (By similarity).
DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (PubMed:16964241). Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (By similarity). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity).

Catalytic Activity

adenosine-5'-diphospho-5'-(DNA) + H2O = AMP + 2 H(+) + phospho-5'-(DNA)
adenosine-5'-diphospho-5'-(ribonucleotide)-(DNA) + H2O = 5'-phospho-(ribonucleotide)-(DNA) + AMP + 2 H(+)
(DNA)-3'-diphospho-5'-guanosine + H2O = (DNA)-3'-phosphate + GMP + 2 H(+)

Keywords

Complete proteome   DNA damage   DNA repair   DNA-binding   Hydrolase   Metal-binding   Nucleus   Reference proteome   Zinc   Zinc-finger   Alternative splicing  

Feature

chain  Aprataxin
splice variant  In isoform D.

Uniprot

H9JQ61   A0A2A4J3D9   A0A0L7L1C0   E3UKI3   A0A3S2NND4   A0A2W1BMF4   + More
R4ITB0   A0A2H1VH84   S4NU31   A0A194PX23   A0A212EL28   A0A194QPF1   E2BV94   A0A151WJH9   A0A026WSJ4   E2A087   T1GHJ7   A0A1Y1N3B0   A0A1Y1N8F8   A0A154NYR0   A0A1A9W9D6   F4WGF1   E9IBB7   D6WH85   A0A0L7QY36   A0A1A9Z3S4   A0A1A9VVX5   A0A2Z5TRA0   A0A1A9XFK4   A0A2A3ENG6   V9IMM9   A0A1I8NNQ0   A0A195CKI6   A0A087ZVY3   B4JZ01   A0A0T6B2V2   A0A0Q9X527   B4LZ11   A0A1B0BXU0   A0A2J7QGU7   A0A067QVZ6   K7JAB6   A0A1B0CB23   B4KD53   A0A1I8NNQ9   A0A1I8MHL3   A0A195F049   A0A0N7Z8N8   A0A069DNQ8   T1I915   A0A2P8Y6G9   A0A232EJM0   N6TYI2   A0A0V0GCY0   J3JU32   A0A0N0BJ39   B3P0B6   B4IHV4   A0A1B0D039   B4QTD4   A0A1W4WAF8   A0A1W4W9A3   P61802   A0A1Q3FDH6   A0A0K8V0Z9   A0A1X7UPR7   F6TMD1   Q16F08   A0A0P4WA49   B4PNG7   A0A1S3IFF8   A0A1S4G3A9   R7TVN5   B3M255   U3J7M8   A0A1S3HE27   A0A091REX9   A0A1V4J5J7   A0A1Y1V7A7   A0A0R1EEH6   A0A093HQ18   A0A1B6J235   H2Z7Z8   A0A093C8G2   Q8MSG8   A0A1Y2ANP7   A0A099ZTS0   G1N246   B0W3D1   C3ZFB4   A0A0P6C2V2   P61798   A0A091NA75   A0A091ET46   F1P5K8   A0A2I0M5F3   U3JES6   A0A0R1E246   A0A093PVG9   A0A3B3SUZ1  

EC Number

3.1.11.7
3.1.12.2
3.-.-.-

Pubmed

19121390    26227816    28756777    23622113    26354079    22118469    + More
20798317    24508170    30249741    28004739    21719571    21282665    18362917    19820115    26760975    17994087    18057021    24845553    20075255    25315136    27129103    26334808    29403074    28648823    23537049    22516182    12481130    15114417    17510324    17550304    23254933    23749191    10731132    12537572    12537569    20838655    18563158    16964241    15592404    23371554    29240929   

EMBL

BABH01012081    NWSH01003314    PCG66575.1    JTDY01003602    KOB69282.1    HM449857    + More
ADO32992.1    RSAL01000209    RVE44246.1    KZ150049    PZC74457.1    JQ744280    AGC39046.1    ODYU01002361    SOQ39762.1    GAIX01011971    JAA80589.1    KQ459590    KPI97314.1    AGBW02014142    OWR42194.1    KQ461190    KPJ07229.1    GL450824    EFN80386.1    KQ983039    KYQ48033.1    KK107111    QOIP01000011    EZA58953.1    RLU16969.1    GL435556    EFN73147.1    CAQQ02094449    GEZM01015066    JAV91908.1    GEZM01015067    JAV91907.1    KQ434783    KZC04702.1    GL888128    EGI66918.1    GL762111    EFZ22153.1    KQ971330    EFA00986.1    KQ414699    KOC63466.1    FX985763    BBA93650.1    KZ288214    PBC32792.1    JR052646    AEY61749.1    KQ977622    KYN01236.1    CH916378    EDV98616.1    LJIG01016109    KRT81588.1    CH964272    KRF99894.1    CH940650    EDW68114.1    KRF83682.1    JXJN01022355    NEVH01014359    PNF27812.1    KK852879    KDR14453.1    AAZX01001080    AJWK01004777    CH933806    EDW14835.1    KQ981897    KYN33731.1    GDKW01002827    JAI53768.1    GBGD01003186    JAC85703.1    ACPB03001920    PYGN01000871    PSN39836.1    NNAY01003970    OXU18557.1    APGK01006429    APGK01031767    KB740823    KB736762    KB632374    ENN78840.1    ENN83138.1    ERL93803.1    GECL01000161    JAP05963.1    BT126744    AEE61706.1    KQ435724    KOX78364.1    CH954181    EDV48490.1    CH480840    EDW49471.1    AJVK01009808    AJVK01009809    CM000364    EDX12336.1    AY208848    GFDL01009414    JAV25631.1    GDHF01020074    JAI32240.1    EAAA01002475    CH478533    EAT32819.1    GDRN01069276    JAI64074.1    CM000160    EDW96030.2    AMQN01002135    AMQN01002136    AMQN01002137    KB308479    ELT97774.1    CH902617    EDV43379.2    ADON01053806    ADON01053807    ADON01053808    ADON01053809    ADON01053810    ADON01053811    ADON01053812    ADON01053813    ADON01053814    ADON01053815    KK700842    KFQ27197.1    LSYS01009041    OPJ67409.1    MCFH01000025    ORX48987.1    CH894455    KRK05588.1    KL206350    KFV81540.1    GECU01014457    JAS93249.1    KL460165    KFV12220.1    AE014297    AY118832    BT011192    BT012473    MCOG01000229    ORY23837.1    KL898210    KGL85191.1    DS231831    EDS31274.1    GG666612    EEN49420.1    GDIP01010189    JAM93526.1    AY208845    KK827131    KFP73576.1    KK718913    KFO59767.1    AC192757    AKCR02000037    PKK24907.1    AGTO01001226    KRK02846.1    KL670897    KFW80431.1   

Proteomes

UP000005204    UP000218220    UP000037510    UP000283053    UP000053268    UP000007151    + More
UP000053240    UP000008237    UP000075809    UP000053097    UP000279307    UP000000311    UP000015102    UP000076502    UP000091820    UP000007755    UP000007266    UP000053825    UP000092445    UP000078200    UP000092443    UP000242457    UP000095300    UP000078542    UP000005203    UP000001070    UP000007798    UP000008792    UP000092460    UP000235965    UP000027135    UP000002358    UP000092461    UP000009192    UP000095301    UP000078541    UP000015103    UP000245037    UP000215335    UP000019118    UP000030742    UP000053105    UP000008711    UP000001292    UP000092462    UP000000304    UP000192223    UP000192221    UP000008144    UP000007879    UP000008820    UP000002282    UP000085678    UP000014760    UP000007801    UP000016666    UP000190648    UP000193719    UP000053584    UP000007875    UP000000803    UP000193920    UP000053641    UP000001645    UP000002320    UP000001554    UP000000539    UP000052976    UP000053872    UP000016665    UP000053258    UP000261540   

PRIDE

H9JQ61    Q8MSG8    P61798   

Pfam

PF16278   zf-C2HE        + More
PF00089   Trypsin
PF17913   FHA_2

Interpro

IPR036265   HIT-like_sf        + More
IPR011146   HIT-like       
IPR032566   Znf-C2HE       
IPR019808   Histidine_triad_CS       
IPR013087   Znf_C2H2_type       
IPR009003   Peptidase_S1_PA       
IPR001254   Trypsin_dom       
IPR033116   TRYPSIN_SER       
IPR008984   SMAD_FHA_dom_sf       
IPR000253   FHA_dom       
IPR041388   FHA_2       

SUPFAM

SSF54197   SSF54197        + More
SSF50494   SSF50494       
SSF49879   SSF49879       

Gene 3D

3.30.428.10    

CDD

cd00060  FHA

ProteinModelPortal

H9JQ61   A0A2A4J3D9   A0A0L7L1C0   E3UKI3   A0A3S2NND4   A0A2W1BMF4   + More
R4ITB0   A0A2H1VH84   S4NU31   A0A194PX23   A0A212EL28   A0A194QPF1   E2BV94   A0A151WJH9   A0A026WSJ4   E2A087   T1GHJ7   A0A1Y1N3B0   A0A1Y1N8F8   A0A154NYR0   A0A1A9W9D6   F4WGF1   E9IBB7   D6WH85   A0A0L7QY36   A0A1A9Z3S4   A0A1A9VVX5   A0A2Z5TRA0   A0A1A9XFK4   A0A2A3ENG6   V9IMM9   A0A1I8NNQ0   A0A195CKI6   A0A087ZVY3   B4JZ01   A0A0T6B2V2   A0A0Q9X527   B4LZ11   A0A1B0BXU0   A0A2J7QGU7   A0A067QVZ6   K7JAB6   A0A1B0CB23   B4KD53   A0A1I8NNQ9   A0A1I8MHL3   A0A195F049   A0A0N7Z8N8   A0A069DNQ8   T1I915   A0A2P8Y6G9   A0A232EJM0   N6TYI2   A0A0V0GCY0   J3JU32   A0A0N0BJ39   B3P0B6   B4IHV4   A0A1B0D039   B4QTD4   A0A1W4WAF8   A0A1W4W9A3   P61802   A0A1Q3FDH6   A0A0K8V0Z9   A0A1X7UPR7   F6TMD1   Q16F08   A0A0P4WA49   B4PNG7   A0A1S3IFF8   A0A1S4G3A9   R7TVN5   B3M255   U3J7M8   A0A1S3HE27   A0A091REX9   A0A1V4J5J7   A0A1Y1V7A7   A0A0R1EEH6   A0A093HQ18   A0A1B6J235   H2Z7Z8   A0A093C8G2   Q8MSG8   A0A1Y2ANP7   A0A099ZTS0   G1N246   B0W3D1   C3ZFB4   A0A0P6C2V2   P61798   A0A091NA75   A0A091ET46   F1P5K8   A0A2I0M5F3   U3JES6   A0A0R1E246   A0A093PVG9   A0A3B3SUZ1  

PDB

6CVR     E-value=1.10188e-30,     Score=328

KEGG

101744383    K10863 aprataxin [EC:3.1.11.7 3.1.11.8 3.1.12.2] | (RefSeq) aprataxin-like protein

GO

GO:0003677   GO:0033699   GO:0006281   GO:1990165   GO:0000012   GO:0003725   GO:0030983   GO:0005634   GO:0003697   GO:0006302   GO:0016021   GO:0004252   GO:0003676   GO:0005730   GO:0120108   GO:0046872   GO:0005654   GO:0003684   GO:0016787   GO:0071011   GO:0000398   GO:0031647   GO:0008967   GO:0003682   GO:0047485   GO:0003690   GO:0042542   GO:0006266   GO:0000790   GO:0051219   GO:0003824   GO:0030001   GO:0046873   GO:0008094   GO:0000166   GO:0015299   GO:0006419   GO:0015923   GO:0006260  

Subcellular location

Nucleus  
Nucleoplasm  
Nucleolus  

Length:

192

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00202

Exp number, first 60 AAs:

0

Total prob of N-in:

0.47928

outside

1  -  192

 

 

Pi

126.063961

Theta

131.229035

Tajima's D

0.092929

CLR

0

CSRT

0.3990800459977

Interpretation

Uncertain